The presence of heme-oxygenase and biliverdin reductase in human cranial ganglia indicates a role for carbon monoxide in neural transmission

Neuroendocrinology Letters

Volumn 25, Issue 6, 2004, Pages 423-428

  Uddman, Rolf ^a   Tajti, Janos ^b   Sundler, Frank ^c   Cardell, Lars Olaf ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

^b UNIVERSITY OF SZEGED   (Hungary)

^c LUND UNIVERSITY   (Sweden)

Author keywords

Autonomic ganglia; Biliverdin reductase; Carbon monoxide; Heme oxygenase

Indexed keywords

BILIVERDIN; CALCITONIN GENE RELATED PEPTIDE; CARBON MONOXIDE; ENZYME ANTIBODY; HEME OXYGENASE; HEME OXYGENASE 1; HEME OXYGENASE 2; ISOENZYME; OXIDOREDUCTASE;

ARTICLE; CELL SIZE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRANIAL NERVE; ENZYME INDUCTION; GANGLION; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOREACTIVITY; NEUROTRANSMISSION; SYNAPTIC TRANSMISSION; TRIGEMINAL NERVE;

EID: 13644249441     PISSN: 0172780X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Alm P, Uvelius B, Ekström J, Holmqvist B, Larsson B & Andersson K-E. Nitric oxide synthase-containing neurons in rat parasympathetic, sympathetic and sensory ganglia: a comparative study. Histochem J 1995; 27:819-831.
2. Barañano DE & Snyder SH. Neural roles for heme oxygenase: contrasts to nitric oxide synthase. Proc Natl Acad Sci USA 2001; 25 10996-11002.
3. Canning BJ & Fischer A. Localization of heme-oxygenase-2 immunoreactivity to parasympathetic ganglia of human and guinea-pig airways. Am J Respir Mol Biol 1998; 18:279-285.
4. Cardell LO, Ueki IF, Stjarne P, Agusti C, Takeyama K, Linden A & Nadel JA. Bronchodilatation in vivo by carbon monoxide, a cyclic GMP related messenger. Br J Pharmacol 1998; 124:1065-1068.
5. Colpaert EE, Timmermans J-P & Lefebvre RA. Immunohistochemical localization of the antioxidant enzymes biliverdin reductase and heme oxygenase-2 in human and pig gastric fundus. Free Radic Biol Med 2002; 32:630-637.
6. Dawson TM & Snyder SH. Gases as biological messengers: nitric oxide and carbon monoxide in the brain. J Neurosci 1994; 14: 5147-5159.
7. Ewing JF & Maines MD. In situ hybridization and immunohistochemical localization of heme oxygenase-2-mRNA and protein in normal rat brain: differential distribution of isozyme 1 and 2. Mol Cell Neurosci 1992; 3:559-570.
8. Ewing JF & Maines MD. Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain. Brain Res Brain Res Protocol 1997; 1:165-174.
9. Furchgott RF & Jothianandan D. Endothelium-dependent and -independent vasodilatation involving cyclic GMP: relaxation induced by nitric oxide, carbon monoxide and light. Blood Vessels 1991; 28 52-61.
10. Grozdanovic Z & Gossrau R. Expression of heme-oxygenase-2 (HO-2)-like immunoreactivity in rat tissues. Acta Histochem 1996; 98 203-214.
11. Hayashi S, Takamiya R, Yamaguchi T, Matsumoto K, Tojo SJ, Tamatani T, Kitajima M, Makino N, Ishimura Y & Suematsu M. Induction of heme oxygenase-1 suppresses venular leukocyte adhesion elicited by oxidative stress: role of bilirubin generated by the enzyme. Circ Res 1999; 15:663-671.
12. Ho KMT, Ny L, McMurray G, Andersson KE, Brading A & Noble JG. Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter. J Urol 1999; 161: 1968-1972.
13. Magnusson S, Ekström J, Elme'r E, Kanje M, Ny L & Alm P. Heme oxygenase-1, heme-oxygenase-2 and biliverdin reductase in peripheral ganglia from rat, expression and plasticity. Neuroscience 2000; 95 821-829.
14. Maines MD, Trakshel GM & Kutty RK. Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem 1986; 5 411-419.
15. Maines MD. Heme oxygenase: functional multiplicity, regulatory mechanisms, and clinical application. FASEB J 1988; 12: 2557-2568.
16. Maines MD. Carbon monoxide: an emerging regulator of cGMP in the brain. Mol Cell Neurosci 1993; 4:389-397.
17. Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol 1997; 37:517-554.
18. Marks GS, Brien JF, Nakatsu K & McLaughlin BE. Does carbon monoxide have a physiological function? Trends Pharmacol Sci 1991; 12 185-188.
19. McCoubrey WK, Huang TJ & Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem 1997; 247:725-732.
20. Nozaki K, Moskowitz M, Maynard KI, Koketsu N, Dawson TM, Bredt DS & Snyder SH. Possible origins and distribution of immunoreactive nitric oxide synthase-containing nerve fibres in cerebral arteries. J Cereb Blood Flow Metab 1993; 13:70-79.
21. Ny L, Alm P, Ekstrom P, Larsson B, Grundemar L & Andersson KE. Localization and activity of haem oxygenase and functional effects of carbon monoxide in the feline lower oesophageal sphincter. Br J Pharmacol 1996; 118:392-399.
22. Otterbein LE & Choi AM. Heme oxygenase: colors of defense against cellular stress. Am J Physiol 2000; 279:L1029-L1037.
23. Snyder SH & Barañano DE. Heme oxygenase: a font of multiple messengers. Neuropsychopharmacology 2001; 25:294-298.
24. Trakshel GM, Ewing JF & Maines MD. Heterogeneity of haem oxygenase 1 and 2 isoenzymes. Rat and primate transcripts for isoenzyme 2 differ in number and size. Biochem J 1991; 1: 159-164.
25. Vachharajani TJ, Work J, Issekutz AC & Granger DN. Heme oxygenase modulates selectin expression in different regional vascular beds. Am J Physiol 2000; 278:H1613-H1617.
26. Vedernikov YP, Graser T & Vanin AF. Similar endothelium-independent arterial relaxation by carbon monoxide and nitric oxide. Biomed Biochim Acta 1989; 48:601-603.
27. Verma A, Hirsch DJ, Glatt CE, Ronnett GV & Snyder SH. Carbon monoxide: a putative neural messenger. Science 1993; 259: 381-384.
28. Vollerthun R, Höhler B & Kummer W. Guinea-pig sympathetic postganglionic neurones contain haem oxygenase-2. Neuro Report 1995; 7 173-176.
29. Vollerthun R, Höhler B & Kummer W. Heme-oxygenase-2 in primary afferent neurons of the guinea-pig. Histochem Cell Biol 1996; 105:453-458.
30. Zakhary R, Gaine SP, Dinerman JL, Ruat M, Flavahan NA & Snyder SH. Heme oxygenase 2: endothelial and neuronal localization and role in endothelium-dependent relaxation. Proc Natl Acad Sci USA 1996; 93:795-798.
31. Zhuo M, Small SA, Kandel ER & Hawkins RD. Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science 1993; 260:1946-1950.