Endomorphins inhibit contractile responses of rat thoracic aorta rings induced by phenylephrine and angiotensin II in vitro

Acta Pharmacologica Sinica

Volumn 23, Issue 1, 2002, Pages 40-44

  Qi, Yuan Ming ^a   Yang, Ding Jian ^a   Duan, Xin ^a   Yang, Fan ^a   Li, Shi Rong ^a   Shen, Jian Min ^a   Wang, Rui ^a  

^a LANZHOU UNIVERSITY   (China)

Author keywords

Angiotensin II; Endomorphins; Morphine; Nitric oxide; Opioid peptides; Phenylephrine; Thoracic arteries

Indexed keywords

ANGIOTENSIN; ENDOMORPHIN 1; ENDOMORPHIN 2; N(G) NITROARGININE; NALOXONE; NITRIC OXIDE; OPIATE RECEPTOR; PHENYLEPHRINE; ANGIOTENSIN II; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; OLIGOPEPTIDE; VASOCONSTRICTOR AGENT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG INHIBITION; DRUG MECHANISM; DRUG RECEPTOR BINDING; IN VITRO STUDY; MALE; MUSCLE CONTRACTION; NONHUMAN; RAT; RAT STRAIN; THORACIC AORTA; VASCULAR ENDOTHELIUM; ANIMAL; DRUG EFFECT; DRUG INTERACTION; DRUG POTENTIATION; PHYSIOLOGY; VASCULAR SMOOTH MUSCLE; WISTAR RAT;

ANALGESICS, OPIOID; ANGIOTENSIN II; ANIMALS; AORTA, THORACIC; DRUG INTERACTIONS; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; OLIGOPEPTIDES; PHENYLEPHRINE; RATS; RATS, WISTAR; RECEPTORS, OPIOID, MU; VASOCONSTRICTOR AGENTS;

EID: 0036147343     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (13)

1. The opioid system in cardiac and vascular regulation of normal and hypertensive states
2. μ- And δ -opioid receptor-mediated contractile effects of rat aorta vascular smooth muscle
3. Cardiovascular effects of endogenous opiate systems
4. The cardiovascular actions of morphine and the endogenous opioid peptides
5. A potent and selective endogenous agonists for the μ-opiate receptor
6. Endomorphin 1 and 2, the endogenous μ-opioid agonists, have novel hypotensive activity in the rabbit
7. Endomorphin 1 and 2, the endogenous μ-opioid, decrease systemic arterial pressure in the rat
8. Endomorphin 1 and 2, the endogenous mu-opioid agonists, produce biphasic changes in systemic arterial pressure in the cat
9. Endomorphin 1 and 2 have vasodepressor activity in the anesthetized mouse
10. The endogenous μ-opioid agonist, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat
11. Presence of the μ-opiate receptor in endothelial cells: Coupling to nitric oxide production and vasodilation
12. 3 opiate receptor subtype
13. Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in isolated rat aorta