Postnatal inorganic lead exposure reduces midbrain dopaminergic impulse flow and decreases dopamine D1 receptor sensitivity in nucleus accumbens neurons

Journal of Pharmacology and Experimental Therapeutics

Volumn 312, Issue 3, 2005, Pages 1280-1288

  Tavakoli Nezhad, Mahboubeh ^a   Pitts, David K ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,4,5 TETRAHYDRO 7,8 DIHYDROXY 1 PHENYL 1H 3 BENZAZEPINE; APOMORPHINE; DOPAMINE 1 RECEPTOR; LEAD; TYROSINE 3 MONOOXYGENASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL MEMBRANE DEPOLARIZATION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; ELECTROPHYSIOLOGY; GROWTH CURVE; HYPERPOLARIZATION; IMMUNOHISTOCHEMISTRY; IONTOPHORESIS; LEAD BLOOD LEVEL; MALE; MESENCEPHALON; NONHUMAN; NUCLEUS ACCUMBENS; PERINATAL DRUG EXPOSURE; POSTSYNAPTIC POTENTIAL; PRESYNAPTIC POTENTIAL; PRIORITY JOURNAL; RAT; RECEPTOR SENSITIVITY; SUBSTANTIA NIGRA; VENTRAL TEGMENTUM;

2,3,4,5-TETRAHYDRO-7,8-DIHYDROXY-1-PHENYL-1H-3-BENZAZEPINE; ANIMALS; APOMORPHINE; GROWTH; HALOPERIDOL; IMMUNOHISTOCHEMISTRY; LEAD; MALE; MESENCEPHALON; NUCLEUS ACCUMBENS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D1; TYROSINE 3-MONOOXYGENASE; VENTRAL TEGMENTAL AREA;

EID: 14344261019     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.076166     Document Type: Article

References (41)

1. Braga MF, Pereira EF, and Albuquerque EX (1999) Nanomolar concentrations of lead inhibit glutamatergic and GABAergic transmission in hippocampal neurons. Brain Res 826:22-34.
2. Bunney BS, Chiodo LA, and Grace AA (1991) Midbrain dopamine system electrophysiological functioning: a review and new hypothesis. Synapse 9:79-94.
3. Bunney BS and Grace AA (1978) Acute and chronic haloperidol treatment: comparison of effects on nigral dopaminergic cell activity. Life Sci 23:715-728.
4. Canfield RL, Henderson CR Jr, Cory-Slechta DA, Cox C, Jusko TA, and Lanphear BP (2003a) Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med 348:1517-1526.
5. Canfield SL, Kreher DA, Cornwell C, and Henderson CR Jr (2003b) Low-level lead exposure, executive functioning and learning in early childhood. Neuropsychol Dev Cogn Sect C Child Neuropsychol 9:35-53.
6. Chiodo LA and Bunney BS (1983) Typical and atypical neuroleptics: differential effects on the activity of A9 and A10 midbrain dopaminergic neurons. J Neurosci 3:1607-1619.
7. Cory-Slechta DA (1997) Relationships between lead induced changes in neurotransmitter system function and behavioral toxicity. Neurotoxicology 18:673-688.
8. Floresco SB, West AR, Ash B, Moore H, and Grace AA (2003) Afferent modulation of dopamine neuron firing differentially regulates tonic and phasic dopamine transmission. Nat Neurosci 8:968-973.
9. Grace AA (1991) Phasic versus tonic dopamine release and the modulation of dopamine system responsivity: a hypothesis for the etiology of schizophrenia. Neuroscience 41:1-24.
10. Grace AA (2000) Gating of information flow within the limbic system and the pathophysiology of schizophrenia. Brain Res Brain Res Rev 31:330-341.
11. Grace AA and Bunney BS (1979) Paradoxical GABA excitation of nigra dopaminergic cells: indirect mediation through reticulata inhibitory neurons. Eur J Pharmacol 59:211-218.
12. Grace AA and Bunney BS (1980) Nigral dopamine neurons: intracellular recording and identification with L-DOPA injection and histofluorescence. Science (Wash DC) 210:654-656.
13. Grace AA and Bunney BS (1986) Induction of depolarization block in midbrain by repeated administration of haloperidol: analysis using in vitro intracellular recording. J Pharmacol Exp Ther 238:1092-1100.
14. Guilarte TR (1997) Glutamatergic system and developmental lead toxicity. Neurotoxicology 18:665-672.
15. Kala SV and Jadhav AL (1995a) Low level lead exposure decreases in vivo release of dopamine in the rat nucleus accumbens: a microdialysis study. J Neurochem 65:1631-1635.
16. Kala SV and Jadhav AL (1995b) Region specific alteration in dopamine and serotonin metabolism in brains of rats exposed to low level of lead. Neurotoxicology 16:297-308.
17. Kuhn W, Winkel R, Woitalla D, Meves S, Przuntek H, and Muller T (1998) High prevalence of parkinsonism after occupational exposure to lead-sulfate batteries. Neurology 50:1885-1886.
18. Lasley SM (1992) Regulation of dopaminergic activity, but not tyrosine hydroxylase, is diminished after chronic inorganic lead exposure. Neurotoxicology 13:625-635.
19. Lasley SM and Gilbert ME (2002) Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level. Toxicol Sci 66:139-147.
20. Lewis MW and Pitts DK (2004) Inorganic lead exposure in the rat activates striatal cFOS expression at lower blood levels and inhibits amphetamine-induced cFOS expression at higher blood levels. J Pharmacol Exp Ther 310:815-820.
21. Lidsky TI and Schneider JS (2003) Lead neurotoxicity in children: basic mechanisms and clinical correlates. Brain 126:5-19.
22. Minabe Y, Ashby CR Jr, Heyser C, Spear LP, and Wang RY (1992) The effects of prenatal cocaine exposure on spontaneously active midbrain dopamine neurons in adult male offspring: an electrophysiological study. Brain Res 586:152-156.
23. Minder B, Das-Smaal EA, Brand EF, and Orlebeke JF (1994) Exposure to lead and specific attentional problems in schoolchildren. J Learn Disabil 27:393-399.
24. Nation JR, Frye GD, Van Stultz J, and Bratton GR (1989) Effects of combined lead and cadmium exposure: changes in schedule-controlled responding and in dopamine, serotonin and their metabolites. Behav Neurosci 103:1108-1114.
25. Needleman HL (1993) The current status of low-level lead toxicity. Neurotoxicology 14:161-166.
26. Nicola SM, Surmerier J, and Malenka RC (2000) Dopaminergic modulation of neuronal excitability in the striatum and nucleus accumben. Annu Rev Neurosci 23:185-214.
27. Paxinos G and Watson C (1986) The Rat Brain in Stereotaxic Coordinates, 2nd ed, Academic Press, Inc., New York.
28. Pitts DK, Kelland MD, Shen R, Freeman AS, and Chiodo LA (1990) Statistical analysis of dose-response curves in extracellular electrophysiological studies of single neurons. Synapse 5:281-293.
29. Pokora MJ, Richfield EK, and Cory-Slechta DA (1996) Preferential vulnerability of nucleus accumbens dopamine binding sites to low-level lead exposure: time course of effects and interactions with chronic dopamine agonist treatment. J Neurochem 87:1540-1550.
30. Robertson HA, Paul ML, Moratalla R, and Graybiel AM (1991) Expression of the immediate early gene c-fos in basal ganglia: induction by dopaminergic drugs. Can J Neurol Sci 18:380-383.
31. Shao Z and Suszkiw JB (1991) Ca2(+)-surrogate action of Pb2+ on acetylcholine release from rat brain synaptosomes. J Neurochem 53:568-574.
32. 2 receptor agonists on type I caudate nucleus neurons: lack of synergistic interaction. Synapse 11:319-329.
33. Shen R-Y, Hannigan JH, and Kapatos G (1999) Prenatal ethanol reduces the activity of adult midbrain dopamine neurons. Alcoholism Clin Exp Res 23:1801-1807.
34. 14C yr BP from a peat bog, Jura Mountains, Switzerland. Science (Wash DC) 281:1635-1640.
35. Tavakoli-Nezhad M, Barron AJ, and Pitts DK (2001) Postnatal inorganic lead exposure decreases the number of spontaneously active midbrain dopamine neurons in the rat. Neurotoxicology 22:259-269.
36. Tuthill RW (1996) Hair lead levels related to children's classroom attention-deficit behavior. Arch Environ Health 51:214-220.
37. Wakefield J (2002) The lead effect? Environ Health Perspect 110:A574-A580.
38. Wang L and Pitts DK (1994) Perinatal cocaine exposure decreases the number of spontaneously active midbrain dopamine neurons in neonatal rats. Synapse 17:275-277.
39. White FJ and Wang RY (1983) Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons in the rat. Science (Wash DC) 221:1054-1057.
40. Zhang J, Wang L, and Pitts DK (1996) Prenatal haloperidol reduces the number of active midbrain dopamine neurons in rat offspring. Neurotoxicol Teratol 18:49-57.
41. Zuch CL, O'Mara DJ, and Cory-Slechta DA (1998) Low-level lead exposure selectively enhances dopamine overflow in nucleus accumbens: an in vivo electrochemistry time course study. Toxicol Appl Pharmacol 150:174-185.