The effect of zinc salts on serum bilirubin levels in hyperbilirubinemic rats

Journal of Pediatric Gastroenterology and Nutrition

Volumn 40, Issue 2, 2005, Pages 135-140

  Vítek, Libor ^a   Muchová, Lucie ^a   Zelenka, Jaroslav ^a   Zadinová, Marie ^a   Malina, Jiří ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b Barrandov Outpatient Center   (Czech Republic)

Author keywords

Bilirubin; Crigler Najjar syndrome; Gunn rats; Neonatal jaundice; Zinc salts

Indexed keywords

BILE PIGMENT; BILIRUBIN; UNCLASSIFIED DRUG; ZINC DERIVATIVE; ZINC METHACRYLATE; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIRUBIN BLOOD LEVEL; BILIRUBIN METABOLISM; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME; DIET; DRUG EFFECT; ENTEROHEPATIC CIRCULATION; FECES ANALYSIS; HYPERBILIRUBINEMIA; IN VITRO STUDY; IN VIVO STUDY; MALE; NEWBORN JAUNDICE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT; ZINC BLOOD LEVEL;

ADMINISTRATION, ORAL; ANIMALS; ASTRINGENTS; BILE ACIDS AND SALTS; BILIRUBIN; CRIGLER-NAJJAR SYNDROME; DISEASE MODELS, ANIMAL; HUMANS; HYPERBILIRUBINEMIA; MALE; METHACRYLATES; RATS; RATS, GUNN; RATS, WISTAR; SOLUBILITY; ZINC SULFATE;

ANIMALIA; RATTUS NORVEGICUS;

EID: 13944282671     PISSN: 02772116     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005176-200502000-00010     Document Type: Article

References (37)

1. Vitek L, Jirsa Jr M, Brodanová M, et al. Gilbert syndrome and ischemic heart disease: a protective effect of elevated bilirubin levels. Atherosclerosis 2002;16:449-56.
2. Shapiro SM. Bilirubin toxicity in the developing nervous system. Ped Neurol 2003;29:410-21.
3. Ostrow JD, Pascolo L, Shapiro SM, Tiribelli C. New concepts in bilirubin encephalopathy. Eur J Clin Invest 2003;33:988-97.
4. Poland RL, Odell GB. Physiologic jaundice: the EHC of bilirubin. New Engl J Med 1971;284:1-6.
5. Van der Veere CN, Jansen PL, Sinaasappel M, et al. Oral calcium phosphate: a new therapy for Crigler-Najjar disease? Gastroenterology 1997;112:455-62.
6. Vítek L, Kotal P, Jirsa M, et al. Intestinal colonization in neonates leading to fecal urobilinoid excretion may play a role in the pathogenesis of neonatal hyperbilirubinemia. J Pediatr Gastroenterol Nutr 2000;30:294-8.
7. Brink MA, Slors JFM, Keulemans YCA, et al. Enterohepatic cycling of bilirubin: A putative mechanism for pigment gallstone formation in ileal Crohn's disease. Gastroenterology 1999;116: 1420-7.
8. Vítek L, Carey MC. Enterohepatic cycling of bilirubin as a cause of "black" pigment gallstones in adult life. Eur J Clin Invest 2003;33: 799-810.
9. Lester R, Ostrow JD, Schmid R. EHC of bilirubin. Nature 1961; 192:372.
10. Gilbertsen AS, Bossenmaier I, Cardinal R. EHC of unconjugated bilirubin in man. Nature 1962;196:141-2.
11. Lester R, Schmid R. The mechanism of intestinal absorption of bilirubin. J Clin Invest 1962;41:1379.
12. Bloomer JR, Zaccaria J. Effect of graded bilirubin load on bilirubin transport by perfused rat liver. Am J Physiol 1976;230:736-42.
13. Gärtner U, Goeser T, Wolkoff AW. Effect of fasting on the uptake of bilirubin and sulfobromophthalein by isolated perfused rat liver. Gastroenterology 1997;113:1707-13.
14. Poland RL, Avery GB, Goetcherian E, Odell GB. Treatment of Crigler-Najjar syndrome with agar [abstract]. Pediatr Res 1972;6: A377/117.
15. Caglayan S, Candemir H, Aksit S, Kansoy S, Asik S, Yaprak I. Superiority of oral agar and phototherapy combination in the treatment of neonatal hyperbilirubinemia. Pediatr 1993;92: 86-9.
16. Odell GB, Gutcher GR, Whitington PF, Yang G. Enteral administration of agar as an effective adjunct to phototherapy of neonatal hyperbilirubinemia. Pediatr Res 1983;17:810-4.
17. Ulstrom RA, Eisenklam E. The enterohepatic shunting of bilirubin in the newborn infant. I. Use of oral-activated charcoal to reduce normal serum bilirubin values. J Pediatr 1964;65:27-37.
18. Davis DR, Yeary RA. Activated charcoal as an adjunct to phototherapy for neonatal jaundice. Dev Pharmacol Ther 1987; 10:12-20.
19. Nicolopoulos D, Hadjigeorgiou E, Malamitsi A, Kalpoyannis N, Karli I, Papadakis D. Combined treatment of neonatal jaundice with cholestyramine and phototherapy. J Pediatr 1978;93:684-8.
20. Arrowsmith WA, Payne RB, Littlewood JM. Comparison of treatments for congenital nonobstructive nonhaemolytic hyperbilirubinemia. Arch Dis Child 1975;50:197-201.
21. Lester R, Hammaker L, Schmid R. A new therapeutic approach to unconjugated hyperbilirubinemia. Lancet 1962;2:1257.
22. Gourley GR, Kreamer BL, Cohen M. Inhibition of β-glucuronidase by casein hydrolysate formula. J Pediatr Gastroenterol Nutr 1997; 25:267-72.
23. Gourley GR, Kreamer B, Cohnen M, Kosorok MR. Neonatal jaundice and diet. Arch Pediatr Adolesc Med 1999;153:184-8.
24. Kemper K, Horwitz RI, McCarthy P. Decreased neonatal serum bilirubin with plain agar: a meta-analysis. Pediatrics 1988;82:631-8.
25. Mendez-Sanchez N, Roldan-Valadez E, Flores MA, Cardenas-Vazquez R, Uribe M. Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters. Eur J Clin Invest 2001;31:773-80.
26. Méndez-Sánchez N, Martínez M, González V, Roldán-Valadez E, Flores MA, Uribe M. Zn sulphate inhibits the enterohepatic cycling of unconjugated bilirubin in subjects with Gilbert's syndrome. Ann Hepatol 2002;1:40-3.
27. Carey MC. Methods and compositions for inhibiting enterohepatic cycling of bilirubin. US Patent 5804218. September 8, 1998.
28. http://www.gelest.com/msds.asp?CXZN050
29. Kotal P, Fevery J. Quantitation of urobilinogen in faeces, urine, bile, and serum by direct spectrophotometry of zinc complex. Clin Chim Acta 1991;202:1-10.
30. Heirwegh KPM, Fevery J, Meuwissen J, De Groote J. Recent advances in the separation and analysis of diazo-positive bile pigments. Methods Bioch Anal 1974;22:205-50.
31. Gies HP, Roy CR. Bilirubin phototherapy and potential UVR hazards. Health Phys 1990;58:313-20.
32. Radermacher EH, Noirfalise A, Hornchen H, Maier RD, Bigalke KH. The bronze-baby syndrome: a complication of phototherapy. Klin Padiatr 1977;189:379-84.
33. Kotal P, Van der Veere C, Sinaasappel M, et al. Intestinal excretion of unconjugated bilirubin in man and rats with inherited unconjugated hyperbilirubinemia. Pediat Res 1997;42:195-200.
34. Soderberg TA, Sunzel B, Holm S, Elmros T, Hallmans G, Sjoberg S. Antibacterial effect of zinc oxide in vitro. Scand J Plast Recons 1990;24:193-7.
35. Belcher EH, Harris EB. Studies of plasma volume, red cell volume and total blood volume in young growing rats. J Physiol 1957;139: 64-78.
36. Cornelius CE. Comparative bile pigment metabolism in vertebrates. In: Ostrow JD, ed. Bile Pigment and Jaundice. New York: Dekker; 1986:601-47.
37. Ciba Geigy Scientific Tables, Vol.1. Basel, Switzerland: Ciba Geigy Ltd.; 1981:147.