BCL1 lymphoma protection induced by idiotype DNA vaccination is entirely dependent on anti-idiotypic antibodies

Cancer Immunology, Immunotherapy

Volumn 54, Issue 4, 2005, Pages 351-358

  Cesco Gaspere, Michela ^a   Benvenuti, Federica ^a,b   Burrone, Oscar R ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b INSTITUT CURIE   (France)

Author keywords

Anti idiotypic antibodies; DNA vaccination; Idiotype; Lymphoma

Indexed keywords

DNA; DNA VACCINE; IMMUNOGLOBULIN IDIOTYPE;

ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; CELL CYCLE; CONFORMATION; CONTROLLED STUDY; FEMALE; IMMUNIZATION; IN VIVO STUDY; LYMPHOMA; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TUMOR CELL; VACCINATION;

ANIMALS; ANTIBODIES, ANTI-IDIOTYPIC; APOPTOSIS; CELL CYCLE; CYCLIN D1; EPITOPES, T-LYMPHOCYTE; FEMALE; GENES, MHC CLASS I; GENES, MHC CLASS II; HUMANS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN IDIOTYPES; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOTHERAPY; LYMPHOMA, B-CELL; MICE; MICE, INBRED BALB C; SURVIVAL RATE; T-LYMPHOCYTES; T-LYMPHOCYTES, CYTOTOXIC; VACCINATION; VACCINES, DNA;

EID: 13744263822     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00262-004-0579-8     Document Type: Article

References (24)

1. Armstrong AC, Dermime S, Allinson CG, Bhattacharyya T, Mulryan K, Gonzalez KR, Stern PL, Hawkins RE (2002) Immunization with a recombinant adenovirus encoding a lymphoma idiotype: induction of tumor-protective immunity and identification of an idiotype-specific T cell epitope. J Immunol 168:3983
2. Batista FD, Anand S, Presani G, Efremov DG, Burrone OR (1996) The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors. J Exp Med 184:2197
3. Benvenuti F, Burrone OR (2001) Anti-idiotypic antibodies induced by genetic immunisation are directed exclusively against combined V(L)/V(H) determinants. Gene Ther 8:1555
4. Benvenuti F, Burrone OR, Efremov DG (2000) Anti-idiotypic DNA vaccines for lymphoma immunotherapy require the presence of both variable region genes for tumor protection. Gene Ther 7:605
5. Benvenuti F, Cesco-Gaspere M, Burrone OR (2002) Anti-idiotypic DNA vaccines for B-cell lymphoma therapy. Front Biosci 7:d228
6. Biragyn A, Tani K, Grimm MC, Weeks S, Kwak LW (1999) Genetic fusion of chemokines to a self tumor antigen induces protective, T-cell dependent antitumor immunity. Nat Biotechnol 17:253
7. Campbell MJ, Carroll W, Kon S, Thielemans K, Rothbard JB, Levy S, Levy R (1987) Idiotype vaccination against murine B cell lymphoma. Humoral and cellular responses elicited by tumor-derived immunoglobulin M and its molecular subunits. J Immunol 139:2825
8. Farrar JD, Katz KH, Windsor J, Thrush G, Scheuermann RH, Uhr JW, Street NE (1999) Cancer dormancy, VII: a regulatory role for CD8+ T cells and IFN-gamma in establishing and maintaining the tumor-dormant state. J Immunol 162:2842
9. George AJ, Tutt AL, Stevenson FK (1987) Anti-idiotypic mechanisms involved in suppression of a mouse B cell lymphoma, BCL1. J Immunol 138:628
10. Hakim I, Levy S, Levy R (1996) A nine-amino acid peptide from IL-1beta augments antitumor immune responses induced by protein and DNA vaccines. J Immunol 157:5503
11. Hanke T, Szawlowski P, Randall RE (1992) Construction of solid matrix-antibody-antigen complexes containing simian immunodeficiency virus p27 using tag-specific monoclonal antibody and tag-linked antigen. J Gen Virol 73(3):653
12. King CA, Spellerberg MB, Zhu D, Rice J, Sahota SS, Thompsett AR, Hamblin TJ, Radl J, Stevenson FK (1998) DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma. Nat Med 4:1281
13. Li E, Pedraza A, Bestagno M, Mancardi S, Sanchez R, Burrone O (1997) Mammalian cell expression of dimeric small immune proteins (SIP). Protein Eng 10:731
14. Lundin KU, Hofgaard PO, Omholt H, Munthe LA, Corthay A, Bogen B (2003) Therapeutic effect of idiotype-specific CD4+ T cells against B-cell lymphoma in the absence of anti-idiotypic antibodies. Blood 102:605
15. Pugatsch T, Weiss L, Slavin S (1993) Minimal residual disease in murine B-cell leukemia (BCL1) detected by PCR. Leuk Res 17:999
16. Racila E, Scheuermann RH, Picker LJ, Yefenof E, Tucker T, Chang W, Marches R, Street NE, Vitetta ES, Uhr JW (1995) Tumor dormancy and cell signaling, II: antibody as an agonist in inducing dormancy of a B cell lymphoma in SCID mice. J Exp Med 181:1539
17. Savelyeva N, Munday R, Spellerberg MB, Lomonossoff GP, Stevenson FK (2001) Plant viral genes in DNA idiotypic vaccines activate linked CD4+ T-cell mediated immunity against B-cell malignancies. Nat Biotechnol 19:760
18. Scheuermann RH, Racila E, Tucker T, Yefenof E, Street NE, Vitetta ES, Picker LJ, Uhr JW (1994) Lyn tyrosine kinase signals cell cycle arrest but not apoptosis in B-lineage lymphoma cells. Proc Natl Acad Sci U S A 91:4048
19. Sepulveda J, Jin H, Sblattero D, Bradbury A, Burrone OR (2003) Binders based on dimerised immunoglobulin VH domains. J Mol Biol 333:355
20. Slavin S, Strober S (1978) Spontaneous murine B-cell leukaemia. Nature 272:624
21. Sugie T, Kubota H, Sato M, Nakamura E, Imamura M, Minato N (1996) NK 1+ CD4- CD8- alphabeta T cells in the peritoneal cavity: specific T cell receptor-mediated cytotoxicity and selective IFN-gamma production against B cell leukemia and myeloma cells. J Immunol 157:3925
22. Syrengelas AD, Levy R (1999) DNA vaccination against the idiotype of a murine B cell lymphoma: mechanism of tumor protection. J Immunol 162:4790
23. Syrengelas AD, Chen TT, Levy R (1996) DNA immunization induces protective immunity against B-cell lymphoma. Nat Med 2:1038
24. Timmerman JM, Caspar CB, Lambert SL, Syrengelas AD, Levy R (2001) Idiotype-encoding recombinant adenoviruses provide protective immunity against murine B-cell lymphomas. Blood 97:1370