The role of amifostine in the treatment of carcinoma of the uterine cervix: An update of RTOG-0116 and review of future directions

Seminars in Oncology

Volumn 31, Issue SUPPL. 18, 2004, Pages 37-41

  De Los Santos, Jennifer F ^a   Small Jr , William ^b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIFOSTINE; CISPLATIN; FLUOROURACIL;

CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL PROTECTION; CHEMOTHERAPY INDUCED EMESIS; CLINICAL TRIAL; CONFERENCE PAPER; DRUG EFFICACY; GASTROINTESTINAL TOXICITY; HUMAN; HYPOTENSION; INTESTINE OBSTRUCTION; INTESTINE PERFORATION; LARGE INTESTINE; LIVER DYSFUNCTION; LYMPH NODE METASTASIS; MUCOSA; NAUSEA; NEUROTOXICITY; NEUTROPENIA; PARAAORTIC LYMPH NODE; PELVIS CANCER; PRIORITY JOURNAL; RADIATION ENTEROPATHY; RADIATION INJURY; RADIATION PROTECTION; SIDE EFFECT; SKIN TOXICITY; UTERINE CERVIX CARCINOMA;

EID: 13844275190     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2004.12.010     Document Type: Conference Paper

References (29)

1. A. Jemal, R.C. Tiwari, T. Murray American Cancer Society Cancer statistics, 2004 CA Cancer J Clin 54 2004 8 29
2. P.W. Grigsby, K. Heydon, D.G. Mutch Long-term follow-up of RTOG 92-10 Cervical cancer with positive para-aortic lymph nodes Int J Radiat Oncol Biol Phys 51 2001 982 987
3. E. Podczaski, J.A. Stryker, P. Kaminski Extended-field radiation therapy for carcinoma of the cervix Cancer 66 1990 251 258
4. M.A. Varia, B.N. Bundy, G. Deppe Cervical carcinoma metastatic to para-aortic nodes: Extended field radiation therapy with concomitant 5-fluorouracil and cisplatin chemotherapy: A Gynecologic Oncology Group study Int J Radiat Oncol Biol Phys 42 1998 1015 1023
5. P.W. Grigsby, J.D. Lu, D.G. Mutch Twice-daily fractionation of external irradiation with brachytherapy and chemotherapy in carcinoma of the cervix with positive para-aortic lymph nodes Phase II study of the Radiation Therapy Oncology Group 92-10 Int J Radiat Oncol Biol Phys 41 1998 817 822
6. H.M. Keys, B.N. Bundy, F.B. Stehman Cisplatin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma N Engl J Med 340 1999 1154 1161
7. W.A. Peters III, P.Y. Liu, R.J. Barrett II Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix J Clin Oncol 18 2000 1606 1613
8. P.G. Rose, B.N. Bundy, E.B. Watkins Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer N Engl J Med 340 1999 1144 1153
9. M. Morris, P.J. Eifel, J. Lu Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer [see comment] New Engl J Med 340 1999 1137 1143
10. C.W. Whitney, W. Sause, B.N. Bundy Randomized comparison of fluorouracil plus cisplatin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes A Gynecologic Oncology Group and Southwest Oncology Group study [see comment] J Clin Oncol 17 1999 1339 1348
11. F.B. Stehman, B.N. Bundy, P.J. DiSaia Carcinoma of the cervix treated with radiation therapy. I. A multi-variate analysis of prognostic variables in the Gynecologic Oncology Group Cancer 67 1991 2776 2785
12. M.L. Berman, H. Keys, W. Creasman Survival and patterns of recurrence in cervical cancer metastatic to periaortic lymph nodes (a Gynecologic Oncology Group study) Gynecol Oncol 19 1984 8 16
13. P.W. Grigsby, C.A. Perez, K.S. Chao Radiation therapy for carcinoma of the cervix with biopsy-proven positive para-aortic lymph nodes Int J Radiat Oncol Biol Phys 49 2001 733 738
14. P. Lepanto, P. Littman, J. Mikuta Treatment of para-aortic nodes in carcinoma of the cervix Cancer 35 1975 1510 1513
15. J.L. Lovecchio, H.E. Averette, D. Donato 5-year survival of patients with periaortic nodal metastases in clinical stage IB and IIA cervical carcinoma Gynecol Oncol 34 1989 43 45
16. D. Nori, E. Valentine, B.S. Hilaris The role of paraaortic node irradiation in the treatment of cancer of the cervix Int J Radiat Oncol Biol Phys 11 1985 1469 1473
17. H.H. Tewfik, H.J. Buchsbaum, H.B. Latourette Para-aortic lymph node irradiation in carcinoma of the cervix after exploratory laparotomy and biopsy-proven positive aortic nodes Int J Radiat Oncol Biol Phys 8 1982 13 18
18. S.C. Rubin, R. Brookland, J.J. Mikuta Para-aortic nodal metastases in early cervical carcinoma Long-term survival following extended-field radiotherapy Gynecol Oncol 18 1984 213 217
19. U.M. Carl, J. Bahnsen, T. Wiegel Radiation therapy of para-aortic lymph nodes in cancer of the uterine cervix Acta Oncol 32 1993 63 67
20. J.H. Malfetano, H. Keys Aggressive multimodality treatment for cervical cancer with paraaortic lymph node metastases Gynecol Oncol 42 1991 44 47
21. S. Mutic, R.S. Malyapa, P.W. Grigsby PET-guided IMRT for cervical carcinoma with positive para-aortic lymph nodes - A dose-escalation treatment planning study Int J Radiat Oncol Biol Phys 55 2003 28 35
22. L. Portelance, K.S. Chao, P.W. Grigsby Intensity-modulated radiation therapy (IMRT) reduces small bowel, rectum, and bladder doses in patients with cervical cancer receiving pelvic and para-aortic irradiation Int J Radiat Oncol Biol Phys 51 2001 261 266
23. T. Aoki, Y. Nagata, T. Mizowaki Clinical evaluation of dynamic arc conformal radiotherapy for paraaortic lymph node metastasis Radiother Oncol 67 2003 113 118
24. H. Athanassiou, D. Antonadou, N. Coliarakis Oncology Hellenic Group. Protective effect of amifostine during fractionated radiotherapy in patients with pelvic carcinomas: Results of a randomized trial Int J Radiat Oncol Biol Phys 56 2003 1154 1160
25. M.I. Koukourakis, G. Kyrias, S. Kakolyris Subcutaneous administration of amifostine during fractionated radiotherapy A randomized phase II study J Clin Oncol 18 2000 2226 2233 ; see comment in J Clin Oncol 19:1582-1583, 2001
26. P.R. Anne, W.J. Curran Jr A phase II trial of subcutaneous amifostine and radiation therapy in patients with head and neck cancer Semin Radiat Oncol 12 SUPPL. 1 2002 18 19
27. D.M. Brizel, T.H. Wasserman, M. Henke Phase III randomized trial of amifostine as a radioprotector in head and neck cancer J Clin Oncol 18 2000 3339 3345 ; see comment in J Clin Oncol 19:1233-1234, 2001
28. S. Wadler, J.J. Beitler, J.S. Rubin Pilot trial of cisplatin, radiation, and WR2721 in carcinoma of the uterine cervix A New York Gynecologic Oncology Group study J Clin Oncol 11 1993 1511 1516
29. D. Gallardo, A. Mohar, G. Calderillo Cisplatin, radiation, and amifostine in carcinoma of the uterine cervix Int J Gynecol Cancer 9 1999 225 230