Discerning an effective balance between equine infectious anemia virus attenuation and vaccine efficacy

Journal of Virology

Volumn 79, Issue 5, 2005, Pages 2666-2677

  Craigo, Jodi K ^a   Li, Feng ^a   Steckbeck, Jonathan D ^a   Durkin, Shannon ^a   Howe, Laryssa ^a   Cook, Sheila J ^b   Issel, Charles ^b   Montelaro, Ronald C ^a,c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIVE VACCINE; NEUTRALIZING ANTIBODY; VIRUS VACCINE;

ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY SPECIFICITY; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EQUINE INFECTIOUS ANEMIA VIRUS; HORSE; IMMUNITY; NONHUMAN; PRIORITY JOURNAL; RETROVIRUS INFECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROLOGY; VACCINATION; VIRUS ENVELOPE; VIRUS INFECTION; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; ANTIBODIES, VIRAL; EQUINE INFECTIOUS ANEMIA; FEMALE; GENES, VIRAL; HORSES; INFECTIOUS ANEMIA VIRUS, EQUINE; MALE; MUTATION; TIME FACTORS; VACCINES, ATTENUATED; VIRAL PROTEINS; VIRAL VACCINES;

ANIMALIA; EQUIDAE; EQUINE INFECTIOUS ANEMIA VIRUS; EQUUS CABALLUS; LENTIVIRUS; RNA VIRUSES; UNIDENTIFIED RETROVIRUS;

EID: 13944272584     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.5.2666-2677.2005     Document Type: Article

References (39)

1. Bogers, W. M., C. Cheng-Mayer, and R. C. Montelaro. 2000. Developments in preclinical AIDS vaccine efficacy models. AIDS 14:S141-S145.
2. Coggins, L., and N. L. Norcross. 1970. Immunodiffusion reaction in equine infectious anemia. Cornell Vet. 60:330-335.
3. Cole, K. S., J. L. Rowles, B. A. Jagerski, M. Murphey-Corb, T. Unangst, J. E. Clements, J. Robinson, M. S. Wyand, R. C. Desrosiers, and R. C. Montelaro. 1997. Evolution of envelope-specific antibody responses in monkeys experimentally infected or immunized with simian immunodeficiency virus and its association with the development of protective immunity. J. Virol. 71:5069-5079.
4. Cole, K. S., J. L. Rowles, M. Murphey-Corb, J. E. Clements, J. Robinson, and R. C. Montelaro. 1997. A model for the maturation of protective antibody responses to SIV envelope proteins in experimentally immunized monkeys. J. Med. Primatol. 26:51-58.
5. Cole, K. S., M. Murphey-Corb, O. Narayan, S. V. Joag, G. M. Shaw, and R. C. Montelaro. 1998. Common themes of antibody maturation to simian immunodeficiency virus, simian-human immunodeficiency virus, and human immunodeficiency virus type 1 infections. J. Virol. 72:7852-7859.
6. Cook, R. F., C. Leroux, S. J. Cook, S. L. Berger, D. L. Lichtenstein, N. N. Ghabrial, R. C. Montelaro, and C. J. Issel. 1998. Development and characterization of an in vivo pathogenic molecular clone of equine infectious anemia virus. J. Virol. 72:1383-1393.
7. Craigo, J. K., C. Leroux, L. Howe, J. D. Steckbeck, S. J. Cook, C. J. Issel, and R. C. Montelaro. 2002. Transient immune suppression of inapparent carriers infected with a principal neutralizing domain-deficient equine infectious anemia virus induces neutralizing antibodies and lowers steady-state virus replication. J. Gen. Virol. 83:1353-1359.
8. Grund, C. H., E. R. Lechman, C. J. Issel, R. C. Montelaro, and K. E. Rushlow. 1994. Lentivirus cross-reactive determinants present in the capsid protein of equine infectious anaemia virus. J. Gen. Virol. 75(Pt. 3):657-662.
9. Hammond, S. A., S. J. Cook, L. D. Falo, Jr., C. J. Issel, and R. C. Montelaro. 1999. A particulate viral protein vaccine reduces viral load and delays progression to disease in immunized ponies challenged with equine infectious anemia virus. Virology 254:37-49.
10. Hammond, S. A., S. J. Cook, D. L. Lichtenstein, C. J. Issel, and R. C. Montelaro. 1997. Maturation of the cellular and humoral immune responses to persistent infection in horses by equine infectious anemia virus is a complex and lengthy process. J. Virol. 71:3840-3852.
11. Hammond, S. A., F. Li, B. M. McKeon, Sr., S. J. Cook, C. J. Issel, and R. C. Montelaro. 2000. Immune responses and viral replication in long-term inapparent carrier ponies inoculated with equine infectious anemia virus. J. Virol. 74:5968-5981.
12. Hammond, S. A., M. L. Raabe, C. J. Issel, and R. C. Montelaro. 1999. Evaluation of antibody parameters as potential correlates of protection or enhancement by experimental vaccines to equine infectious anemia virus. Virology 262:416-430.
13. Harrold, S. M., S. J. Cook, R. F. Cook, K. E. Rushlow, C. J. Issel, and R. C. Montelaro. 2000. Tissue sites of persistent infection and active replication of equine infectious anemia virus during acute disease and asymptomatic infection in experimentally infected squids. J. Virol. 74:3112-3121.
14. Issel, C. J., D. W. Horohov, D. F. Lea, W. V. Adams, Jr, S. D. Hagius, J. M. McManus, A. C. Allison, and R. C. Montelaro. 1992. Efficacy of inactivated whole-virus and subunit vaccines in preventing infection and disease caused by equine infectious anemia virus. J. Virol. 66:3398-3408.
15. Johnson, R. P., and R. C. Desrosiers. 1998. Protective immunity induced by live attenuated simian immunodeficiency virus. Curr. Opin. Immunol. 10: 436-443.
16. Johnson, R. P., J. D. Lifson, S. C. Czajak, K. S. Cole, K. H. Manson, R. Glickman, J. Yang, D. C. Montefiori, R. Montelaro, M. S. Wyand, and R. C. Desrosiers. 1999. Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation. J. Virol. 73:4952-4961.
17. Leroux, C., C. Issel, and R. C. Montelaro. 1997. Novel and dynamic evolution of equine infectious anemia virus genomic quasispecies associated with sequential disease cycles in an experimentally infected pony. J. Virol. 71: 9627-9639.
18. Li, F., C. Leroux, J. K. Craigo, S. J. Cook, C. J. Issel, and R. C. Montelaro. 2000. The S2 gene of equine infectious anemia virus is a highly conserved determinant of viral replication and virulence properties in experimentally infected ponies. J. Virol. 74:573-579.
19. Li, F., B. A. Puffer, and R. C. Montelaro. 1998. The S2 gene of equine infectious anemia virus is dispensable for viral replication in vitro. J. Virol. 72:8344-8348.
20. Li, F., J. K. Craigo, L. Howe, J. D. Steckbeck, S. Cook, C. Issel, and R. C. Montelaro. 2003. A live attenuated equine infectious anemia virus proviral vaccine with a modified S2 gene provides protection from detectable infection by intravenous virulent virus challenge of experimentally inoculated horses. J. Virol. 77:7244-7253.
21. Lichtenstein, D. L., C. J. Issel, and R. C. Montelaro. 1996. Genomic quasi-species associated with the initiation of infection and disease in ponies experimentally infected with equine infectious anemia virus. J. Virol. 70: 3346-3354.
22. Lichtenstein, D. L., K. E. Rushlow, R. F. Cook, M. L. Raabe, C. J. Swardson, G. J. Kociba, C. J. Issel, and R. C. Montelaro. 1995. Replication in vitro and in vivo of an equine infectious anemia virus mutant deficient in dUTPase activity. J. Virol. 69:2881-2888.
23. Lockridge, K. M., M. Chien, G. A. Dean, S. C. Kelly, R. C. Montelaro, P. A. Luciw, and E. E. Sparger. 2000. Protective immunity against feline immunodeficiency virus induced by inoculation with vif-deleted proviral DNA. Virology 273:67-79.
24. Maniatis, T., E. F. Fritsch, and J. E. Sambrook. 1982. Molecular cloning: a laboratory manual, 2nd ed, Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y.
25. Mills, J., R. C. Desrosiers, E. Rod, and N. Almond. 2000. Live attenuated HIV vaccines: a proposal for further research and development. AIDS Res. Hum. Retrovir. 16:1453-1461.
26. Montelaro, R. C., J. M. Ball, and K. Rushlow. 1993. Equine retroviruses, p. 257-360. In J. A. Levy (ed.), The retroviridae. Plenum Press, Inc., New York, N.Y.
27. Montelaro, R. C., K. S. Cole, and S. A. Hammond. 1998. Maturation of immune responses to lentivirus infection: implications for AIDS vaccine development. AIDS Res. Hum. Retrovir. 14(Suppl. 3):S255-S259.
28. Montelaro, R. C., C. H. Grund, M. R. Raabe, B. Woodson, R. F. Cook, S. J. Cook, and C. J. Issel. 1996. Characterization of protective and enhancing immune responses to equine infectious anemia virus resulting from experimental vaccines. AIDS Res. Hum. Retrovir. 12:413-415.
29. Nilsson, C., B. Makitalo, R. Thorstensson, S. Norley, D. Binninger-Schinzel, M. Cranage, E. Rud, G. Biberfeld, and P. Putkonen. 1998. Live attenuated simian immunodeficiency virus (SIV)mac in macaques can induce protection against mucosal infection with SIVsm. AIDS 12:2261-2270.
30. Payne, S. L., J. Rausch, K. Rushlow, R. C. Montelaro, C. Issel, M. Flaherty, S. Perry, D. Sellon, and F. Fuller. 1994. Characterization of infectious molecular clones of equine infectious anaemia virus. J. Gen. Virol. 75(Pt. 2):425-429.
31. Raabe, M. L., C. J. Issel, S. J. Cook, R. F. Cook, B. Woodson, and R. C. Montelaro. 1998. Immunization with a recombinant envelope protein (rgp90) of EIAV produces a spectrum of vaccine efficacy ranging from lack of clinical disease to severe enhancement. Virology 245:151-162.
32. Raabe, M. L., C. J. Issel, and R. C. Montelaro. 1999. In vitro antibody-dependent enhancement assays are insensitive indicators of in vivo vaccine enhancement of equine infectious anemia virus. Virology 259:416-427.
33. Rwambo, P. M., C. J. Issel, W. V. Adams, Jr., K. A. Hussain, M. Miller, and R. C. Montelaro. 1990. Equine infectious anemia virus (EIAV) humoral responses of recipient ponies and antigenic variation during persistent infection. Arch. Virol. 111:199-212.
34. Shen, R.-X., and Z. Wang. 1985. Development and use of an equine infectious anemia donkey leucocyte attenuated vaccine. EIAV: a national review of policies, programs, and future objectives. American Quarter Horse Association, Amarillo, Tex.
35. Threadgill, D. S., W. K. Steagall, M. T. Flaherty, F. J. Fuller, S. T. Perry, K. E. Rushlow, S. F. Le Grice, and S. L. Payne. 1993. Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant. J. Virol. 67:2592-2600.
36. Ui, M., T. Kuwata, T. Igarashi, K. Ibuki, Y. Miyazaki, I. L. Kozyrev, Y. Enose, T. Shimada, H. Uesaka, and H. Vamamoto. 1999. Protection of macaques against a SHIV with a homologous HIV-1 Env and a pathogenic SHIV-89.6P with a heterologous Env by vaccination with multiple gene-deleted SHIVs. Virology 265:252-263.
37. Wyand, M. S., K. H. Manson, M. Garcia-Moll, D. Montefiori, and R. C. Desrosiers. 1996. Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J. Virol. 70:3724-3733.
38. Wyand, M. S., K. Manson, D. C. Montefiori, J. D. Lifson, R. P. Johnson, and R. C. Desrosiers. 1999. Protection by live, attenuated simian immunodeficiency virus against heterologous challenge. J. Virol. 73:8356-8363.
39. Zheng, Y. H., H. Sentsui, T. Nakaya, V. Kono, and K. Ikuta. 1997. In vivo dynamics of equine infectious anemia viruses emerging during febrile episodes: insertions/duplications at the principal neutralizing domain. J. Virol. 71:5031-5039.