Zinc salts precipitate unconjugated bilirubin in vitro and inhibit enterohepatic cycling of bilirubin in hamsters

European Journal of Clinical Investigation

Volumn 31, Issue 9, 2001, Pages 773-780

  Mendez Sanchez N ^a,b   Roldan Valadez E ^a,b   Flores, M A ^a,b   Cardenas Vazquez R ^a,b   Uribe, M ^a,b  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b LIVER RESEARCH UNIT   (Mexico)

Author keywords

Bile salts; Bilirubin; Hamster; Pigment gallstone; Zinc salts

Indexed keywords

BILIRUBIN; ZINC DERIVATIVE; ZINC SULFATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE; BODY WEIGHT; CONTROLLED STUDY; DIET; DRUG MECHANISM; ENTEROHEPATIC CIRCULATION; FLOCCULATION; GALLSTONE; HAMSTER; MALE; NONHUMAN; PH; PRECIPITATION; PRIORITY JOURNAL; RAT;

ANIMALS; BILE ACIDS AND SALTS; BILIARY FISTULA; BILIRUBIN; CARBONATES; CHOLELITHIASIS; CRICETINAE; HYDROGEN-ION CONCENTRATION; LIVER; MALE; MESOCRICETUS; PRECIPITATION; RATS; RATS, WISTAR; ZINC ACETATE; ZINC COMPOUNDS; ZINC SULFATE;

EID: 0035724499     PISSN: 00142972     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.2001.00879.x     Document Type: Article

References (47)

1. Gallstone in patients with disorders of the terminal ileum and disturbed bile salt metabolism
2. Gallstone with ulcerative proctitis
3. Effect of partial ileal bypass surgery on mortality and morbidity from coronary heart disease in patients with hypercholesterolemia. Report of the Program on the Surgical Control of the Hyperlipidemias
4. Jejunoileal bypass for morbid obesity
5. Gallstone after ileostomy and ileal resection
6. Cholelithiasis in inflammatory bowel disease. A case-control study
7. Bilirubin cycles enterohepatically after ileal resection in the rat
8. Enterohepatic cycling of bilirubin: A putative mechanism for pigment gallstone formation in ileal Crohn's disease
9. Gallbladder bile composition in Crohn's disease
10. Intestinal absorption of bile pigments. II. Bilirubin absorption in man
11. Bilirubin metabolism and hyperbilirubinemic disorders
12. Uridine diphosphate-glucuronic acid-independent conversion of bilirubin monoglucuronides to diglucuronide in presence of plasma membranes from rat liver in nonenzymatic
13. Studies of bilirubin kinetics in normal adults
14. Intestinal deconjugation of bilirubin in germfree and conventional rats
15. Preferential reduction of conjugated bilirubin to urobilinogen by normal fecal flora
16. Intestinal and renal metabolism of bilirubin including enterohepatic circulation
17. Intestinal absorption of bile pigments. III. The enterohepatic circulation of urobilinogen in the rat
18. Intestinal absorption of bile pigments. I. The enterohepatic circulation of bilirubin in the rat
19. The etiology of pigment gallstones
20. The ready isomerization of bilirubin IXa in aqueous solutions
21. Application of a rapid and efficient h.p.l.c. method for bilirubin and its conjugates from native bile and in model bile systems
22. Re-evaluation of the 3α-hydroxysteroid dehydrogenase assay for total bile acids in bile
23. Bilirubin solubility and interaction with albumin and phospholipid
24. Bilirubin chemistry, ionization and solubilization by bile salts
25. Physical chemistry of bile pigments and porphyrins with particular reference to bile
26. ++ electrode studies of model bile salt solutions and other biological systems
27. Calcium in bile and calcium salts in gallstones
28. Increased total and free ionized calcium in a canine model of pigment gallstones
29. Electrochemical behavior of zinc (II)-bilirubin complex in N,N-dimethylformamide
30. Metal complexes of bilirubin in aprotic solvents
31. Considerations concerning the formation of metal chelates of bilirubin: The zinc-bilirubin system
32. High colonic pH promotes colorectal cancer
33. Molecular and micellar associations in the pH dependent stable and metastable dissolution of unconjugated bilirubin by bile salts
34. Rapid association of unconjugated bilirubin with amorphous calcium phosphate
35. An enzymatic defect in human neonatal jaundice and in Gunn's strain of jaundiced rats
36. Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar disease
37. The hydrophobic-hydrophilic balance of bile salts. Inverse correlation between reverse-phase high performance liquid chromatography mobilities and micellar cholesterol-solubilizing capacities
38. Fasting-related hyperbilirubinemia in rats. The effect of decreased intestinal motility
39. On the binding of bilirubin and its structural analogous to hepatic microsomal bilirubin UDP glucuronyltransferase
40. Uridine diphosphate-glucuronic acid-independent conversion of bilirubin monoglucuronides to diglucuronide in presence of plasma membranes from rat liver is nonenzymatic
41. Hepatic disposition and biliary excretion of bilirubin and bilirubin glucuronids in intact rats
42. Cystic fibrosis. Its influence on the liver, biliary tree and bile salt metabolism
43. Physiologic jaundice. The enterohepatic circulation of bilirubin
44. Physical-chemical pathogenesis of pigment gallstones
45. Unconjugated bilirubin, and the hydrolysis of unconjugated bilirubin, in gallbladder bile of patients with cholelithiasis