Antitumor-promoting activity of coumarins from Citrus plants

Planta Medica

Volumn 71, Issue 1, 2005, Pages 84-87

  Ito, Chihiro ^a   Itoigawa, Masataka ^b   Ju Ichi, Motoharu ^c   Sakamoto, Naoyuki ^d   Tokuda, Harukuni ^d   Nishino, Hoyoku ^d   Furukawa, Hiroshi ^a  

^a MEIJO UNIVERSITY   (Japan)

^b TOKAI GAKUEN UNIVERSITY   (Japan)

^c MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

8 FORMYL 7 HYDROXYCOUMARIN; COUMARIN DERIVATIVE; DIHYDROOSTHENON; EARLY ANTIGEN; NORAURAPTENOL; OSTHENOL; OSTHENON; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG; VIRUS ANTIGEN;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL VIABILITY; CITRUS FRUIT; CONTROLLED STUDY; DRUG ISOLATION; DRUG SCREENING; DRUG STRUCTURE; EPSTEIN BARR VIRUS; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAJI CELL; RUTACEAE; SKIN CARCINOGENESIS; SKIN TUMOR; STATISTICAL SIGNIFICANCE;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CITRUS; COUMARINS; INHIBITORY CONCENTRATION 50; MICE; PHYTOTHERAPY; SKIN NEOPLASMS;

EID: 13544270873     PISSN: 00320943     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2005-837758     Document Type: Article

References (15)

1. Ito C, Matsuoka M, Oka T, Ju-ichi M, Niwa M, Omura M, Furukawa H. New binary coumarins from Citrus plants. Chemical & Pharmaceutical Bulletin. 1990; 38: 1230-2
2. Ito C, Fujiwara K, Kajita M, Ju-ichi M, Takemura Y, Suzuki Y et al. New coumarins from Citrus plants. Chemical & Pharmaceutical Bulletin. 1991; 39: 2509-13
3. Takemura Y, Kawaguchi H, Maki S, Ju-ichi M, Omura M, Ito C, Furukawa H. Studies on the constituents of Yalaha. Structures of a new acridone alkaloid and two new coumarins. Chemical & Pharmaceutical Bulletin 1996; 44: 804-9
4. Kan WS. Manual of Medicinal Plants in Taiwan Vol 25. National Research Institute of Chinese Medicine, Taiwan: 1972: pp 77-8 and 359-72
5. Iwase Y, Takemura Y, Ju-ichi M, Kawaii S, Yano M, Okuda Yet al. Inhibitory effect of Epstein-Barr virus activation by Citrus fruits, a cancer chemopreventor. Cancer Letters. 1999; 139: 227-36
6. Ito C, Itoigawa M, Furukawa H, Tokuda H, Okuda Y, Mukainaka T et al. Anti-tumor-promoting effects of 8-substituted 7-methoxycoumarins on Epstein-Barr virus activation assay. Cancer Letters 1999; 138: 87-92
7. Murakami A, Kuki W, Takahashi Y, Yonei H, Nakamura Y, Ohto Y et al. Auraptene, a Citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate- induced tumor promotion in ICR mouse skin, possibly through suppression of superoxide generation in leukocytes. Japanese Journal of Cancer Research 1997; 88: 443-52
8. Iwase Y, Takemura Y, Ju-ichi M, Ito C, Furukawa H, Kawaii S et al. Inhibitory effect of flavonoids from Citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors. Cancer Letters 2000; 154: 101-5
9. Iwase Y, Takemura Y, Ju-ichi M, Yano M, Ito C, Furukawa H et al. Cancer chemopreventive activity of 3,5,6,7,8,3′,4′-heptamethoxyflavone from the peel of Citrus plants. Cancer Letters 2001; 163: 7-9
10. Takemura Y, Ju-ichi M, Ito C, Furukawa H, Tokuda H. Studies on the inhibitory effects of some acridone alkaloids on Epstein-Barr virus activation. Planta Medica 1995; 61: 366-8
11. Itoigawa M, Ito C, Wu T-S, Enjo F, Tokuda H, Nishino H et al. Cancer chemopreventive activity of acridone alkaloids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Letters 2003; 193: 133-8
12. Murakami A, Ohigashi H, Koshimizu K. Anti-tumor promotion with food phytochemicals: A strategy for cancer chemoprevention. Bioscience Biotechnology and Biochemistry 1996; 60: 1-8
13. Tsushima M, Maoka T, Katsuyama M, Kozuka M, Matsuno T, Tokuda H et al. Inhibitory effect of natural carotenoids on Epstein-Barr virus activation activity of a tumor promoter in Raji cells. A screening study for anti-tumor promoters. Biological & Pharmaceutical Bulletin. 1995; 18: 227-33
14. Huang MT, Ma W, Lu YP, Chang RL, Fisher C, Manchand PS et al. Effects of curcumin, demethoxycurcumin, bisdemethoxycurcumin and tetrahydrocurcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion. Carcinogenesis 1995; 16: 2493-7
15. Ishida J, Kozuka M, Wang H, Konoshima T, Tokuda H, Okuda M et al. Antitumor-promoting effects of cyclic diarylheptanoids on Epstein-Barr virus activation and two-stage mouse skin carcinogenesis. Cancer Letters 2000; 159: 135-40