188Re-labeled bisphosphonates as potential bifunctional agents for therapy in patients with bone metastases

Applied Radiation and Isotopes

Volumn 62, Issue 4, 2005, Pages 541-549

  El Mabhouh, Amal ^a   Mercer, John R ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Bisphosphonates; Bone pain palliation; Radiotherapy; Rhenium radioisotopes

Indexed keywords

BONE; DOSIMETRY; MEDICAL PROBLEMS; RADIOACTIVITY; RADIOISOTOPES; RHENIUM;

BISPHOSPHONATES; BONE METASTASES; RADIOCHEMICAL PURITY;

RADIOTHERAPY;

BISPHOSPHONIC ACID DERIVATIVE; FLUOROURACIL; RHENIUM 188; PENTETIC ACID; RADIOISOTOPE; RADIOPHARMACEUTICAL AGENT; RHENIUM;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; CONTROLLED STUDY; FEMALE; ISOTOPE LABELING; MOUSE; NONHUMAN; PLASMA CLEARANCE; PRIORITY JOURNAL; RADIATION DOSE; RADIOCHEMISTRY; ANIMAL; BAGG ALBINO MOUSE; BONE TUMOR; CHEMISTRY; METABOLISM; METASTASIS; SYNTHESIS; TISSUE DISTRIBUTION;

ANIMALS; BONE NEOPLASMS; DIPHOSPHONATES; FEMALE; FLUOROURACIL; ISOTOPE LABELING; MICE; MICE, INBRED BALB C; PENTETIC ACID; RADIOISOTOPES; RADIOPHARMACEUTICALS; RHENIUM; TISSUE DISTRIBUTION;

EID: 13444292921     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2004.10.004     Document Type: Article

References (38)

1. 188Re for bone pain palliation, Appl Radiat. Isot. 54 2001 435 442
2. 4](-) Nucl. Med. Biol. 30 2003 381 387
3. L.G. Bouchet, W.E. Bolch, S.M. Goddu, R.W. Howell, and D.V. Rao Considerations in the selection of radiopharmaceuticals for palliation of bone pain from metastatic osseous lesions J. Nucl. Med. 41 2000 682 687
4. 50 of 5-fluorouracil in mice Pharmacology 28 1984 296 300
5. F.D. Chen, B.T. Hsieh, H.E. Wang, Y.H. Ou, W.K. Yang, J. Whang-Peng, R.S. Liu, F.F. Knapp, G. Ting, and S.H. Yen Efficacy of Re-188-labelled sulphur colloid on prolongation of survival time in melanoma-bearing animals Nucl. Med. Biol. 7 2001 835 844
6. R.E. Coleman Metastatic bone disease clinical features, pathophysiology and treatment strategies Cancer Treat. Rev. 27 2001 165 176
7. E. Deutsch, K. Libson, J.L. Vanderheyden, A.R. Ketring, and H.R. Maxon The chemistry of rhenium and technetium as related to the use of isotopes of these elements in therapeutic and diagnostic nuclear medicine Int. J. Radiat. Appl. Instrum. B. 13 1986 465 477
8. J. Du, M. Marquez, J. Hiltunen, S. Nilsson, and A.R. Holmberg Radiolabeling of dextran with rhenium-188 Appl Radiat Isot 53 2000 443 448
9. El Mabhouh, A., Angelov, C.A., McEwan, A.J.B., Jia, G., Mercer, J.R., 2004. Preclinical investigations of drug and radionuclide conjugates of bisphosphonates for the treatment of metastatic bone cancer. Cancer Biother. Radiopharm. 19(5).
10. H. Fleisch Bisphosphonates mechanisms of action Endocrine Rev 19 1998 80 100
11. 188Re, and a study of its stability Appl. Radiat. Isot. 49 1998 351 356
12. 186,188Re for nuclear medicine Top. Curr. Chem. 176 1996 275 291
13. G.N. Hortobagyi Novel approaches to the management of bone metastases in patients with breast cancer Semin. Oncol. 29 2002 134 144
14. F. Hosain, R.P. Spencer, H.M. Couthon, and G.L. Sturtz Targeted delivery of antineoplastic agent to bone biodistribution studies of technetium-99m- labeled gem-bisphosphonate conjugate of methotrexate J. Nucl. Med. 37 1996 105 107
15. B.T. Hsieh, C.J. Liu, H.S. Hsieh, Z.T. Tsai, G. Ting, and F.F. Knapp Jr. The preparation of W-188/Re-188 generator for therapeutic and diagnostic applications Nucl. Sci. J. (Taiwan) 23 1996 26 38
16. B.T. Hsieh, J.F. Hsieh, S.C. Tsai, W.Y. Lin, S.J. Wang, and G. Ting Comparison of various rhenium-188-labeled diphosphonates for the treatment of bone metastases Nucl. Med. Biol. 26 1999 973 976
17. D. Kantoci, J.K. Denike, and W.J. Wechter Synthesis of aminobisphosphonates Synth. Comm. 26 1996 2037 2039
18. F.F. Knapp Jr, A.L. Beets, S. Guhlke, P.O. Zamora, H. Bender, H. Palmedo, and H.J. Biersack Availability of rhenium-188 from the alumina-based tungsten-188/rhenium-188 generator for preparation of rhenium-188-labeled radiopharmaceuticals for cancer treatment Anticancer Res 17 1997 1783 1795
19. M. Koudelkova, and V. Jedinakova-Krizova Capillary electrophoretic and thin-layer chromatographic characterization of rhenium complexation with 1-hydroxyethylidenediphosphonic acid J. Chromatogr. A. 990 2003 317 323
20. S. Li, J. Liu, H. Zhang, M. Tian, J. Wang, and X. Zheng Rhenium-188 HEDP to treat painful bone metastases Clin. Nucl. Med. 26 2001 919 922
21. K. Liepe, J. Kropp, R. Runge, and J. Kotzerke Therapeutic efficiency of rhenium-188-HEDP in human prostate cancer skeletal metastases Br. J. Cancer 89 2003 625 629
22. W.Y. Lin, C.P. Lin, S.J. Yeh, B.T. Hsieh, Z.T. Tsai, G. Ting, T.C. Yen, S.J. Wang, F.F. Knapp, and M.G. Stabin Rhenium-188 hydroxyethylidene diphosphonate a new generator-produced radiotherapeutic drug of potential value for the treatment of bone metastases Eur. J. Nucl. Med. 24 1997 590 595
23. W.Y. Lin, J.F. Hsieh, C.P. Lin, B.T. Hsieh, G. Ting, S.J. Wang, and F.F. Knapp Jr. Effect of reaction conditions on preparations of rhenium-188 hydroxyethylidene diphosphonate complexes Nucl. Med. Biol. 26 1999 455 459
24. E.C. Lisic, M. Phillips, D. Ensor, K.L. Nash, A. Beets, and F.F. Knapp Synthesis of a new bisphosphonic acid ligand (SEDP) and preparation of a (188)Re-(Sn)SEDP bone seeking radiotracer Nucl. Med. Biol. 28 2001 419 424
25. H.R. Maxon III., L.E. Schroder, S.R. Thomas, V.S. Hertzberg, E.A. Deutsch, H.I. Scher, R.C. Samaratunga, K.F. Libson, C.C. Williams, and J.S. Moulton Re-186(Sn) HEDP for treatment of painful osseous metastases initial clinical experience in 20 patients with hormone-resistant prostate cancer Radiology 176 1990 155 159
26. H.R. Maxon III., L.E. Schroder, L.C. Washburn, S.R. Thomas, R.C. Samaratunga, D. Biniakiewicz, J.S. Moulton, D. Cummings, G.J. Ehrhardt, and V. Morris Rhenium-188(Sn)HEDP for treatment of osseous metastases J. Nucl. Med. 39 1998 659 663
27. H. Palmedo, S. Guhlke, H. Bender, J. Sartor, G. Schoeneich, J. Risse, F. Grunwald, F.F. Knapp Jr., and H.J. Biersack Dose escalation study with rhenium-188 hydroxyethylidene diphosphonate in prostate cancer patients with osseous metastases Eur. J. Nucl. Med. 27 2000 123 130
28. H. Palmedo, A. Manka-Waluch, P. Albers, I.G. Schmidt-Wolf, M. Reinhardt, S. Ezziddin, A. Joe, R. Roedel, R. Fimmers, F.F. Knapp Jr., S. Guhlke, and H.J. Biersack Repeated bone-targeted therapy for hormone-refractory prostate carcinoma tandomized phase II trial with the new, high-energy radiopharmaceutical rhenium-188 hydroxyethylidenediphosphonate J. Clin. Oncol. 21 2003 2869 2875
29. P. Pecher Biological investigation with radioactive calcium and strontium Preliminary report on the use of radioactive strontium in the treatment of metastatic bone cancer. Univ. Calif. Publ. Pharmacol. 2 1942 117 149
30. A.A. Reszka, and G.A. Rodan Bisphosphonate mechanism of action Curr. Rheumatol. Rep. 5 2003 65 74
31. Roque, M., Martinez, M.J., Alonso, P., Catala, E., Garcia, J.L., Ferrandiz, M., 2003. Radioisotopes for metastatic bone pain. Cochrane Database Syst. Rev. (4); CD003347.
32. J.R. Ross, Y. Saunders, P.M. Edmonds, S. Patel, D. Wonderling, C. Normand, and K. Broadley A systematic review of the role of bisphosphonates in metastatic disease Health Technol. Assess. 8 2004 1 176
33. A.N. Serafini Therapy of metastatic bone pain J. Nucl. Med. 42 2001 895 906
34. F.M. Swailem, G.T. Krishnamurthy, S.C. Srivastava, M.L. Aguirre, D.L. Ellerson, T.K. Walsh, L. Simpson, and J. Shah In vivo tissue uptake and retention of Sn-117m(4+)DTPA in a human subject with metastatic bone pain and in normal mice Nucl. Med. Biol. 25 1998 279 287
35. S.J. Wang, W.Y. Lin, B.T. Hsieh, L.H. Shen, Z.T. Tsai, G. Ting, and F.F. Knapp Jr. Rhenium-188 sulphur colloid as a radiation synovectomy agent Eur. J. Nucl. Med. 22 1995 505 507
36. S.J. Wang, W.Y. Lin, M.N. Chen, B.T. Hsieh, L.H. Shen, Z.T. Tsai, G. Ting, and F.F. Knapp Jr. Biodistribution of rhenium-188 lipiodol infused via the hepatic artery of rats with hepatic tumours Eur. J. Nucl. Med. 23 1996 13 17
37. F. Wingen, H. Sterz, H. Blum, H. Moller, W. Pittermann, B.L. Pool, H.J. Sinn, H. Spring, and D. Schmahl Synthesis, antitumor activity, distribution and toxicity of 4-[4-[bis(2-chloroethyl)amino]phenyl]-1-hydroxybutane-1 1-bisphosphonic acid (BAD), a new lost derivative with increased accumulation in rat osteosarcoma J. Cancer Res. Clin. Oncol. 111 1986 209 219
38. H. Zhang, M. Tian, S. Li, J. Liu, S. Tanada, and K. Endo Rhenium-188-HEDP therapy for the palliation of pain due to osseous metastases in lung cancer patients Cancer Biother. Radiopharm. 18 2003 719 726