Pim kinases are upregulated during Epstein-Barr virus infection and enhance EBNA2 activity

Virology

Volumn 333, Issue 2, 2005, Pages 201-206

  Rainio, Eeva Marja ^a   Ahlfors, Helena ^a   Carter, Kara L ^b,c,e   Ruuska, Marja ^a   Matikainen, Sampsa ^a,d   Kieff, Elliott ^b,c   Koskinen, Päivi J ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^e Praecis Pharmaceuticals Incorporated   (United States)

Author keywords

EBNA2; EBV; Pim; Transcription

Indexed keywords

EPSTEIN BARR VIRUS ANTIGEN; MESSENGER RNA; PIM KINASE; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ARTICLE; B LYMPHOCYTE; CANCER GROWTH; CARCINOGENESIS; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; EPSTEIN BARR VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION; VIRUS INFECTION;

EID: 13844266003     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2005.01.001     Document Type: Article

References (23)

1. C. Alfieri, M. Birkenbach, and E. Kieff Early events in Epstein-Barr virus infection of human B lymphocytes Virology 181 1991 595 608
2. 112 gatekeeper site FEBS Lett. 571 2004 43 49
3. J.D. Allen, E. Verhoeven, J. Domen, M. van der Valk, and A. Berns Pim-2 transgene induces lymphoid tumors, exhibiting potent synergy with c-myc Oncogene 15 1997 1133 1141
4. R. Amson, F. Sigaux, S. Przedborski, G. Flandrin, D. Givol, and A. Telerman The human protooncogene product p33pim is expressed during fetal hematopoiesis and in diverse leukemias Proc. Natl. Acad. Sci. U. S. A. 86 1989 8857 8861
5. E.D. Cahir-McFarland, K.M. Izumi, and G. Mosialos Epstein-Barr virus transformation: involvement of latent membrane protein 1-mediated activation of NF-κB Oncogene 18 1999 6959 6964
6. I. Callebaut, and J.P. Mornon The human EBNA-2 coactivator p100: multidomain organization and relationship to the staphylococcal nuclease fold and to the tudor protein involved in Drosophila melanogaster development Biochem. J. 321 1997 125 132
7. K.L. Carter, E. Cahir-MacFarland, and E. Kieff Epstein-Barr virus-induced changes in B-lymphocyte gene expression J. Virol. 76 2002 10427 10436
8. A.A. Caudy, R.F. Ketting, S.M. Hammond, A.M. Denli, A.M.P. Bathoorn, B.B.J. Tops, J.M. Silva, M.M. Myers, G.J. Hannon, and R.H.A. Plasterk A micrococcal nuclease homologue in RNAi effector complexes Nature 425 2003 411 414
9. X.P. Chen, J.A. Losman, S. Cowan, E. Donahue, S. Fay, B.Q. Young, M.C. Nawijn, D. Capece, V.L. Cuhan, and P. Rothman Pim serine/threonine kinases regulate the stability of Socs-1 protein Proc. Natl. Acad. Sci. U. S. A. 99 2002 2175 2180
10. J.I. Cohen, and E. Kieff An Epstein-Barr virus nuclear protein 2 domain essential for transformation is a direct transcriptional activator J. Virol. 65 1991 5880 5885
11. C.J. Fox, P.S. Hammerman, R.M. Cinalli, S.R. Master, L.A. Chodosh, and C.B. Thompson The serine/threonine kinase Pim-2 is a transcriptionally regulated apoptotic inhibitor Genes Dev. 17 2003 1841 1854
12. I. Han, Y. Xue, S. Harada, S. Orstavik, B. Skalhegg, and E. Keiff Protein kinase A associates with HA95 and affects transcriptional coactivation by Epstein-Barr virus nuclear proteins Mol. Cell. Biol. 22 2002 2136 2146
13. J.D. Leverson, P.J. Koskinen, F.C. Orrico, E.M. Rainio, K.J. Jalkanen, A.B. Dash, R.N. Eisenman, and S.A. Ness Pim-1 kinase and p100 cooperate to enhance c-Myb activity Mol. Cell 2 1998 417 425
14. M. Lilly, T. Le, P. Holland, and S.L. Hendrickson Sustained expression of the pim-1 kinase is specifically induced in myeloid cells by cytokines whose receptors are structurally related Oncogene 7 1992 727 732
15. M. Lilly, J. Sandholm, J.J. Cooper, P.J. Koskinen, and A. Kraft The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway Oncogene 18 1999 4022 4031
16. S. Matikainen, T. Saraneva, T. Ronni, A. Lehtonen, P.J. Koskinen, and I. Julkunen Interferon-α activates multiple STAT proteins and upregulates proliferation-associated IL-2Rα, c-myc, and pim-1 genes in human T cells Blood 93 1999 1980 1991
17. G. Mosialos Cytokine signaling and Epstein-Barr virus-mediated cell transformation Cytokine Growth Factor Rev. 12 2001 259 270
18. K.J. Peltola, K. Paukku, T.L.T. Aho, M. Ruuska, O. Silvennoinen, and P.J. Koskinen Pim-1 kinase inhibits STAT5-dependent transcription via its interactions with SOCS1 and SOCS3 Blood 103 2004 3744 3750
19. E.M. Rainio, J. Sandholm, and P.J. Koskinen Cutting Edge: transcriptional activity of NFATc1 is enhanced by the Pim-1 kinase J. Immunol. 168 2002 1524 1527
20. X. Tong, R. Drapkin, R. Yalamanchili, G. Mosialos, and E. Kieff The Epstein-Barr virus nuclear protein 2 acidic domain forms complex with a novel cellular coactivator that can interact with TFIIE Mol. Cell. Biol. 15 1995 4735 4744
21. M. van Lohuizen, S. Verbeek, P. Krimpenfort, J. Domen, C. Saris, T. Radaszkiewicz, and A. Berns Predisposition to lymphomagenesis in pim-1 transgenic mice: cooperation with c-myc and N-myc in murine leukemia virus-induced tumors Cell 56 1989 673 682
22. B. Yan, M. Zemskova, S. Holder, V. Chin, A. Kraft, P.J. Koskinen, and M. Lilly The PIM-2 kinase phosphorylates BAD on serine-112 and reverses BAD-induced cell death J. Biol. Chem. 278 2003 45358 45367
23. L. Young, C. Alfieri, K. Hennessy, H. Evans, C. O'Hara, K.C. Anderson, J. Ritz, R.S. Shapiro, A. Rickinson, E. Kieff, and J.I. Cohen Expression of Epstein-Barr virus transformation-associated genes in tissues of patients with EBV lymphoproliferative disease N. Engl. J. Med. 321 1989 1080 1085