No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes

American Journal of Human Genetics

Volumn 76, Issue 3, 2005, Pages 517-521

  Maier, Lisa M ^a,d   Chapman, Juliet ^a   Howson, Joanna M M ^a   Clayton, David G ^a   Pask, Rebecca ^a   Strachan, David P ^b   McArdle, Wendy L ^c   Twells, Rebecca C J ^a   Todd, John A ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; INTERLEUKIN 4 RECEPTOR A; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; EPISTASIS; GENE INTERACTION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RECEPTOR GENE;

EID: 13844269028     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/428387     Document Type: Article

References (23)

1. Altmüller J, Palmer LJ, Fischer G, Scherb H, Wjst M (2001) Genomewide scans of complex human diseases: true linkage is hard to find. Am J Hum Genet 69:936-950
2. Bain SC, Todd JA, Barnett AH (1990) The British Diabetic Association - Warren repository. Autoimmunity 7:83-85
3. Bugawan TL, Mirel DB, Valdes AM, Panelo A, Pozzilli P, Erlich HA (2003) Association and interaction of the IL4R, IL4, and IL13 loci with type 1 diabetes among Filipinos. Am J Hum Genet 72:1505-1514
4. Chapman JM, Cooper JD, Todd JA, Clayton DG (2003) Detecting disease associations due to linkage disequilibrium using haplotype tags: a class of tests and the determinants of statistical power. Hum Hered 56:18-31
5. Clayton D, Chapman J, Cooper J (2004) The use of unphased multilocus genotype data in indirect association studies. Genet Epidemiol 27:415-428
6. Clayton D, McKeigue PM (2001) Epidemiological methods for studying genes and environmental factors in complex diseases. Lancet 358:1356-1360
7. Colhoun HM, McKeigue PM, Davey Smith G (2003) Problems of reporting genetic associations with complex outcomes. Lancet 361:865-872
8. Cordell HJ (2002) Epistasis: what it means, what it doesn't mean, and statistical methods to detect it in humans. Hum Mol Genet 11:2463-2468
9. Culverhouse R, Suarez BK, Lin J, Reich T (2002) A perspective on epistasis: limits of models displaying no main effect. Am J Hum Genet 70:461-471
10. Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, Gough SC, Allahabadia A, Franklyn JA, Tuomilehto J, Tuomilehto-Wolf E, Cucca F, Guja C, Ionescu-Tirgoviste C, Stevens H, Carr P, Nutland S, McKinney P, Shield JP, Wang W, Cordell HJ, Walker N, Todd JA, Concannon P (2002) Parameters for reliable results in genetic association studies in common disease. Nat Genet 30:149-150
11. Hirschhorn JN, Lohmueller K, Byrne E, Hirschhorn K (2002) A comprehensive review of genetic association studies. Genet Med 4:45-61
12. Hoh J, Ott J (2004) Genetic dissection of diseases: design and methods. Curr Opin Genet Dev 14:229-232
13. Ioannidis JP, Trikalinos TA, Ntzani EE, Contopoulos-Ioannidis DG (2003) Genetic associations in large versus small studies: an empirical assessment. Lancet 361:567-571
14. Lernmark A (1991) Human cell lines from families available for diabetes research. Diabetologia 34:61
15. Lohmueller KE, Pearce CL, Pike M, Lander ES, Hirschhorn JN (2003) Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat Genet 33:177-182
16. Maier LM, Twells RC, Howson JM, Lam AC, Clayton DG, Smyth DJ, Savage D, Carson D, Patterson CC, Smink LJ, Walker NM, Burren OS, Nutland S, Rance H, Tuomilehto-Wolf E, Tuomilehto J, Guja C, Ionescu-Tirgoviste C, Undlien DE, Ronningen KS, Cucca F, Todd JA (2003) Testing the possible negative association of type 1 diabetes and atopic disease by analysis of the interleukin 4 receptor gene. Genes Immun 4:469-475
17. Mirel DB, Valdes AM, Lazzeroni LC, Reynolds RL, Erlich HA, Noble JA (2002) Association of IL4R haplotypes with type 1 diabetes. Diabetes 51:3336-3341
18. Moore JH (2003) The ubiquitous nature of epistasis in determining susceptibility to common human diseases. Hum Hered 56:73-82
19. Piegorsch WW, Weinberg CR, Taylor JA (1994) Non-hierarchical logistic models and case-only designs for assessing susceptibility in population-based case-control studies. Stat Med 13:153-162
20. Thomas DC, Clayton DG (2004) Betting odds and genetic associations. J Natl Cancer Inst 96:421-423
21. Umbach DM, Weinberg CR (1997) Designing and analysing case-control studies to exploit independence of genotype and exposure. Stat Med 16:1731-1743
22. 45Thr polymorphism and other common variants of the NeuroD gene with type 1 diabetes. Diabetes 53:1158-1161
23. Wang WYS, Barratt BJ, Clayton DG, Todd JA (2005) Genomewide association studies: theoretical issues and practical concerns. Nat Rev Genet 6:109-118