The low molecular weight inhibitor of NCX1 interacts with a cytosolic domain that differs from the ion-transport site of the Na/Ca exchanger

Biochemical and Biophysical Research Communications

Volumn 324, Issue 4, 2004, Pages 1346-1351

  Shpak, Chagit ^a   Hiller, Reuben ^a   Shpak, Beni ^a   Boyman, Liron ^a   Khananshvili, Daniel ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Calcium; Endogenous inhibitor; Na Ca exchange; NCX1; NCXIF

Indexed keywords

NCX1 PROTEIN; PROTEIN; SODIUM CALCIUM EXCHANGE PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL FACTOR; CALCIUM; SODIUM CALCIUM EXCHANGER 1; SODIUM-CALCIUM EXCHANGER 1;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; IC 50; ION TRANSPORT; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SARCOLEMMA; ANIMAL; CATTLE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; PROTEIN TERTIARY STRUCTURE;

ANIMALS; BIOLOGICAL FACTORS; CALCIUM; CATTLE; CYTOSOL; ION TRANSPORT; PROTEIN STRUCTURE, TERTIARY; SARCOLEMMA; SODIUM-CALCIUM EXCHANGER;

EID: 14344262861     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.09.210     Document Type: Article

References (36)

1. E. Carafoli Intracellular calcium homeostasis Ann. Rev. Biochem. 56 1987 395 433
2. M.P. Blaustein, and W.J. Lederer Sodium/calcium exchange: its physiological implications Physiol. Rev. 79 1999 763 854
3. 2+ exchanger, in: Ion pumps-'Adv. Mol. & Cell Biol.' Life Sciences Program, JAI Press, 1998, 23B, pp. 309-356
4. D.M. Bers Cardiac excitation-contraction coupling Nature 415 2002 198 205
5. J.P. Reeves, and C.C. Hale The stoichiometry of the cardiac sodium-calcium exchange system J. Biol. Chem. 259 1984 7733 7739
6. 2+ exchange system Biochemistry 29 1990 2437 2442
7. G. Hasenfuss Alterations of calcium-regulatory proteins in heart failure Cardiovasc. Res. 37 1998 279 289
8. S.M. Pogwizd, K. Schlotthauer, L. Li, W. Yuan, and D.M. Bers Arrhythmogenesis and contractile dysfunction in heart failure: roles of sodium-calcium exchange, inward rectifier potassium current and residual β-adrenergic responsiveness Circ. Res. 88 2001 1159 1167
9. K.R. Sipido, P.G.A. Volders, M.A. Vos, and F. Vendonck Altered Na/Ca exchange activity in cardiac hypertrophy and heart failure: a new target for therapy? Cardiovasc. Res. 53 2000 782 805
10. S.M. Pogwizd Clinical potential of sodium-calcium exchanger inhibitors as antiarrhythmic agents Drugs 63 2003 439 452
11. J. Meszaros, D. Khananshvili, and G. Hart Mechanisms underlying delayed after depolarizations in hypertrophied left ventricular myocytes of the rat heart Am. J. Physiol. 281 2001 H903 H914
12. 2+ exchanger: molecular and pharmacological aspects Circ. Res. 88 2001 864 876
13. 2+ exchanger J. Biol. Chem. 266 1991 1014 1020
14. 2+ exchange J. Biol. Chem. 270 1995 16182 16188
15. 2+ exchanger by conformationally constraint small peptides Mol. Pharmacol. 51 1997 126 131
16. R. Hiller, C. Shpak, G. Shavit, B. Shpak, and D. Khananshvili An unknown endogenous inhibitor of Na/Ca exchange can enhance the cardiac muscle contractility Biochem. Biophys. Res. Commun. 277 2000 138 146
17. C. Shpak, R. Hiller, B. Shpak, and D. Khananshvili The endogenous inhibitor of NCX1 does not resemble the properties of digitalis compound Biochem. Biophys. Res. Commun. 308 2003 114 119
18. B. Shpak, C. Shpak, R. Hiller, L. Boyman, and D. Khananshvili Inotropic and lusitropic effects induced by the inhibitory factor of the Na/Ca exchanger are not mediated by the β-adrenergic activation J. Cardiovasc. Pharmacol. 44 2004 466 472
19. D.M. Bers Cardiac Na/Ca exchange function in rabbit mouse and man: what's the difference? J. Mol. Cell Cardiol. 34 2002 369 373
20. 2+exchanger blocks the ion transport without preventing the binding of either sodium or calcium Biochemistry 35 1996 15933 15940
21. 2+ exchanger: relative rates of calcium and sodium movements and their modulation by protonation-deprotonation of the carrier Biochemistry 33 1994 312 319
22. 2+ exchanger Biochemistry 34 1995 10290 10297
23. 2+ exchange in the isolated cardiac sarcolemma vesicles by using a rapid-response fluorescent probe Biochemistry 38 1999 1435 1445
24. 2+ exchange in cardiac sarcolemma vesicles J. Biol. Chem. 268 1993 200 205
25. 2+ exchanger J. Biol. Chem. 266 1991 13764 13769
26. I.A. Hobai, D. Khananshvili, and A.J. Levi The peptide 'FRCRCFa,' dialyzed intracellularly, inhibits the Na/Ca exchange with high affinity in rabbit ventricular myocytes Plugers Archiv. 433 1997 455 463
27. T.K. Chin, K.W. Spitzer, K.D. Philipson, and J.H.B. Bridge The effect of exchanger inhibitory peptide (XIP) on sodium-calcium exchange current in guinea pig ventricular cells Circ. Res. 72 1993 497 503
28. S.B. Kleiboeker, M.A. Milanick, and C.C. Hale Interactions of the exchange inhibitory peptide with Na-Ca exchange in bovine cardiac sarcolemmal vesicles and ferret red cells J. Biol. Chem. 267 1992 17836 17841
29. T. Watano, J. Kimura, T. Morita, and H. Nakanishi A novel antagonist, No 7943, of the Na-Ca exchange current in guinea-pig cardiac ventricular cells Br. J. Pharmacol. 119 1996 555 563
30. H. Tanaka, K. Nishimaru, T. Aikawa, W. Hirayama, Y. Tanaka, and K. Shigenobu Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents Br. J. Pharmacol. 135 2002 1096 1100
31. M.K. Convery, A.J. Levi, D. Khananshvili, and J.C. Hancox Actions of myrisyl-FRCRCFa, a cell-permeant blocker of the cardiac sarcolemmal Na-Ca exchanger, tested in rabbit ventricular myocytes Plugers Archiv. 436 1998 581 590
32. 2+ exchanger Science 250 1990 562 564
33. K.D. Philipson, and D.A. Nicoll Sodium-calcium exchange: a molecular perspective Annu. Rev. Physiol. 62 2000 111 133
34. C.C. Hale Mechanism of XIP in cardiac sarcolemmal vesicles Ann. N. Y. Acad. Sci. 779 1996 171 181
35. 2+ pump interacts both with calmodulin and with another part of the pump J. Biol. Chem. 264 1989 12313 12321
36. 2+ transporters cross-react J. Biol. Chem. 23 1993 17120 17125