Comparison of the enthalpy recovery and free volume of polyvinylpyrrolidone during anomalous glassy to rubbery transition

European Journal of Pharmaceutical Sciences

Volumn 21, Issue 4, 2004, Pages 519-523

  Zelkó, Romána ^a   Süvegh, Károly ^b  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Enthalpy recovery; Free volume; Glassy to rubbery transition; Polyvinylpyrrolidone; Positron lifetime measurement

Indexed keywords

KOLLIDON K25; POLYMER; POVIDONE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL STRUCTURE; DISSOLUTION; DRUG FORMULATION; ENTHALPY; PHASE TRANSITION; PRIORITY JOURNAL; TABLET; TENSILE STRENGTH;

DIFFERENTIAL THERMAL ANALYSIS; GLASS; PHASE TRANSITION; POVIDONE; RUBBER; THERMODYNAMICS; WATER;

EID: 1442333448     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2003.11.013     Document Type: Article

References (18)

1. Craig D.Q.M., Royall P.G., Kett V.L., Hopton M.L. The relevance of the amorphous state to pharmaceutical dosage forms: glassy drugs and freeze dried systems. Int. J. Pharm. 179:1999;179-207.
2. Feldstein M.M., Shandryuk G.A., Platé N.A. Relation of glass transition temperature to the hydrogen-bonding degree and energy in poly(N-vinyl pyrrolidone) blends with hydroxyl-containing plysticizers. Part 1. Effects of hydroxyl group number in plasticizer molecule. Polymer. 42:2001;971-979.
3. Fitzpatrick S., McCabe J.F., Petts C.R., Booth S.W. Effect of moisture on polyvinylpyrrolidone in accelerated stability testing. Int. J. Pharm. 246:2002;143-151.
4. Gomez Ribelles J.L., Greus A.R., Calleja R.D. A phenomenological study of the structural relaxation of poly(methyl methacrylate). Polymer. 31:1990;223-230.
5. Guo J.-H. A theoretical and experimental study of additive effects of physical aging and antiplasticization on the water permeability of polymer film coatings. J. Pharm. Sci. 83:1994;447-449.
6. Hancock B.C., Shamblin S.L., Zografi G. Molecular mobility of amorphous pharmaceutical solids below their glass transition temperatures. Pharm. Res. 12:1995;799-806.
7. Hancock B.C., Zografi G. Characteristics and significance of the amorphous state in pharmaceutical systems. J. Pharm. Sci. 86(1):1997;1-12.
8. Heymans N., Dequenne B. Relationship between conformation and enthalpy or volume relaxation in polycarbonate. Polymer. 42(12):2001;5337-5342.
9. Lebedeva T.L., Feldstein M.M., Kuptsov S.A., Platé N.A. Stable hydrogen-bonded complexes of poly(N-vinyl pyrrolidone) with water. Polym. Sci. 42:2000;989-1005.
10. Lippold B.C., Pagés M. Film formation, reproducibility of production and curing with respect to release stability of functional coatings from aqueous polymer dispersions. Pharmazie. 56:2001;5-17.
11. MacKenzie, I.K., 1983. Experimental methods of annihilation time and energy spectrometry. In: Brandt, W., Dupasquier, A. (Eds.), Positron Solid-State Physics. North-Holland, Amsterdam, p. 196.
12. Oksanen C.A., Zografi G. The relationship between the glass transition temperature and water vapor absorption by poly(vinylpyrrolidone). Pharm. Res. 7(6):1990;654-657.
13. g, and processing on tensile strength of compacts and lactose/polyvinylpyrrolidone. Drug Dev. Technol. 1:1996;195-204.
14. Süvegh K., Zelkó R. Physical ageing of polyvinylpyrrolidone under different humidity conditions. Macromolecules. 35(3):2002;795-800.
15. Van den Mooter G., Augustijns P., Kinget R. Stability prediction of amorphous benzodiazepines by calculation of the mean relaxation time constant using the William-Watts decay function. Eur. J. Pharm. Biopharm. 48:1999;43-48.
16. Zelkó R., Süvegh K., Marton S., Rácz I. Effect of storage conditions on the free volume of polyvinylpyrrolidone: comparison of positron lifetime data with the tensile strength of tablets. Pharm. Res. 17:2000;1028-1030.
17. Zhang J., Zografi G. The relationship between "BET"- and "free volume"-derived parameters for water vapor absorption into amorphous solids. J. Pharm. Sci. 89(8):2000;1063-1072.
18. Zografi G. States of water associated with solids. Drug Dev. Ind. Pharm. 14:1988;1905-1926.