Inhibitors of poly (ADP-ribose) polymerase ameliorate myocardial reperfusion injury by modulation of activator protein-1 and neutrophil infiltration

Shock

Volumn 23, Issue 3, 2005, Pages 233-238

  Kaplan, Jennifer ^a   O'Connor, Michael ^a   Hake, Paul W ^a   Zingarelli, Basilia ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

Adhesion molecules; AP 1; Caspase 3; Neutrophils

Indexed keywords

1,5 DIHYDROXYISOQUINOLINE; 3 AMINOBENZAMIDE; CASPASE 3; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NICOTINIC ACID; PADGEM PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); QUINOLINE DERIVATIVE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENDOTHELIUM CELL; ENZYME ACTIVITY; HEART PROTECTION; HUMAN; HUMAN CELL; LEFT ANTERIOR DESCENDING CORONARY ARTERY; MALE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION;

ANIMALS; BENZAMIDES; CASPASE 3; CASPASES; CELL ADHESION MOLECULES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; ENZYME INHIBITORS; ISOQUINOLINES; MALE; MYOCARDIAL REPERFUSION INJURY; NEUTROPHILS; POLY(ADP-RIBOSE) POLYMERASES; RATS; RATS, WISTAR; TRANSCRIPTION FACTOR AP-1;

EID: 14344251296     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.shk.0000151026.30624.ef     Document Type: Article

References (45)

1. Ambrosio G, Tritto I: Reperfusion injury: experimental evidence and clinical implications. Am Heart J 138:S69-S75, 1999.
2. Grisham MB, Granger DN, Lefer DJ: Modulation of leukocyte-endothelial interactions by reactive metabolites of oxygen and nitrogen: relevance to ischemic heart disease. Free Radical Biol Med 25:404-433, 1998.
3. Liu P, Xu B, Forman LJ, Carsia R, Hock CE: L-NAME enhances microcirculatory congestion and cardiomyocyte apoptosis during myocardial ischemia-reperfusion in rats. Shock 17:185-192, 2002.
4. Karin M, Liu Zg, Zandi E: AP-1 function and regulation. Curr Opin Cell Biol 9:240-246, 1997.
5. Kokura S, Wolf RE, Yoshikawa T, Granger DN, Aw TY: Molecular mechanisms of neutrophil-endothelial cell adhesion induced by redox imbalance. Circ Res 84:516-524, 1999.
6. Ahmad M, Theofanidis P, Medford RM: Role of activating protein-1 in the regulation of the vascular cell adhesion molecule-1 gene expression by tumor necrosis factor-α. J Biol Chem 273:4616-4621, 1998.
7. Chandrasekar B, Freeman GL: Induction of nuclear factor-κB and activation protein 1 in postischemic myocardium. FEBS Lett 401:30-34, 1997.
8. Shimizu N, Yoshiyama M, Omura T, Hanatani A, Kim S, Takeuchi K, Iwao H, Yoshikawa J: Activation of mitogen-activated protein kinases and activator protein-1 in myocardial infarction in rats. Cardiovasc Res 38:116-124, 1998.
9. Zingarelli B, Hake PW, Yang Z, O'Connor M, Denenberg A, Wong HR; Absence of inducible nitric oxide synthase modulates early reperfusion-induced NF-κB and AP-1 activation and enhances myocardial damage. FASEB J 16:327-342, 2002.
10. Valen G, Hansson GK, Dumitrescu A, Vaage J: Unstable angina activates myocardial heat shock protein 72, endothelial nitric oxide synthase, and transcription factors NF-κB and AP-1. Cardiovasc Res 47:49-56, 2000.
11. Lautier D, Lagueux J. Thibodeau J, Ménard L, Poirier GG: Molecular and biochemical features of poly (ADP-ribose) metabolism. Mol Cell Biochem 122:171-193, 1993.
12. Kasid UN, Halligan B, Liu LF, Dritschilo A, Smulson ME: Poly (ADP-ribose) mediated post-translational modification of chromatin-associated human topoisomerase I. Inhibitory effects on catalytic activity. J Biol Chem 264:18687-18692, 1989.
13. Desmarais Y, Ménard L, Lagueux J, Poirier GG: Enzymological properties of poly (ADP-ribose) polymerase: characterization of automodification sites and of its NADase activity. Biochem Biophys Acta 1078:179-186, 1991.
14. D'Amours D, Desnoyers S, D'Silva I, Poirier GG: Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J 342:249-268, 1999.
15. D'Silva I, Pelletier JD, Lagueux J, D'Amours D, Chaudhry MA, Weinfeld M, Lees-Miller SP, Poirier GG: Relative affinities of poly (ADP-ribose) polymerase and DNA-dependent protein kinase for DNA strand interruptions. Biochim Biophys Acta 1430:119-126, 1999.
16. Virag L, Szabó C: The therapeutic potential of poly(ADP-ribose) polymerase inhibitors. Pharmacol Rev 54:375-429, 2002.
17. Zingarelli B, Cuzzocrea S, Zsengeller Z, Salzman AL, Szabó C: Protection against myocardial ischemia and reperfusion injury by 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthetase. Cardiovasc Res 36:205-212, 1997.
18. Zingarelli B, Salzman AL, Szabó C: Genetic disruption of poly (ADP-ribose) synthetase inhibits the expression of P-selectin and intercellular adhesion molecule-1 in myocardial ischemia/reperfusion injury. Circ Res 83:85-94, 1998.
19. Yang Z, Zingarelli B, Szabó C: Effect of genetic disruption of poly (ADP-ribose) synthetase on delayed production of inflammatory mediators and delayed necrosis during myocardial ischemia-reperfusion injury. Shock 13:60-66, 2000.
20. Thiemermann C, Bowes J, Myint FP, Vane JR: Inhibition of the activity of poly (ADP ribose) synthetase reduces ischemia-reperfusion injury in the heart and skeletal muscle. Proc Natl Acad Sci USA 94:679-683, 1997.
21. Pieper AA, Walles T, Wei G, Clements EE, Verma A, Snyder SH, Zweier JL: Myocardial postischemic injury is reduced by poly(ADP-ribose) polymerase-1 gene disruption. Mol Med 6:271-282, 2000.
22. Banasik M, Komura H, Shimoyama M, Ueda K: Specific inhibitors of poly(ADP-ribose) synthetase and mono(ADP-ribosyl)transferase. J Biol Chem 267:1569-1575, 1992.
23. Chatterjee PK, Zacharowski K, Cuzzocrea S, Otto M, Thiemermann C: Inhibitors of poly (ADP-ribose) synthetase reduce renal ischemia-reperfusion injury in the anesthetized rat in vivo. FASEB J 14:641-651, 2000.
24. Mullane KM. Kraemer R, Smith B: Myeloperoxidase activity as a quantitative assessment of neutrophil infiltration into ischemic myocardium. J Pharmacol Methods 14:157-167, 1985.
25. Vanags DM, Orrenius S, Aguilar-Santelises M: Alterations in Bcl-2/Bax protein levels in platelets form part of an ionomycin-induced process that resembles apoptosis. Br J Haematol 99:824-831, 1997.
26. Lum H, Roebuck KA: Oxidant stress and endothelial cell dysfunction. Am J Physiol Cell Physiol 280:C719-C741, 2001.
27. Andreone TL, Denenberg A, O'Connor M, Hake PW, Zingarelli B: Poly (ADP-ribose) polymerase-1 regulates activation of activator protein-1 in murine fibroblasts. J Immunol 170:2113-2120, 2003.
28. Zingarelli B, Hake PW, O'Connor M, Denenberg A, Wong HR, Kong S, Aronow BJ: Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1. Am J Physiol Heart Circ Physiol 286:H1408-H415, 2004.
29. Zingarelli B, Hake PW, O'Connor M, Denenberg A, Kong S, Aronow BJ: Absence of poly(ADP-ribose)polymerase-1 alters nuclear factor-κB activation and gene expression of apoptosis regulators after reperfusion injury. Mol Med 9:143-153, 2003.
30. -/- cell line expressing PARP-1 DNA-binding domain. Biochem Biophys Res Commun 285:289-294, 2001.
31. Watson CY, Whish WJ, Threadgill MD: Synthesis of 3-substituted benzamides and 5-substituted isoquinolin-1(2H)-ones and preliminary evaluation as inhibitors of poly(ADP-ribose)polymerase (PARP). Bioorg Med Chem 6:721-734, 1998.
32. Meng X, Harken AH: The interaction between Hsp70 and TNF-α expression: a novel mechanism for protection of the myocardium against post-injury depression. Shock 17:345-353, 2002.
33. Shames BD, Barton HH, Reznikov LL, Cairns CB, Banerjee A, Harken AH, Meng X: Ischemia alone is sufficient to induce TNF-α mRNA and peptide in the myocardium. Shock 17:114-119, 2002.
34. Szabó G, Soos P, Mandera S, Heger U, Flechtenmacher C, Bahrle S, Seres L, Cziraki A, Gries A, Zsengeller Z, Vahl CF, Hagl S, Szabó C: INO-1001 a novel poly(ADP-ribose) polymerase (PARP) inhibitor improves cardiac and pulmonary function after crystalloid cardioplegia and extracorporal circulation. Shock 21:426-432, 2004.
35. Amstad PA, Krupitza G, Cerutti PA: Mechanism of c-fos induction by active oxygen. Cancer Res 52:3952-3960, 1992.
36. Butler AJ, Ordahl CP: Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription. Mol Cell Biol 19:296-306, 1999.
37. Rawling JM. Alvarez-Gonzalez R: TFIIF, a basal eukaryotic transcription factor, is a substrate for poly(ADP-ribosyl)ation. Biochem J 324:249-253, 1997.
38. Oei SL, Griesenbeck J, Schweiger M, Ziegler M: Regulation of RNA polymerase II-dependent transcription by poly(ADP-ribosyl)ation of transcription factors. J Biol Chem 273:31644-31647, 1998.
39. Kameoka M, Ota K, Tetsuka T, Tanaka Y, Itaya A, Okamoto T, Yoshihara K: Evidence for regulation of NF-κB by poly(ADP-ribose) polymerase. Biochem J 346:641-649, 2000.
40. Chiarugi A: Poly(ADP-ribose) polymerase: killer or conspirator? The "suicide hypothesis" revisited. Trends Pharmacol Sci 23:122-129, 2002.
41. Hassa PO, Covic M, Hasan S, Imhof R, Hottiger MO: The enzymatic and DNA binding activity of PARP-1 are not required for NF-κB coactivator function. J Biol Chem 276:45588-45597, 2001.
42. Kannan P, Yu Y, Wankhade S, Tainsky MA: Poly(ADP-ribose) polymerase is a coactivator for AP-2-mediated transcriptional activation. Nucleic Acids Res 27:866-874, 1999.
43. Nie J, Sakamoto S, Song D, Qu Z, Ota K, Taniguchi T: Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase. FEBS Lett 424:27-32, 1998.
44. Oei SL, Griesenbeck J, Schweiger M, Babich V, Kropotov A, Tomilin N: Interaction of the transcription factor YY1 with human poly(ADP-ribosyl) transferase. Biochem Biophys Res Commun 240:108-111, 1997.
45. Butler AJ, Ordahl CP: Poly(ADP-ribose) polymerase binds with transcription enhancer factor 1 to MCAT1 elements to regulate muscle-specific transcription. Mol Cell Biol 19:296-306, 1999.