Electrophysiological characterization of cardiac muscarinic acetylcholine receptors: Different subtypes mediate different potassium currents

Cellular Physiology and Biochemistry

Volumn 13, Issue 2, 2003, Pages 59-74

  Shi, Hong ^a   Yang, Baofeng ^c   Xu, Donghui ^d   Wang, Huizhen ^a   Wang, Zhiguo ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c HARBIN MEDICAL UNIVERSITY   (China)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Canine atrial myocyte; I KACh , I KM3 , I K4AP; K + currents; M 2 receptor; M 3 receptor; M 4 receptor; Muscarinic acetylcholine receptors

Indexed keywords

4 AMINOPYRIDINE; 4 DIPHENYLACETOXY 1 METHYLPIPERIDINE; ACETYLCHOLINE; ARECAIDINE; HEART RECEPTOR; ISOPRENALINE; METHOCTRAMINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M1 RECEPTOR AGONIST; MUSCARINIC M1 RECEPTOR ANTAGONIST; MUSCARINIC M2 RECEPTOR; MUSCARINIC M2 RECEPTOR AGONIST; MUSCARINIC M2 RECEPTOR ANTAGONIST; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; PERTUSSIS TOXIN; POTASSIUM CHANNEL; POTASSIUM ION; PROPRANOLOL; RECEPTOR SUBTYPE; TETRAMETHYLAMMONIUM; TROPICAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOCKING FACTOR; CELL KINETICS; CONTROLLED STUDY; HEART MUSCLE FIBER MEMBRANE POTENTIAL; HEART MUSCLE POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CONDUCTANCE; POTASSIUM CURRENT; POTENTIAL DIFFERENCE; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR SENSITIVITY; STEADY STATE; WAVEFORM;

EID: 0037234875     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000070250     Document Type: Article

References (38)

1. Barry DM, Nerbonne JM: Myocardial potassium channels: electrophysiological and molecular diversity. Annu Rev Physiol 1996;58:363-394.
2. Wang Z: Ionic mechanisms and molecular basis of human cardiac repolarization: Implication for drug development. Current Topics in Pharmacol in Res Trends 1998;4:19-35.
3. + current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol 1990;96:195-215.
4. Wang Z, Fermini B, Nattel S: Rapid and slow components of delayed rectifier outward current in human atrial myocytes. Cardiovasc Res 1994;28:1540-1515.
5. K ) in human atrial myocytes. Circ Res 1993;73:276-285.
6. Wang Z, Fermini B, Nattel S: Sustained depolarization-induced outward current in human atrial myocytes: Evidence for a novel delayed rectifier potassium current similar to Kv1.5 cloned channel currents. Circ Res 1993;73:1061-1076.
7. + currents in adult mouse ventricular myocytes. J Gen Physiol 1999;113:661-677.
8. + channels in excised membrane patches is mediated by PKC. Am J Physiol 1999;276:H488-H495.
9. + channels in mammalian ventricular myocytes. Am J Physiol 1994;266:H1812-H1821.
10. 2+ -independent transient outward current in mammalian heart. In Molecular Physiology and Pharmacology of Cardiac Ion Channes and Transporters. Morad M, Kurachi Y, Noma A, Hosada M, editors. Kluwer Press, Ltd., Amsterdam, Netherlands 1996, p. 141-168.
11. nd ed. Zipes DP, Jalife, editors. W.B. Saunders Co., Philadelphia, 1995, p. 74-82.
12. Boyden PA, Jeck CD: Ion channel function in disease. Circulation 1995;29:312-318.
13. Näbauer M, Kääb S: Potassium channel down-regulation in heart failure. Cardiovasc Res 1998;37:324-334.
14. nd ed. Sperelakis N, editor. Martinus Nijhoff, Boston, MA, 1989, p. 573-594.
15. Heidbuchel H, Vereecke J, Carmeliet E: Three different potassium channels in human atrium. Circ Res 1990;66:1277-1286.
16. Sato R, Wasserstrom J, Arentzen C, Singer D: Acetylcholine-sensitive potassium channels in human atrial myocytes. Am J Physiol 1990;259:H1730-H1735.
17. + currents in dog atrial myocytes. Am J Physiol 1994;266:C42-C51.
18. Navarro-Polanco RA, Sànchez-Chapula JA: 4-aminopyridine activates potassium currents by activation of a muscarinic receptor in feline atrial myocytes J Physiol 1997;498:663-678.
19. Shi H, Wang H, Wang Z: Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts. Mol Pharmacol 1999;55:497-507.
20. + channel. J Membrane Biol 1999;169:55-64.
21. + current. Br J Pharmacol 1999;162:1725-1734.
22. Kiehn J, Villena P, Beyer T, Brachmann J: Differential effects of the new class III agent dofetilide on potassium currents in guinea pig cardiomyocytes. J Cardiovasc Pharmacol 1994;24:566-572.
23. + current, on repolarization in human and guinea pig ventricular myocytes. Cardiovasc Res 1998;38:441-50.
24. Ks in guinea pig tricular myocytes. Circulation 1996;94:I-529.
25. + current, by the diuretic agent indapamide in guinea pig myocytes. Circ Res 1994;75:879-886.
26. Peralta EG, Ashkenazi A, Winslow JW, Ramachandran J, Capon DJ: Differential regulation of PI hydrolysis and adenylyl cyclase by muscarinic receptor subtypes. Nature 1988;334:434-437.
27. Sanguinetti MC, Jurkiewicz NK, Scott A, Siegl PK: Isoproterenol antagonizes prolongation of refractory period by the class III antiarrhythmic agent E-4031 in guinea pig myocytes. Mechanism of action. Circ Res 1991;68:77-84.
28. Felder CC: Muscarinic acetylcholine receptors: signal transduction through multiple effectors. FASEB J 1995;9:619-625.
29. Hulme EC, Birdsall NJ, Buckley NJ: Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol 1990;30:633-673.
30. + current in guinea pig sino-atrial node is not mediated by muscarinic receptors Mol Pharmacol 1995;47:1248-1254.
31. 2 receptors activate a novel chloride current in Xenopus oocytes. Br J Pharmacol 1998;74:A390.
32. o requirements. Am J Physiol 1997;273:C500-C507.
33. + channel. J Biol Chem 1996;271:6398-6402.
34. 4 muscarinic receptor subtype activates an inwardly rectifying potassium conductance in AtT20 cells. Neurosci Lett 1992;147:125-130.
35. 1 muscarinic acetylcholine receptors in rat ventricular myocytes. Circ Res 1996;79:86-93.
36. Escande D, Coulombe A, Faivre JF, Deroubaix E, Coraboeuf E. Two types of transient outward currents in adult human atrial cells. Am J Physiol. 1987;252:H142-H148.
37. Yue L, Feng J, Li GR, Nattel S. Transient outward and delayed rectifier currents in canine atrium: properties and role of isolation methods. Am J Physiol. 1996;270:H2157-H2168.
38. Lee JH, Rosen MR. Alpha 1-adrenergic receptor modulation of repolarization in canine Purkinje fibers. J Cardiovasc Electrophysiol. 1994;5:232-240.