Mitotic instability associated with late genomic changes in bone and soft tissue tumours

Cancer Letters

Volumn 206, Issue 1, 2004, Pages 69-76

  Gisselsson, David ^a   Pålsson, Eva ^a   Yu, Christina ^a   Mertens, Fredrik ^a   Mandahl, Nils ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

ALT, atypical lipomatous tumour; BFB, breakage fusion bridge; Breakage fusion bridge cycles; BSTT, bone and soft tissue tumours; Centrosome; Chromosome instability; Multipolar mitosis; PBS, phosphate buffered saline; Sarcoma

Indexed keywords

ADOLESCENT; ADULT; AGED; ANAPHASE; ARTICLE; BONE CANCER; BONE TUMOR; CELL DIVISION; CENTRIOLE; CENTROSOME; CHONDROSARCOMA; CHROMOSOME SEGREGATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOGENETICS; EVALUATION; FEMALE; GENETIC ASSOCIATION; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MESENCHYMOMA; MITOSIS; PRIORITY JOURNAL; SOFT TISSUE CANCER; SOFT TISSUE TUMOR;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BONE NEOPLASMS; CENTROSOME; CHROMOSOME ABERRATIONS; DNA, NEOPLASM; FEMALE; GENOMIC INSTABILITY; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; MALE; MIDDLE AGED; MITOSIS; PLOIDIES; SOFT TISSUE NEOPLASMS;

EID: 1442310965     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2003.10.022     Document Type: Article

References (23)

1. Mandahl N. Cytogenetics and molecular genetics of bone and soft tissue tumors. Adv. Cancer Res. 69:1996;63-99.
2. Lengauer C., Kinzler K.W., Vogelstein B. Genetic instabilities in human cancers. Nature. 396:1998;643-649.
3. Hande M.P., Samper E., Lansdorp P., Blasco M.A. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J. Cell Biol. 144:1999;589-601.
4. de Lange T. Protection of mammalian telomeres. Oncogene. 21:2002;532-540.
5. McClintock B. The production of homozygous deficient tissues with mutant characteristics by means of the aberrant behavior of ring-shaped chromosomes. Genetics. 23:1938;215-376.
6. Scheel C., Schaefer K.-L., Jauch A., Keller M., Wai D., Brinkschmidt C., et al. Alternative lengthening of telomeres is associated with chromosomal instability in osteosarcomas. Oncogene. 20:2001;3835-3844.
7. Gisselsson D., Jonson T., Petersén Å., Strömbeck B., Dal Cin P., Höglund M., et al. Telomere dysfunction triggers extensive DNA fragmentation and evolution of complex chromosome abnormalities in human malignant tumours. Proc. Natl Acad. Sci. USA. 98:2001;12683-12688.
8. Gisselsson D., Pettersson L., Höglund M., Heidenblad M., Gorunova L., Wiegant J., et al. Chromosomal breakage-fusion-bridge events cause genetic intratumor heterogeneity. Proc. Natl Acad. Sci. USA. 97:2000;5357-5362.
9. Lingle W.L., Lutz W.H., Ingle J.N., Maihle N.J., Salisbury J.L. Centrosome hypertrophy in human breast tumors: implications for genomic stability and cell polarity. Proc. Natl Acad. Sci. USA. 95:1998;2950-2955.
10. Ghadimi B.M., Sackett D.L., Difilippantonio M.J., Schröck E., Neumann T., Jauho A., et al. Centrosome amplification and instability occurs exclusively in aneuploid, but not in diploid colorectal cancer cell lines, and correlates with numerical chromosomal aberrations. Genes Chromosomes Cancer. 27:2000;183-190.
11. Sato N., Mizumoto K., Nakamura M., Nakamura K., Kusumoto M., Niiyama H., et al. Centrosome abnormalities in pancreatic ductal carcinoma. Clin. Cancer Res. 5:1999;963-970.
12. Setoguchi A., Okuda M., Nishida E., Yazawa M., Ishizaka T., Hong S., et al. Results of hyperamplification of centrosomes in naturally developing tumors of dogs. Am. J. Vet. Res. 62:2001;1134-1141.
13. Mandahl N. Methods in solid tumour cytogenetics. Rooney D.E. Human Cytogenetics: Malignancy and Acquired Abnormalities: A Practical Approach. 3rd ed. 2001;Oxford University Press, London.
14. Gisselsson D., Jonson T., Yu C., Martins C., Jin Y., Wiegant J., et al. Centrosome abnormalities, multipolar mitoses, and chromosomal instability in head and neck tumours with dysfunctional telomeres. Br. J. Cancer. 87:2002;202-207.
15. Roberts W.M., Douglass E.C., Peiper S.C., Houghton P.J., Look A.T. Amplification of the gli gene in childhood sarcomas. Cancer Res. 49:1989;5407-5413.
16. Kuriyama R. Effect of colcemid on the centriole cycle in Chinese hamster ovary cells. J. Cell Sci. 53:1982;155-171.
17. Rabinovitch P.S., Dziadon S., Brentnall T.A., Emond M.J., Crispin D.A., Haggitt R.C., Bronner M.P. Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res. 59:1999;5148-5153.
18. Mandahl N., Gustafson P., Mertens F., Åkerman M., Baldetorp B., Gisselsson D., et al. Cytogenetic aberrations and their prognostic impact in chondrosarcoma. Genes Chromosomes Cancer. 33:2001;103-109.
19. Bridge J.A., Bhatia P.S., Anderson J.R., Neff J.R. Biologic and clinical significance of cytogenetic and molecular cytogenetic abnormalities in benign and malignant cartilaginous lesions. Cancer Genet. Cytogenet. 69:1993;79-90.
20. Lingle W.L., Barrett S.L., Negron V.C., D'Assoro A.B., Boeneman K., Liu W., et al. Centrosome amplification drives chromosomal instability in breast tumor development. Proc. Natl Acad. Sci. USA. 99:2002;1978-1983.
21. Salisbury J.L., Whitehead C.M., Lingle W.L., Barrett S.L. Centrosomes and cancer. Biol. Cell. 91:1999;451-460.
22. Meraldi P., Honda R., Nigg E.A. Aurora-A overexpression reveals tetraploidization as a major route to centrosome amplification in p53-/- cells. Eur. Mol. Biol. Org. J. 21:2002;483-492.
23. Gisselsson D., Hoglund M., Mertens F., Mandahl N. Variable stability of chromosomes containing amplified alpha-satellite sequences in human mesenchymal tumours. Chromosoma. 108:1999;271-277.