Prenatal haloperidol reduces the number of active midbrain dopamine neurons in rat offspring

Neurotoxicology and Teratology

Volumn 18, Issue 1, 1996, Pages 49-57

  Zhang, Jing ^a   Wang, Liping ^a   Pitts, David K ^a  

^a WAYNE STATE UNIVERSITY   (United States)

Author keywords

Antipsychotic drugs; Development; Dopamine; Electrophysiology; Neuroleptics; Ontogeny; Substantia nigra; Ventral tegmental area

Indexed keywords

HALOPERIDOL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; MALE; MESENCEPHALON; NERVE CELL; NONHUMAN; PREGNANCY; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0029919663     PISSN: 08920362     EISSN: None     Source Type: Journal    
DOI: 10.1016/0892-0362(95)02023-3     Document Type: Article

References (78)

1. Alberch, J.; Brito, B.; Notario, V.; Castro, R. Prenatal haloperidol treatment decreases nerve growth factor receptor and mRNA in neonate rat forebrain. Neurosci. Lett. 131:228-232; 1991.
2. Blackhouse, B.; Barochovsky, O.; Malik, C.; Patel, A. J.; Lewis, P. D. Effect of haloperidol on cell proliferation in the early postnatal brain. Neuropathol. Appl. Neurobiol. 8:109-116; 1982.
3. Bruinink, A.; Lichtensteiger, W.; Schlumpf, M. Pre- and postnatal ontogeny and characterization of dopaminergic D2, serotonergic, S2 and spirodecanone binding sites in rat forebrain. J. Neurochem. 40:1227-1236; 1983.
4. Bunney, B. S.; Grace, A. A. Acute and chronic haloperidol treatment: Comparison of effects on nigral dopaminergic cell activity. Life Sci. 23:1715-1728; 1978.
5. Bunney, B. S.; Chiodo, L. A.; Grace, A. A. Midbrain dopamine system electrophysiological functioning: A review and new hypothesis. Synapse 9:79-94; 1991.
6. Burke, R. E.; Macaya, A.; DeVivo, D.; Kenyon, N.; Janec, E. M. Neonatal hypoxic-ischemic or excitotoxic striatal injury results in a decreased adult number of substantia nigra neurons. Neuroscience 50:559-569; 1992.
7. Burt, D. R.; Creese, I.; Snyder, S. H. Antischizophrenic drugs: Chronic treatment elevates dopamine receptor binding in brain. Science 196:326-327; 1977.
8. Castro, R.; Brito, B.; Notario, V. Prenatal haloperidol alters the expression of DNA polymerases in brain regions of neonate rats. Cell. Mol. Neurobiol. 10:281-289; 1990.
9. Chergui, K.; Charlety, P. J.; Akaoka, H.; Saunier, C. F.; Brunet, J.-L.; Buda, M.; Svesson, T. H.; Chouvet, G. Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. Eur. J. Neurosci. 5:137-144; 1993.
10. Chiodo, L. A.; Bunney, B. S. Typical and atypical neuroleptics: Differential effects on the activity of A9 and A10 midbrain dopaminergic neurons. J. Neurosci. 3:1607-1619; 1983.
11. Chiodo, L. A.; Bannon, M. J.; Grace, A. A.; Roth, R. H.; Bunney, B. S. Evidence for the absence of impulse-modulating somatodendritic and synthesis-modulating nerve terminal autoreceptors on subpopulations of mesocortical dopamine neurons. Neuroscience 12:1-16; 1984.
12. Chiodo, L. A.; Bunney, B. S. Possible mechanisms by which repeated clozapine administration differentially affects the activity of two subpopulations of midbrain dopamine neurons. J. Neurosci. 5:2539-2544; 1985.
13. Chiodo, L. A.; Bunney, B. S. Population response of midbrain dopaminergic neurons to neuroleptics: further studies on time course and nondopaminergic influences. J. Neurosci. 7:629-633; 1987.
14. Chiodo, L. A. Dopamine-containing neurons in the mammalian central nervous system: Electrophysiology and pharmacology. Neurosci. Biobehav. Rev. 12:49-91; 1988.
15. Cuomo, V.; Cagiano, R.; Renna, G.; Serinell, A.; Brunello, N.; Racagni, G. Comparative evaluation of the behavioral consequences of prenatal and early postnatal exposure to haloperidol in rats. Neurobehav. Toxicol. Teratol. 7:489-492; 1985.
16. Friedhoff, A. J.; Miller, J. C. Prenatal psychotropic drug exposure and the development of central dopaminergic and cholinergic transmitter systems. In: Schlumpf, M.; Lichtensteiger, W., eds. Drugs and hormones in brain development. Basel: Karger; 1983:91-98.
17. 1 dopamine receptors and dopamine content in the rat striatum. Dev. Brain Res. 35:283-290; 1987.
18. Gonon, F. G.; Buda, M. J. Regulation of dopamine release by impulse flow and dopamine autoreceptors as studied by in vivo voltammetry in the rat striatum. Neuroscience 14:765-774; 1985.
19. Gonon, F. G. Nonlinear relationship between impulse flow and dopamine release by midbrain dopaminergic neurons as studied by in vivo electrochemistry. Neuroscience 24:19-28; 1988.
20. Grace, A. A.; Bunney, B. S. Paradoxical GABA excitation of nigral dopaminergic cells: Indirect mediation through reticulata inhibitory neurons. Eur. J. Pharmacol. 59:211-218; 1979.
21. Grace, A. A.; Bunney, B. S. The control of firing pattern in nigral dopamine neurons: Single spike firing. J. Neurosci. 4:2866-2876; 1984.
22. Grace, A. A.; Bunney, B. S. The control of firing pattern in nigral dopamine neurons: Burst firing. J. Neurosci. 4:2877-2890; 1984.
23. Grace, A. A.; Bunney, B. S. Induction of depolarization block in midbrain dopamine neurons by repeated administration of haloperidol: Analysis using in vivo intracellular recording. J. Pharmacol. Exp. Ther. 238:1092-1100; 1986.
24. Grace, A. A.; Onn, S. P. Morphology and electrophysiological properties of immunocytochemically identified rat dopamine neurons recorded in vitro. J. Neurosci. 9:3463-3481; 1989.
25. Graybiel, A. M. Correspondence between the dopamine islands and striosomes of the mammalian striatum. Neuroscience 13: 1157-1187; 1984.
26. Grenhoff, J.; Ugedo, L.; Svensson, T. H. Firing patterns of midbrain dopamine neurons: Differences between A9 and A10 cells. Acta Physiol. Scand. 134:127-132; 1988.
27. Janec, E. M.; Burke, R. E. Naturally occurring cell death during postnatal development of the substantia nigra pars compacta of rat. Mol. Cell Neurosci. 4:30; 1993.
28. Johnson, S. W.; Seutin, V.; North, R. A. Burst firing in dopamine neurons induced by N-methyl-D-aspartate: Role of electrogenic sodium pump. Science 258:665-667; 1992.
29. Kalsbeek, A.; Buijs, R. M.; Hofman, M. A.; Matthijssen, M. A. H.; Pool, C. W.; Uylings, H. B. M. Effects of neonatal thermal lesioning of the mesocortical dopaminergic projection on the development of the rat prefrontal cortex. Dev. Brain Res. 32:123-132; 1987.
30. 1-type dopamine receptors inhibit growth cone motility in cultured retina neurons: Evidence that neurotransmitters act as morphogenic growth regulators in the developing central nervous system. Proc. Natl. Acad. Sci. USA 85:4567-4571; 1988.
31. Lauder, J. M.; Bloom, F. E. Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation. J. Comp. Neurol. 155:469-482; 1974.
32. Lauder, J. M. Neurotransmitters as morphogens. Prog. Brain Res. 73:365-387; 1988.
33. Loizou, L. A. The postnatal ontogeny of monoamine-containing neurones in the central nervous system of the albino rat. Brain Res. 40:395-418; 1972.
34. Macaya, A.; Burke, R. E. Effect of striatal lesion with quinolinate on the development of substantia nigra dopaminergic neurons: A quantitative morphological analysis. Dev. Neurosci. 14: 362-368; 1992.
35. Macaya, A.; Munell, F.; Gubits, R. M.; Burke, R. E. Apoptosis in substantia nigra following developmental striatal excitotoxic injury. Proc. Natl. Acad. Sci. USA 91:8117-8121; 1994.
36. Madsen, J. R.; Campbell, A.; Baldessarini, R. J. Effects of prenatal treatment of rats with haloperidol due to altered drug distribution in neonatal brain. Neuropharmacology 20:931-939; 1991.
37. Miller, J. C.; Friedhoff, A. J. Development of specificity and stereoselectivity of rat brain dopamine receptors. Int. J. Dev. Neurosci. 4:21-26; 1986.
38. Minabe, Y.; Ashby, C. R., Jr.; Heyser, C.; Spear, L. P.; Wang, R. Y. The effects of prenatal cocaine exposure on spontaneously active midbrain dopamine neurons in adult male offspring: An electrophysiological study. Brain Res. 586:152-156; 1992.
39. Mobley, W. C.; Rutkowski, J. L.; Tennekoon, G. I.; Buchanan, K.; Johnston, M. V. Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science 229: 284-287;1985.
40. 2 receptor manipulations. Pharmacol. Biochem. Behav. 44: 843-850; 1993.
41. Moon, S. L. Prenatal haloperidol alters striatal dopamine and opiate receptors. Brain Res. 323:109-113; 1984.
42. Moon-Eldey, S.; Herkenham, M. Comparative development of striatal opiate receptors and dopamine revealed by autoradiography and histofluorescence. Brain Res. 305:27-42; 1984.
43. Nomura, Y.; Yotsumoto, I.; Segawa, T. Ontogenic development of high potassium- and acetylcholine-induced release of dopamine from striatal slices of the rat. Dev. Brain Res. 1:171-177; 1981.
44. Olson, L.; Seiger, A.; Fuxe, K. Heterogeneity of striatal and limbic dopamine innervation: Highly fluorescent islands in developing and adult rats. Brain Res. 44:283-288; 1972.
45. Patel, A. J.; Lewis, P. D. Effect of chlorpromazine on cell proliferation in the developing rat brain. A combined biochemical and morphological study. Brain Res. 202:415-428; 1980.
46. Patel, A. J.; Lewis, P. D. Brain cell acquisition and neurotrophic drugs with special reference to functional teratogenesis. Prog. Brain Res. 73:389-403; 1988.
47. Pitts, D. K.; Kelland, M. D.; Shen, R.; Freeman, A. S.; Chiodo, L. A. Statistical analysis of dose-response curves in extracellular electrophysiological studies of single neurons. Synapse 5:281-293; 1990.
48. Pitts, D. K.; Freeman, A. S.; Chiodo, L. A. Dopamine neuron ontogeny: Electrophysiological studies. Synapse 6:309-320; 1990.
49. +-like neurotoxicity of a pyridinium metabolite derived from haloperidol: In vivo microdialysis and in vitro mitochondrial studies. J. Pharmacol. Exp. Ther. 268:380-387; 1994.
50. Rosegarten, H.; Friendhoff, A. J. Enduring changes in dopamine receptor cells of pups from drug administration to pregnant and nursing rat. Science 203:1133-1135; 1979.
51. Rosengarten, H.; Friedman, E.; Friedhoff, A. J. Sensitive periods to the neuroleptic effect of haloperidol to reduce dopamine receptors. In: Guiffrida-Stella, A. M.; Haber, B.; Hashim, G.; Perez-Polo, J. R., eds. Nervous system regeneration. New York: Alan Liss; 1983:511-513.
52. Rupniak, N. M.; Kilpatrick, G.; Hall, M. D.; Jenner, P.; Marsden, C. D. Differential alterations in striatal dopamine receptor sensitivity induced by repeated administration of clinically equivalent doses of haloperidol, sulpiride or clozapine in rats. Psychopharmacology (Berlin) 84:512-519; 1984.
53. Sakaguchi, T.; Nakamura, S. Some in vivo electrophysiological properties of locus coeruleus neurones in fetal rats. Exp. Brain Res. 68:122-130; 1987.
54. 125I]iodosulpride. Neuroscience 28:673-700; 1989.
55. Scalzo, F. M.; Spear, L. P. Chronic haloperidol during development attenuates dopamine autoreceptor function in striatal and mesolimbic brain regions of young and older adult rats. Psychopharmacology (Berlin) 85:271-276; 1985.
56. Scalzo, F. M.; Holson, R. R.; Gough, B. J.; Ali, S. F. Neurochemical effects of prenatal haloperidol exposure. Pharmacol. Biochem. Behav. 34:721-725; 1989.
57. Scalzo, F. M.; Ali, S. F.; Holson, R. R. Behavioral effects of prenatal haloperidol exposure. Pharmacol. Biochem. Behav. 34: 727-731; 1989.
58. 2 receptor acquisition following prenatal neuroleptic exposure. Psychiatry Res. 36:319-328; 1991.
59. Seiger, A.; Olson, L. Late prenatal ontogeny of central monoamine neurons in the rat: Fluorescence histochemical observations. Z. Anat. Entwickl.-Gesch. 140:281-318; 1973.
60. Seeman, P. Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1:133-152; 1987.
61. + conductance. Exp. Brain Res. 86:141-150; 1991.
62. Smith, I. D.; Grace, A. A. Role of the subthalamic nucleus in the regulation of nigral dopamine neuron activity. Synapse 12:287-303; 1992.
63. Spear, L. P.; Shalaby, A.; Brick, J. Chronic administration of haloperidol during development: Behavioral and psychopharmacological effects. Psychopharmacology (Berlin) 70:47-58; 1980.
64. Svensson, T. H.; Tung, C. S. Local cooling of prefrontal cortex induces pacemaker-like firing of dopamine neurons in rat ventral tegmental area in vivo. Acta Physiol. Scand. 136:135-136; 1989.
65. Tepper, J. M.; Trent, F.; Nakamura, S. Postnatal development of the electrical activity of rat nigrostriatal dopaminergic neurons. Dev. Brain Res. 54:21-33; 1990.
66. Tepper, J. M.; Damlama, M.; Tent, F. Postnatal changes in the distribution and morphology of rat substantia nigra dopaminergic neurons. Neuroscience 60:469-77; 1994.
67. Van Der Kooy, D.; Fishell, G. Embryonic lesions of the substantia nigra prevent the patchy expression of opiate receptors, but not the segregation of patch and matrix compartment neurons, in the developing rat striatum. Dev. Brain Res. 66:141-145; 1992.
68. Van Gent, C. M.; Sandberg, L. B.; Boucek, R. J. Haloperidol administration to rats during pregnancy induces permanent alterations in serum lipoprotein patterns of progeny. J. Clin. Psychopharmacol. 11:113-115; 1991.
69. Voorn, P.; Kalsbeek, A.; Jorritsma-Byham, B.; Groenewegen, H. J. The pre- and postnatal development of the dopaminergic cell groups in the ventral mesencephalon and the dopaminergic innervation of the striatum of the rat. Neuroscience 25:857-887; 1988.
70. Wang, L.; Pitts, D. K. Postnatal development of mesoaccumbens dopamine neurons in the rat: Electrophysiological studies. Dev. Brain Res. 79:19-28; 1994.
71. Wang, L.; Pitts, D. K. Perinatal cocaine exposure decreases the number of spontaneously active midbrain dopamine neurons in neonatal rats. Synapse 17:275-277; 1994.
72. Wang, L.; Pitts, D. K. Ontogeny of nigrostriatal dopamine autoreceptors: Iontophoretic studies. J. Pharmacol. Exp. Ther. 272: 164-176; 1995.
73. Williams, R.; Ali, S. F.; Scalzo, F. M.; Soliman, K.; Holson, R. R. Prenatal haloperidol exposure: Effects on brain weights and caudate neurotransmitter levels in rats. Brain Res. Bull. 29:449-458; 1992.
74. White, F. J.; Wang, R. Y. Differential effects of classical and atypical antipsychotic drugs on A9 and A10 dopamine neurons. Science 221:1054-1057; 1983.
75. White, F. J.; Wang, R. Y. Comparasion of the effects of chronic haloperidol treatment on A9 and A10 dopamine neurons in the rat. Life Sci. 32:983-993; 1983.
76. Yotsumoto, I.; Nomura, Y. Ontogenesis of the dopamine uptake into P2 fractions and slices of the rat brain. Jpn. J. Pharmacol. 31:298-300; 1981.
77. Zhang, J.; Chiodo, L. A.; Freeman, A. S. Repeated administration of sigma receptor ligands alters the population activity of rat midbrain dopaminergic neurons. Synapse 13:223-230; 1993.
78. Zhang, J.; Chiodo, L. A.; Freeman, A. S. Influence of excitatory amino acid receptor subtypes on the electrophysiological activity of dopaminergic and nondopaminergic neurons in rat substantia nigra. J. Pharmacol. Exp. Ther. 269:313-321; 1994.