Cognitive deficits and magnetic resonance spectroscopy in adult monozygotic twins with lead poisoning

Environmental Health Perspectives

Volumn 112, Issue 5, 2004, Pages 620-625

  Weisskopf, Marc G ^a   Hu, Howard ^a,b,c   Mulkern, Robert V ^d   White, Roberta ^a,e,f   Aro, Antonio ^a,b   Oliveira, Steve ^b   Wright, Robert O ^a,b,d  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Northeast Specialty Hospital   (United States)

^d BOSTON CHILDREN S HOSPITAL   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

^f BOSTON UNIVERSITY   (United States)

Author keywords

Lead poisoning; Magnetic resonance spectroscopy; Monozygotic; Neuropsychological tests; Paint; Twins

Indexed keywords

ACYLTRANSFERASE; CHELATING AGENT; CREATINE; EDETIC ACID; LEAD;

AGED; ANAMNESIS; CASE REPORT; CELL DENSITY; CLINICAL FEATURE; COGNITIVE DEFECT; CONCENTRATION (PARAMETERS); DIAGNOSTIC VALUE; DISEASE MARKER; FRONTAL LOBE; GENETIC IDENTIFICATION; HIPPOCAMPUS; HUMAN; HYPOTHESIS; LEAD POISONING; LIFE EVENT; LONG TERM EXPOSURE; MALE; MONOZYGOTIC TWINS; NERVE CELL DEGENERATION; NEUROLOGIC EXAMINATION; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCUPATIONAL DISEASE; OCCUPATIONAL MEDICINE; PATELLA; PRIORITY JOURNAL; RETIREMENT; REVIEW; SCORING SYSTEM; SHORT TERM MEMORY; TIBIA; WORKING MEMORY; X RAY FLUORESCENCE;

RAPHIA FRATER;

EID: 13544254144     PISSN: 00916765     EISSN: None     Source Type: Journal    
DOI: 10.1289/ehp.6687     Document Type: Review

References (60)

1. 2+ promotes lipid oxidation and alterations in membrane physical properties. Toxicology 132:19-32.
2. Araki S, Sato H, Yokoyama K, Murata K. 2000. Subclinical neurophysiological effects of lead: a review on peripheral, central, and autonomic nervous system effects in lead workers. Am J Ind Med 37:193-204.
3. Arnold DL, De Stefano N. 1997. Magnetic resonance spectroscopy in vivo: applications in neurological disorders. Ital J Neurol Sci 18:321-329.
4. Arnvig E, Grandjean P, Beckmann J. 1980. Neurotoxic effects of heavy lead exposure determined with psychological tests. Toxicol Lett 5:399-404.
5. 109Cd K X-ray fluorescence systems for measuring bone lead in vivo. Phys Med Biol 39:2263-2271.
6. ATSDR. 1998. The Nature and Extent of Lead Poisoning in Children in the United States: A Report to Congress. Atlanta, GA:Agency for Toxic Substances and Disease Registry.
7. ATSDR. 1999. Toxicological Profile for Lead. Atlanta, GA:Agency for Toxic Substances and Disease Registry.
8. Baker EL, Feldman RG, White RA, Harley JP, Niles CA, Dinse GE, et al. 1984. Occupational lead neurotoxicity: a behavioural and electrophysiological evaluation. Study design and year one results. Br J Ind Med 41:352-361.
9. Balbus-Kornfeld JM, Stewart W, Bolla KI, Schwartz BS. 1995. Cumulative exposure to inorganic lead and neurobehavioural test performance in adults: an epidemiological review. Occup Environ Med 52:2-12.
10. Banks EC, Ferretti LE, Shucard DW. 1997. Effects of low level lead exposure on cognitive function in children: a review of behavioral, neuropsychological and biological evidence. Neurotoxicology 18:237-281.
11. Barker PB, Szopinski K, Horska A. 2000. Metabolic heterogeneity at the level of the anterior and posterior commissures. Magn Reson Med 43:348-354.
12. Barth A, Schaffer AW, Osterode W, Winker R, Konnaris C, Valic E, et al. 2002. Reduced cognitive abilities in lead-exposed men. Int Arch Occup Environ Health 75:394-398.
13. Bechara EJ. 1996. Oxidative stress in acute intermittent porphyria and lead poisoning may be triggered by 5-aminolevulinic acid. Braz J Med Biol Res 29:841-851.
14. Bleecker ML, Lindgren KN, Ford DP. 1997. Differential contribution of current and cumulative indices of lead dose to neuropsychological performance by age. Neurology 48:639-645.
15. Bleecker ML, Lindgren KN, Ford DP, Tiburzi MJ. 2002. The interaction of education and cumulative lead exposure on the Mini-Mental State Examination. J Occup Environ Med 44:574-578.
16. Campara P, D'Andrea F, Micciolo R, Savonitto C, Tansella M, Zimmermann-Tanselle C. 1984. Psychological performance of workers with blood-lead concentration below the current threshold limit value. Int Arch Occup Environ Health 53:233-246.
17. Canfield RL, Henderson CR Jr, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. 2003. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med 348:1517-1526.
18. CDC (Centers for Disease Control and Prevention). 1999. Adult blood lead epidemiology and surveillance - United States, second and third quarters, 1998, and annual 1994-1997. MMWR Morb Mortal Wkly Rep 48:213-216, 223.
19. Chan S, Shungu DC, Douglas-Akinwande A, Lange DJ, Rowland LP. 1999. Motor neuron diseases: comparison of single-voxel proton MR spectroscopy of the motor cortex with MR imaging of the brain. Radiology 212:763-769.
20. Cheng Y, Schwartz J, Vokonas PS, Weiss ST, Aro A, Hu H. 1998. Electrocardiographic conduction disturbances in association with low-level lead exposure (the Normative Aging Study). Am J Cardiol 82:594-599.
21. 109Cd. Environ Health Perspect 91:49-55.
22. Chia SE, Chia HP, Ong CN, Jeyaratnam J. 1997. Cumulative blood lead levels and neurobehavioral test performance. Neurotoxicology 18:793-803.
23. Doraiswamy PM, Charles HC, Krishnan KR. 1998. Prediction of cognitive decline in early Alzheimer's disease [Letter]. Lancet 352:1678.
24. Fiedler N, Weisel C, Lynch R, Kelly-McNeil K, Wedeen R, Jones K, et al. 2003. Cognitive effects of chronic exposure to lead and solvents. Am J Ind Med 44:413-423.
25. Folstein MF, Folstein SE, McHugh PR. 1975. "Mini-Mental State." A practical method for grading the cognitive state of patents for the clinician. J Psychiatr Res 12:189-198.
26. Fox DA, He L, Poblenz AT, Medrano CJ, Blocker YS, Srivastava D. 1998. Lead-induced alterations in retinal cGMP phosphodiesterase trigger calcium overload, mitochondrial dysfunction and rod photoreceptor apoptosis. Toxicol Lett 102-103:359-361.
27. Grandjean P, Arnvig E, Beckmann J. 1978. Psychological dysfunctions in lead-exposed workers. Relation to biological parameters of exposure. Scand J Work Environ Health 4:295-303.
28. Haenninen H, Hernberg S, Mantere P, Vesanto R, Jalkanen M. 1978. Psychological performance of subjects with low exposure to lead. J Occup Med 20:683-689.
29. Hanninen H, Aitio A, Kovala T, Luukkonen R, Matikainen E, Mannelin T, et al. 1998. Occupational exposure to lead and neuropsychological dysfunction. Occup Environ Med 55:202-209.
30. Hogstedt C, Hane M, Agrell A, Bodin L. 1983. Neuropsychological test results and symptoms among workers with well-defined long-term exposure to lead. Br J Ind Med 40:99-105.
31. Hu H, Payton M, Korrick S, Aro A, Sparrow D, Weiss ST, et al. 1996. Determinants of bone and blood lead levels among community-exposed middle-aged to elderly men. The Normative Aging Study. Am J Epidemiol 144:749-759.
32. Jayasundar R, Raghunathan P. 1997. Evidence for left-right asymmetries in the proton MRS of brain in normal volunteers. Magn Reson Imaging 15:223-234.
33. Kreis R, Ernst T, Ross BD. 1993. Development of the human brain: in vivo quantification of metabolite and water content with proton magnetic resonance spectroscopy. Magn Reson Med 30:424-437.
34. Levin SM, Goldberg M. 2000. Clinical evaluation and management of lead-exposed construction workers. Am J Ind Med 37:23-43.
35. Lezak M. 1998. Neuropsychological Assessment. 3rd ed. New York:Oxford University Press.
36. Lindgren KN, Masten VL, Ford DP, Bleecker ML. 1996. Relation of cumulative exposure to inorganic lead and neuropsychological test performance. Occup Environ Med 53:472-477.
37. Lucchini R, Albini E, Cortesi I, Placidi D, Bergamaschi E, Traversa F, et al. 2000. Assessment of neurobehavioral performance as a function of current and cumulative occupational lead exposure. Neurotoxicology 21:805-811.
38. Lundbom N, Barnett A, Bonavita S, Patronas N, Rajapakse J, Tedeschi, et al. 1999. MR image segmentation and tissue metabolite contrast in 1H spectroscopic imaging of normal and aging brain. Magn Reson Med 41:841-845.
39. Muldoon SB, Cauley JA, Kuller LH, Morrow L, Needleman HL, Scott J, et al. 1996. Effects of blood lead levels on cognitive function of older women. Neuroepidemiology 15:62-72.
40. Needleman HL, Gatsonis CA. 1990. Low-level lead exposure and the IQ of children. A meta-analysis of modern studies. JAMA 263:673-678.
41. OSHA (Occupational Safety and Health Administration). 1993. Safety and Health Regulations for Construction. 29CFR1926. Available: http://www.access.gpo.gov/nara/cfr/waisidx_99/29cfr1926_99.html [accessed 1 March 2004].
42. Osterberg K, Borjesson J, Gerhardsson L, Schutz A, Skerfving S. 1997. A neurobehavioural study of long-term occupational inorganic lead exposure. Sci Total Environ 201:39-51.
43. Payton M, Riggs KM, Spiro A III, Weiss ST, Hu H. 1998. Relations of bone and blood lead to cognitive function: the VA Normative Aging Study. Neurotoxicol Teratol 20:19-27.
44. Rabin R, Brooks DR, Davis LK. 1994. Elevated blood lead levels among construction workers in the Massachusetts Occupational Lead Registry. Am J Public Health 84:1483-1485.
45. Ricci PE, Pitt A, Keller PJ, Coons SW, Heiserman JE. 2000. Effect of voxel position on single-voxel MR spectroscopy findings. AJNR Am J Neuroradiol 21:367-374.
46. Schwartz BS, Lee BK, Lee GS, Stewart WF, Lee SS, Hwang KY, et al. 2001. Associations of blood lead, dimercaptosuccinic acid-chelatable lead, and tibia lead with neurobehavioral test scores in South Korean lead workers. Am J Epidemiol 153:453-464.
47. Schwartz BS, Stewart WF, Bolla KI, Simon PD, Bandeen-Roche K, Gordon PB, et al. 2000. Past adult lead exposure is associated with longitudinal decline in cognitive function. Neurology 55:1144-1150.
48. Schwartz J. 1994. Low-level lead exposure and children's IQ: a meta-analysis and search for a threshold. Environ Res 65:42-55.
49. Seeber A, Meyer-Baron M, Schaper M. 2002. A summary of two meta-analyses on neurobehavioural effects due to occupational lead exposure. Arch Toxicol 76:137-145.
50. Spreen O, Strauss E. 1998. A Compendium of Neuropsychological Tests. New York:Oxford University Press.
51. Stewart WF, Schwartz BS, Simon D, Bolla KI, Todd AC, Links J. 1999. Neurobehavioral function and tibial and chelatable lead levels in 543 former organolead workers. Neurology 52:1610-1617.
52. Stewart WF, Schwartz BS, Simon D, Kelsey K, Todd AC. 2002. ApoE genotype, past adult lead exposure, and neurobehavioral function. Environ Health Perspect 110:501-505.
53. Stollery BT. 1996. Reaction time changes in workers exposed to lead. Neurotoxicol Teratol 18:477-483.
54. Stollery BT, Broadbent DE, Banks HA, Lee WR. 1991. Short term prospective study of cognitive functioning in lead workers. Br J Ind Med 48:739-749.
55. Trope I, Lopez-Villegas D, Cecil KM, Lenkinski RE. 2001. Exposure to lead appears to selectively alter metabolism of cortical gray matter. Pediatrics 107:1437-1442.
56. Trope I, Lopez-Villegas D, Lenkinski RE. 1998. Magnetic resonance imaging and spectroscopy of regional brain structure in a 10-year-old boy with elevated blood lead levels. Pediatrics 101:1066-1067.
57. Valciukas JA, Lilis R, Eisinger J, Blumberg WE, Fischbein A, Selikoff IJ. 1978. Behavioral indicators of lead neurotoxicity: results of a clinical field survey. Int Arch Occup Environ Health 41:217-236.
58. 31P magnetic resonance spectroscopy of the brain in degenerative cerebral disorders. Ann Neurol 31:202-211.
59. Wechsler O. 1981. Wechsler Adult Intelligence Scale - Revised. New York:Harcourt, Brace Jovanovich.
60. Wright RO, Tsaih SW, Schwartz J, Spiro A III, McDonald K, Weiss ST, et al. 2003. Lead exposure biomarkers and Mini-Mental Status Exam scores in older men. Epidemiology 14:713-718.