The chemokine receptor CCR7 is expressed on epithelium of non-inflamed gastric mucosa, Helicobacter pylori gastritis, gastric carcinoma and its precursor lesions and up-regulated by H. pylori

Clinical and Experimental Immunology

Volumn 139, Issue 2, 2005, Pages 323-327

  Schmaußer, Bernd ^a   Endrich, S ^a   Brandlein S ^a   Schar J ^b   Beier, D ^b   Muller Hermelink H K ^a   Eck, M ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

CCR7; Gastric carcinoma; Helicobacter pylori; Helicobacter pylori gastritis; Intestinal metaplasia dysplasia

Indexed keywords

CHEMOKINE RECEPTOR CCR7;

ARTICLE; BACTERIAL STRAIN; CARCINOGENESIS; CELL SELECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DYSPLASIA; GASTRITIS; HELICOBACTER PYLORI; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE METAPLASIA; NONHUMAN; PRIORITY JOURNAL; STOMACH CARCINOMA; STOMACH EPITHELIUM; STOMACH MUCOSA;

EID: 13544274097     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2005.02703.x     Document Type: Article

References (21)

1. Luster AD. Chemokines - chemotactic cytokines that mediate inflammation. N Engl J Med 1998; 338:436-45.
2. Campbell JJ, Butcher EC. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr Opin Immunol 2000; 2:336-41.
3. Moser B, Loetscher P. Lymphocyte traffic control by chemokines. Nat Immunol 2001; 2:123-8.
4. Muller G, Hopken UE, Lipp M. The impact of CCR7 and CXCR5 on lymphoid organ development and systemic immunity. Immunol Rev 2003; 195:117-35.
5. Muller A, Homey B, So to H et al. Involvement of chemokine receptors in breast cancer metastasis. Nature 2001; 410:50-6.
6. Takanami I. Overexpression of CCR7 mRNA in nonsmall cell lung cancer: correlation with lymph node metastasis. Int J Cancer 2003; 105:186-9.
7. Payne AS, Cornelius LA. The role of chemokines in melanoma tumor growth and metastasis. J Invest Dermatol 2002; 118:915-22.
8. Mashino K, Sadanaga N, Yamaguchi H et al. Expression of chemokine receptor CCR7 is associated with lymph node metastasis of gastric carcinoma. Cancer Res 2002; 62:2937-41.
9. IARC. Working Group on the Evaluation of Carcinogenic Risks to Humans: Helicobacter pylori. In: Schistosomes, liver flukes, and Helicobacter pylori: views and expert opinions of an IARC Working Group on the evaluation of carcinogenic risks to humans. Lyon: IARC, 1994:177-240.
10. Sallusto F, Schaerli P, Loetscher P et al. A rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol 1998; 28:2760-9.
11. Jarrossay D, Napolitani G, Colonna M et al. Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells. Eur J Immunol 2001; 31:3388-93.
12. Means TK, Hayashi F, Smith KD et al. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J Immunol 2003; 170:5165-75.
13. Eck M, Schmausser B, Scheller K et al. Pleiotropic effects of CXC chemokines in gastric carcinoma: differences in CXCL8 and CXCL1 expression between diffuse and intestinal types of gastric carcinoma. Clin Exp Immunol 2003; 134:508-15.
14. Schmausser B, Andrulis M, Endrich S et al. Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Clin Exp Immunol 2004; 136:521-6.
15. Murdoch C, Monk PN, Finn A. Functional expression of chemokine receptor CXCR4 on human epithelial cells. Immunology 1999; 98:35-41.
16. Jordan NJ, Kolios G, Abbot SE et al. Expression of functional CXCR4 chemokine receptors on human colonic epithelial cells. J Clin Invest 1999; 104:1061-9.
17. Banas B, Wornle M, Berger T et al. Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J Immunol 2002; 168:4301-7.
18. Blaser MJ, Perez-Perez GI, Kleanthous H et al. Infection with Helicobacter pylori strains possessing cag A is associated with an increased of developing adenocarcinoma of the stomach. Cancer Res 1995; 55:2111-15.
19. Eck M, Schmaußer B, Haas R et al. MALT-type lymphoma of the stomach is associated with Helicobacter pylori strains expressing CagA protein. Gastroenterology 1997; 112:1482-6.
20. Wang J, Xi L, Hunt JL et al. Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res 2004; 64:1861-6.
21. Xiang Z, S.Censini PF, Bayeli JL et al. Analysis of expression of CagA and VacA virulence factors in 43 strains of Helicobacter pylori reveals that clinical isolates can be divided into two major types and that CagA is not necessary for expression of the vacuolating cytotoxin. Infect Immun 1995; 63:94-8.