The two membrane isoforms of human IgE assemble into functionally distinct B cell antigen receptors

Journal of Experimental Medicine

Volumn 184, Issue 6, 1996, Pages 2197-2205

  Batista, Facundo D ^a   Anand, Shubha ^a   Presani, Gianni ^b   Efremov, Dimitar G ^a   Burrone, Oscar R ^a  

^a INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

^b INSTITUTE FOR MATERNAL AND CHILD HEALTH IRCCS BURLO GAROFOLO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN E; LYMPHOCYTE ANTIGEN RECEPTOR; POLYCLONAL ANTIBODY;

ARTICLE; B LYMPHOCYTE DIFFERENTIATION; CELL DIFFERENTIATION; CROSS LINKING; FLOW CYTOMETRY; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOMA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

AMINO ACID SEQUENCE; B-LYMPHOCYTES; CELL DIVISION; CELL LINE; CELL MEMBRANE; FLOW CYTOMETRY; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN HEAVY CHAINS; KINETICS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; RECEPTORS, ANTIGEN, B-CELL; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0030469752     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.184.6.2197     Document Type: Article

References (42)

1. DeFranco, A.L. 1993. Structure and function of the B cell antigen receptor. Annu. Rev. Cell. Biol. 9:377-410.
2. Hombach, J., L. Leclercq, A. Radbruch, K. Rajewsky, and M. Reth. 1988. A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells EMBO (Eur. Mol. Biol. Organ.) J. 7:3451-3456.
3. Hombach, J., T. Tsubata, L. Leclercq, H. Stappert, and M. Reth. 1990. Molecular components of the B-cell antigen receptor complex of the IgM class. Nature (Lond.). 43:760-762.
4. Reth, M. 1992. Antigen receptors on B lymphocytes. Annu. Rev. Immunol. 10:97-121.
5. Reth, M. 1994. B cell antigen receptors. Curr. Opin. Immunol. 6:3-8.
6. Hermanson, G.G., D. Eisenberg, P.W. Kincade, and R. Wall. 1988. B29: a member of the immunoglobulin gene superfamily exclusively expressed on beta-lineage cells. Prof. Natl. Acad. Sci. USA. 85:6890-6894.
7. Sakaguchi, N., S. Kashiwamura, M. Kimoto, P. Thalmann, and F. Melchers. 1988. B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties. EMBO (Eur. Mol. Biol. Organ.) J. 7:3457-3464.
8. Venkitaraman, A.R., G.T. Williams, P. Dariavach, and M.S. Neuberger. 1991. The B-cell antigen receptor of the five immunoglobulin classes. Nature (Lond.). 352:777-781.
9. Cambier, J.C., C.M. Pleiman, and M.R. Clark. 1994. Signal transduction by the B cell antigen receptor and its coreceptors. Annu. Rev. Immunol. 12:457-486.
10. Flaswinkel, H., and M. Reth. 1994. Dual role of the tyrosine activation motif of the Ig-alpha protein during signal transduction via the B cell antigen receptor. EMBO (Eur. Mol. Biol. Organ.) J. 13:83-89.
11. Kim, K.M., G. Alber, P. Weiser, and M. Reth. 1993. Differential signalling through the Ig-alpha and Ig-beta components of the B cell antigen receptor. Eur. J. Immunol. 23:911-916.
12. Matsuo, T., J. Nomura, K. Kuwahara, H. Igarashi, S. Inui, M. Hamaguchi, M. Kimoto, and N. Sakaguchi. 1993. Cross-linking of B cell receptor-related MB-1 molecule induces protein tyrosine phosphorylation in early B lineage cells. J. Immunol. 150:3766-3775.
13. Clark, M.R., K.S. Campbell, A. Kazlauskas, S.A. Johnson, M. Hertz, T.A. Potter, C. Pleiman, and J.C. Cambier. 1992. The B cell antigen receptor complex: association of Ig-alpha and Ig-beta with distinct cytoplasmic effectors. Science (Wash. DC). 258:123-126.
14. Clark, M.R., S.A. Johnson, and J.C. Cambier. 1994. Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO (Eur. Mol. Biol. Organ.) J. 13:1911-1919.
15. Dymecki, S.M., P. Zwollo, K. Zeller, F.P. Kuhajda, and S.V. Desiderio. 1992. Structure and developmental regulation of the B-lymphoid tyrosine kinase gene blk. J. Biol. Chem. 267: 4815-4823.
16. Rudd, C.E., O. Janssen, K.V. Prasad, M. Raab, A. da Silva, J.C. Telfer, and M. Yamamoto. 1993. src-related protein tyrosine kinases and their surface receptors. Biochim. Biophys. Acta. 1155:239-266.
17. Yamanashi, Y., T. Kakiuchi, J. Mizuguchi, T. Yamamoto, and K. Toyoshima. 1991. Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science (Wash. DC). 251:192-194.
18. Gold, M.R., L. Matsuuchi, R.B. Kelly, and A.L. DeFranco. 1991. Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking. Proc. Natl. Acad. Sci. USA. 88:3436-3440.
19. Goding, J.W., D.W. Scott, and J.E. Layton. 1977. Genetics, cellular expression and function of IgD and IgM receptors. Immunol. Rev. 37:152-186.
20. Vitetta, E.S., and J.W. Uhr. 1977. IgD and B-cell differentiation. Immunol. Rev. 37:50-88.
21. Goodnow, C.C. 1992. Transgenic mice and analysis of B-cell tolerance. Annu. Rev. Immunol. 10:489-518.
22. Batista, F.D., D.G. Efremov, and O.R. Burrone. 1995. Characterization and expression of alternatively spliced IgE heavy chains transcripts produced by peripheral blood lymphocytes. J. Immunol. 154:209-218.
23. Batista, F.D., D.G. Efremov, T. Tkach, and O.R. Burrone. 1995. Characterization of the human immunoglobulin epsilon mRNAs and their polyadenylation sites. Nucleic Acids Res. 23:4805-4811.
24. Diaz-Sanchez, D., A.R. Dotson, H. Takenaka, and A. Saxon. 1994. Diesel exhaust particles induce local IgE production in vivo and alter the pattern of IgE messenger RNA isoforms. J. Clin. Invest. 94:1417-1425.
25. Efremov, D.G., F.D. Batista, and O.R. Burrone. 1993. Molecular analysis of IgE H-chain transcripts expressed in vivo by peripheral blood lymphocytes from normal and atopic individuals. J. Immunol. 151:2195-2207.
26. Hellman, L. 1993. Characterisation of four novel ∈ chain mRNA and a comparative analysis of genes for immunoglobulin E in rodents and man. Eur. J. Immunol. 23:159-167.
27. Peng, C., F.M. Davis, L.K. Sun, R.S. Liou, Y.W. Kim, and T.W. Chang. 1992. A new isoform of human membrane-bound IgE. J. Immunol. 148:129-136.
28. Zhang, K., E.E. Max, H.K. Cheah, and A. Saxon. 1994. Complex alternative RNA splicing of ∈-immunoglobulin transcripts produces mRNAs encoding four potential secreted protein isoforms. J. Biol. Chem. 269:456-462.
29. Zhang, K., A. Saxon, and E.E. Max. 1992. Two unusual forms of human immunoglobulin E encoded by alternative RNA splicing of ∈ heavy chain membrane exon. J. Exp. Med. 176:233-243.
30. Batista, F.D., D.G. Efremov, and O.R. Burrone. 1996. Characterization of a second secreted IgE isoform and identification of an asymmetric pathway of IgE assembly. Proc. Natl. Acad. Sci. USA. 93:3399-3404.
31. Kim, K.M., and M. Reth. 1995. The B cell antigen receptor of class IgD induces a stronger and more prolonged protein tyrosine phosphorylation than that of class IgM. J. Exp. Med. 181:1005-1014.
32. Campbell, K.S., E.J. Hager, and J.C. Cambier. 1991. Alpha-chains of IgM and IgD antigen receptor complexes are differentially N-glycosylated MB-1-related molecules. J. Immunol. 147:1575-1580.
33. Pogue, S.L., and C.C. Goodnow. 1994. Ig heavy chain extracellular spacer confers unique glycosylation of the Mb-1 component of the B cell antigen receptor complex. J. Immunol. 152:3925-3934.
34. van Noesel, C.J.M., G.S. Brouns, G.M.W. van Schijndel, R.J. Bende, D.Y. Mason, J. Borst, and R.A.W. van Lier. 1992. Comparison of human B cell antigen receptor complexes: membrane-expressed forms of immunoglobulin (Ig)M, IgD, and IgG are associated with structurally related heterodimers. J. Exp. Med. 175:1511-1519.
35. Gold, M.R., D.W. Law, and A.L. DeFranco. 1990. Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor. Nature (Lond.). 345:810-813.
36. Boyd, A.W., and J.W. Schrader. 1981. The regulation of growth and differentiation of a murine B cell lymphoma. II. The inhibition of WEHI 231 by anti-immunoglobulin antibodies. J. Immunol. 126:2466-2469.
37. Tisch, R., C.M. Roifman, and N. Hozumi. 1988. Functional differences between immunoglobulins M and D expressed on the surface of an immature B-cell line. Proc. Natl. Acad. Sci. USA. 85:6914-6918.
38. Yuan, D. 1984. Regulation of IgM and IgD synthesis of murine immunglobulin D: heterogeneity of glycosylation. J. Immunol. 132:1566-1571.
39. Terashima, M., K.M. Kim, T. Adachi, P.J. Nielsen, M. Reth, G. Kohler, and M.C. Lamers. 1994. The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. EMBO (Eur. Mol. Biol. Organ.) J. 13: 3782-3792.
40. Kim, K.M., T. Adachi, P.J. Nielsen, M. Terashima, M.C. Lamers, G. Kohler, and M. Reth. 1994. Two new proteins preferentially associated with membrane immunoglobulin D. EMBO (Eur. Mol. Biol. Organ.) J. 13:3793-3800.
41. MacKenzie, T., and H.M. Dosch. 1989. Clonal and molecular characteristics of the human IgE committed B cell subset. J. Exp. Med. 169:407-430.
42. Chan, M.A., S.H. Benedict, H.M. Dosch, M.F. Hui, and L.D. Stein. 1990. Expression of IgE from a nonrearranged ∈ locus in cloned B lymphoblastoid cells that also express IgM. J. Immunol. 136:3563-3568.