In vivo [11C]Flumazenil-PET correlates with ex vivo [3H]Flumazenil autoradiography in hippocampal sclerosis

Annals of Neurology

Volumn 43, Issue 5, 1998, Pages 618-626

  Koepp, Matthias J ^a,b   Hand, Kieran S P ^c   Labbé, Claire ^a   Richardson, Mark P ^a,b   Van Paesschen, Wim ^b   Baird, Virginia H ^d   Cunningham, Vincent J ^a   Bowery, Norman G ^d   Brooks, David J ^a   Duncan, John S ^a,b  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF LONDON   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BENZODIAZEPINE RECEPTOR; FLUMAZENIL; CARBON; DIAGNOSTIC AGENT; TRITIUM;

ADULT; ARTICLE; AUTORADIOGRAPHY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; INTRAVENOUS DRUG ADMINISTRATION; MALE; NEUROSURGERY; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCLEROSIS; TEMPORAL LOBE EPILEPSY; COMPARATIVE STUDY; COMPUTER ASSISTED EMISSION TOMOGRAPHY; ELECTROENCEPHALOGRAPHY; METHODOLOGY; MIDDLE AGED; NEOCORTEX; PATHOLOGY; SCINTISCANNING;

ADULT; AUTORADIOGRAPHY; CARBON RADIOISOTOPES; ELECTROENCEPHALOGRAPHY; EPILEPSY, TEMPORAL LOBE; FEMALE; FLUMAZENIL; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; NEOCORTEX; SCLEROSIS; TOMOGRAPHY, EMISSION-COMPUTED; TRITIUM;

EID: 14444267765     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410430510     Document Type: Article

References (50)

1. During MJ, Ryder KM, Spencer DD. Hippocampal GABA transporter Function in temporal lobe epilepsy. Nature 1995; 376:174-177
2. Knowles WD, Awad IA, Nayel MH. Differences of in vitro electrophysiology of neurons from epileptic patients with mesiotemporal sclerosis versus structural lesions. Epilepsia 1992; 33:601-609
3. Johnson EW, de Lanerolle NC, Kim JH, et al. "Central" and "peripheral" benzodiazepine receptors: opposite changes in human epileptogenic tissue. Neurology 1992;42:811-815
4. Burdette DE, Sakurai SY, Henry TR, et al. Temporal lobe central benzodiazepine binding in unilateral mesial temporal lobe epilepsy. Neurology 1995;45:934-941
5. Hand KSP, Baird VH, Van Paesschen W, et al. Central benzodiazepine receptor autoradiography in hippocampal sclerosis. Br J Pharmacol 1997;122:358-364
6. A receptor subtypes: autoradiographic comparison of GABA, benzodiazepine and convulsant binding sites in rat central nervous system. J Chem Neuroanat 1990;3:59-76
7. 11C): a specific radioligand for the in vivo study of central benzodiazepine receptors by positron emission tomography. Int J Appl Radiat Isot 1984;35:973-976
8. Koepp MJ, Richardson MP, Brooks DJ, et al. Cerebral benzodiazepine receptors in hippocampal sclerosis: an objective in vivo analysis. Brain 1996;119:1677-1687
9. 11C-Flumazenil PET, volumetric MRI and quantitative pathology in mesial temporal lobe epilepsy. Neurology 1997;49:764-773
10. 11C flumazenil PET in temporal lobe epilepsy with unilateral and bilateral hippocampal sclerosis. Brain 1997;120: 1865-1876
11. Meltzer CC, Zubieta JK, Links JM, et al. MR-based correction for brain PET measurements for heterogenous gray marter radioactivity distribution. J Cereb Blood Flow Metab 1996;16: 650-658
12. Commission on Classification and Terminology of the International League Against Epilepsy. Proposal for revised classification of epilepsies and epileptic syndromes. Epilepsia 1989;30: 389-399
13. Jackson GD, Berkovic SF, Duncan JS, Connelly A. Optimizing the diagnosis of hippocampal sclerosis using MR imaging. Am J Neuroradiol 1993;14:753-762
14. Van Paesschen W, Connelly A, King MD, et al. The spectrum of hippocampal sclerosis: a quantitative magnetic resonance imaging study. Ann Neurol 1997;41:41-51
15. Engel JJ. Outcome with respect to seizures. In: Engel JJ, ed. Surgical treatment of the epilepsies. New York: Raven Press, 1987:553-572
16. Williams RW, Rakic P. Three-dimensional counting: an accurate and direct method to estimate numbers of cells in sectioned material. J Comp Neurol 1988;278:344-352
17. Van Paesschen W, Revesz T, Duncan JS, et al. Quantitative neuropathology and quantitative MRI of hippocampus in temporal lobe epilepsy. Ann Neurol 1997;42:756-766
18. Houser CR, Olsen RW, Richards JG, Möhler H. Immunohistochemical localisation of benzodiazepine/GABAA receptors in the human hippocampal formation. J Neurosci 1988;8:1370-1383
19. Spinks TJ, Jones T, Bailey DL, et al. Physical performance of a positron tomograph for brain imaging with retractable septa. Phys Med Biol 1992;37:1637-1655
20. 11C-flumazenil PET study. Ann Neurol 1996;40:188-198
21. Bailey DL. 3D acquisition and reconstruction in positron emission tomography. Ann Nucl Med 1992;6:121-130
22. Friston KJ, Ashburner J, Poline JB, Frackowiak RSJ. Spatial registration and normalisation of images. Hum Brain Map 1995;2:165-189
23. Cunningham VJ, Jones T. Spectral analysis of dynamic PET data. J Cereb Blood Flow Metab 1993;13:15-23
24. Robb RA. A software system for interactive and quantitative analysis of biomedical images. In Hönne KH, Iuchs H, Pizer SM, eds. 3D imaging in medicine. 60th ed. NATO ASI Series, 1990:333-361
25. Labbé C, Koepp MJ, Ashburner J, et al. Absolute PET quantification with correction for partial volume effects with cerebral structures. In Carson R, Daube-Witherspoon M, Herscovitch P, eds. Quantitative functional brain imaging with positron emission tomography. San Diego: Academic Press, 1998 (in press)
26. Cook MJ, Fish DR, Shorvon SD, et al. Hippocampal volumetric and morphometric studies in frontal and temporal lobe epilepsy. Brain 1992;115:1001-1015
27. Haritigan JA. Clustering algorithms. New York: John Wiley, 1975
28. Woods RP, Mazziotta JC, Cherry SR. MRI-PET registration with automated algorithm. J Comp Assist Tomogr 1993;17: 536-546
29. Labbé C, Fromment JC, Kennedy A, et al. Positron emission tomography metabolic data corrected for cortical atrophy using magnetic resonance imaging. Alzheimer Dis Assoc Disord 1996; 10:141-170
30. Haycock KA, Roth J, Gagnon J, et al. Abacus concepts, Stat-View. Berkeley, CA: Abacus Concepts, 1992
31. Hoffman EJ, Huang SC, Phelps ME. Quantitation in positron emission computed tomography: 1. Effect of object size. J Comput Assist Tomogr 1979;3:299-308
32. Müller Gartner HW, Links JM, Prince JL, et al. Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab 1992;12:571-583
33. Meltzer CC, Zubieta JK, Brandt J, et al. Regional hypometabolism in Alzheimer's disease as measured by positron emission tomography after correction for effects of partial volume averaging. Neurology 1996;47:454-461
34. Margerison JHM, Corsellis JAN. Epilepsy and the temporal lobes. A clinical, electroencephalographic and neuropathological study of the brain in epilepsy. Brain 1966;89:479-530
35. 3H]gamma-aminobutyric acid (GABA) binding in the human brain. Brain Res 1979;163: 77-87
36. Zezula J, Cortes R, Probst A, Palacios JM. Benzodiazepine receptor sites in the human brain: autotadiographic mapping. Neuroscience 1988;25:771-795
37. Petroff OAC, Rothman DL, Behar KL, Mattson RH. Initial observations on the effect of gabapentin on brain GABA in patients with epilepsy. Ann Neurol 1996;39:95-99
38. Löscher W, Siemes H. Valproic acid increases gamma-aminobutyric acid in CSF of epileptic children. Lancet 1984;2: 225 (Letter)
39. Leidermann DB, Balish M, Sato S, et al. Comparison of PET measurements of cerebral blood flow and glucose metabolism for the localisation of human epileptic foci. Epilepsy Res 1992; 13:153-157
40. Frey KA, Holthoff VA, Koeppe RA, et al. Parametric in vivo imaging of benzodiazepine receptor distribution in human brain. Ann Neurol 1991;30:663-672
41. Möhler H, Richards JG. Agonist and antagonist benzodiazepine receptor interaction in vitro. Nature 1981;294:763-765
42. Savic I, Persson A, Roland P, et al. In vivo demonstration of reduced benzodiazepine teceptor binding in human epileptic foci. Lancet 1988;2:863-866
43. 11C]flumazenil and positron emission tomography. Epilepsia 1995;36:113-121
44. 3H] RO 15-1788 in mice by acute stress -possible changes in in vivo binding availability of brain benzodiazepine receptor. Int J Nucl Med Biol 1985;12:369-374
45. A/ benzodiazepine receptors. EMBO J 1990;9:3261-3267
46. Kamphuis W, De Rijk TC, Lopes da Silva FH. Expression of GABAA receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridisation study. Mol Brain Res 1995;31:33-47
47. Wolf HK, Spanle M, Müller MB, et al. Hippocampal loss of the GABAA receptor alpha 1 subunit in patients with chronic pharmacoresistant epilepsies. Acta Neuropathol 1994;3:313-319
48. McDonald JW, Garofalo EA, Hood T, et al. Altered excitatory and inhibitory amino acid receptor binding in hippocampus of patients with temporal lobe epilepsy. Ann Neurol 1991;29: 529-541
49. Babb TL, Pretorius JK, Kupfer WR, Crandall PH. Glutamate decarboxylase-immunoreactive neurons are preserved in human epileptic hippocampus. J Neurosci 1989;9:2562-2574
50. Sloviter RS. The functional organisation of the hippocampal dentate gyrus and its relevance to the pathogenesis of temporal lobe epilepsy. Ann Neurol 1994;35:640-654