Chiral polyamines from reduction of polypeptides: Asymmetric pyridoxamine-mediated transaminations

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 5, 2005, Pages 1351-1355

  Zhou, Wenjun ^a   Yerkes, Nancy ^a   Chruma, Jason J ^a   Liu, Lei ^a   Breslow, Ronald ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 OXOACID; POLYAMINE DERIVATIVE; POLYPEPTIDE; PYRIDOXAMINE;

ARTICLE; CATALYST; CHIRALITY; ENANTIOSELECTIVITY; SYNTHESIS; TRANSAMINATION;

EID: 13944268239     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.01.021     Document Type: Article

References (23)

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13. 2O, 300 MHz): 8.10, m, 3H; 7.60, m, 9H; 4.90, s, 2H; 4.35, s, 2H; 3.61, m, 12H. CI MS: 377.4 (tetramine M+1)
14. 2O, 300 MHz) for 2: 8.05, d, 1H, J = 8.1 Hz; 7.60, m, 5H; 4.12, m, 1H; 3.50, s, 3H; 2.39, m, 2H; 2.19, s, 6H; 1.19, d, 3H, J = 6.6 Hz
15. 2O, 300 MHz) for 2′: 8.10, d, 1H, J = 8.1 Hz; 7.60, m, 5H; 4.12, m, 1H; 3.60, s, 3H; 2.51, m, 2H; 2.28, s, 6H; 1.10, d, 3H, J = 6.6 Hz
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21. 3OD, 300 MHz): 8.57, s, 1H; 7.35, m, 5H; 4.68, m, 2H; 4.55, s, 2H; 4.45, m, 1H; 4.20, m, 2H; 3.80, s, 3H; 3.30-2.90, m, 4H; 2.85, s, 3H; 2.05, s, 3H; 1.52, d, 3H, J = 7.2 Hz. CI MS: 546.1 (M+1)
22. 2O, 300 MHz): 7.99, s, 1H; 7.25, m, 5H; 4.31, s, 2H; 3.80, s, 3H; 3.65-2.60, 15H; 2.59, s, 3H; 1.31, m, 6H. CI MS: 476.3 (M+1)
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