Fibromyalgia pain: Do we know the source?

Current Opinion in Rheumatology

Volumn 16, Issue 2, 2004, Pages 157-163

  Staud, Roland ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Fibromyalgia syndrome; Fibrositis

Indexed keywords

AMINO ACID; CYTOKINE;

ACUTE STRESS DISORDER; CELL ACTIVATION; CENTRAL NERVOUS SYSTEM; EXPOSURE; FIBROMYALGIA; GLIA CELL; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; JOINT HYPERMOBILITY; NERVE CELL; NOCICEPTION; PAIN; PRIORITY JOURNAL; REVIEW; RHEUMATIC POLYMYALGIA; SENSITIZATION; SPINAL CORD; WHIPLASH INJURY;

CYTOKINES; ENDOCRINE SYSTEM DISEASES; FIBROMYALGIA; GENETIC PREDISPOSITION TO DISEASE; HUMANS; NOCICEPTORS; PAIN; POLYMYALGIA RHEUMATICA; VIRUS DISEASES; WOUNDS AND INJURIES;

EID: 1442274697     PISSN: 10408711     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002281-200403000-00016     Document Type: Review

References (95)

1. Wolfe F, Smythe HA, Yunus MB, et al.: The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990, 33:160-172.
2. Macfarlane GJ, McBeth J, Silman AJ: Widespread body pain and mortality: prospective population based study. BMJ 2001, 323:662-6646.
3. McBeth J, Silman AJ, Macfarlane GJ: Association of widespread body pain with an increased risk of cancer and reduced cancer survival: A prospective, population-based study. Arthritis Rheum 2003, 48:1686-1692. This prospective study showed that widespread pain reported in population surveys is associated with a substantial subsequent increased incidence of cancer and reduced cancer survival.
4. Gowin KM: Diffuse pain syndromes in the elderly. Rheum Dis Clin North Am 2000, 26:673-682.
5. Sultan SM, Ioannou Y, Moss K, et al.: Outcome in patients with idiopathic inflammatory myositis: morbidity and mortality. Rheumatology (Oxford) 2002, 41:22-26.
6. Tench C, Bentley D, Vleck V, et al.: Aerobic fitness, fatigue, and physical disability in systemic lupus erythematosus. J Rheumatol 2002, 29:474-481.
7. Nef W, Gerber NJ: Hypermobility syndrome. When too much activity causes pain. Schweiz Med Wochenschr 1998, 128:302-310.
8. Barkhuizen A: Rational and targeted pharmacologic treatment of fibromyalgia. Rheum Dis Clin North Am 2002, 28:261-290.
9. Brattberg G, Parker MG, Thorslund M: A longitudinal study of pain: reported pain from middle age to old age. Clin J Pain 1997, 13:144-149.
10. Graven-Nielsen T, Sorensen J, Henriksson KG, et al.: Central hyperexcitability in fibromyalgia. J Musculoskel Pain 1999, 7:261-271.
11. Granges G, Littlejohn G: Pressure pain threshold in pain-free subjects, in patients with chronic regional pain syndromes, and in patients with fibromyalgia syndrome. Arthritis Rheum 1993, 36:642-646.
12. Arroyo JF, Cohen ML: Abnormal responses to electrocutaneous stimulation in fibromyalgia. J Rheumatol 1993, 20:1925-1931.
13. Sorensen J, Graven-Nielsen T, Henriksson KG, et al.: Hyperexcitability in fibromyalgia. J Rheumatol 1998, 25:152-155.
14. Gracely RH, Petzke F, Wolf JM, et al.: Functional magnetic resonance imaging evidence of augmented pain processing in fibromyalgia. Arthritis Rheum 2002, 46:1333-1343. This study showed that comparable subjectively painful conditions resulted in activation patterns that were similar in FMS patients and controls, whereas similar pressures resulted in greater brain activation of FMS patients. These findings support the hypothesis that FMS is characterized by cortical or subcortical augmentation of pain processing.
15. Staud R, Cannon RC, Mauderli AP, et al.: Temporal summation of pain from mechanical stimulation of muscle tissue in normal controls and subjects with fibromyalgia syndrome. Pain 2003, 102:87-95.
16. Staud R, Vierck CJ, Cannon RL, et al.: Abnormal sensitization and temporal summation of second pain (wind-up) in patients with fibromyalgia syndrome. Pain 2001, 91:165-175.
17. Woolf CJ: Windup and central sensitization are not equivalent. Pain 1996, 66:105-108.
18. Li J, Simone DA, Larson AA: Windup leads to characteristics of central sensitization. Pain 1999, 79:75-82.
19. Davies SN, Lodge D: Evidence for involvement of N-methylaspartate receptors in 'wind-up' of class 2 neurones in the dorsal horn of the rat. Brain Res 1987, 424:402-406.
20. Price DD, Staud R, Robinson ME, et al.: Enhanced temporal summation of second pain and its central modulation in fibromyalgia patients. Pain 2002, 99:49-59.
21. Buskila D, Neumann L: Fibromyalgia syndrome (FM) and nonarticular tenderness in relatives of patients with FM. J Rheumatol 1997, 24:941-944.
22. Yunus MB: Genetic factors in fibromyalgia syndrome. Z Rheumatol 1998, 57(Suppl2):61-62.
23. Stormorken H, Brosstad F: Fibromyalgia: family clustering and sensory urgency with early onset indicate genetic predisposition and thus a "true" disease. Scand J Rheumatol 1992, 21:207.
24. Pellegrino MJ, Waylonis GW, Sommer A: Familial occurrence of primary fibromyalgia. Arch Phys Med Rehabil 1989, 70:61-63.
25. Hudson JI, Goldenberg DL, Pope HG Jr, et al.: Comorbidity of fibromyalgia with medical and psychiatric disorders. Am J Med 1992, 92:363-367.
26. Messinger HB, Spierings EL, Vincent AJ, et al.: Headache and family history. Cephalalgia 1991, 11:13-18.
27. Buskila D, Neumann L: The development of widespread pain after injuries. J Musculoskel Pain 2002, 10:261-267.
28. Waylonis GW, Perkins RH: Post-traumatic fibromyalgia. A long-term follow-up. Am J Phys Med Rehabil 1994, 73:403-412.
29. Greenfield S, Fitzcharles MA, Esdaile JM: Reactive fibromyalgia syndrome. Arthritis Rheum 1992, 35:678-681.
30. Middleton GD, McFarlin JE, Lipsky PE: The prevalence and clinical impact of fibromyalgia in systemic lupus erythematosus. Arthritis Rheum 1994 37:1181-1188.
31. Sapolsky RM, Romero LM, Munck AU: How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 2000, 21:55-89.
32. Viau V, Sharma S, Plotsky PM, et al.: Increased plasma ACTH responses to stress in nonhandled compared with handled rats require basal levels of cor ticosterone and are associated with increased levels of ACTH secretagogues in the median eminence. J Neurosci 1993, 13:1097-1105.
33. Chrousos GP, Gold PW: The concepts of stress and stress system disorders. Overview of physical and behavioral homeostasis. JAMA 1992 267:1244-1252.
34. Gold PW, Goodwin FK, Chrousos GP: Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (1). N Engl J Med 1988, 319:348-353.
35. Gold PW, Goodwin FK, Chrousos GP: Clinical and biochemical manifestations of depression. Relation to the neurobiology of stress (2). N Engl J Med 1988, 319:413-420.
36. McNamara RK, Huot RL, Lenox RH, et al.: Postnatal Maternal Separation Elevates the Expression of the Postsynaptic Protein Kinase C Substrate RC3, but Not Presynaptic GAP-43, in the Developing Rat Hippocampus. Dev Neurosci 2002, 24:485-494.
37. Sapolsky RM: Why stress is bad for your brain. Science 1996, 273:749-750.
38. Anderberg UM, Marteinsdottir I, Theorell T, et al.: The impact of life events in female patients with fibromyalgia and in female healthy controls. European Psychiatry 2000, 15:295-301.
39. Bailey BE, Freedenfeld RN, Kiser RS, et al.: Lifetime physical and sexual abuse in chronic pain patients: psychosocial correlates and treatment outcomes. Disabil Rehabil 2003, 25:331-342.
40. Sherman JJ, Turk DC, Okifuji A: Prevalence and impact of posttraumatic stress disorder-like symptoms on patients with fibromyalgia syndrome. Clin J Pain 2000, 16:127-134.
41. Cohen H, Neumann L, Haiman Y, et al.: Prevalence of post-traumatic stress disorder in fibromyalgia patients: Overlapping syndromes or post-traumatic fibromyalgia syndrome? Semin Arthritis Rheum 2002, 32:38-50.
42. Green MM, McFarlane AC, Hunter CE, et al.: Undiagnosed post-traumatic stress disorder following motor vehicle accidents. Med J Aust 1993, 159:529-534.
43. Shore JH, Tatum EL, Vollmer WM: Psychiatric reactions to disaster: the Mount St. Helens experience. Am J Psychiatry 1986, 143:590-595.
44. Beckham JC, Crawford AL, Feldman ME, et al.: Chronic posttraumatic stress disorder and chronic pain in Vietnam combat veterans. J Psychosom Res 1997, 43:379-389.
45. Beckham JC, Moore SD, Feldman ME, et al.: Health status, somatization, and severity of posttraumatic stress disorder in Vietnam combat veterans with posttraumatic stress disorder. Am J Psychiatry 1998, 155:1565-1569.
46. Amir M, Kaplan Z, Neumann L, et al.: Posttraumatic stress disorder, tenderness and fibromyalgia. J Psychosom Res 1997, 42:607-613.
47. Aaron LA, Bradley LA, Alarcon GS, et al.: Perceived physical and emotional trauma as precipitating events in fibromyalgia. Associations with health care seeking and disability status but not pain severity. Arthritis Rheum 1997, 40:453-460.
48. Turk DC, Okifuji A, Starz TW, et al.: Effects of type of symptom onset on psychological distress and disability in fibromyalgia syndrome patients. Pain 1996, 68:423-430.
49. Buskila D, Neumann L, Vaisberg G, et al.: Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury. Arthritis Rheum 1997, 40:446-452.
50. Kasch H, Bach FW, Stengaard-Pedersen K, et al.: Development in pain and neurologic complaints after whiplash - A 1-year prospective study. Neurology 2003, 60:743-749.
51. Berglund A, Alfredsson L, Jensen I, et al.: The association between exposure to a rear-end collision and future health complaints. J Clin Epidemiol 2001, 54:851-856.
52. Arendt-Nielsen L, Svensson P: Referred muscle pain: Basic and clinical findings. Clin J Pain 2001, 17:11-19.
53. Carli G: Neuroplasticity and clinical pain. Prog Brain Res 2000, 129:325-330.
54. White KP, Harth M, Speechley M, et al.: A general population study of fibromyalgia tender points in noninstitutionalized adults with chronic widespread pain. J Rheumatol 2000, 27:2677-2682.
55. Koelbaek-Johansen M, Graven-Nielsen T, Schou OA, et al.: Generalised muscular hyperalgesia in chronic whiplash syndrome. Pain 1999, 83:229-234.
56. Elert J, Kendall SA, Larsson B, et al.: Chronic pain and difficulty in relaxing postural muscles in patients with fibromyalgia and chronic whiplash associated disorders. J Rheumatol 2001, 28:1361-1368.
57. Buskila D, Neumann L: Musculoskeletal injury as a trigger for fibromyalgia/posttraumatic fibromyalgia. Curr Rheumatol Rep 2000, 2:104-108.
58. Deans GT, McGalliard JN, Rutherford WH: Incidence and duration of neck pain among patients injured in car accidents. Br Med J (Clin Res Ed) 1986, 292:94-95.
59. Deans GT, Magalliard JN, Kerr M, et al.: Neck sprain - a major cause of disability following car accidents. Injury 1987, 18:10-12.
60. Croft PR, Lewis M, Papageorgiou AC, et al.: Risk factors for neck pain: a longitudinal study in the general population. Pain 2001, 93:317-325.
61. Young WB, Packard RC: Headaches associated with head trauma. In Wolff's Headache and Other Head Pain. Edited by Silberstein SD, Lipton RB, Dalessio DJ. New York: Oxford University Press; 2001:325-348.
62. Stemper BD, Yoganandan N, Pintar FA: Kinetics of the head-neck complex in low-speed rear impact. Biomed Sci Instrum 2003, 39:245-250.
63. Hohl M: Soft tissue neck injuries - a review. Rev Chir Orthop Reparatrice Appar Mot 1990, 76(suppl 1):15-25.
64. Gebhard JS, Donaldson DH, Brown CW: Soft-tissue injuries of the cervical spine. Orthop Rev 1994, (suppl):9-17.
65. Hudson N, Fitzcharles MA, Cohen M, et al.: The association of soft-tissue rheumatism and hypermobility. Br J Rheumatol 1998, 37:382-386.
66. Gedalia A, Press J, Klein M, et al.: Joint hypermobility and fibromyalgia in schoolchildren. Ann Rheum Dis 1993, 52:494-496.
67. Grahame R: Pain, distress and joint hyperlaxity. Joint Bone Spine 2000, 67:157-163.
68. Acasuso DM, Collantes-Estevez E: Joint hypermobility in patients with fibromyalgia syndrome. Arthritis Care Res 1998, 11:39-42.
69. Granges G, Littlejohn G: Prevalence of myofascial pain syndrome in fibromyalgia syndrome and regional pain syndrome: a comparative study. J Musculoskel Pain 1993, 1:19-35.
70. Travell JG, Simons LS, Simons DG: Myofascial Pain and Dysfunction: The Trigger Point Manual, edn 2. New York: Lippincott, Williams & Wilkins; 1999.
71. Abbadie C, Lindia JA, Cumiskey AM, et al.: Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2. PNAS 2003, 100:7947-7952.
72. Kelley KW, Bluthe RM, Dantzer R, et al.: Cytokine-induced sickness behavior. Brain Behav Immun 2003, 17:S112-S118. Similar to FMS patients, sick individuals are listless, complain of fatigue and malaise, lose interest in social activities, and have significant changes in sleep patterns. They display an inability to experience pleasure, have exaggerated responses to pain, and fail to concentrate. Proinflammatory cytokines acting in the brain cause sickness behaviors. These nearly universal behavioral changes are a manifestation of a central motivational state.
73. Hayley S, Merali Z, Anisman H: Stress and cytokine-elicited neuroendocrine and neurotransmitter sensitization: implications for depressive illness. Stress 2003, 6:19-32.
74. Watkins LR, Maier SF: The pain of being sick: implications of immune-to-brain communication for understanding pain. Annu Rev Psychol 2000, 51:29-57.
75. Quan N, Herkenham M: Connecting cytokines and brain: a review of current issues. Histol Histopathol 2002, 17:273-288.
76. Maier SF: Bi-directional immune-brain communication: Implications for understanding stress, pain, and cognition. Brain Behav Immun 2003, 17:69-85. Pro-inflammatory cytokine play a critical role for pain in both the periphery and the nervous system. In the periphery, these cytokines initiate the processes that signal the brain that immune activation has occurred and communicate this information over both neural and blood-borne routes. The arrival of these signals in the central nervous system induces a neural cascade that includes the de novo induction of pro-inflammatory cytokines. These cytokines in the nervous system play a key role in regulating the neural control of immune processes in the periphery.
77. Daoud KF, Barkhuizen A: Rheumatic mimics and selected triggers of fibromyalgia. Curr Pain Headache Rep 2002, 6:284-288.
78. Weyand CM, Hicok KC, Hunder GG, et al.: Tissue cytokine patterns in patients with polymyalgia rheumatica and giant cell arteritis. Ann Intern Med 1994, 121:484-491.
79. Pountain G, Hazleman B, Cawston TE: Circulating levels of IL-1 beta, IL-6 and soluble IL-2 receptor in polymyalgia rheumatica and giant cell arteritis and rheumatoid arthritis. Br J Rheumatol 1998, 37:797-798.
80. Cohen MD, Ginsburg WW: Polymyalgia rheumatica. Rheum Dis Clin North Am 1990, 16:325-339.
81. Vaeroy H: Impaired neuroendocrine axis and FMS. J Rheumatol 1989, 16:1460-1465.
82. Haddad JJ, Saade NE, Safieh-Garabedian B: Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary- adrenal revolving axis. J Neuroimmunol 2002, 133:1-19.
83. Reichlin S: Neuroendocrinology. In Williams Textbook of Endocrinology. Edited by Wilson JD, Foster DW, Kronenberg HM, Larsen PR. Philadelphia: W.B. Saunders Co.; 1998:165-248.
84. Magiakou MA, Chrousos GP: Corticosteroid therapy, nonendocrine disease, and corticosteroid withdrawal. Curr Ther Endocrinol Metab 1994, 5:120-124.
85. Maes M, Lin A, Bonaccorso S, et al.: Increased 24-hour urinary cortisol excretion in patients with post-traumatic stress disorder and patients with major depression, but not in patients with fibromyalgia. Acta Psychiatr Scand 1998, 98:328-335.
86. Crofford LJ: The hypothalamic pituitary adrenal stress axis in fibromyalgia and chronic fatigue syndrome. Z Rheumatol 1998, 57:67-71.
87. Adler GK, Kinsley BT, Hurwitz S, et al.: Reduced hypothalamic-pituitary and sympathoadrenal responses to hypoglycemia in women with fibromyalgia syndrome. Am J Med 1999, 106:534-543.
88. Torpy DJ, Papanicolaou DA, Lotsikas AJ, et al.: Responses of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis to interleukin-6 - A pilot study in fibromyalgia. Arthritis Rheum 2000, 43:872-880.
89. Lariviere WR, Melzack R: The role of corticotropin-releasing factor in pain and analgesia. Pain 2000, 84:1-12.
90. Barkhuizen A, Rosen HR, Wolf S, et al.: Musculoskeletal pain and fatigue are associated with chronic hepatitis C - A report of 239 hepatology clinic patients. Am J Gastroenterol 1999, 94:1355-1360.
91. Buskila D, Shnaider A, Neumann L, et al.: Fibromyalgia in hepatitis C virus infection. Another infectious disease relationship. Arch Intern Med 1997, 157:2497-2500.
92. Simms RW, Zerbini CA, Ferrante N, et al.: Fibromyalgia syndrome in patients infected with human immunodeficiency virus. The Boston City Hospital Clinical AIDS Team. Am J Med 1992, 92:368-374.
93. Fukuda K, Nisenbaum R, Stewart G, et al.: Chronic multisymptom illness affecting Air Force veterans of the Gulf War. JAMA 1998, 280:981-988.
94. Beckham JC, Crawford AL, Feldman ME, et al.: Chronic posttraumatic stress disorder and chronic pain in Vietnam combat veterans. J Psychosom Res 1997, 43:379-389.
95. Soetekouw PMMB, de Vries M, Preijers FWMB, et al.: Persistent symptoms in former UNTAC soldiers are not associated with shifted cytokine balance. Eur J Clin Invest 1999, 29:960-963.