HIV transmission during paediatric health care in sub-Saharan Africa - Risks and evidence

South African Medical Journal

Volumn 94, Issue 2, 2004, Pages 109-116

  Gisselquist, David ^a   Potterat, John J ^a   Brody, Stuart ^b  

^a University of Tübingen ^*  (United States)

^b UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICA; CHILD; CHILD HEALTH CARE; CHILDHOOD DISEASE; EPIDEMIC; HEALTH CARE PERSONNEL; HOSPITAL PATIENT; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMAN IMMUNODEFICIENCY VIRUS PREVALENCE; IATROGENIC DISEASE; INFECTION RISK; LIBYAN ARAB JAMAHIRIYA; MAJOR CLINICAL STUDY; NEEDLESTICK INJURY; OUTPATIENT; PRIMARY PREVENTION; REVIEW; ROMANIA; RUSSIAN FEDERATION; SURVIVAL; VIRUS LOAD; VIRUS TRANSMISSION;

ADOLESCENT; AFRICA SOUTH OF THE SAHARA; CHILD; CHILD HEALTH SERVICES; CHILD, PRESCHOOL; DISEASE TRANSMISSION, HORIZONTAL; DISEASE TRANSMISSION, VERTICAL; HIV INFECTIONS; HUMANS; INFANT; RISK FACTORS;

EID: 1442280749     PISSN: 02569574     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (84)

1. Cotton MF, Schaaf HS, Willemsen E, van Veenendal M, van Rensburg AJ, van Rensburg EJ. The burden of mother-to-child transmission of HIV-1 disease in a 'low' prevalence region - a five-year study of hospitalised children. South African Journal of Epidemiology and Infection 1998; 13: 46-49.
2. Walraven G, Nicoll A, Njau M, Timaeus I. The impact of HIV-1 infection on child health in sub-Saharan Africa: the burden on the health services. Trop Med Int Health 1996; 1: 3-14.
3. Brody S, Gisselquist D, Potterat JJ, Drucker E. Evidence of iatrogenic HIV transmission in children in South Africa. British Journal of Obstetrics and Gynaecology 2003; 110: 450-452.
4. Bakaki P, Kayita J, Machada JEM, et al. Epidemiologica and clinical features of HIV-infected and HIV-uninfected Ugandan children younger than 18 months. J Acquir Immune Defic Syndr Hum Retrovirol 2001; 28: 35-42.
5. Marum LH, Tindyebwa D, Gibb D. Care of children with HIV infection and AIDS in Africa. AIDS 1997; 11: suppl B, S125-S134.
6. Schwartlander B, Stanecki KA, Brown T, et al. Country-specific estimates and models of HIV and AIDS: methods and limitations. AIDS 1999; 13: 2445-2458.
7. The UNAIDS Reference Group on Estimates, Modelling and Projections. Improved methods and assumptions for estimation of the HIV/AIDS epidemic and its impact: Recommendations of the UNAIDS Reference Group on Estimates, Modelling and Projections. AIDS 2002; 16: W1-W14.
8. World Health Organisation. Preventing HIV infection in infants and young children. www.who.int/hiv/topics/mtct/en/ (accessed 18 July 2003).
9. World Health Organisation. AIDS Epidemic Update: December 2002. Geneva: WHO, 2002.
10. Quinn TC, Ruff A, Halsey N. Pediatric acquired immunodeficiency syndrome: special considerations for developing nations. Pediatr Infect Dis J 1992; 11: 558-568.
11. Chin J, Sato PA, Mann JM. Projections of HIV infections and AIDS cases to the year 2000. Bull World Health Organ 1990; 68: 1-11.
12. World Health Organisation. The current global situation of the HIV/AIDS pandemic. Wkly Epidemiol Rec 1995; 70: 7-8.
13. Wold Health Organisation. AIDS Epidemic Update - December 1998. Geneva: WHO, 1998.
14. European Collaboration Study: Children born to women with HIV-1 infection: natural history and risk of transmission. Lancet 1991; 337: 253-260.
15. Pavia AT, Long EG, Ryder RW, et al. Diarrhea among African children born to human immunodeficiency virus 1-infected mothers: clinical, microbiologic and epidemiologic features. Pediatr Infect Dis J 1992; 11: 996-1003.
16. Thea DM, St. Louis ME, Atido U, et al. A prospective study of diarrhea and HIV-1 infection among 429 Zairian infants. N Engl J Med 1993; 329: 1696-1702.
17. Taha TE, Graham SM, Kumwenda NI, et al. Morbidity among human immunodeficiency virus-1 infected and -uninfected African children. Pediatrics 2000; 106 (6): E77.
18. Vetter KM, Djomand G, Zadi F, et al. Clinical spectrum of human immunodeficiency virus disease in children in a West African city. Pediatr Infect Dis J 1996; 15: 438-442.
19. World Health Organisation. Cote d'Ivoire: Epidemiological Fact Sheet, 2000 Update. Geneva: WHO, 2000.
20. Mann JM, Francis H, Davachi F, et al. Human immunodeficiency virus seroprevalence in pediatric patients 2 to 14 years of age at Mama Yemo Hospital, Kinshasa, Zaire. Pediatrics 1986; 78: 673-677.
21. Mann JM, Francis H, Davachi F, et al. Risk factors for human immunodeficiency virus seropositivity among children 1-24 months old in Kinshasa, Zaire. Lancet 1986; ii: 654-657.
22. World Health Organisation. Democratic Republic of the Congo: Epidemiological Fact Sheet, 2000 Update. Geneva; WHO, 2000.
23. Colebunders R, Greenberg AE, Phuc Nguyen-Dinh, et al. Evaluation of a clinical case definition of AIDS in African children. AIDS 1987; 1: 151-153.
24. Zwi K, Pettifor J, Soderlund N, Meyers T. HIV infection and in-hospital mortality at an adacemic hospital in South Africa. Arch Dis Child 2000; 83: 227-230.
25. World Health Organisation. South Africa: Epidemiological Fact Sheet, 2000 Update. Geneva: WHO, 2000.
26. Yeung S, Wilkinson D, Escott S, Gilks CF. Pediatric HIV infection in a rural South African district hospital (abstract). J Trop Pediatr 2000; 46: 107-110.
27. Meyers TM, Pettifor JM, Gray GE, Crewe-Brown, Galpin JS. Pediatr admissions with human immunodeficiency virus infection at a regional hospital in Soweto, South Africa (abstract). J Trop Pediatr 2000; 46: 224-230.
28. Pillay K, Colvin M, Williams R, Coovadia HM. Impact of HIV-1 infection in South Africa. Arch Dis Child 2001; 85: 50-51.
29. Kawo G, Karlsson K, Lyamuya E, et al. Prevalence of HIV type 1 infection, associated clinical features, and mortality among hospitalized children in Dar es Salaam, Tanzania. Scand J Infect Dis 2000; 32: 357-363.
30. World Health Organisation. United Republic of Tanzania: Epidemiological Fact Sheet, 2000 Update. Geneva: WHO, 2000.
31. Nguyen-Dinh P, Greenberg AE, Mann JM, et al. Absence of association between Plasmodium falcifarum malaria and human immunodeficiency virus infection in children Kinshasa, Zaire. World Health Organ Bull 1987; 65: 607-613.
32. Horwood C, Liebenscheutz S, Blaauw D, Callos S, Qazi S. Paediatric HIV infection among outpatients attending a district hospital in Kwa-Zulu Natal, South Africa. Proceedings of the South African AIDS Conference, Durban, 3 - August 2003, Abstract T3-S2-A8.
33. Shisana O, Simbayi L, Bezuidenhout F, et al. Nelson Mandela/HSRC Study of HIV/AIDS: South African National HIV Prevalence, Behavioural Risks and Mass Media Household Survey 2002. Cape Town: Human Sciences Council, 2002.
34. Palumbo PE, Raskino C, Fiscus S. Predictive value of quantitative plasma RNA and CD4+ lymphocyte count HIV-infected infants and children. JAMA 1998; 279: 756-760.
35. Mofensen LM, Korelitz, Meyer WA, III, et al. The relationship between serum human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1 infected children. J Infect Dis 1997; 175: 1029-1038.
36. Biggar RJ, Pilon R, et al. Virus levels in untreated African infants infected with human immunodeficiency virus type. J Infect Dis 1999; 180: 1838-1843.
37. Busch MP, Satten GA. The course of viremia and antibody seroconversion following human immunodeficiency virus exposure. Am J Med 1997; 102: 117-124.
38. Quinn TC, Wawer MJ, Sewankambo NK, et la. Viral load and heterosexual transmission of human immunodeficiency virus type 1. N Engl J Med 2000; 432: 921-929.
39. Schellenberg A, Victoria CG, Mushi A, et al. Inequities among the very poor: health care for children in rural southern Tanzania. Lancet 2003; 361: 561-566.
40. Simonsen L, Kane A, Lloyd J, Zaffran M, Kane M. Unsafe injections in the developing world and transmission of bloodborne pathogens: a review. Bull Wold Health Organ 1999; 77: 789-800.
41. Hauri AM, Armstrong GL, Hutin YJF. The global burden of disease attributable to contaminated injections given in health care settings. Int J STD AIDS 2004; 15: 7-16.
42. Shisana O, Hall E, Maluleke KR, et la. The Impact of HIV/AIDS on the Health Sector. Cape Town: Human Sciences Research Council, 2002.
43. Gisselquist D, Hutin YJF, eds. Pilot-testing the WHO Tools to Assess and Evaluate Injection Practices. Geneva: WHO, 2003.
44. World Health Organisation, Regional Committe for Africa. Ensuring blood transfusion safety in Africa. Available at: www.afro.who.int/press/2001/regionalcommitte/rc51004.html (last accessed 26 November 2003).
45. Bobkov A, Garaev MM, Rzhaninova A, et al. Molecular epidemiology of HIV-1 in the former Soviet Union: analysis of env V3 sequences and their correlation with epidemiologic data. AIDS 1994; 8: 619-624.
46. Gisselquist DP. Estimating HIV-1 transmission efficiency through unsafe medical injections. Int J STD AIDS 2002; 13: 152-159.
47. Patrascu IV, Dumitrescu O. The epidemic of human immunodeficiency virus infection in Romanian children. AIDS Res Hum Retroviruses 1993; 9: 99-104.
48. Yerly S, Quadri R, Negro F, et al Nosocomial outbreak of multiple bloodborne viral infections. J Infect Dis 2001; 184:369-372.
49. Kane A, Lloyd J, Zaffran M, Kane M, Simonsen L. Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates. Bull World Health Organ 1999; 77: 801-807.
50. Cardo DM, Culver DH, Ciesielski CA, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. N Engl J Med 1997; 337: 1485-1490.
51. Resnick L, Veren K, Salahuddin SZ, Tondreau S, Markham PD. Stability and inactivation of HTLV-III/LAV under clinical and laboratory environments. JAMA 1986; 255: 1887-1891.
52. Barre-Sinoussi F, Nugeyre MT, Chermann JC. Resistance of AIDS virus at room temperature. Lancet 1985; ii: 721-722.
53. Moudgil T, Daar ES. Infections decay of human immunodeficiency virus type 1 in plasma. J Infect Dis 1993; 167: 210-212.
54. Abdala N, Stephens PC, Griffith BP, Heimer R. Survival of HIV-1 on syringes. J Acquir Immune Defic Syndr 1999; 20: 73-80.
55. World Health Organisation. Global Program on AIDS. 1992 - 1993 Progress Report. Geneva: WHO, 1993.
56. Irova TI, Burtonboy G, Ninane J. HIV infection in children born before and after immigration to Belgium (abstract). J Travel Med 1995; 2: 169-173.
57. Gama A, Silva PC, Ferreira S, Cruz A, Carvalho A, Soares A. Epidemiology and clinical features of HIV infection among children in Cabinda, Angola, West Africa (abstract, paper presented at: Second Residential Meeting, Royal Society of Physicians of Edinburgh, Edinburgh, Scotland, 5-7 July 1993). Trans R Soc Trop Med Hyg 1993; 87: 367.
58. Prazuck T, Tall F, Nacro B, et al. HIV infection and severe malnutrition: a clinical and epidemiological study in Burkina Faso. AIDS 1993; 7: 103-108.
59. Schuerman L, Synhaeve V, Doustin P, et al. HIV-1 and HIV-2 infection and pediatric AIDS in Dabou protestant hospital - Ivory Coast. Proceedings of the IV international conference: AIDS and associated cancers in Africa, Marseille, 18-20 October 1989, poster 246. In: US Census Bureau. HIV/AIDS Surveillance Data Base. June 2000 version. Washington DC: US Census Bureau, 2000.
60. Gayle HD, Gnaore E, Adjorlolo, et al. HIV-1 and HIV-2 infection in children in Abidjan, Cote d'Ivoire. J Acquir Immune Defic Syndr 1992; 5: 513-517.
61. De Cock KM, Zadi F, Adjorlolo G, et al. Retrospective study of maternal HIV-1 and HIV-2 infections and child survival in Abidjan, Cote d'Ivoire. BMJ 1994; 308: 441-442.
62. Colebunders R, Greenberg AE, Francis H, et al. Acute HIV illness following blood transfusion in three African children. AIDS 1988; 2: 125-127.
63. Colebunders RI, Greenberg A, Nguyen-Dinh P, et al. Evaluation of a clinical case definition of AIDS in African children. AIDS 1987; 1: 151-153.
64. Fontanet AL, Messele A, et al. Age and sex-specific HIV-1 prevalence in the urban community setting of Addis Abada, Ethiopia. AIDS 1998; 12: 315-322.
65. Poulsen AG, Aaby P, Gottschau A, et al. HIV-2 infection in Bissau, West Africa, 1987-89: incidence, prevalence, and routes of transmission. J Acquir Immune Defic Syndr 1993; 6: 941-948.
66. Emodi IJ, Okafor GO. Clinical manifestations of HIV in children at Enugu, Nigeria. J Trop Pediatr 1998; 44: 73-76.
67. Lepage P, Van de Perre P, Carael M, Butzler JP. Are medical infections a risk factor for HIV infection in children? Lancet 1986; ii: 1103-1104.
68. Lepage P, Van de Perre P. Nosocomial transmission of HIV in Africa: what tribute is paid to contaminated transfusions and medical injections. Infect Control Hosp Epidemiol 1988; 9: 200-203.
69. Commenges D, Alioum A, Lepage P, Van de Perre P, Msellati P, Dabis F. Estimating the incubation period of paediatric AIDS in Rwanda. AIDS 1992; 6: 1515-1520.
70. Mabena K. HIV baby: we ask-medical experts. The Sowetan 2003; 9 January.
71. Heimstra R, Rabie H, Schaaf HS, Eley B, Mehtar S, Cotton MF. Evidence for unusual HIV transmission in children. Proceedings of the 2nd International AIDS Society Conference on HIV pathogenesis and treatment, Paris 13-16 July 2003, Abstract no. LB 49.
72. Eley BS, Argent AA, Hatherill M, Reynolds L, Rinquist C, Beatty DW. HIV infection of undetermined origin during infancy. Proceedings of the South African AIDS Conference, Durban, 3-6 August 2003, Abstract T1-P34.
73. Mgone CS, Mhalu FS, Shao JF, et al. Prevalence of HIV-1 infection and symptomatology of AIDS in severely malnourished children in Dar Es Salaam, Tanzania. J Acquir Immune Defic Syndr 1991; 4: 910-913.
74. Muller O, Moser R. Risk factors for paediatric HIV-1 infection in Uganda (abstract). Proceedings of the VIII International Conference on AIDS, Amsterdam, 19-24 July 1992. abstract no. PoC4733.
75. Kengeya-Kayondo J-F, Malamba SS, Nunn AJ, Seeley JA, SSali A, Mulder DW. Human immunodeficiency virus (HIV-1) seropositivity among children in a rural population of south-west Uganda: probable routes of exposures. Ann Trop Paediatr 1995; 15: 115-120.
76. Katongole-Mbidde E, Kazura JW, Banura C, et al. Latency period to the development of childhood AIDS-associated Kaposi's sarcoma (KS) in Africa children (abstract). Proceedings of the International Conference on AIDS, Florence, 16-21 June 1991. Abstact MC3185.
77. Zeigler JL., Katongole-Mbidde E. Kaposi's sarcoma in childhood: an analysis of 100 cases from Uganda and relationship to HIV infection. Int J Cancer 1996; 65: 200-203.
78. Lindegren ML, Hanson IC, Hammett TA, Beil J, Fleming PL, Ward JW. Sexual abuse of children: intersection with the HIV epidemic. Pediatrics 1998; 102: E46.
79. van As AB, Withers M, Du Toit N, Millar AJW, Rode H. Child rape-patterns of injury, management and outcome. S Afr Med J 2001; 91: 1035-1038.
80. Rwandan HIV Seroprevalence Study Group. Nationwide community-based serological survey of HIV-1 and other human retrovirus infections in a central African country. Lancet 1989; i: 941-943.
81. Ministry of Health. 1997 Population Based Serosurvey Report. Kigali: Ministry of Health, 1998.
82. Barongo LR, Rugemalila JB, Gabone RM, Senkoro KP. Kagera 1989 health survey: 1 human immunodeficiency virus in adolescents. East Afr Med J 1992; 69: 323-326.
83. Belitsky V. Children infect mothers in AIDS outbreak at a Soviet hospital. Nature 1989; 337: 493
84. Caelers D. HIV injury study causes alarm among doctors. Cape Argus 2003; 25 June.