Granule cell apoptosis induced by overdose copper and ethanol is counterbalanced by co-induced cellular proliferation in rat dentate gyrus

Tohoku Journal of Experimental Medicine

Volumn 205, Issue 2, 2005, Pages 171-178

  Akdogan, Ilgaz ^a   Adiguzel, Esat ^a   Turgut, Gunfer ^a   Genc, Osman ^a   Tufan, A Cevik ^a  

^a PAMUKKALE UNIVERSITY   (Turkey)

Author keywords

Apoptosis; Cell proliferation; Copper; Dentate gyrus; Ethanol

Indexed keywords

ALCOHOL; BROXURIDINE; COPPER;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL COUNT; CELL PROLIFERATION; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DENTATE GYRUS; GRANULE CELL; INTOXICATION; NICK END LABELING; NONHUMAN; RAT; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; COPPER; DENTATE GYRUS; ETHANOL; OVERDOSE; RATS; RATS, WISTAR;

EID: 13944284561     PISSN: 00408727     EISSN: None     Source Type: Journal    
DOI: 10.1620/tjem.205.171     Document Type: Article

References (34)

1. Adiguzel, E., Akdogan, I., Duzcan, S.E. & Tufan, A.C. (2002) Effect of penicillin induced epilepsy seizure on granulare cell layer of dentate gyrus in rat: A stereological study. Neurosci. Res. Commun. 31, 101-109.
2. Akdogan, I., Unal, N. & Adiguzel, E. (2002) Estimation of the number of neurons in the hippocampus of rats with penicillin induced epilepsy. Image Anal. Stereol., 21, 117-120.
3. Amaral, D.G. & Witter, M.P. (1989) The three-dimensional organization of the hippocampal formation: A review of anatomical data. Neuroscience, 31, 571-591.
4. Arendt, T., Hennig, D., Gray, J.A. & Marchbanks, R. (1988) Loss of neurons in the rat basal forebrain cholinergic projection system after prolonged intake of alcohol. Brain Res. Bull., 21, 563-570.
5. +3), and zinc in the hippocampus. Brain Res., 892, 51-62.
6. Barranguet, C., Plans, M., Grinten, E., Sinke, J.J. & Admiraal, W. (2002) Development of photosynthetic biofilms affected by dissolved and sorbed copper in a eutrophic river. Environ. Toxicol. Chem., 21, 1955-1965.
7. Bayer, S.A., Yackel, J.W. & Puri, P.S. (1982) Neurons in the rat dentate gyrus granular layer substantially increase during juvenile and adult life. Science, 216, 890-892.
8. Bengochea, O. & Gonzalo, L.M. (1990) Effect of chronic alcoholism on the human hippocampus. Histol. Histopathol., 5, 349-357.
9. Berry, M., Bannister, L.H. & Standring, S.M. (1995) In: Gray's Anatomy 38th edition, edited by P.L. Williams. Churchill Livingstone, New York, pp. 901-1399.
10. Cadete-Leite, A., Alves, M.C., Tavares, M.A. & Paula-Barbosa, M.M. (1990) Effects of choronic alcohol intake and withdrawal on the prefrontal neurons and synapses. Alcohol, 7, 145-152.
11. Cadete-Leite, A., Tavares, M.A., Uylings, H.B.M. & Paula-Barbosa, M. (1988) Granule cell loss and dendritic regrowth in the hippocampal dentate gyrus of the rat after chronic alcohol consumption. Brain Res., 473, 1-14.
12. Charness, M.E. (1993) Brain lesions in alcoholics. Alcohol. Clin. Exp. Res., 17, 2-11.
13. Chen, W.J., Berryhill, E.C. & West, J.R. (2001) Zinc supplementation does not attenuate alcohol-induced cerebellar Purkinje cell loss during the brain growth spurt period. Alcohol. Clin. Exp. Res., 25, 600-605.
14. Covolan, L., Ribeiro, L.T., Longo, B.M. & Mello, L.E. (2000) Cell damage and neurogenesis in the dentate granule cell layer of adult rats after pilocarpine- or kainate-induced status epilepticus. Hippocampus, 10, 169-180.
15. Eriksson, P.S., Perfilieva, E., Bjork-Erikson, T., Alborn, A.M., Nordborg, C., Peterson, D.A. & Gage, F.H. (1998) Neurogenesis in adult human hippocampus. Nat. Med., 4, 1313-1317.
16. Gage, F.H., Kempermann, G., Palmer, TD., Peterson, D.A. & Ray, J. (1998) Multipotent progenitor cells in the adult dentate gyrus. J. Neurobiol., 36, 249-266.
17. Gray, W.P. & Sundstrom, L.E. (1998) Kainic acid increases the proliferation of granule cell progenitors in the dentate gyrus of the adult rat. Brain Res., 790, 52-59.
18. Horning, M.S., Blakemore, L.J. & Trombley, P.Q. (2000) Endogeneous mechanisms of neuroprotection: role of zinc, copper, and carnosine. Brain Res., 852, 56-61.
19. Kee, N.J., Preston, E. & Wojtowicz, J.M. (2001) Enhanced neurogenesis after transient global ischemia in the dentate gyms of the rat. Exp. Brain Res., 136, 313-320.
20. Lukoyanov, N.V., Brandao, F., Cadete-Leite, A., Maderia, M.D. & Paula-Barbosa, M.M. (2000) Synaptic reorganization in the hippocampal formation of alcohol-fed rats may compensate for functional deficits related to neuronal loss. Alcohol, 20, 139-148.
21. Lukoyanov, N.V., Maderia, M.D. & Paula-Barbosa, M.M. (1999) Behavioral and neuroanatomical consequences of choronic ethanol intake and witdrawal. Physiol. Behav., 66, 337-346.
22. Meldrum, B.S. & Bruton, C.J. (1992) In: Greenfield's Neuropathology edited by J.B. Geenfield, J.H. Adams & L.W. Duchen. Oxford University Press, pp. 1246-1279.
23. Obernier, J.A., White, A.M., Swartzwelder, H.S. & Crews, F.T. (2002) Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats. Pharmacol. Biochem. Behav., 72, 521-532.
24. Paula-Barbosa, M.M., Brandao, F., Andrade, J.P., Maderia, M.D., Zimmer, J. & Cadete-Leite, A. (1991) Intracerebral grafting impedes hippocampal cell loss during withdrawal after long-term alcohol consumption in rats. Alcohol Alcoholism, 26, 177-190.
25. Paula-Barbosa, M.M., Brandao, F., Maderia, M.D. & Cadete-Leite, A. (1993) Structural changes in the hippocampal formation after long-term alcohol consumption and withdrawal in the rat. Addiction, 88, 237-247.
26. Pawlak, R., Skrzypiec, A., Sulkowski, S. & Buczko, W. (2002) Ethanol-induced neurotoxicity is counterbalanced by increased cell proliferation in mouse dentate gyrus. Neurosci. Lett., 327, 83-86.
27. Proper, E.A., Hoogland, G., Van Veelen, C.W.M. & Grann, P.N.E. (2001) Morphological changes in the human epileptogenic hippocampus. Neurosci. Res. Commun., 29, 129-146.
28. Sarkar, B. (2000) Copper transport and its defect in Wilson disease: characterization of the copper-binding domain of Wilson disease ATPase. J. Inorg. Biochem., 79, 187-191.
29. Scott, B.W., Wojtowicz, J.M. & Burnham, W.M. (2000) Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures. Exp. Neurol., 165, 231-236.
30. Shallari, S., Schwartz, C., Hasko, A. & Morel, J.L. (1998) Heavy metals in soils and plants of serpentine and industrial sites of Albania. Sci. Total Environ., 209, 133-142.
31. Turgut, G., Akdogan, I., Adiguzel, E. & Genc, O. (2003) Effect of copper overload with ethanol uptake on hippocampal neurons. Tohoku J. Exp. Med., 199, 239-245.
32. Waggoner, D.J., Bartnikas, T.B. & Gitlin, J.D. (1999) The role of copper in neurodegenerative disease. Neurobiol. Dis., 6 221-230.
33. West, M.J., Slomianka, L. & Gundersen, H.J.G. (1991) Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator. Anat. Rec., 231, 482-487.
34. Zharkovsky, T., Kaasik, A., Jaako, K. & Zharkovsky, A. (2003) Neurodegeneration and production of the new cells in the dentate gyrus of juvenile rat hippocampus after a single administration of ethanol. Brain Res., 978, 115-123.