Brevetoxin metabolism and elimination in the Eastern oyster (Crassostrea virginica) after controlled exposures to Karenia brevis

Toxicon

Volumn 44, Issue 6, 2004, Pages 677-685

  Plakas, Steven M ^a   Wang, Zhihong ^a   El Said, Kathleen R ^a   Jester, Edward L E ^a   Granade, Hudson R ^a   Flewelling, Leanne ^b   Scott, Paula ^b   Dickey, Robert W ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b FLORIDA MARINE RESEARCH INSTITUTE   (United States)

Author keywords

Brevetoxin; Eastern oyster; Elimination; Liquid chromatography mass spectrometry; Metabolism

Indexed keywords

BREVETOXIN; CYSTEINE; BREVETOXIN T17; MARINE TOXIN; OXOCIN DERIVATIVE; TRITIUM;

ALGA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONJUGATE; CONTROLLED STUDY; CORRELATION COEFFICIENT; CRASSOSTREA VIRGINICA; CYTOTOXICITY; ELIMINATION REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; IN VITRO STUDY; KARENIA BREVIS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITE; MOLLUSC; NONHUMAN; OYSTER; PRIORITY JOURNAL; RECEPTOR BINDING; ANIMAL; BINDING COMPETITION; BIOASSAY; CHEMISTRY; COMPARATIVE STUDY; DINOFLAGELLATE; DNA ADDUCT; DOSE RESPONSE; DRUG EFFECT; MOUSE; RAT;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL ASSAY; CHROMATOGRAPHY, LIQUID; DINOFLAGELLIDA; DNA ADDUCTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; MARINE TOXINS; MASS SPECTROMETRY; MICE; OSTREIDAE; OXOCINS; RATS; TRITIUM;

EID: 14244267439     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2004.07.027     Document Type: Article

References (22)

1. APHA Subcommittee of Laboratory Methods for Examination of Shellfish. Method for the bioassay of Gymnodinium breve toxin(s) in shelfish Fourth ed. Recommended Procedures for the Examination of Seawater and Shellfish 1970 American Public Health Association Washington, DC pp. 61-66
2. D.G. Baden, and T.J. Mende Toxicity of two toxins from the Florida red tide marine dinoflagellate, Ptychodiscus brevis Toxicon 20 1982 457 461
3. R. Dickey, E. Jester, R. Granade, D. Mowdy, C. Moncreiff, D. Rebarchik, M. Robl, S. Musser, and M. Poli Monitoring brevetoxins during a Gymnodinium breve red tide: comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shellfish extracts Natural Toxins 7 1999 157 165
4. R.W. Dickey, S.M. Plakas, E.L.E. Jester, K.R. El Said, J.N. Johannessen, L.J. Flewelling, P. Scott, D.G. Hammond, F.M. Van Dolah, T.A. Leighfield, M.-Y. Bottein Dachraoui, J.S. Ramsdell, R.H. Pierce, M.S. Henry, M.A. Poli, C. Walker, J. Kurtz, J. Naar, D.G. Baden, S.M. Musser, K.D. White, P. Truman, T.P. Hawryluk, M.M. Wekell, D. Stirling, M.A. Quilliam, and J.K. Lee Multi-laboratory study of five methods for the determination of brevetoxins in shellfish tissue extracts K.A. Steidinger J.H. Landsberg C.R. Tomas G.A. Vargo Harmful Algae 2002. Proceedings of the X International Conference on Harmful Algae 2004 Florida Fish and Wildlife Conservation Commission and Intergovernmental Oceanographic Commission of UNESCO (in press)
5. H. Ishida, A. Nozawa, K. Totoribe, N. Muramatsu, H. Nukaya, K. Tsuji, K. Yamaguchi, T. Yasumoto, H. Kaspar, N. Berkett, and T. Kosuge Brevetoxin B1, a new polyether marine toxin from the New Zealand shellfish, Austrovenus stutchburyi Tetrahedron Letters 36 1995 725 728
6. H. Ishida, A. Nozawa, H. Hamano, H. Naoki, T. Fujita, H.F. Kaspar, and K. Tsuji Brevetoxin B5, a new brevetoxin analog isolated from cockle Austrovenus stutchburyi in New Zealand, the marker for monitoring shellfish neurotoxicity Tetrahedron Letters 45 2004 29 33
7. H. Ishida, A. Nozawa, H. Nukaya, L. Rhodes, P. McNabb, P.T. Holland, and K. Tsuji Confirmation of brevetoxin metabolism in cockle, Austrovenus stutchburyi, and greenshell mussel, Perna canaliculus, associated with New Zealand neurotoxic shellfish poisoning, by controlled exposure to Karenia brevis culture Toxicon 43 2004 701 712
8. H. Ishida, A. Nozawa, H. Nukaya, and K. Tsuji Comparative concentrations of brevetoxins PbTx-2, PbTx-3, BTX-B1 and BTX-B5 in cockle, Austrovenus stutchburyi, greenshell mussel, Perna canaliculus, and Pacific oyster, Crassostrea gigas, involved neurotoxic shellfish poisoning in New Zealand Toxicon 43 2004 779 789
9. J.H. Landsberg The effects of harmful algal blooms on aquatic organisms Reviews in Fisheries Science 10 2002 113 390
10. A. Morohashi, M. Satake, K. Murata, H. Naoki, H.F. Kaspar, and T. Yasumoto Brevetoxin B3, a new brevetoxin analog isolated from the greenshell mussel Perna canaliculus involved in neurotoxic shellfish poisoning in New Zealand Tetrahedron Letters 36 1995 8995 8998
11. A. Morohashi, M. Satake, H. Naoki, H.F. Kaspar, Y. Oshima, and T. Yasumoto Brevetoxin B4 isolated from greenshell mussel Perna canaliculus, the major toxin involved in neurotoxic shellfish poisoning in New Zealand Natural Toxins 7 1999 45 48
12. K. Murata, M. Satake, H. Naoki, H.F. Kaspar, and T. Yasumoto Isolation and structure of a new brevetoxin analog, brevetoxin B2, from greenshell mussels from New Zealand Tetrahedron 54 1998 735 742
13. J. Naar, A. Bourdelais, C. Tomas, J. Kubanek, P.L. Whitney, L. Flewelling, K. Steidinger, J. Lancaster, and D.G. Baden A competitive ELISA to detect brevetoxins from Karenia brevis (formerly Gymnodinium breve) in seawater, shellfish, and mammalian body fluid Environmental Health Perspectives 110 2002 179 185
14. J. Naar, A. Weidner, J. Kubanek, A.J. Bourdelais, H. Jacocks, K. Steidinger, R. Pierce, and D.G. Baden Bioaccumulation, bio-depuration and biotransformation of brevetoxins by shellfish: an issue for shellfish monitoring K.A. Steidinger J.H. Landsberg C.R. Tomas G.A. Vargo Harmful Algae 2002. Proceedings of the Xth International Conference on Harmful Algae. Florida Fish and Wildlife Conservation Commission and Intergovernmental Oceanographic Commission of UNESCO 2004 (in press)
15. A. Nozawa, K. Tsuji, and H. Ishida Implication of brevetoxin B1 and PbTx-3 in neurotoxic shellfish poisoning in New Zealand by isolation and quatitative determination with liquid chromatography-tandem mass spectrometry Toxicon 42 2003 91 103
16. S.M. Plakas, K.R. El Said, E.L.E. Jester, H.R. Granade, S.M. Musser, and R.W. Dickey Confirmation of brevetoxin metabolism in the Eastern oyster (Crassostrea virginica) by controlled exposures to pure toxins and to Karenia brevis cultures Toxicon 40 2002 721 729
17. S.M. Plakas, K.R. El Said, E.L.E. Jester, Z. Wang, P.E. Eilers, H.R. Granade, and R.W. Dickey Brevetoxin metabolism and elimination in the Eastern oyster (Crassostrea virginica): implications for methods development K.A. Steidinger J.H. Landsberg C.R. Tomas G.A. Vargo Harmful Algae 2002. Proceedings of the Xth International Conference on Harmful Algae. Florida Fish and Wildlife Conservation Commission and Intergovernmental Oceanographic Commission of UNESCO 2004 (in press)
18. M.A. Poli, S.M. Musser, R.W. Dickey, P.P. Eilers, and S. Hall Neurotoxic shellfish poisoning and brevetoxin metabolites: a case study from Florida Toxicon 38 2000 981 993
19. V.L. Trainer, and M.A. Poli Assays for dinoflagellate toxins, specifically brevetoxin, ciguatoxin, and saxitoxin H. Rochat M.-F. Martin-Eauclaire Methods and Tools in Biosciences and Medicine, Animal Toxins 2000 Birkhauser Verlag Basel New York 1 19
20. F.M. Van Dolah, and J.S. Ramsdell Review and assessment of in vitro detection methods for algal toxins Journal of the AOAC International 84 2001 1617 1625
21. Z. Wang, S.M. Plakas, K.R. El Said, E.L.E. Jester, H.R. Granade, and R.W. Dickey LC/MS analysis of brevetoxin metabolites in the Eastern oyster (Crassostrea virginica) Toxicon 43 2004 455 465
22. Z. Wang, K.R. El Said, S.M. Plakas, and R.W. Dickey Sample preparation methods for analysis of brevetoxins in oysters by LC/MS K.A. Steidinger J.H. Landsberg C.R. Tomas G.A. Vargo Harmful Algae 2002. Proceedings of the Xth International Conference on Harmful Algae. Florida Fish and Wildlife Conservation Commission and Intergovernmental Oceanographic Commission of UNESCO 2004 (in press)