Inhibitory effect of flavonoids from Citrus plants on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors

Cancer Letters

Volumn 154, Issue 1, 2000, Pages 101-105

  Iwase, Yukiko ^a   Takemura, Yuko ^a   Ju Ichi, Motoharu ^a   Ito, Chihiro ^b   Furukawa, Hiroshi ^b   Kawaii, Satoru ^c   Yano, Masamichi ^c   Mou, Xiao Yang ^d   Takayasu, Junko ^d   Tokuda, Harukuni ^d   Nishino, Hoyoku ^d  

^a MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^b MEIJO UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF FRUIT TREE SCIENCE   (Japan)

^d KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

Author keywords

Anti tumor promoter; Citrus; Flavone; Two stage carcinogenesis

Indexed keywords

EARLY ANTIGEN; EPSTEIN BARR VIRUS ANTIGEN; FLAVONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; DRUG SCREENING; FEMALE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN PAPILLOMA;

ANIMALS; ANTIGENS, VIRAL; FEMALE; FLAVONOIDS; MICE; MICE, INBRED ICR; PAPILLOMA; PLANT EXTRACTS; SKIN NEOPLASMS; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS; VIRUS ACTIVATION;

CITRUS; HUMAN HERPESVIRUS 4;

EID: 17644442018     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(00)00386-4     Document Type: Article

References (9)

1. Iwase Y., Takemura Y., Ju-ichi M., Kawai S., Yano M., Okuda Y., Mukainaka T., Tsuruta A., Okuda M., Takayasu J., Tokuda H., Nishino H. Inhibitory effect of Epstein-Barr virus activation by Citrus fruits, a cancer chemopreventor. Cancer Lett. 139:1999;227-236.
2. Henle G., Henle W. Immunofluorescence in cells derived from Burkitt's Lymphoma. J. Bacteriol. 91:1966;1248-1256.
3. Tokuda H., Konoshima T., Kozuka M., Kimura T. Inhibitory effects of 12-O-tetradecanoylphorbol 13-acetate and teleocidin B induced Epstein-Barr virus by saponin and its related compounds. Cancer Lett. 40:1988;309-317.
4. Konoshima T., Tokuda H., Kozuka M., Okamoto E., Tanabe M. Inhibitory effects on Epstein-Barr virus activation and anti-tumor promoting effects of crude drugs (I). Shoyakugaku Zasshi. 41:1987;344-348.
5. Konoshima T., Takasaki M., Tatsumoto T., Kozuka M., Kasai R., Tanaka O., Nie R.L., Tokuda H., Nishino H., Iwashima A. Inhibitory effects of cucurbitane triterpenoids on Epstein-Barr virus activation and two-stage carcinogenesis of skin tumors. Biol. Pharmacol. Bull. 17:1994;668-671.
6. Tokuda H., Ohigashi H.T., Koshimizu K., Ito Y. Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol 13-acetate. Cancer Lett. 33:1986;279-285.
7. Kawaii S., Tomono Y., Katase E., Ogawa K., Yano M. HL-60 differentiating activity and flavonoid content of the readily extractable fraction prepared from Citrus juices. J. Agric. Food Chem. 47:1999;128-135.
8. Kawaii S., Tomono Y., Katase E., Ogawa K., Yano M. Effect of Citrus flavonoids on HL-60 cell differentiation. Anticancer Res. 19:1999;1261-1270.
9. Zi X., Mukhtar H., Agarwal R. Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNFα Biochem. Biophys. Res. Commun. 239:1997;334-339.