메뉴 건너뛰기




Volumn 8, Issue 4, 2004, Pages

A systematic review of the role bisphosphonates in metastatic disease

Author keywords

[No Author keywords available]

Indexed keywords

ADRONAT; ALENDRONIC ACID; ASCREDAR; BISPHOSPHONIC ACID DERIVATIVE; CALCITONIN; CALCIUM; CLODRONIC ACID; ETIDRONIC ACID; FUROSEMIDE; GALLIUM NITRATE; HYDROCORTISONE; IBANDRONIC ACID; LORON; LYTOS; MITHRAMYCIN; NERIDRONIC ACID; OCTREOTIDE; OLPADRONIC ACID; OSTEODIDRONEL; OSTEUM; PAMIDRONIC ACID; PHOSPHATE; RISEDRONIC ACID; SALCATONIN; TILUDRONIC ACID; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 1442351128     PISSN: 13665278     EISSN: None     Source Type: Journal    
DOI: 10.3310/hta8040     Document Type: Review
Times cited : (116)

References (335)
  • 1
    • 0002446620 scopus 로고
    • History of bisphosphonates: Discovery and history of non-medical uses of bisphosphonates
    • Bijvoet OL, Fleisch H, Canfield RE, Russell RG, editors. Amsterdam: Elsevier
    • Blomen LJ. History of bisphosphonates: discovery and history of non-medical uses of bisphosphonates. In Bijvoet OL, Fleisch H, Canfield RE, Russell RG, editors. Bisphosphonate on bones. Amsterdam: Elsevier, 1995. pp. 111-24.
    • (1995) Bisphosphonate on Bones , pp. 111-124
    • Blomen, L.J.1
  • 2
    • 0001372897 scopus 로고
    • Isolation from urine of pyrophosphate, a calcification inhibitor
    • Fleisch H, Bisaz S. Isolation from urine of pyrophosphate, a calcification inhibitor. Am J Physiol 1962;203:671-5.
    • (1962) Am. J. Physiol. , vol.203 , pp. 671-675
    • Fleisch, H.1    Bisaz, S.2
  • 3
    • 34250509114 scopus 로고
    • Influence of pyrophosphate on the transformation of amorphous to crystalline calcium phosphate
    • Berlin: Springer
    • Fleisch H, Russell RG, Bisaz S. Influence of pyrophosphate on the transformation of amorphous to crystalline calcium phosphate. Berlin: Springer, 1968. pp. 49-59.
    • (1968) , pp. 49-59
    • Fleisch, H.1    Russell, R.G.2    Bisaz, S.3
  • 4
    • 34250517118 scopus 로고
    • The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate invitro and invivo
    • Fleisch H, Russell RG, Bisaz S. The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution of calcium phosphate invitro and invivo. Calcif Tissue Res 1968;2:49-59.
    • (1968) Calcif. Tissue Res. , vol.2 , pp. 49-59
    • Fleisch, H.1    Russell, R.G.2    Bisaz, S.3
  • 5
    • 0032468984 scopus 로고    scopus 로고
    • Bisphosphonates: Mechanism of action
    • Fleisch H. Bisphosphonates: mechanism of action. Endocrine Rev 1998;9:80-100.
    • (1998) Endocrine Rev. , vol.9 , pp. 80-100
    • Fleisch, H.1
  • 6
    • 0014684364 scopus 로고
    • Diphosphonates inhibit formation of calcium phosphate crystals in-vitro and pathological calcification in-vivo
    • Francis M, Russell RG, Fleisch H. Diphosphonates inhibit formation of calcium phosphate crystals in-vitro and pathological calcification in-vivo. Science 1969;165:1264-6.
    • (1969) Science , vol.165 , pp. 1264-1266
    • Francis, M.1    Russell, R.G.2    Fleisch, H.3
  • 7
    • 0014684354 scopus 로고
    • Diphosphonates inhibit hydroxyapatite dissolution in-vitro and bone resorption in tissue culture and in-vivo
    • Fleisch H, Russell RG, Francis M. Diphosphonates inhibit hydroxyapatite dissolution in-vitro and bone resorption in tissue culture and in-vivo. Science 1969;165:1262-4.
    • (1969) Science , vol.165 , pp. 1262-1264
    • Fleisch, H.1    Russell, R.G.2    Francis, M.3
  • 9
    • 0015939609 scopus 로고
    • The binding of pyophosphate and two diphosphonates by hydroxyappatite crystals
    • Jung A, Bisaz S, Fleisch H. The binding of pyophosphate and two diphosphonates by hydroxyappatite crystals. Calcif Tissue Res 1973;11:269-80.
    • (1973) Calcif. Tissue Res. , vol.11 , pp. 269-280
    • Jung, A.1    Bisaz, S.2    Fleisch, H.3
  • 11
    • 0026318521 scopus 로고
    • Bisphosphonates: Pharmacology and use in the treatment of tumour induced hypercalcaemic and metastatic bone disease
    • Fleisch H. Bisphosphonates: pharmacology and use in the treatment of tumour induced hypercalcaemic and metastatic bone disease. Drugs 1991;42:919-44.
    • (1991) Drugs , vol.42 , pp. 919-944
    • Fleisch, H.1
  • 14
    • 0015576420 scopus 로고
    • The hyperphosphatemic effect of disodium ethane-1-hydroxy-1,1-diphosphonates: Renal handling of phosphorus and the renal response to parathyroid hormone
    • Recker RR, Hassing GS, Lau JR, Saville PD. The hyperphosphatemic effect of disodium ethane-1-hydroxy-1,1-diphosphonates: renal handling of phosphorus and the renal response to parathyroid hormone. J Lab Clin Med 1973;81:258-66.
    • (1973) J. Lab. Clin. Med. , vol.81 , pp. 258-266
    • Recker, R.R.1    Hassing, G.S.2    Lau, J.R.3    Saville, P.D.4
  • 15
    • 85054199355 scopus 로고    scopus 로고
    • Chemical, biochemical and medicinal properties of the diphosphonates
    • Hilderbrand JD, editor. Boca Raton, FL: CRC Press
    • Francis MD, Martodam RR. Chemical, biochemical and medicinal properties of the diphosphonates. In Hilderbrand JD, editor. The role of bisphosphonates in living systems. Boca Raton, FL: CRC Press, 2001. pp. 55-96.
    • (2001) The Role of Bisphosphonates in Living Systems , pp. 55-96
    • Francis, M.D.1    Martodam, R.R.2
  • 16
    • 0026064309 scopus 로고
    • Pamidronate: A review of its pharmacological properties and therapeutic efficacy in resorptive bone disease
    • Fitton A, McTavish D. Pamidronate: a review of its pharmacological properties and therapeutic efficacy in resorptive bone disease. Drugs 1991; 41:289-318.
    • (1991) Drugs , vol.41 , pp. 289-318
    • Fitton, A.1    McTavish, D.2
  • 17
    • 0001502142 scopus 로고
    • Structure of disodium dihydrogen 1-hydroxyethylidenediphosphonate tetrahydrate: A bone growth regulator
    • Barnett B, Stickland L. Structure of disodium dihydrogen 1-hydroxyethylidenediphosphonate tetrahydrate: a bone growth regulator. Acta Crystallogra B 1979;35:1212-14.
    • (1979) Acta Crystallogra. B , vol.35 , pp. 1212-1214
    • Barnett, B.1    Stickland, L.2
  • 19
    • 0029926353 scopus 로고    scopus 로고
    • Adverse effects of bisphosphonates: A comparative review
    • Adami S, Zamberlan N. Adverse effects of bisphosphonates: a comparative review. Drug Saf 1996;14:158-70.
    • (1996) Drug Saf. , vol.14 , pp. 158-170
    • Adami, S.1    Zamberlan, N.2
  • 20
    • 0002987908 scopus 로고
    • The use of clodronate in disorders of calcium and skeletal metabolism
    • Lomax P, Vessel E, editors. Basel: Karger
    • Kanis J, McCloskey E. The use of clodronate in disorders of calcium and skeletal metabolism. In: Lomax P, Vessel E, editors. Progress in basic and clinical pharmacology. Basel: Karger, 1990. pp. 89-136.
    • (1990) Progress in Basic and Clinical Pharmacology , pp. 89-136
    • Kanis, J.1    McCloskey, E.2
  • 22
    • 0029021326 scopus 로고
    • Multiple ulcerative esophagitis caused by alendronate
    • Maconi G, Bianchi Porro G. Multiple ulcerative esophagitis caused by alendronate. Am J Gastroenterol 1995;90:1889-90.
    • (1995) Am. J. Gastroenterol. , vol.90 , pp. 1889-1890
    • Maconi, G.1    Bianchi Porro, G.2
  • 25
    • 0027339190 scopus 로고
    • Bisphosphonates and iritis
    • Siris ES. Bisphosphonates and iritis. Lancet 1993; 341:436.
    • (1993) Lancet , vol.341 , pp. 436
    • Siris, E.S.1
  • 27
    • 0027964579 scopus 로고
    • Pamidronate disodium and possible ocular adverse drug reactions
    • Macarol V, Fraunfelder FT. Pamidronate disodium and possible ocular adverse drug reactions. Am J Opthalmol 1994;118:220-4.
    • (1994) Am. J. Opthalmol. , vol.118 , pp. 220-224
    • Macarol, V.1    Fraunfelder, F.T.2
  • 28
    • 0014759515 scopus 로고
    • The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo
    • Fleisch H, Russell RG, Bisaz S, Muhlvauer RC, Williams DA. The inhibitory effect of phosphonates on the formation of calcium phosphate crystals in vitro and on aortic and kidney calcification in vivo. Eur J Clin Invest 1970; 1:12-18.
    • (1970) Eur. J. Clin. Invest. , vol.1 , pp. 12-18
    • Fleisch, H.1    Russell, R.G.2    Bisaz, S.3    Muhlvauer, R.C.4    Williams, D.A.5
  • 29
    • 0014463723 scopus 로고
    • The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates
    • Francis MD. The inhibition of calcium hydroxyapatite crystal growth by polyphosphonates and polyphosphates. Calcif Tissue Res 1969; 3:151-62.
    • (1969) Calcif. Tissue Res. , vol.3 , pp. 151-162
    • Francis, M.D.1
  • 31
    • 0031977199 scopus 로고    scopus 로고
    • Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras
    • Luckman SP, Hughes DE, Coxon FP, Russell RG, Rogers MJ. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras. J Bone Miner Res 1998;13:581-9.
    • (1998) J. Bone Miner. Res. , vol.13 , pp. 581-589
    • Luckman, S.P.1    Hughes, D.E.2    Coxon, F.P.3    Russell, R.G.4    Rogers, M.J.5
  • 32
    • 0033930168 scopus 로고    scopus 로고
    • Protein geranylgeranylation is required for osteoclast formation, function and survival: Inhibition by bisphosphonates and GGTI-298
    • Coxon FP, Helfrich MH, Van't Hof R, Sebti S, Ralston SH, Hamilton A, et al. Protein geranylgeranylation is required for osteoclast formation, function and survival: inhibition by bisphosphonates and GGTI-298. J Bone Miner Res 2000;15:1467-76.
    • (2000) J. Bone Miner. Res. , vol.15 , pp. 1467-1476
    • Coxon, F.P.1    Helfrich, M.H.2    Van't Hof, R.3    Sebti, S.4    Ralston, S.H.5    Hamilton, A.6
  • 33
    • 0035146537 scopus 로고    scopus 로고
    • Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates
    • Dunford JE, Thompson K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, et al. Structure-activity relationships for inhibition of farnesyl diphosphate synthase in vitro and inhibition of bone resorption in vivo by nitrogen-containing bisphosphonates. J Pharmacol Exp Ther 2001;296:235-42.
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 235-242
    • Dunford, J.E.1    Thompson, K.2    Coxon, F.P.3    Luckman, S.P.4    Hahn, F.M.5    Poulter, C.D.6
  • 34
    • 1442345752 scopus 로고    scopus 로고
    • Cancer Research Campaign London: Cancer Research Campaign
    • Cancer Research Campaign. Cancer statistics: mortality - UK. London: Cancer Research Campaign, 2001. pp. 1-6.
    • (2001) Cancer Statistics: Mortality - UK , pp. 1-6
  • 35
    • 0034659786 scopus 로고    scopus 로고
    • Complications of bone metastases. Surgical management
    • Healey JH, Brown HK. Complications of bone metastases. Surgical management. Cancer 2000; 88:2940-51.
    • (2000) Cancer , vol.88 , pp. 2940-2951
    • Healey, J.H.1    Brown, H.K.2
  • 36
    • 0030749321 scopus 로고    scopus 로고
    • Skeletal complications of malignancy
    • Coleman RE. Skeletal complications of malignancy. Cancer (Suppl) 1997;80:1588-94.
    • (1997) Cancer (Suppl) , vol.80 , pp. 1588-1594
    • Coleman, R.E.1
  • 37
    • 0029126824 scopus 로고
    • Bone and cancer: Pathophysiology and treatment of metastases
    • Kanis JA. Bone and cancer: pathophysiology and treatment of metastases. Bone 1995;17 (2 Suppl): 101S-105S.
    • (1995) Bone , vol.17 , Issue.2 SUPPL.
    • Kanis, J.A.1
  • 38
    • 0034659875 scopus 로고    scopus 로고
    • Bisphosphonates in multiple myeloma
    • Kanis JA, McCloskey EV. Bisphosphonates in multiple myeloma. Cancer 2000; 88 (12 Suppl): 33022-32.
    • (2000) Cancer , vol.88 , Issue.12 SUPPL. , pp. 33022-33032
    • Kanis, J.A.1    McCloskey, E.V.2
  • 39
    • 1442296731 scopus 로고    scopus 로고
    • Breast cancer
    • editors. Oxford: Blackwell Science
    • Souhami R, Tobias J, editors. Breast cancer. In Cancer and its management. Oxford: Blackwell Science, 1998. pp. 216-34.
    • (1998) Cancer and Its Management , pp. 216-234
    • Souhami, R.1    Tobias, J.2
  • 41
    • 0023137823 scopus 로고
    • The clinical course of bone metastases from breast cancer
    • Coleman RE, Rubens RD. The clinical course of bone metastases from breast cancer. Br J Cancer 1987;55:61-6.
    • (1987) Br. J. Cancer , vol.55 , pp. 61-66
    • Coleman, R.E.1    Rubens, R.D.2
  • 42
    • 1442321238 scopus 로고    scopus 로고
    • Genitourinary cancer
    • editors Oxford: Blackwell Science
    • In Souhami R, Tobias J, editors. Genitourinary cancer. Cancer and its management. Oxford: Blackwell Science, 1998. pp. 308-33.
    • (1998) Cancer and Its Management , pp. 308-333
    • Souhami, R.1    Tobias, J.2
  • 43
    • 0034659964 scopus 로고    scopus 로고
    • The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma
    • Carlin BI, Andriole GL. The natural history, skeletal complications, and management of bone metastases in patients with prostate carcinoma. Cancer 2001;88:2989-94.
    • (2001) Cancer , vol.88 , pp. 2989-2994
    • Carlin, B.I.1    Andriole, G.L.2
  • 44
    • 1442321237 scopus 로고
    • Cancer Research Campaign Factsheet 20. London: Cancer Research Campaign
    • Cancer Research Campaign. Cancer of the prostate. Factsheet 20. London: Cancer Research Campaign, 1994. pp. 1-5.
    • (1994) Cancer of the Prostate , pp. 1-5
  • 45
    • 1442272174 scopus 로고    scopus 로고
    • Myeloma and other paraproteinaemias
    • editors. Oxford: Blackwell Science
    • Souhami R, Tobias J, editors. Myeloma and other paraproteinaemias. In Cancer and its management. Oxford: Blackwell Science, 1998. pp. 470-82.
    • (1998) Cancer and Its Management , pp. 470-482
    • Souhami, R.1    Tobias, J.2
  • 47
    • 1442321235 scopus 로고    scopus 로고
    • Biochemical syndromes
    • Twycross R, editor. Oxford: Radcliffe Medical Press
    • Twycross R. Biochemical syndromes. In Twycross R, editor. Symptom management in advanced cancer. Oxford: Radcliffe Medical Press, 1997. pp. 132-42.
    • (1997) Symptom Management in Advanced Cancer , pp. 132-142
    • Twycross, R.1
  • 48
    • 0032512915 scopus 로고    scopus 로고
    • Parathyroid hormone-related protein (PTHrP) and hypercalcaemia
    • Grill V, Rankin W, Martin TJ. Parathyroid hormone-related protein (PTHrP) and hypercalcaemia. Eur J Cancer 1998;34:222-9.
    • (1998) Eur. J. Cancer , vol.34 , pp. 222-229
    • Grill, V.1    Rankin, W.2    Martin, T.J.3
  • 49
    • 0021220858 scopus 로고
    • Relative contribution of humoral and metastatic factors to the pathogenesis of hypercalcaemia of malignancy
    • Ralston SH, Fogelman I, Gardner MD, Boyle IT. Relative contribution of humoral and metastatic factors to the pathogenesis of hypercalcaemia of malignancy. BMJ 1984;288:1405-8.
    • (1984) BMJ , vol.288 , pp. 1405-1408
    • Ralston, S.H.1    Fogelman, I.2    Gardner, M.D.3    Boyle, I.T.4
  • 50
    • 0028297667 scopus 로고
    • Significance of plasma PTH-rP in patients with hypercalcemia of malignancy treated with bisphosphonate
    • Wimalawansa SJ. Significance of plasma PTH-rP in patients with hypercalcemia of malignancy treated with bisphosphonate. Cancer 1994;73:2223-30.
    • (1994) Cancer , vol.73 , pp. 2223-2230
    • Wimalawansa, S.J.1
  • 52
    • 49649151267 scopus 로고
    • The calcium fractions of normal serum
    • Raman A. The calcium fractions of normal serum. Clin Biochem 1971;4:141-6.
    • (1971) Clin. Biochem. , vol.4 , pp. 141-146
    • Raman, A.1
  • 53
    • 0021913191 scopus 로고
    • Measuring serum calcium
    • Kanis JA, Yates AJ. Measuring serum calcium. BMJ 1985;290:728-9.
    • (1985) BMJ , vol.290 , pp. 728-729
    • Kanis, J.A.1    Yates, A.J.2
  • 54
    • 0024472198 scopus 로고
    • Comparison of different dose regimes of aminohydroxypropylidene-1,1-bisphosphonate (APD) in hypercalcaemia of malignancy
    • Davis JR, Heath DA. Comparison of different dose regimes of aminohydroxypropylidene-1,1-bisphosphonate (APD) in hypercalcaemia of malignancy. Br J Clin Pharmacol 1989;28:269-74.
    • (1989) Br. J. Clin. Pharmacol. , vol.28 , pp. 269-274
    • Davis, J.R.1    Heath, D.A.2
  • 55
    • 84970797239 scopus 로고
    • Leading article. Correcting the calcium
    • Leading article. Correcting the calcium. BMJ 1977;1:598.
    • (1977) BMJ , vol.1 , pp. 598
  • 56
    • 0027078807 scopus 로고
    • Disodium pamidronate versus mithramycin in the management of tumour-associated hypercalcemia
    • Ostenstad B, Andersen OK. Disodium pamidronate versus mithramycin in the management of tumour-associated hypercalcemia. Acta Oncol 1992;31:861-4.
    • (1992) Acta Oncol. , vol.31 , pp. 861-864
    • Ostenstad, B.1    Andersen, O.K.2
  • 57
    • 0028040828 scopus 로고
    • Treatment of cancer-associated hypercalcemia. Double-blind comparison of rapid and slow intravenous infusion regimens of pamidronate disodium and saline alone
    • Gucalp R, Theriault R, Gill I, Madajewicz S, Chapman R, Navari R, et al. Treatment of cancer-associated hypercalcemia. Double-blind comparison of rapid and slow intravenous infusion regimens of pamidronate disodium and saline alone. Arch Intern Med 1994;154:1935-44.
    • (1994) Arch. Intern. Med. , vol.154 , pp. 1935-1944
    • Gucalp, R.1    Theriault, R.2    Gill, I.3    Madajewicz, S.4    Chapman, R.5    Navari, R.6
  • 58
    • 0025270315 scopus 로고
    • Fast (4-h) or slow (24-h) infusions of pamidronate disodium (aminohydroxypropylidene diphosphonate (APD)) as single shot treatment of hypercalcaemia
    • Sawyer N, Newstead C, Drummond A, Cunningham J. Fast (4-h) or slow (24-h) infusions of pamidronate disodium (aminohydroxypropylidene diphosphonate (APD)) as single shot treatment of hypercalcaemia. Bone Miner 1990;9:121-8.
    • (1990) Bone Miner. , vol.9 , pp. 121-128
    • Sawyer, N.1    Newstead, C.2    Drummond, A.3    Cunningham, J.4
  • 59
    • 49649151267 scopus 로고
    • The calcium fractions of normal serum
    • Raman A. The calcium fractions of normal serum. Clin Biochem 1971;4:141-6.
    • (1971) Clin. Biochem. , vol.4 , pp. 141-146
    • Raman, A.1
  • 60
    • 9044238068 scopus 로고    scopus 로고
    • Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy
    • Pecherstorfer M, Herrmann Z, Body JJ, Manegold C, Degardin M, Clemens MR, et al. Randomized phase II trial comparing different doses of the bisphosphonate ibandronate in the treatment of hypercalcemia of malignancy. J Clin Oncol 1996;14:268-76.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 268-276
    • Pecherstorfer, M.1    Herrmann, Z.2    Body, J.J.3    Manegold, C.4    Degardin, M.5    Clemens, M.R.6
  • 63
    • 0025868556 scopus 로고
    • A randomized double-blind study of gallium nitrate compared with etidronate for acute control of cancer-related hypercalcemia
    • Wharrell RPJ, Murphy WK, Schulman P, O'Dwyer PJ, Heller G. A randomized double-blind study of gallium nitrate compared with etidronate for acute control of cancer-related hypercalcemia. J Clin Oncol 1991;9:1467-75.
    • (1991) J. Clin. Oncol. , vol.9 , pp. 1467-1475
    • Wharrell, R.P.J.1    Murphy, W.K.2    Schulman, P.3    O'Dwyer, P.J.4    Heller, G.5
  • 64
    • 0018425695 scopus 로고
    • Interpretation of serum total calcium: Effects of adjustment for albumin concentration frequency of abnormal values and on detection of change in the individual
    • Payne RB, Carver ME, Morgan DB. Interpretation of serum total calcium: effects of adjustment for albumin concentration frequency of abnormal values and on detection of change in the individual. J Clin Pathol 1979;32:56-60.
    • (1979) J. Clin. Pathol. , vol.32 , pp. 56-60
    • Payne, R.B.1    Carver, M.E.2    Morgan, D.B.3
  • 66
    • 0027214135 scopus 로고
    • Single-dose intravenous therapy with pamidronate for the treatment of hypercalcemia of malignancy: Comparison of 30-, 60-, and 90-mg dosages
    • Nussbaum SR, Younger J, Vandepol CJ, Gagel RF, Zubler MA, Chapman R, et al. Single-dose intravenous therapy with pamidronate for the treatment of hypercalcemia of malignancy: comparison of 30-, 60-, and 90-mg dosages. Am J Med 1993;95:297-304.
    • (1993) Am. J. Med. , vol.95 , pp. 297-304
    • Nussbaum, S.R.1    Younger, J.2    Vandepol, C.J.3    Gagel, R.F.4    Zubler, M.A.5    Chapman, R.6
  • 67
    • 0026593561 scopus 로고
    • Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia
    • Gucalp R, Ritch P, Wiernik PH, Sarma PR, Keller A, Richman SP, et al. Comparative study of pamidronate disodium and etidronate disodium in the treatment of cancer-related hypercalcemia. J Clin Oncol 1992;10:134-42.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 134-142
    • Gucalp, R.1    Ritch, P.2    Wiernik, P.H.3    Sarma, P.R.4    Keller, A.5    Richman, S.P.6
  • 68
    • 0024818568 scopus 로고
    • Aminohydroxypropylidene bisphosphonate (APD) treatment for tumor-associated hypercalcemia: A randomized comparison between a 3-day treatment and single 24-hour infusions
    • Body JJ, Magritte A, Seraj F, Sculier JP, Borkowski A. Aminohydroxypropylidene bisphosphonate (APD) treatment for tumor-associated hypercalcemia: a randomized comparison between a 3-day treatment and single 24-hour infusions. J Bone Min Res 1989;4:923-8.
    • (1989) J. Bone Min. Res. , vol.4 , pp. 923-928
    • Body, J.J.1    Magritte, A.2    Seraj, F.3    Sculier, J.P.4    Borkowski, A.5
  • 69
    • 0026579844 scopus 로고
    • Effect of a single infusion of alendronate in malignant hypercalcaemia: Dose dependency and comparison with clodronate
    • Rizzoli R, Buchs B, Bonjour JP. Effect of a single infusion of alendronate in malignant hypercalcaemia: dose dependency and comparison with clodronate. Int J Cancer 1992;50:706-12.
    • (1992) Int. J. Cancer , vol.50 , pp. 706-712
    • Rizzoli, R.1    Buchs, B.2    Bonjour, J.P.3
  • 70
    • 0026644743 scopus 로고
    • Comparison of a rapid (2-h) versus a slow (24-h) infusion of alendronate in the treatment of hypercalcemia of malignancy
    • Zysset E, Ammann P, Jenzer A, Gertz BJ, Portmann L, Rizzoli R, et al. Comparison of a rapid (2-h) versus a slow (24-h) infusion of alendronate in the treatment of hypercalcemia of malignancy. Bone Miner 1992;18:237-49.
    • (1992) Bone Miner. , vol.18 , pp. 237-249
    • Zysset, E.1    Ammann, P.2    Jenzer, A.3    Gertz, B.J.4    Portmann, L.5    Rizzoli, R.6
  • 71
    • 0015701066 scopus 로고
    • Variation in plasma calcium with induced changes in plasma specific gravity, total protein and albumin
    • Berry EM, Gupta MM, Turner SJ, Burns RR. Variation in plasma calcium with induced changes in plasma specific gravity, total protein and albumin. BMJ 1973;4:640-3.
    • (1973) BMJ , vol.4 , pp. 640-643
    • Berry, E.M.1    Gupta, M.M.2    Turner, S.J.3    Burns, R.R.4
  • 72
    • 0015709291 scopus 로고
    • Interpretation of serum calcium in patients with abnormal serum proteins
    • Payne R. Interpretation of serum calcium in patients with abnormal serum proteins. BMJ 1973;4:643-6.
    • (1973) BMJ , vol.4 , pp. 643-646
    • Payne, R.1
  • 73
    • 0019869234 scopus 로고
    • Predictive value of derived calcium figures based on the measurement of ionised calcium
    • Gardner MD, Dryburgh FJ, Fyffe JA, Jenkins AS. Predictive value of derived calcium figures based on the measurement of ionised calcium. Ann Clin Biochem 1981;18:106-9.
    • (1981) Ann. Clin. Biochem. , vol.18 , pp. 106-109
    • Gardner, M.D.1    Dryburgh, F.J.2    Fyffe, J.A.3    Jenkins, A.S.4
  • 74
    • 0018425695 scopus 로고
    • Interpretation of serum total calcium: Effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual
    • Payne RB, Carver ME, Morgan DB. Interpretation of serum total calcium: effects of adjustment for albumin concentration on frequency of abnormal values and on detection of change in the individual. J Clin Pathol 1979;32:56-60.
    • (1979) J. Clin. Pathol. , vol.32 , pp. 56-60
    • Payne, R.B.1    Carver, M.E.2    Morgan, D.B.3
  • 75
    • 0027129189 scopus 로고
    • Management of acute hypercalcaemia
    • Bilezikian JP. Management of acute hypercalcaemia. N Engl J Med 1992; 326:1196-203.
    • (1992) N. Engl. J. Med. , vol.326 , pp. 1196-1203
    • Bilezikian, J.P.1
  • 76
    • 0032758687 scopus 로고    scopus 로고
    • Comparative tolerability of drug therapies for hypercalcaemia of malignancy
    • Zojer N, Keck AV, Pecherstorfer M. Comparative tolerability of drug therapies for hypercalcaemia of malignancy. Drug Saf 1999;21:389-406.
    • (1999) Drug Saf. , vol.21 , pp. 389-406
    • Zojer, N.1    Keck, A.V.2    Pecherstorfer, M.3
  • 77
    • 0028923259 scopus 로고
    • Hypercalcaemia and bone resorption in malignancy
    • Walls J, Bundred N, Howell A. Hypercalcaemia and bone resorption in malignancy. Clinical Orthop 1995;312:51-63.
    • (1995) Clinical Orthop. , vol.312 , pp. 51-63
    • Walls, J.1    Bundred, N.2    Howell, A.3
  • 78
    • 0041700964 scopus 로고
    • Hypercalcaemia associated with hematologic malignancies
    • Mundy GR, editor. London: Martin Dunitz
    • Mundy GR. Hypercalcaemia associated with hematologic malignancies. In Mundy GR, editor. Calcium homeostasis: hypercalcaemia and hypocalcaemia. London: Martin Dunitz, 1990. pp. 100-15.
    • (1990) Calcium Homeostasis: Hypercalcaemia and Hypocalcaemia , pp. 100-115
    • Mundy, G.R.1
  • 80
    • 0025311623 scopus 로고
    • Clinical manifestations of cancer related hypercalcaemia
    • Bajorunas DR. Clinical manifestations of cancer related hypercalcaemia. Semin Oncol 1990; 17 [2 (Suppl 5)]:16-25.
    • (1990) Semin. Oncol. , vol.17 , Issue.2 SUPPL. 5 , pp. 16-25
    • Bajorunas, D.R.1
  • 81
    • 0031814482 scopus 로고    scopus 로고
    • Survival in breast cancer patients after the first episode of hypercalcaemia
    • Kristensen B, Ejlertsen B, Mouridsen HT, Loft H. Survival in breast cancer patients after the first episode of hypercalcaemia. J Intern Med 1998; 244:189-98.
    • (1998) J. Intern. Med. , vol.244 , pp. 189-198
    • Kristensen, B.1    Ejlertsen, B.2    Mouridsen, H.T.3    Loft, H.4
  • 82
    • 85089713382 scopus 로고
    • Control of hypercalcaemia with mithramycin
    • Elias EG, Reynoso G, Mittleman A. Control of hypercalcaemia with mithramycin. Ann Surg 1972;175:435.
    • (1972) Ann. Surg. , vol.175 , pp. 435
    • Elias, E.G.1    Reynoso, G.2    Mittleman, A.3
  • 84
    • 0021738685 scopus 로고
    • Hepatic toxicity of low doses of mithramycin in hypercalcaemia
    • Green L, Donehower RC. Hepatic toxicity of low doses of mithramycin in hypercalcaemia. Cancer Treat Rep 1984;68:1379-81.
    • (1984) Cancer Treat. Rep. , vol.68 , pp. 1379-1381
    • Green, L.1    Donehower, R.C.2
  • 86
    • 0025099333 scopus 로고
    • Salmon calcitonin in the acute management of hypercalcaemia
    • Wineski LA. Salmon calcitonin in the acute management of hypercalcaemia. Calcif Tissue Int 1990; Suppl 46:S26-S30.
    • (1990) Calcif. Tissue Int. , Issue.SUPPL. 46
    • Wineski, L.A.1
  • 88
    • 0034068581 scopus 로고    scopus 로고
    • Are biochemical markers for bone turnover clinically useful for monitoring therapy in individual osteoporotic patients?
    • Riggs BL. Are biochemical markers for bone turnover clinically useful for monitoring therapy in individual osteoporotic patients? Bone 2000; 26:551-2.
    • (2000) Bone , vol.26 , pp. 551-552
    • Riggs, B.L.1
  • 89
    • 0010430990 scopus 로고
    • Hormonal factors which regulate bone resorption
    • Mundy GR, Martin TJ, editors. New York: Springer
    • Mundy GR. Hormonal factors which regulate bone resorption. In Mundy GR, Martin TJ, editors. Physiology and pharmacology of bone. New York: Springer, 1993. pp. 215-38.
    • (1993) Physiology and Pharmacology of Bone , pp. 215-238
    • Mundy, G.R.1
  • 91
    • 0029166052 scopus 로고
    • Role of cytokines in bone resorption
    • Manolagas SC. Role of cytokines in bone resorption. Bone 1995;17(2 Suppl):63s-67s.
    • (1995) Bone , vol.17 , Issue.2 SUPPL.
    • Manolagas, S.C.1
  • 92
    • 0028925088 scopus 로고
    • Bone marrow, cytokines and bone remodelling
    • Manolagas SC, Jilka RL. Bone marrow, cytokines and bone remodelling. N Engl J Med 1995; 332:305-11.
    • (1995) N. Engl. J. Med. , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 93
    • 0030039250 scopus 로고    scopus 로고
    • A new model for the regulation of bone resorption with particular reference to the effects of bisphosphonates
    • Parfitt AM, Mundy GR, Roodman GD, Hughes DE, Boyce BF. A new model for the regulation of bone resorption with particular reference to the effects of bisphosphonates. J Bone Miner Res 1996;11:150-9.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 150-159
    • Parfitt, A.M.1    Mundy, G.R.2    Roodman, G.D.3    Hughes, D.E.4    Boyce, B.F.5
  • 94
    • 0032584208 scopus 로고    scopus 로고
    • Osteoclast differentiation factor is a ligand for osteoprotogerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
    • Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, et al. Osteoclast differentiation factor is a ligand for osteoprotogerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL. Proc Natl Acad Sci USA 1998;95:3597-602.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 3597-3602
    • Yasuda, H.1    Shima, N.2    Nakagawa, N.3    Yamaguchi, K.4    Kinosaki, M.5    Mochizuki, S.6
  • 95
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotogerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lecey DL, Dunstan C, Kelley M, Chang M, Luthy R, et al. Osteoprotogerin: a novel secreted protein involved in the regulation of bone density. Cell 1997;89:309-19.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lecey, D.L.2    Dunstan, C.3    Kelley, M.4    Chang, M.5    Luthy, R.6
  • 96
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotogerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N, Sarosi I, Dunstan C, Morony S, Tarpley J, Capparelli C, et al. Osteoprotogerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998;12:1260-8.
    • (1998) Genes Dev. , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.3    Morony, S.4    Tarpley, J.5    Capparelli, C.6
  • 97
    • 0034660097 scopus 로고    scopus 로고
    • Markers of bone turnover in bone metastases
    • Fontana A, Delmas PD. Markers of bone turnover in bone metastases. Cancer 2000;88:2952-60.
    • (2000) Cancer , vol.88 , pp. 2952-2960
    • Fontana, A.1    Delmas, P.D.2
  • 98
    • 0034659963 scopus 로고    scopus 로고
    • Biochemical markers and skeletal metastases
    • Demers LM, Costa L, Lipton A. Biochemical markers and skeletal metastases. Cancer 2000; 88:2919-26.
    • (2000) Cancer , vol.88 , pp. 2919-2926
    • Demers, L.M.1    Costa, L.2    Lipton, A.3
  • 99
    • 50549121134 scopus 로고
    • The distribution of secondary growths in cancer of the breast
    • Paget S. The distribution of secondary growths in cancer of the breast. Lancet 1889;i:571-3.
    • (1889) Lancet , vol.1 , pp. 571-573
    • Paget, S.1
  • 100
    • 0034658725 scopus 로고    scopus 로고
    • Molecular mechanisms of osteolytic bone metastases
    • Guise TA. Molecular mechanisms of osteolytic bone metastases. Cancer 2000;88:2892.
    • (2000) Cancer , vol.88 , pp. 2892
    • Guise, T.A.1
  • 101
    • 0034659807 scopus 로고    scopus 로고
    • Pathophysiologic interactions in skeletal metastasis
    • Orr FW, Lee J, Duivenvoorden WCM, Singh G. Pathophysiologic interactions in skeletal metastasis. Cancer 2000;88:2912-18.
    • (2000) Cancer , vol.88 , pp. 2912-2918
    • Orr, F.W.1    Lee, J.2    Duivenvoorden, W.C.M.3    Singh, G.4
  • 102
    • 0032833144 scopus 로고    scopus 로고
    • Low cell motility induced by hsp27 overexpression decreases osteolytic bone metastases of human breast cancer cells in-vivo
    • Lemieux P, Harvey J, Guise TA, Dallas M, Oesterreich S, Yin JJ, et al. Low cell motility induced by hsp27 overexpression decreases osteolytic bone metastases of human breast cancer cells in-vivo. J Bone Miner Res 1999;14:1570-5.
    • (1999) J. Bone Miner. Res. , vol.14 , pp. 1570-1575
    • Lemieux, P.1    Harvey, J.2    Guise, T.A.3    Dallas, M.4    Oesterreich, S.5    Yin, J.J.6
  • 103
    • 0033579957 scopus 로고    scopus 로고
    • Overproduction of parathyroid hormone related peptide results in increased osteolytic skeletal metastases by prostate cancer cells in-vivo
    • Rabbani SA, Gladu J, Harakidas P, Jamison B, Goltzman D. Overproduction of parathyroid hormone related peptide results in increased osteolytic skeletal metastases by prostate cancer cells in-vivo. Int J Cancer 1999;80:257-64.
    • (1999) Int. J. Cancer , vol.80 , pp. 257-264
    • Rabbani, S.A.1    Gladu, J.2    Harakidas, P.3    Jamison, B.4    Goltzman, D.5
  • 104
    • 0027253667 scopus 로고
    • Bone destruction in cancer
    • Garrett IR. Bone destruction in cancer. Semin Oncol 1993;20 (3 Suppl 2):4-9.
    • (1993) Semin. Oncol. , vol.20 , Issue.3 SUPPL. 2 , pp. 4-9
    • Garrett, I.R.1
  • 105
    • 0032510163 scopus 로고    scopus 로고
    • Production of interleukin-11 in bone derived endothelial cells and its role in the formation of osteolytic bone metastases
    • Zhang Y, Fujita N, Oh-hara T, Morinaga Y, Nakagawa T, Yamada M, et al. Production of interleukin-11 in bone derived endothelial cells and its role in the formation of osteolytic bone metastases. Oncogene 1998;16:693-703.
    • (1998) Oncogene , vol.16 , pp. 693-703
    • Zhang, Y.1    Fujita, N.2    Oh-hara, T.3    Morinaga, Y.4    Nakagawa, T.5    Yamada, M.6
  • 106
    • 0018120428 scopus 로고
    • Direct resorption of bone by human breast cells in-vitro
    • Eilon G, Mundy GR. Direct resorption of bone by human breast cells in-vitro. Nature 1978;276:726-8.
    • (1978) Nature , vol.276 , pp. 726-728
    • Eilon, G.1    Mundy, G.R.2
  • 107
    • 0034659857 scopus 로고    scopus 로고
    • Establishment of human prostate carcinoma skeletal metastasis models
    • Zhau HE, Li C, Chung LWK. Establishment of human prostate carcinoma skeletal metastasis models. Cancer 2000;88:2995-3001.
    • (2000) Cancer , vol.88 , pp. 2995-3001
    • Zhau, H.E.1    Li, C.2    Chung, L.W.K.3
  • 108
    • 0031723689 scopus 로고    scopus 로고
    • Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies
    • Autzen P, Robson CN, Bjartell A, Malcolm AJ, Johnson MI, Neal DE, et al. Bone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies. Br J Cancer 1998;78:1219-23.
    • (1998) Br. J. Cancer , vol.78 , pp. 1219-1223
    • Autzen, P.1    Robson, C.N.2    Bjartell, A.3    Malcolm, A.J.4    Johnson, M.I.5    Neal, D.E.6
  • 109
    • 0035425227 scopus 로고    scopus 로고
    • Biology of osteoclast activation in cancer
    • Roodman GD. Biology of osteoclast activation in cancer. J Clin Oncol 2001;19:3562-71.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 3562-3571
    • Roodman, G.D.1
  • 110
    • 0033050799 scopus 로고    scopus 로고
    • Site specific experimental metastases patterns of two human breast cancer cell lines in nude rats
    • Engebraaten O, Fodstad O. Site specific experimental metastases patterns of two human breast cancer cell lines in nude rats. Int J Cancer 1999;82:219-25.
    • (1999) Int. J. Cancer , vol.82 , pp. 219-225
    • Engebraaten, O.1    Fodstad, O.2
  • 111
    • 0033083822 scopus 로고    scopus 로고
    • Transcription of the bone sialoprotein gene is stimulated by v-Src acting through an inverted CCAAT box
    • Kim RH, Sodek J. Transcription of the bone sialoprotein gene is stimulated by v-Src acting through an inverted CCAAT box. Cancer Res 1999;59:565-71.
    • (1999) Cancer Res. , vol.59 , pp. 565-571
    • Kim, R.H.1    Sodek, J.2
  • 112
    • 0034660140 scopus 로고    scopus 로고
    • Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma
    • Yoneda F, Michigami T, Yi B, Williams PJ, Niewolna M, Hiraga T. Actions of bisphosphonate on bone metastasis in animal models of breast carcinoma. Cancer 2000;88:2979-88.
    • (2000) Cancer , vol.88 , pp. 2979-2988
    • Yoneda, F.1    Michigami, T.2    Yi, B.3    Williams, P.J.4    Niewolna, M.5    Hiraga, T.6
  • 113
    • 0034980406 scopus 로고    scopus 로고
    • Preclinical studies with zoledronic acid and other bisphosphonates: Impact on the bone microenvironment
    • Mundy GR, Yoneda T, Hiraga T. Preclinical studies with zoledronic acid and other bisphosphonates: impact on the bone microenvironment. Semin Oncol 2001;28 (2 Suppl 6):35-44.
    • (2001) Semin. Oncol. , vol.28 , Issue.2 SUPPL. 6 , pp. 35-44
    • Mundy, G.R.1    Yoneda, T.2    Hiraga, T.3
  • 114
    • 0034659915 scopus 로고    scopus 로고
    • The potential role of bisphosphonates as adjuvant therapy in the prevention of bone metastases
    • Paterson AHG. The potential role of bisphosphonates as adjuvant therapy in the prevention of bone metastases. Cancer 2000; 88:3038-46.
    • (2000) Cancer , vol.88 , pp. 3038-3046
    • Paterson, A.H.G.1
  • 115
    • 0018854165 scopus 로고
    • The effect of prostagladin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis
    • Galasko CS, Samuel AW, Rushton S, Lacey E. The effect of prostagladin synthesis inhibitors and diphosphonates on tumour-mediated osteolysis. Br J Surg 1980;67:493-6.
    • (1980) Br. J. Surg. , vol.67 , pp. 493-496
    • Galasko, C.S.1    Samuel, A.W.2    Rushton, S.3    Lacey, E.4
  • 116
    • 0028096180 scopus 로고
    • Effect of bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system
    • Hall DG, Stoica G. Effect of bisphosphonate risedronate on bone metastases in a rat mammary adenocarcinoma model system. J Bone Miner Res 1994;9:221-30.
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 221-230
    • Hall, D.G.1    Stoica, G.2
  • 117
    • 0002900593 scopus 로고
    • Morphological findings in bone metastasis, tumorosteopathy and anti-osteolytic therapy
    • Diel IJ, Kaufman M, Bastert G, editors. Berlin: Springer
    • Krempien B. Morphological findings in bone metastasis, tumorosteopathy and anti-osteolytic therapy. In Diel IJ, Kaufman M, Bastert G, editors. Metastatic bone disease: fundamental and clinical aspects. Berlin: Springer, 1994. pp. 59-85.
    • (1994) Metastatic Bone Disease: Fundamental and Clinical Aspects , pp. 59-85
    • Krempien, B.1
  • 118
    • 0034214362 scopus 로고    scopus 로고
    • Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases
    • Boissier S, Ferreras M, Peyruchaud O, Magnetto S, Ebetino F, Colombel M, et al. Bisphosphonates inhibit breast and prostate carcinoma cell invasion, an early event in the formation of bone metastases. Cancer Res 2000;60:2949-54.
    • (2000) Cancer Res. , vol.60 , pp. 2949-2954
    • Boissier, S.1    Ferreras, M.2    Peyruchaud, O.3    Magnetto, S.4    Ebetino, F.5    Colombel, M.6
  • 119
    • 0035866791 scopus 로고    scopus 로고
    • Bisphosphonate treatment inhibits the growth of prostate cancer cells
    • Lee M, Fong E, Singer FR, Guenette R. Bisphosphonate treatment inhibits the growth of prostate cancer cells. Cancer Res 2001;61:2602-8.
    • (2001) Cancer Res. , vol.61 , pp. 2602-2608
    • Lee, M.1    Fong, E.2    Singer, F.R.3    Guenette, R.4
  • 120
    • 0034062815 scopus 로고    scopus 로고
    • American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer
    • American Society of Clinical Oncology Bisphosphonates Expert Panel
    • Hillner BE, Ingle JN, Berenson JR, Janjan NA, Albain KS, Lipton A, et al. American Society of Clinical Oncology guideline on the role of bisphosphonates in breast cancer. American Society of Clinical Oncology Bisphosphonates Expert Panel. J Clin Oncol 2000;18:1378-91.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 1378-1391
    • Hillner, B.E.1    Ingle, J.N.2    Berenson, J.R.3    Janjan, N.A.4    Albain, K.S.5    Lipton, A.6
  • 121
    • 77950117427 scopus 로고    scopus 로고
    • Bisphosphonates for the relief of pain secondary to bone metastases
    • (Cochrane Review) Oxford: Update Software
    • Wong R, Wiffen PJ. Bisphosphonates for the relief of pain secondary to bone metastases (Cochrane Review). Cochrane Database Syst. rev. Oxford: Update Software, 2002; (2). CD002068.
    • (2002) Cochrane Database Syst. Rev. , Issue.2
    • Wong, R.1    Wiffen, P.J.2
  • 122
    • 0004223602 scopus 로고    scopus 로고
    • BMA London: BMA and Royal Pharmaceutical Society of Great Britain
    • BMA. British National Formulary. London: BMA and Royal Pharmaceutical Society of Great Britain, 2001. pp. 364-7.
    • (2001) British National Formulary , pp. 364-367
  • 123
    • 0035082946 scopus 로고    scopus 로고
    • Use of bisphosphonates for the treatment of metastatic bone pain. A survey of palliative physicians in the UK
    • Johnson IJ. Use of bisphosphonates for the treatment of metastatic bone pain. A survey of palliative physicians in the UK. Palliat Med 2001; 15:141-7.
    • (2001) Palliat. Med. , vol.15 , pp. 141-147
    • Johnson, I.J.1
  • 124
    • 0025739557 scopus 로고
    • An evaluation of the potential cost reductions resulting from the use of clodronate in the treatment of metastatic carcinoma of the breast to bone
    • Biermann WA, Cantor RI, Fellin FM, Jakobowski J, Hopkins L, Newbold RC III. An evaluation of the potential cost reductions resulting from the use of clodronate in the treatment of metastatic carcinoma of the breast to bone. Bone 1991; 12 (Suppl 1):S37-S42.
    • (1991) Bone , vol.12 , Issue.SUPPL. 1
    • Biermann, W.A.1    Cantor, R.I.2    Fellin, F.M.3    Jakobowski, J.4    Hopkins, L.5    Newbold III, R.C.6
  • 125
    • 84970861456 scopus 로고
    • Identifying relevant studies for systematic reviews
    • Dickersin K, Scherer R, Lefebvre C. Identifying relevant studies for systematic reviews. BMJ 1994;309:1286-91.
    • (1994) BMJ , vol.309 , pp. 1286-1291
    • Dickersin, K.1    Scherer, R.2    Lefebvre, C.3
  • 127
    • 1442345750 scopus 로고    scopus 로고
    • StatXact 4.0.1. Cambridge, MA: Cytel Software
    • StatXact 4.0.1. Cambridge, MA: Cytel Software, 2001.
    • (2001)
  • 128
    • 0038223465 scopus 로고    scopus 로고
    • Stata statistical software: Release 7.0
    • Stata. College Station, TX: Stata
    • Stata. Stata statistical software: release 7.0. College Station, TX: Stata, 2001.
    • (2001)
  • 129
    • 1442272172 scopus 로고    scopus 로고
    • Selection bias
    • Cochrane Library Clarke M, Oxman AD, editors. [updated June 2001]. The Cochrane Library, Oxford: Update Software. updated quarterly
    • Cochrane Library. Selection bias. In: Clarke M, Oxman AD, editors. Cochrane Reviewers Handbook 6.3 [updated June 2001]. The Cochrane Library, Issue 3. Oxford: Update Software. 2001, updated quarterly.
    • (2001) Cochrane Reviewers Handbook 6.3 , Issue.3
  • 130
    • 0028823554 scopus 로고
    • A randomised double-blind comparison of intravenous pamidronate and clodronate in the hypercalcaemia of malignancy
    • Purohit OP, Radstone CR, Anthony C, Kanis JA, Coleman RE. A randomised double-blind comparison of intravenous pamidronate and clodronate in the hypercalcaemia of malignancy. Br J Cancer 1995;72:1289-93.
    • (1995) Br. J. Cancer , vol.72 , pp. 1289-1293
    • Purohit, O.P.1    Radstone, C.R.2    Anthony, C.3    Kanis, J.A.4    Coleman, R.E.5
  • 131
    • 0035863508 scopus 로고    scopus 로고
    • Zoledronic acid is superior to pamidronate in the treatment of hypercalcaemia of malignancy: A pooled analysis of two randomised, controlled clinical trials
    • Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcaemia of malignancy: a pooled analysis of two randomised, controlled clinical trials. J Clin Oncol 2001;19:558-67.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 558-567
    • Major, P.1    Lortholary, A.2    Hon, J.3    Abdi, E.4    Mills, G.5    Menssen, H.D.6
  • 132
    • 0003979401 scopus 로고    scopus 로고
    • NHS Executive Leeds: Department of Health
    • NHS Executive. Reference Costs 2000. Leeds: Department of Health, 2000.
    • (2000) Reference Costs 2000
  • 133
    • 0006238922 scopus 로고    scopus 로고
    • NHS Executive Leeds: Department of Health
    • NHS Executive. NHS Costing Manual. Leeds: Department of Health, 2000.
    • (2000) NHS Costing Manual
  • 134
    • 0021021373 scopus 로고
    • The Markov process in medical prognosis
    • Beck J, Pauker S. The Markov process in medical prognosis. Med Decis Making 1983;3:419-58.
    • (1983) Med. Decis. Making , vol.3 , pp. 419-458
    • Beck, J.1    Pauker, S.2
  • 135
    • 0034162528 scopus 로고    scopus 로고
    • Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases
    • Lipton A, Theriault R, Hortobagyi GN, Simeone J, Knight RD, Mellars K, et al. Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases. Cancer 2000;88:1082-90.
    • (2000) Cancer , vol.88 , pp. 1082-1090
    • Lipton, A.1    Theriault, R.2    Hortobagyi, G.N.3    Simeone, J.4    Knight, R.D.5    Mellars, K.6
  • 136
    • 0033429593 scopus 로고    scopus 로고
    • Efficacy of pamidronate in breast cancer with bone metastases: A randomized, double-blind placebo-controlled multicenter study
    • Hultborn R, Gundersen S, Ryden S, Holmberg E, Carstensen J, Wallgren UB, et al. Efficacy of pamidronate in breast cancer with bone metastases: a randomized, double-blind placebo-controlled multicenter study. Anticancer Res 1999; 19(4C):3383-92.
    • (1999) Anticancer Res. , vol.19 , Issue.4 C , pp. 3383-3392
    • Hultborn, R.1    Gundersen, S.2    Ryden, S.3    Holmberg, E.4    Carstensen, J.5    Wallgren, U.B.6
  • 137
    • 0031911183 scopus 로고    scopus 로고
    • A randomized trial of the effect of clodronate on skeletal morbidity in Multiple myeloma. MRC Working Party on Leukaemia in Adults
    • McCloskey EV, MacLennan IC, Drayson MT, Chapman C, Dunn J, Kanis JA. A randomized trial of the effect of clodronate on skeletal morbidity in Multiple myeloma. MRC Working Party on Leukaemia in Adults. Br J Haematol 1998;100: 317-25.
    • (1998) Br. J. Haematol. , vol.100 , pp. 317-325
    • McCloskey, E.V.1    MacLennan, I.C.2    Drayson, M.T.3    Chapman, C.4    Dunn, J.5    Kanis, J.A.6
  • 139
    • 0033050818 scopus 로고    scopus 로고
    • Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: A randomized, placebo-controlled trial
    • Theriault RL, Lipton A, Hortobagyi GN, Leff R, Gluck S, Stewart JF, et al. Pamidronate reduces skeletal morbidity in women with advanced breast cancer and lytic bone lesions: a randomized, placebo-controlled trial. J Clin Oncol 1999; 17:846-54.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 846-854
    • Theriault, R.L.1    Lipton, A.2    Hortobagyi, G.N.3    Leff, R.4    Gluck, S.5    Stewart, J.F.6
  • 140
    • 0032961576 scopus 로고    scopus 로고
    • Pamidronate for the prevention of skeletal related events in multiple myeloma. What does the public think it is worth?
    • Dranitsaris G. Pamidronate for the prevention of skeletal related events in multiple myeloma. What does the public think it is worth? Int J Technol Assess Health Care 2001;15:108-22.
    • (2001) Int. J. Technol. Assess. Health Care , vol.15 , pp. 108-122
    • Dranitsaris, G.1
  • 141
    • 0032969475 scopus 로고    scopus 로고
    • Cost utility analysis of prophylactic pamidronate for the prevention of skeletal related events in patients with advanced breast cancer
    • Dranitsaris G, Hsu T. Cost utility analysis of prophylactic pamidronate for the prevention of skeletal related events in patients with advanced breast cancer. Support Care Cancer 1999;7:271-9.
    • (1999) Support Care Cancer , vol.7 , pp. 271-279
    • Dranitsaris, G.1    Hsu, T.2
  • 143
  • 144
    • 0029917817 scopus 로고    scopus 로고
    • Direct costs of osteoporosis for New Zealand women
    • Lane A. Direct costs of osteoporosis for New Zealand women. Pharmacoeconomics 1996;9:231-45.
    • (1996) Pharmacoeconomics , vol.9 , pp. 231-245
    • Lane, A.1
  • 145
    • 0032585982 scopus 로고    scopus 로고
    • The costs of hip fracture in Germany; a prospective evaluation
    • Pientka L, Friedrich C. The costs of hip fracture in Germany; a prospective evaluation. Z Gerontol Geriatr 1999;32:326-32.
    • (1999) Z. Gerontol. Geriatr. , vol.32 , pp. 326-332
    • Pientka, L.1    Friedrich, C.2
  • 147
    • 0031647979 scopus 로고    scopus 로고
    • The cost of treating osteoporotic fractures in the United Kingdom female population
    • Dolan P, Torgeson DJ. The cost of treating osteoporotic fractures in the United Kingdom female population. Osteoporos Int 1998;8:611-17.
    • (1998) Osteoporos. Int. , vol.8 , pp. 611-617
    • Dolan, P.1    Torgeson, D.J.2
  • 148
    • 0003462471 scopus 로고    scopus 로고
    • Unit costs of health and social care
    • Canterbury: Personal Social Services Research Unit, University of Kent and Canterbury
    • Netten A, Rees T, Harrison G. Unit costs of health and social care. Canterbury: Personal Social Services Research Unit, University of Kent and Canterbury, 2001.
    • (2001)
    • Netten, A.1    Rees, T.2    Harrison, G.3
  • 149
    • 0026918214 scopus 로고
    • Establishing the cost of comfort. Effectiveness of pressure sore prevention
    • Rimmer C. Establishing the cost of comfort. Effectiveness of pressure sore prevention. Prof Nurse 1992;810-15.
    • (1992) Prof. Nurse , pp. 810-815
    • Rimmer, C.1
  • 150
    • 0004003371 scopus 로고    scopus 로고
    • Appraisal and evaluation in central government
    • HM Treasury. Norwich: The Stationery Office
    • HM Treasury. Appraisal and evaluation in central government. 1997. Norwich: The Stationery Office.
    • (1997)
  • 151
    • 0003690608 scopus 로고    scopus 로고
    • Guidance for manufacturers and sponsors
    • NICE. London: National Institute for Clinical Excellence (NICE)
    • NICE. Guidance for manufacturers and sponsors. London: National Institute for Clinical Excellence (NICE). 2001.
    • (2001)
  • 152
    • 0029794708 scopus 로고    scopus 로고
    • Recommendations of the panel on cost-effectiveness in health and medicine
    • Weinstein NC, Siegel JE, Gold MR, Kamlet MS, Russell LB. Recommendations of the panel on cost-effectiveness in health and medicine. JAMA 1996;276:1253-8.
    • (1996) JAMA , vol.276 , pp. 1253-1258
    • Weinstein, N.C.1    Siegel, J.E.2    Gold, M.R.3    Kamlet, M.S.4    Russell, L.B.5
  • 153
    • 0035036382 scopus 로고    scopus 로고
    • The impact of pamidronate on inpatient and outpatient services among metastatic breast cancer patients
    • Beusterien KM, Hill MC, Ackerman SJ, Zacker C. The impact of pamidronate on inpatient and outpatient services among metastatic breast cancer patients. Support Care Cancer 2001;9:169-76.
    • (2001) Support Care Cancer , vol.9 , pp. 169-176
    • Beusterien, K.M.1    Hill, M.C.2    Ackerman, S.J.3    Zacker, C.4
  • 154
    • 1442345737 scopus 로고
    • Gallium nitrate (GN) versus pamidronate (APD) for acute control of cancer-related hypercalcaemia (CRH): Interim results of a randomised double-blind multi-national study
    • (meeting abstract)
    • Bertheault-Cvitkovic F, Tubiana-Hulin M, Chevalier B, Clavel M, Rossy JF, Warrell RP. Gallium nitrate (GN) versus pamidronate (APD) for acute control of cancer-related hypercalcaemia (CRH): interim results of a randomised double-blind multi-national study (meeting abstract). Proc Annu Meet Am Soc Clin Oncol 1995;14:A369.
    • (1995) Proc. Annu. Meet. Am. Soc. Clin. Oncol. , vol.14
    • Bertheault-Cvitkovic, F.1    Tubiana-Hulin, M.2    Chevalier, B.3    Clavel, M.4    Rossy, J.F.5    Warrell, R.P.6
  • 155
    • 0026648340 scopus 로고
    • Infusion rate and pharmacokinetics of intravenous pamidronate in the treatment of tumour-induced hypercalcaemia
    • Dodwell DJ, Howell A, Morton AR, Daley-Yates PT, Hoggarth CR. Infusion rate and pharmacokinetics of intravenous pamidronate in the treatment of tumour-induced hypercalcaemia. Postgrad Med J 1992;68:434-9.
    • (1992) Postgrad. Med. J. , vol.68 , pp. 434-439
    • Dodwell, D.J.1    Howell, A.2    Morton, A.R.3    Daley-Yates, P.T.4    Hoggarth, C.R.5
  • 156
    • 0028230998 scopus 로고
    • Treatment of malignancy-associated hypercalcemia with YM175, a new bisphosphonate: Elevated threshold for parathyroid hormone secretion in hypercalcemic patients
    • Fukumoto S, Matsumoto T, Takebe K, Onaya T, Eto S, Nawata H, et al. Treatment of malignancy-associated hypercalcemia with YM175, a new bisphosphonate: elevated threshold for parathyroid hormone secretion in hypercalcemic patients. J Clin Endocrinol Metab 1994;79:165-70.
    • (1994) J. Clin. Endocrinol. Metab. , vol.79 , pp. 165-170
    • Fukumoto, S.1    Matsumoto, T.2    Takebe, K.3    Onaya, T.4    Eto, S.5    Nawata, H.6
  • 158
    • 0023029435 scopus 로고
    • Etidronate disodium for treating hypercalcaemia of malignancy: A double blind, placebo-controlled study
    • Hasling C, Charles P, Mosekilde L. Etidronate disodium for treating hypercalcaemia of malignancy: a double blind, placebo-controlled study. Euro J Clin Invest 1986;16:433-7.
    • (1986) Euro. J. Clin. Invest. , vol.16 , pp. 433-437
    • Hasling, C.1    Charles, P.2    Mosekilde, L.3
  • 159
    • 0023625144 scopus 로고
    • Etidronate disodium in the management of malignancy-related hypercalcemia
    • Hasling C, Charles P, Mosekilde L. Etidronate disodium in the management of malignancy-related hypercalcemia. Am J Med 1987;82(2A):51-4.
    • (1987) Am. J. Med. , vol.82 , Issue.2 A , pp. 51-54
    • Hasling, C.1    Charles, P.2    Mosekilde, L.3
  • 160
    • 0023887633 scopus 로고
    • Single dose versus daily intravenous aminohydroxypropylidene biphosphonate (APD) for the hypercalcaemia of malignancy
    • Morton AR, Cantrill JA, Craig AE, Howell A, Davies M, Anderson DC. Single dose versus daily intravenous aminohydroxypropylidene biphosphonate (APD) for the hypercalcaemia of malignancy. BMJ 1988;296:811-14.
    • (1988) BMJ , vol.296 , pp. 811-814
    • Morton, A.R.1    Cantrill, J.A.2    Craig, A.E.3    Howell, A.4    Davies, M.5    Anderson, D.C.6
  • 161
    • 0022388765 scopus 로고
    • Comparison of aminohydroxypropylidene diphosphonate, mithramycin, and corticosteroids/calcitonin in treatment of cancer-associated hypercalcaemia
    • Ralston SH, Gardner MD, Dryburgh FJ, Jenkins AS, Cowan RA, Boyle IT. Comparison of aminohydroxypropylidene diphosphonate, mithramycin, and corticosteroids/calcitonin in treatment of cancer-associated hypercalcaemia. Lancet 1985;ii:907-10.
    • (1985) Lancet , vol.2 , pp. 907-910
    • Ralston, S.H.1    Gardner, M.D.2    Dryburgh, F.J.3    Jenkins, A.S.4    Cowan, R.A.5    Boyle, I.T.6
  • 163
    • 0033304568 scopus 로고    scopus 로고
    • Serum parathyroid hormone-related protein levels and response to bisphosphonate treatment in hypercalcemia of malignancy
    • Rizzoli R, Thiebaud D, Bundred N, Pecherstorfer M, Herrmann Z, Huss HJ, et al. Serum parathyroid hormone-related protein levels and response to bisphosphonate treatment in hypercalcemia of malignancy. J Clin Endocrinol Metab 1999;84:3545-50.
    • (1999) J. Clin. Endocrinol. Metab. , vol.84 , pp. 3545-3550
    • Rizzoli, R.1    Thiebaud, D.2    Bundred, N.3    Pecherstorfer, M.4    Herrmann, Z.5    Huss, H.J.6
  • 164
    • 0026519585 scopus 로고
    • Intravenous clodronate for the treatment of hypercalcaemia in breast cancer patients with bone metastases - A prospective randomised placebo-controlled multicentre study
    • Rotstein S, Glas U, Eriksson M, Pfeiffer P, Hansen J, Soderqvist J, et al. Intravenous clodronate for the treatment of hypercalcaemia in breast cancer patients with bone metastases - a prospective randomised placebo-controlled multicentre study. Eur J Cancer 1992;28A:890-3.
    • (1992) Eur. J. Cancer , vol.28 A , pp. 890-893
    • Rotstein, S.1    Glas, U.2    Eriksson, M.3    Pfeiffer, P.4    Hansen, J.5    Soderqvist, J.6
  • 165
    • 0031032567 scopus 로고    scopus 로고
    • Evaluation of new bone resorption markers in a randomized comparison of pamidronate or clodronate for hypercalcemia of malignancy
    • Vinholes J, Guo CY, Purohit OP, Eastell R, Coleman RE. Evaluation of new bone resorption markers in a randomized comparison of pamidronate or clodronate for hypercalcemia of malignancy. J Clin Oncol 1997;15:131-8.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 131-138
    • Vinholes, J.1    Guo, C.Y.2    Purohit, O.P.3    Eastell, R.4    Coleman, R.E.5
  • 167
    • 0028006777 scopus 로고
    • Optimal frequency of administration of pamidronate in patients with hvpercalcaemia of malignancy
    • Wimalawansa SJ. Optimal frequency of administration of pamidronate in patients with hvpercalcaemia of malignancy. Clin Endocrinol 1994;41:591-15.
    • (1994) Clin. Endocrinol. , vol.41 , pp. 591-615
    • Wimalawansa, S.J.1
  • 168
    • 1442321229 scopus 로고    scopus 로고
    • Single IV infusion of clodronate 1500mg is effective in the treatment of hypercalcaemia of malignancy
    • Atula S, Tahtela R, Nevalainen J, Pyikkanen L. Single IV infusion of clodronate 1500mg is effective in the treatment of hypercalcaemia of malignancy. Eur J Cancer 37 (Suppl 6), 2001;S354.
    • (2001) Eur. J. Cancer , vol.37 , Issue.SUPPL. 6
    • Atula, S.1    Tahtela, R.2    Nevalainen, J.3    Pyikkanen, L.4
  • 169
    • 0023572365 scopus 로고
    • Dichloromethylene diphosphate action in hematologic and other malignancies
    • Canfield RE, Siris ES, Jacobs TP. Dichloromethylene diphosphate action in hematologic and other malignancies. Bone 1987;8(suppl. 1):557-562.
    • (1987) Bone , vol.8 , Issue.SUPPL. 1 , pp. 557-562
    • Canfield, R.E.1    Siris, E.S.2    Jacobs, T.P.3
  • 170
    • 0018955564 scopus 로고
    • Effects of disodium dichloromethylene diphosphonate on hypercalcemia produced by bone metastases
    • Chapuy MC, Meunier PJ, Alexandre CM, Vignon EP. Effects of disodium dichloromethylene diphosphonate on hypercalcemia produced by bone metastases. J Clin Invest 1980;65:1243-7.
    • (1980) J. Clin. Invest. , vol.65 , pp. 1243-1247
    • Chapuy, M.C.1    Meunier, P.J.2    Alexandre, C.M.3    Vignon, E.P.4
  • 171
    • 0025816755 scopus 로고
    • Treatment of hypercalcemia of malignancy with intravenous aminohydroxypropylidene bisphosphonate. Results of a stratified, double-blind, randomized two-month dose-response study
    • Daragon A, Peyron R, Serrurier D, Deshayes P. Treatment of hypercalcemia of malignancy with intravenous aminohydroxypropylidene bisphosphonate. Results of a stratified, double-blind, randomized two-month dose-response study. Curr Ther Res Clin Exp 1991;50:10-21.
    • (1991) Curr. Ther. Res. Clin. Exp. , vol.50 , pp. 10-21
    • Daragon, A.1    Peyron, R.2    Serrurier, D.3    Deshayes, P.4
  • 172
    • 0020026037 scopus 로고
    • Dichloromethylene diphosphonate (C12MDP) treatment of hypercalcaemia produced from bone metastases
    • Delmas P, Chapuy MC, Vignon E, Briancon D, Charhon S, Meunier PJ. Dichloromethylene diphosphonate (C12MDP) treatment of hypercalcaemia produced from bone metastases. Nouv Presse Med 1982;11:1471-4.
    • (1982) Nouv Presse Med. , vol.11 , pp. 1471-1474
    • Delmas, P.1    Chapuy, M.C.2    Vignon, E.3    Briancon, D.4    Charhon, S.5    Meunier, P.J.6
  • 175
    • 0020671635 scopus 로고
    • Comparative study of available medical therapy for hypercalcemia of malignancy
    • Mundy GR, Wilkinson R, Heath DA. Comparative study of available medical therapy for hypercalcemia of malignancy. Am J Med 1983;74:421-32.
    • (1983) Am. J. Med. , vol.74 , pp. 421-432
    • Mundy, G.R.1    Wilkinson, R.2    Heath, D.A.3
  • 176
    • 4444284926 scopus 로고
    • A randomised trial of varying doses of aminohydroxypropylidene bisphosphonate (APD) in the treatment of hypercalcaemia of malignancy. Seventeenth annual scientific meeting
    • Murray R, Pitt P, Jerums G. A randomised trial of varying doses of aminohydroxypropylidene bisphosphonate (APD) in the treatment of hypercalcaemia of malignancy. Seventeenth annual scientific meeting, Clinical Oncology Society of Australia, 1990; IS28.
    • (1990) Clinical Oncology Society of Australia
    • Murray, R.1    Pitt, P.2    Jerums, G.3
  • 177
    • 1442321232 scopus 로고    scopus 로고
    • Ibandronic acid is more effective than pamidronate in lowering serum calcium in patients with severe hypercalcaemia of malignancy (HCM) and has at least equal efficacy to pamidronate in HCM patients with lower baseline calciums. Results of a randomised, open-label, comparative study
    • abstract
    • Pecherstorfer M, Steinhauer EU, Pawsev S. Ibandronic acid is more effective than pamidronate in lowering serum calcium in patients with severe hypercalcaemia of malignancy (HCM) and has at least equal efficacy to pamidronate in HCM patients with lower baseline calciums. Results of a randomised, open-label, comparative study. Proc Am Soc Clin Oncol 2001; 20:abstract 1535.
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 1535
    • Pecherstorfer, M.1    Steinhauer, E.U.2    Pawsev, S.3
  • 178
    • 1442321232 scopus 로고    scopus 로고
    • Ibandronic acid is more effective than pamidronate in lowering serum calcium in patients with severe hypercalcaemia of malignancy (HCM) and has at least equal efficacy to pamidronate in HCM patients with lower baseline calciums. Results of a randomised, open-label, comparative study
    • abs
    • Pecherstorfer M, Steinhauer EU, Pawsey S. Ibandronic acid is more effective than pamidronate in lowering serum calcium in patients with severe hypercalcaemia of malignancy (HCM) and has at least equal efficacy to pamidronate in HCM patients with lower baseline calciums. Results of a randomised, open-label, comparative study. Proc Am Soc Clin Oncol 2001; 20;abs 1535
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 1535
    • Pecherstorfer, M.1    Steinhauer, E.U.2    Pawsey, S.3
  • 179
    • 0024093615 scopus 로고
    • Clinical experience with aminohydroxypropylidene bisphosphonate (APD) in the management of cancer-associated hypercalcaemia
    • Ralston SH, Alzaid AA, Gallacher SJ, Gardner MD, Cowan RA, Boyle IT. Clinical experience with aminohydroxypropylidene bisphosphonate (APD) in the management of cancer-associated hypercalcaemia. Q J Med 1988;68:825-34.
    • (1988) Q. J. Med. , vol.68 , pp. 825-834
    • Ralston, S.H.1    Alzaid, A.A.2    Gallacher, S.J.3    Gardner, M.D.4    Cowan, R.A.5    Boyle, I.T.6
  • 181
    • 0020676177 scopus 로고
    • Effects of dichloromethylene diphosphonate in women with breast carcinoma metastatic to the skeleton
    • Siris ES, Hyman GA, Canfield RE. Effects of dichloromethylene diphosphonate in women with breast carcinoma metastatic to the skeleton. Am J Med 1983;74:401-6.
    • (1983) Am. J. Med. , vol.74 , pp. 401-406
    • Siris, E.S.1    Hyman, G.A.2    Canfield, R.E.3
  • 182
    • 0026658639 scopus 로고
    • Plicamycin and pamidronate in symptomatic tumor-related hypercalcemia: A prospective randomized crossover trial
    • Thurlimann B, Waldburger R, Senn HJ, Thiebaud D. Plicamycin and pamidronate in symptomatic tumor-related hypercalcemia: a prospective randomized crossover trial. Ann Oncol 1992;3:619-23.
    • (1992) Ann. Oncol. , vol.3 , pp. 619-623
    • Thurlimann, B.1    Waldburger, R.2    Senn, H.J.3    Thiebaud, D.4
  • 184
    • 0032849198 scopus 로고    scopus 로고
    • Radiation therapy vs radiation therapy + pamidronate (Aredia) in elderly patients with breast cancer and lytic bone metastases: A GROG-GIOGER randomized clinical trial
    • Ausili-Cefaro G, Capirci C, Crivellari D, Fontana V, Mandoliti G, Olmi P, et al. Radiation therapy vs radiation therapy + pamidronate (Aredia) in elderly patients with breast cancer and lytic bone metastases: a GROG-GIOGER randomized clinical trial. Rays 1999; 24 (Suppl 2):49-52.
    • (1999) Rays , vol.24 , Issue.SUPPL. 2 , pp. 49-52
    • Ausili-Cefaro, G.1    Capirci, C.2    Crivellari, D.3    Fontana, V.4    Mandoliti, G.5    Olmi, P.6
  • 186
    • 0031872826 scopus 로고    scopus 로고
    • The efficacy of pamidronate disodium in the treatment of osteolytic lesions and bone pain in multiple myeloma
    • Berenson JR. The efficacy of pamidronate disodium in the treatment of osteolytic lesions and bone pain in multiple myeloma. Rev Contemp Pharmacother 1998;9:195-203.
    • (1998) Rev. Contemp. Pharmacother. , vol.9 , pp. 195-203
    • Berenson, J.R.1
  • 187
    • 0035312469 scopus 로고    scopus 로고
    • Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases
    • Berenson JR, Rosen LS, Howell A, Porter L, Coleman RE, Morley W, et al. Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases. Cancer 2001;91:1191-200.
    • (2001) Cancer , vol.91 , pp. 1191-1200
    • Berenson, J.R.1    Rosen, L.S.2    Howell, A.3    Porter, L.4    Coleman, R.E.5    Morley, W.6
  • 188
    • 0034993316 scopus 로고    scopus 로고
    • Zoledronic acid in cancer patients with bone metastases: Results of phase I and II trials
    • Berenson JR. Zoledronic acid in cancer patients with bone metastases: results of phase I and II trials. Semin Oncol 2001;28 [2 (Suppl 6)]:25-34.
    • (2001) Semin. Oncol. , vol.28 , Issue.2 SUPPL. 6 , pp. 25-34
    • Berenson, J.R.1
  • 189
    • 0031810467 scopus 로고    scopus 로고
    • Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: A double-blind placebo-controlled trial
    • Danish-Swedish co-operative study group
    • Brincker H, Westin J, Abildgaard N, Gimsing P, Turesson I, Hedenus M, et al. Failure of oral pamidronate to reduce skeletal morbidity in multiple myeloma: a double-blind placebo-controlled trial. Danish-Swedish co-operative study group. Br J Haematol 1998;101:280-6.
    • (1998) Br. J. Haematol. , vol.101 , pp. 280-286
    • Brincker, H.1    Westin, J.2    Abildgaard, N.3    Gimsing, P.4    Turesson, I.5    Hedenus, M.6
  • 190
    • 0028102949 scopus 로고
    • Delayed progression of bone metastases with pamidronate therapy in breast cancer patients: A randomized, multicenter phase III trial
    • Conte PF, Giannessi PG, Latreille J, Mauriac L, Koliren L, Calabresi F, et al. Delayed progression of bone metastases with pamidronate therapy in breast cancer patients: a randomized, multicenter phase III trial. Ann Oncol 1994;5 (Suppl 7):S41-S44.
    • (1994) Ann. Oncol. , vol.5 , Issue.SUPPL. 7
    • Conte, P.F.1    Giannessi, P.G.2    Latreille, J.3    Mauriac, L.4    Koliren, L.5    Calabresi, F.6
  • 191
    • 0029782630 scopus 로고    scopus 로고
    • Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: Results from a multinational randomized controlled trial
    • Conte PF, Latreille J, Mauriac L, Calabresi F, Santos R, Campos D, et al. Delay in progression of bone metastases in breast cancer patients treated with intravenous pamidronate: results from a multinational randomized controlled trial. J Clin Oncol 1996;14:2552-9.
    • (1996) J. Clin. Oncol. , vol.14 , pp. 2552-2559
    • Conte, P.F.1    Latreille, J.2    Mauriac, L.3    Calabresi, F.4    Santos, R.5    Campos, D.6
  • 192
    • 0030227291 scopus 로고    scopus 로고
    • Pamidronate in the treatment of bone metastases - The European experience
    • Ford JF. Pamidronate in the treatment of bone metastases - the European experience. Br J Clin Pract Suppl 1996;87:3-4.
    • (1996) Br. J. Clin. Pract. Suppl. , vol.87 , pp. 3-4
    • Ford, J.F.1
  • 193
    • 0027331171 scopus 로고
    • Treatment of multiple myeloma with etidronate: Results of a multicentre double-blind study
    • Daragon A, Humez C, Michot C, Le Loet X, Grosbois B, Pouyol F, et al. Treatment of multiple myeloma with etidronate: results of a multicentre double-blind study. Eur J Med 1993;2:449-52.
    • (1993) Eur. J. Med. , vol.2 , pp. 449-452
    • Daragon, A.1    Humez, C.2    Michot, C.3    Le Loet, X.4    Grosbois, B.5    Pouyol, F.6
  • 195
    • 0000414237 scopus 로고    scopus 로고
    • Continuous oral versus intravenous interval therapy with bisphosphonates in patients with breast cancer and bone metastases
    • abs
    • Diel IJ, Marschner N, Kindler M, Lange O, Untch M, Hurtz HJ, et al. Continuous oral versus intravenous interval therapy with bisphosphonates in patients with breast cancer and bone metastases. J Clin Oncol (ASCO) 1999; abs 488.
    • (1999) J. Clin. Oncol. (ASCO) , pp. 488
    • Diel, I.J.1    Marschner, N.2    Kindler, M.3    Lange, O.4    Untch, M.5    Hurtz, H.J.6
  • 196
    • 0020666819 scopus 로고
    • Long-term controlled trial with diphosphonate in patients with osteolytic bone metastases
    • Elomaa I, Blomqvist C, Grohn P, Porkka L, Kairento AL, Selander K, et al. Long-term controlled trial with diphosphonate in patients with osteolytic bone metastases. Lancet 1983; i:146-9.
    • (1983) Lancet , vol.1 , pp. 146-149
    • Elomaa, I.1    Blomqvist, C.2    Grohn, P.3    Porkka, L.4    Kairento, A.L.5    Selander, K.6
  • 197
    • 0023585003 scopus 로고
    • Treatment of skeletal disease in breast cancer: A controlled clodronate trial
    • Elomaa I, Blomqvist C, Porkka L, Lamberg-Allardt C, Borgstrom GH. Treatment of skeletal disease in breast cancer: a controlled clodronate trial. Bone 1987;8 (Suppl 1):S53-S56.
    • (1987) Bone , vol.8 , Issue.SUPPL. 1
    • Elomaa, I.1    Blomqvist, C.2    Porkka, L.3    Lamberg-Allardt, C.4    Borgstrom, G.H.5
  • 199
    • 0027949284 scopus 로고
    • Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer
    • Glover D, Lipton A, Keller A, Miller AA, Browning S, Fram RJ, et al. Intravenous pamidronate disodium treatment of bone metastases in patients with breast cancer. Cancer 1994;74:2949-55.
    • (1994) Cancer , vol.74 , pp. 2949-2955
    • Glover, D.1    Lipton, A.2    Keller, A.3    Miller, A.A.4    Browning, S.5    Fram, R.J.6
  • 202
    • 0028846777 scopus 로고
    • Prospective randomised trial of dichloromethylene bisphosphonate (clodronate) in patients with multiple myeloma requiring treatment. A multicenter study
    • Heim ME, Clemens MR, Queirber W, Pecherstorfer M, Boewer C, Herold M, et al. Prospective randomised trial of dichloromethylene bisphosphonate (clodronate) in patients with multiple myeloma requiring treatment. A multicenter study. Onkologie 1995;18:439-48.
    • (1995) Onkologie , vol.18 , pp. 439-448
    • Heim, M.E.1    Clemens, M.R.2    Queirber, W.3    Pecherstorfer, M.4    Boewer, C.5    Herold, M.6
  • 203
    • 0027411455 scopus 로고
    • Multiple myeloma: Effect of daily dichloromethylene bisphosphonate on skeletal complications
    • Clemens MR, Fessele K, Heim ME. Multiple myeloma: effect of daily dichloromethylene bisphosphonate on skeletal complications. Ann Hematol 1993;66:141-6.
    • (1993) Ann. Hematol. , vol.66 , pp. 141-146
    • Clemens, M.R.1    Fessele, K.2    Heim, M.E.3
  • 205
    • 0023200599 scopus 로고
    • Reduced morbidity from skeletal metastases in breast cancer patients during long-term bisphosphonate (APD) treatment
    • Holten-Verzantvoort AT, Bijvoet OL, Cleton FJ, Hermans J, Kroon HM, Harinck HI, et al. Reduced morbidity from skeletal metastases in breast cancer patients during long-term bisphosphonate (APD) treatment. Lancet 1987;ii:983-5.
    • (1987) Lancet , vol.2 , pp. 983-985
    • Holten-Verzantvoort, A.T.1    Bijvoet, O.L.2    Cleton, F.J.3    Hermans, J.4    Kroon, H.M.5    Harinck, H.I.6
  • 206
    • 0024350365 scopus 로고
    • Effect of long-term bisphosphonate treatment on morbidity due to bone metastases in breast cancer patients
    • Cleton FJ, Holten-Verzantvoort AT, Bijvoet OL. Effect of long-term bisphosphonate treatment on morbidity due to bone metastases in breast cancer patients. Recent Results Cancer Res 1989;116:73-8.
    • (1989) Recent Results Cancer Res. , vol.116 , pp. 73-78
    • Cleton, F.J.1    Holten-Verzantvoort, A.T.2    Bijvoet, O.L.3
  • 207
  • 209
    • 10544228130 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases
    • Hortobagyi GN, Theriault RL, Porter L, Blayney D, Lipton A, Sinoff C, et al. Efficacy of pamidronate in reducing skeletal complications in patients with breast cancer and lytic bone metastases. N Engl J Med 1996;335:1785-91.
    • (1996) N. Engl. J. Med. , vol.335 , pp. 1785-1791
    • Hortobagyi, G.N.1    Theriault, R.L.2    Porter, L.3    Blayney, D.4    Lipton, A.5    Sinoff, C.6
  • 210
    • 0030483518 scopus 로고    scopus 로고
    • Efficacy of pamidronate in breast cancer with bone metastases: A randomized double-blind placebo controlled multicenter study
    • Hultborn R, Gundersen S, Ryden S, Holmberg E, Carstensen J, Wallgren UB, et al. Efficacy of pamidronate in breast cancer with bone metastases: a randomized double-blind placebo controlled multicenter study. Acta Oncol 1996; 35 (Suppl 5):73-4.
    • (1996) Acta Oncol. , vol.35 , Issue.SUPPL. 5 , pp. 73-74
    • Hultborn, R.1    Gundersen, S.2    Ryden, S.3    Holmberg, E.4    Carstensen, J.5    Wallgren, U.B.6
  • 211
    • 0034510168 scopus 로고    scopus 로고
    • Effect of pamidronate on skeletal morbidity in myelomatosis. Part 1. The results of the first 12 months of pamidronate therapy
    • Kraj M, Poglod R, Pawlikowski J, Maj S, Nasilowska B. Effect of pamidronate on skeletal morbidity in myelomatosis. Part 1. The results of the first 12 months of pamidronate therapy. Acta Pol Pharm 2000;57:113-16.
    • (2000) Acta Pol. Pharm. , vol.57 , pp. 113-116
    • Kraj, M.1    Poglod, R.2    Pawlikowski, J.3    Maj, S.4    Nasilowska, B.5
  • 212
    • 0034484749 scopus 로고    scopus 로고
    • The effect of long-term pamidronate treatment on skeletal morbidity in advanced multiple myeloma
    • Kraj M, Poglod R, Pawlikowski J, Maj S. The effect of long-term pamidronate treatment on skeletal morbidity in advanced multiple myeloma. Acta Haematol Pol 2000;31:379-89.
    • (2000) Acta Haematol. Pol. , vol.31 , pp. 379-389
    • Kraj, M.1    Poglod, R.2    Pawlikowski, J.3    Maj, S.4
  • 214
    • 0026646339 scopus 로고
    • Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma
    • Lahtinen R, Laakso M, Palva I, Virkkunen P, Elomaa I. Randomised, placebo-controlled multicentre trial of clodronate in multiple myeloma. Lancet 1992;340:1049-52.
    • (1992) Lancet , vol.340 , pp. 1049-1052
    • Lahtinen, R.1    Laakso, M.2    Palva, I.3    Virkkunen, P.4    Elomaa, I.5
  • 215
    • 0028106385 scopus 로고
    • Sub-group and cost-benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma
    • Laakso M, Lahtinen R, Virkkunen P, Elomaa I. Sub-group and cost-benefit analysis of the Finnish multicentre trial of clodronate in multiple myeloma. Br J Haematol 1994;87:725-9.
    • (1994) Br. J. Haematol. , vol.87 , pp. 725-729
    • Laakso, M.1    Lahtinen, R.2    Virkkunen, P.3    Elomaa, I.4
  • 216
    • 0030225519 scopus 로고    scopus 로고
    • Pamidronate in the treatment of osteolytic bone metastases in breast cancer patients
    • Theriault R. Pamidronate in the treatment of osteolytic bone metastases in breast cancer patients. Br J Clin Pract Suppl 1996;87:8-12.
    • (1996) Br. J. Clin. Pract. Suppl. , vol.87 , pp. 8-12
    • Theriault, R.1
  • 217
    • 0026033670 scopus 로고
    • Controlled clinical study on the use of dichloromethylene diphosphonate in patients with breast carcinoma metastasizing to the skeleton
    • Martoni A, Guaraldi M, Camera P, Biagi R, Marri S, Beghe F, et al. Controlled clinical study on the use of dichloromethylene diphosphonate in patients with breast carcinoma metastasizing to the skeleton. Oncology 1991;48:97-101.
    • (1991) Oncology , vol.48 , pp. 97-101
    • Martoni, A.1    Guaraldi, M.2    Camera, P.3    Biagi, R.4    Marri, S.5    Beghe, F.6
  • 218
    • 0027531814 scopus 로고
    • Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer
    • Paterson AH, Powles TJ, Kanis JA, McCloskey E, Hanson J, Ashley S. Double-blind controlled trial of oral clodronate in patients with bone metastases from breast cancer. J Clin Oncol 1993;11:59-65.
    • (1993) J. Clin. Oncol. , vol.11 , pp. 59-65
    • Paterson, A.H.1    Powles, T.J.2    Kanis, J.A.3    McCloskey, E.4    Hanson, J.5    Ashley, S.6
  • 219
    • 0029166436 scopus 로고
    • Effect of oral clodronate on metastatic bone pain: A double-blind, placebo-controlled study
    • Robertson AG, Reed NS, Ralston SH. Effect of oral clodronate on metastatic bone pain: a double-blind, placebo-controlled study. J Clin Oncol 19951;13:2427-30.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 2427-2430
    • Robertson, A.G.1    Reed, N.S.2    Ralston, S.H.3
  • 220
    • 17444435152 scopus 로고    scopus 로고
    • Double-blinded controlled study comparing clodronate versus placebo in patients with breast cancer bone metastases
    • Tubiana-Hulin M, Beuzeboc P, Mauriac L, Barbet N, Frenay M, Monnier A, et al. Double-blinded controlled study comparing clodronate versus placebo in patients with breast cancer bone metastases. Bull Cancer 2001;88:701-7.
    • (2001) Bull. Cancer , vol.88 , pp. 701-707
    • Tubiana-Hulin, M.1    Beuzeboc, P.2    Mauriac, L.3    Barbet, N.4    Frenay, M.5    Monnier, A.6
  • 221
    • 1442321230 scopus 로고
    • Double blind placebo controlled trial of oral clodronate in patients with bone metastases from breast cancer
    • Hulin MT, Beuzeboc P, Mauriac L, Clavel M, Barbet N, Frenay M, et al. Double blind placebo controlled trial of oral clodronate in patients with bone metastases from breast cancer. Ann Oncol 1994;5 (Suppl 8):198.
    • (1994) Ann. Oncol. , vol.5 , Issue.SUPPL. 8 , pp. 198
    • Hulin, M.T.1    Beuzeboc, P.2    Mauriac, L.3    Clavel, M.4    Barbet, N.5    Frenay, M.6
  • 223
    • 0035463593 scopus 로고    scopus 로고
    • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
    • Rosen LS, Gordon D, Kaminski M, Howell A, Belch A, Mackey J, et al. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial. Cancer 2001; 7:377-87.
    • (2001) Cancer , vol.7 , pp. 377-387
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3    Howell, A.4    Belch, A.5    Mackey, J.6
  • 224
    • 0037009822 scopus 로고    scopus 로고
    • A randomized, placebo-controlled trial of zoledronic acid in patients with hormone refractory metastatic prostate carcinoma
    • Saad F, Gleason DM, Murray R, Tchekmedyian S, Venner P, Lacombe L, et al. A randomized, placebo-controlled trial of zoledronic acid in patients with hormone refractory metastatic prostate carcinoma. J Natl Cancer Inst 2002; 94:1458-68.
    • (2002) J. Natl. Cancer Inst. , vol.94 , pp. 1458-1468
    • Saad, F.1    Gleason, D.M.2    Murray, R.3    Tchekmedyian, S.4    Venner, P.5    Lacombe, L.6
  • 225
    • 0027729779 scopus 로고
    • Bonefos efficacy in combined treatment of multiple myeloma
    • Abdulkadyrov KM, Bessmelisev SS. Bonefos efficacy in combined treatment of multiple myeloma. Terapeut Arkh 1993;65(12):70-2.
    • (1993) Terapeut. Arkh. , vol.65 , Issue.12 , pp. 70-72
    • Abdulkadyrov, K.M.1    Bessmelisev, S.S.2
  • 226
    • 0031876780 scopus 로고    scopus 로고
    • Long-term oral pamidronate treatment inhibits osteoclastic bone resorption and bone turnover without affecting osteoblastic function in multiple myeloma
    • Abildgaard N, Rungby J, Glerup H, Brixen K, Kassem M, Brincker H, et al. Long-term oral pamidronate treatment inhibits osteoclastic bone resorption and bone turnover without affecting osteoblastic function in multiple myeloma. Eur J Haematol 1998;61:128-34.
    • (1998) Eur. J. Haematol. , vol.61 , pp. 128-134
    • Abildgaard, N.1    Rungby, J.2    Glerup, H.3    Brixen, K.4    Kassem, M.5    Brincker, H.6
  • 227
    • 0024350364 scopus 로고
    • Clodronate therapy and metastatic bone disease in patients with prostatic carcinoma
    • Adami S, Mian M. Clodronate therapy and metastatic bone disease in patients with prostatic carcinoma. Recent Results Cancer Res 1989; 116:s67-s72.
    • (1989) Recent Results Cancer Res. , vol.116
    • Adami, S.1    Mian, M.2
  • 228
    • 0032857491 scopus 로고    scopus 로고
    • The effect of two different doses of oral clodronate on pain in patients with bone metastases
    • Arican A, Icli F, Akbulut H, Cakir M, Sencan O, Samur M, et al. The effect of two different doses of oral clodronate on pain in patients with bone metastases. Med Oncol 1999;16:204-10.
    • (1999) Med. Oncol. , vol.16 , pp. 204-210
    • Arican, A.1    Icli, F.2    Akbulut, H.3    Cakir, M.4    Sencan, O.5    Samur, M.6
  • 229
    • 0023230963 scopus 로고
    • Effects of a new aminodiphosphonate (aminohydroxybutylidene diphosphonate) in patients with osteolytic lesions from metastases and myelomatosis. Comparison with dichloromethylene diphosphonate
    • Attardo-Parrinello G, Merlini G, Pavesi F, Crema F, Fiorentini ML, Ascari E. Effects of a new aminodiphosphonate (aminohydroxybutylidene diphosphonate) in patients with osteolytic lesions from metastases and myelomatosis. Comparison with dichloromethylene diphosphonate. Arch Intern Med 1987;147:1629-33.
    • (1987) Arch. Intern. Med. , vol.147 , pp. 1629-1633
    • Attardo-Parrinello, G.1    Merlini, G.2    Pavesi, F.3    Crema, F.4    Fiorentini, M.L.5    Ascari, E.6
  • 230
    • 1442272169 scopus 로고    scopus 로고
    • Behandlung des hormonrefraktären Prostatakarzinomsmit schmerzhaften Knochenmetastasen
    • Ausgabe A. Behandlung des hormonrefraktären Prostatakarzinomsmit schmerzhaften Knochenmetastasen. Urologe 1997;36:568.
    • (1997) Urologe , vol.36 , pp. 568
    • Ausgabe, A.1
  • 233
    • 0030842843 scopus 로고    scopus 로고
    • High dose pamidronate: Clinical and biochemical effects in metastatic bone disease
    • Coleman RE, Purohit OP, Vinholes J, Zekri J. High dose pamidronate: clinical and biochemical effects in metastatic bone disease. Cancer 1997; 80:1686-90.
    • (1997) Cancer , vol.80 , pp. 1686-1690
    • Coleman, R.E.1    Purohit, O.P.2    Vinholes, J.3    Zekri, J.4
  • 234
    • 0032078278 scopus 로고    scopus 로고
    • A randomised phase II study of oral pamidronate for the treatment of bone metastases from breast cancer
    • Coleman RE, Houston SJ, Purohit OP, Rubens RD, Kandra A, Ford J. A randomised phase II study of oral pamidronate for the treatment of bone metastases from breast cancer. Eur J Cancer 1998; 34:820-4.
    • (1998) Eur. J. Cancer , vol.34 , pp. 820-824
    • Coleman, R.E.1    Houston, S.J.2    Purohit, O.P.3    Rubens, R.D.4    Kandra, A.5    Ford, J.6
  • 235
    • 0032956195 scopus 로고    scopus 로고
    • Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease
    • Coleman RE, Purohit OP, Black C, Vinholes JJ, Schlosser K, Huss H, et al. Double-blind, randomised, placebo-controlled, dose-finding study of oral ibandronate in patients with metastatic bone disease. Ann Oncol 1999; 10:311-16.
    • (1999) Ann. Oncol. , vol.10 , pp. 311-316
    • Coleman, R.E.1    Purohit, O.P.2    Black, C.3    Vinholes, J.J.4    Schlosser, K.5    Huss, H.6
  • 236
    • 0026057511 scopus 로고
    • Clodronate treatment increases serum osteocalcin in normocalcemic osteolytic bone metastases
    • Conte N, Di Virgilio R, Da Rin G, Roiter I, Pavan P, Legovini P, et al. Clodronate treatment increases serum osteocalcin in normocalcemic osteolytic bone metastases. Oncology 1991;48:54-7.
    • (1991) Oncology , vol.48 , pp. 54-57
    • Conte, N.1    Di Virgilio, R.2    Da Rin, G.3    Roiter, I.4    Pavan, P.5    Legovini, P.6
  • 237
    • 0027550862 scopus 로고
    • Pamidronato dissódico (APD) no tatamento das metástases ósseas
    • Costa L, Moreira C, Da Costa EB. Pamidronato dissódico (APD) no tatamento das metástases ósseas. [Disodium pamidronate (APD) in the treatment of bone metastases]. Acta Méd Port 1993;6:71-3.
    • (1993) Acta Méd. Port. , vol.6 , pp. 71-73
    • Costa, L.1    Moreira, C.2    Da Costa, E.B.3
  • 238
    • 0003295266 scopus 로고    scopus 로고
    • Preliminary evidence that oral clodronate delays symptomatic progression of bone metastases from prostate cancer: First results of the MRC Pr05 trial
    • Abs 693
    • Dearnaley DP, Sydes MR. Preliminary evidence that oral clodronate delays symptomatic progression of bone metastases from prostate cancer: first results of the MRC Pr05 trial. J Clin Oncol (ASCO) 2001;Abs 693.
    • (2001) J. Clin. Oncol. (ASCO)
    • Dearnaley, D.P.1    Sydes, M.R.2
  • 239
    • 0000846044 scopus 로고    scopus 로고
    • Improvement of bone pain, quality of life and survival time of breast cancer patients with metastatic bone disease treated with intravenous ibandronate
    • Diel IJ, Lichinitser MR, Body JJ, Schlosser K, Moecks J, Cavalli F, et al. Improvement of bone pain, quality of life and survival time of breast cancer patients with metastatic bone disease treated with intravenous ibandronate. Eur J Cancer 1999;35 (Suppl 4):S83.
    • (1999) Eur. J. Cancer , vol.35 , Issue.SUPPL. 4
    • Diel, I.J.1    Lichinitser, M.R.2    Body, J.J.3    Schlosser, K.4    Moecks, J.5    Cavalli, F.6
  • 240
    • 0026633284 scopus 로고
    • Effect of oral clodronate on bone pain. A controlled study in patients with metastatic prostate cancer
    • Elomaa I, Kylmala T, Tammela T, Viitanen J, Ottelin J, Ruutu M, et al. Effect of oral clodronate on bone pain. A controlled study in patients with metastatic prostate cancer. Int Urol Nephrol 1992;24:159-66.
    • (1992) Int. Urol. Nephrol. , vol.24 , pp. 159-166
    • Elomaa, I.1    Kylmala, T.2    Tammela, T.3    Viitanen, J.4    Ottelin, J.5    Ruutu, M.6
  • 241
    • 0007723637 scopus 로고    scopus 로고
    • Monitoring the action of clodronate with type I collagen metabolites in multiple myeloma
    • Elomaa I, Risteli L, Laakso M, Lahtinen R, Virkkunen P, Risteli J. Monitoring the action of clodronate with type I collagen metabolites in multiple myeloma. Eur J Cancer 1996;32A:1166-70.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 1166-1170
    • Elomaa, I.1    Risteli, L.2    Laakso, M.3    Lahtinen, R.4    Virkkunen, P.5    Risteli, J.6
  • 243
  • 245
    • 0034008718 scopus 로고    scopus 로고
    • Economic analysis of terminal care for patients with malignant osteolytic bone disease and pain treated with pamidronate
    • Gessner U, Koeberle D, Thuerlimann B, Bacchus L, Horisberger B. Economic analysis of terminal care for patients with malignant osteolytic bone disease and pain treated with pamidronate. Support Care Cancer 2000;8:115-22.
    • (2000) Support Care Cancer , vol.8 , pp. 115-122
    • Gessner, U.1    Koeberle, D.2    Thuerlimann, B.3    Bacchus, L.4    Horisberger, B.5
  • 246
    • 0033054489 scopus 로고    scopus 로고
    • Pamidronate treatment in patients with malignant osteolytic bone disease and pain: A prospective randomised double-blind trial
    • Koeberle D, Bacchus L, Thurlimann B, Senn HJ. Pamidronate treatment in patients with malignant osteolytic bone disease and pain: a prospective randomised double-blind trial. Support Care Cancer 1999;7:21-7.
    • (1999) Support Care Cancer , vol.7 , pp. 21-27
    • Koeberle, D.1    Bacchus, L.2    Thurlimann, B.3    Senn, H.J.4
  • 247
    • 0027473946 scopus 로고
    • Evaluation of the effect of oral clodronate on skeletal metastases with type 1 collagen metabolites
    • A controlled trial of the Finnish Prostate Cancer Group
    • Kylmala T, Tammela T, Risteli L, Risteli J, Taube T, Elomaa I. Evaluation of the effect of oral clodronate on skeletal metastases with type 1 collagen metabolites. A controlled trial of the Finnish Prostate Cancer Group. Eur J Cancer 1993;29A(6):821-5.
    • (1993) Eur. J. Cancer , vol.29 A , Issue.6 , pp. 821-825
    • Kylmala, T.1    Tammela, T.2    Risteli, L.3    Risteli, J.4    Taube, T.5    Elomaa, I.6
  • 248
    • 0030823523 scopus 로고
    • Concomitant IV and oral clodronate in the relief of bone pain - A double blind placebo controlled study in patients with prostate cancer
    • Kylmala T, Taube T, Tammela T, Risteli L, Risteli J, Elomaa I. Concomitant IV and oral clodronate in the relief of bone pain - a double blind placebo controlled study in patients with prostate cancer. Br J Cancer 1697;76:939-42.
    • (1697) Br. J. Cancer , vol.76 , pp. 939-942
    • Kylmala, T.1    Taube, T.2    Tammela, T.3    Risteli, L.4    Risteli, J.5    Elomaa, I.6
  • 249
    • 0028131861 scopus 로고
    • Pamidronate in the treatment of bone metastases: Results of 2 dose-ranging trials in patients with breast or prostate cancer
    • Lipton A, Glover D, Harvey H, Grabelsky S, Zelenakas K, Macerata R, et al. Pamidronate in the treatment of bone metastases: results of 2 dose-ranging trials in patients with breast or prostate cancer. Ann Oncol 1994;5 (Suppl 7):s31-s35.
    • (1994) Ann. Oncol. , vol.5 , Issue.SUPPL. 7
    • Lipton, A.1    Glover, D.2    Harvey, H.3    Grabelsky, S.4    Zelenakas, K.5    Macerata, R.6
  • 250
    • 0342347698 scopus 로고    scopus 로고
    • Zolendronate in the treatment of osteolytic bone metastases
    • Lipton A. Zolendronate in the treatment of osteolytic bone metastases. Br J Clin Pract Suppl 1996;87:21.
    • (1996) Br. J. Clin. Pract. Suppl. , vol.87 , pp. 21
    • Lipton, A.1
  • 252
    • 0025215416 scopus 로고
    • Long-term effects of parenteral dichloromethylene bisphosphonate (CL2MBP) on bone disease of myeloma patients treated with chemotherapy
    • Merlini G, Parrinello GA, Piccinini L, Crema F, Fiorentini ML, Riccardi A, et al. Long-term effects of parenteral dichloromethylene bisphosphonate (CL2MBP) on bone disease of myeloma patients treated with chemotherapy. Hematol Oncol 1990;8(1):23-30.
    • (1990) Hematol. Oncol. , vol.8 , Issue.1 , pp. 23-30
    • Merlini, G.1    Parrinello, G.A.2    Piccinini, L.3    Crema, F.4    Fiorentini, M.L.5    Riccardi, A.6
  • 253
    • 0032242962 scopus 로고    scopus 로고
    • Randomised trial of two intravenous schedules of bonefos (clodronate) in patients with painful bone metastases
    • Moiseenko VM, Blinov NN, Semiglazov VV, Konstantinova MM, Trishkina EA. Randomised trial of two intravenous schedules of bonefos (clodronate) in patients with painful bone metastases. Vopr Onkol 1998;44:725-8.
    • (1998) Vopr. Onkol. , vol.44 , pp. 725-728
    • Moiseenko, V.M.1    Blinov, N.N.2    Semiglazov, V.V.3    Konstantinova, M.M.4    Trishkina, E.A.5
  • 254
    • 0028941663 scopus 로고
    • Double-blind, placebo-controlled, dose-response trial of oral clodronate in patients with bone metastases
    • O'Rourke N, McCloskey E, Houghton F, Huss H, Kanis JA. Double-blind, placebo-controlled, dose-response trial of oral clodronate in patients with bone metastases. J Clin Oncol 1995;13:929-34.
    • (1995) J. Clin. Oncol. , vol.13 , pp. 929-934
    • O'Rourke, N.1    McCloskey, E.2    Houghton, F.3    Huss, H.4    Kanis, J.A.5
  • 255
    • 0030297676 scopus 로고    scopus 로고
    • Pyridinium cross-links in multiple myeloma: Correlation with clinical parameters and use for monitoring of intravenous clodronate therapy - A pilot study of the German Myeloma Treatment Group (GMTG)
    • Peest D, Deicher H, Fett W, Harms P, Braun HJ, Planker M, et al. Pyridinium cross-links in multiple myeloma: correlation with clinical parameters and use for monitoring of intravenous clodronate therapy - a pilot study of the German Myeloma Treatment Group (GMTG). Eur J Cancer 1996;32A:2053-7.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 2053-2057
    • Peest, D.1    Deicher, H.2    Fett, W.3    Harms, P.4    Braun, H.J.5    Planker, M.6
  • 256
    • 13144294096 scopus 로고    scopus 로고
    • A double blind randomised study of oral clodronate in the treatment of bone metastases from tumours poorly responsive to chemotherapy
    • Piga A, Bracci R, Ferretti B, Sandri P, Nortilli R, Acito L, et al. A double blind randomised study of oral clodronate in the treatment of bone metastases from tumours poorly responsive to chemotherapy. J Exp Clin Cancer Res 1998; 17:213-17.
    • (1998) J. Exp. Clin. Cancer Res. , vol.17 , pp. 213-217
    • Piga, A.1    Bracci, R.2    Ferretti, B.3    Sandri, P.4    Nortilli, R.5    Acito, L.6
  • 257
    • 0032609868 scopus 로고    scopus 로고
    • An experience with combined therapy of radiation and Bonephos for osteolytic metastases of breast cancer
    • Poliakov PI, Larionova NA, Bychenkov OA, Moskin VG. An experience with combined therapy of radiation and Bonephos for osteolytic metastases of breast cancer. Vopr Onkol 1999;45:311-13.
    • (1999) Vopr. Onkol. , vol.45 , pp. 311-313
    • Poliakov, P.I.1    Larionova, N.A.2    Bychenkov, O.A.3    Moskin, V.G.4
  • 258
    • 0023278729 scopus 로고
    • Efficacy of oral administration of etidronate disodium in maintaining normal serum calcium levels in previously hypercalcemic cancer patients
    • Ringenberg QS, Ritch PS. Efficacy of oral administration of etidronate disodium in maintaining normal serum calcium levels in previously hypercalcemic cancer patients. Clin Ther 1987;9:318-25.
    • (1987) Clin. Ther. , vol.9 , pp. 318-325
    • Ringenberg, Q.S.1    Ritch, P.S.2
  • 261
    • 0024557878 scopus 로고
    • Palliation of painful bone metastases from prostate cancer using sodium etidronate: Results of a randomised, prospective, double-blind, placebo-controlled study
    • Smith JA. Palliation of painful bone metastases from prostate cancer using sodium etidronate: results of a randomised, prospective, double-blind, placebo-controlled study. J Urol 1989;141:85-7.
    • (1989) J. Urol. , vol.141 , pp. 85-87
    • Smith, J.A.1
  • 262
    • 6844236996 scopus 로고    scopus 로고
    • The analgesic effect of clodronate compared with placebo in patients with painful bone metastases from prostatic cancer
    • Strang P, Nilsson S, Brandstedt S, Sehlin J, Borghede G, Varenhorst E, et al. The analgesic effect of clodronate compared with placebo in patients with painful bone metastases from prostatic cancer. Anticancer Res 1997;17:4717-22.
    • (1997) Anticancer Res. , vol.17 , pp. 4717-4722
    • Strang, P.1    Nilsson, S.2    Brandstedt, S.3    Sehlin, J.4    Borghede, G.5    Varenhorst, E.6
  • 263
    • 0027301738 scopus 로고
    • Comparative effects of clodronate and calcitonin on bone in metastatic breast cancer: A histomorphometric study
    • Taube T, Elomaa I, Blomqvist C, Beneton MN, Kanis JA. Comparative effects of clodronate and calcitonin on bone in metastatic breast cancer: a histomorphometric study. Eur J Cancer 1993;29A:1677-81.
    • (1993) Eur. J. Cancer , vol.29 A , pp. 1677-1681
    • Taube, T.1    Elomaa, I.2    Blomqvist, C.3    Beneton, M.N.4    Kanis, J.A.5
  • 264
    • 0028291835 scopus 로고
    • The effect of clodronate on bone in metastatic prostate cancer. Histomorphometric report of a double-blind randomised placebo-controlled study
    • Taube T, Kylmala T, Lamberg-Allardt C, Tammela T, Elomaa I. The effect of clodronate on bone in metastatic prostate cancer. Histomorphometric report of a double-blind randomised placebo-controlled study. Eur J Cancer 1994:30A:751-8.
    • (1994) Eur. J. Cancer , vol.30 A , pp. 751-758
    • Taube, T.1    Kylmala, T.2    Lamberg-Allardt, C.3    Tammela, T.4    Elomaa, I.5
  • 265
    • 0033744201 scopus 로고    scopus 로고
    • Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma
    • Terpos E, Palermos J, Tsionos K, Anargyrou K, Viniou N, Papassavas P, et al. Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma. Eur J Haematol 2000;65:331-6.
    • (2000) Eur. J. Haematol. , vol.65 , pp. 331-336
    • Terpos, E.1    Palermos, J.2    Tsionos, K.3    Anargyrou, K.4    Viniou, N.5    Papassavas, P.6
  • 266
    • 0028250531 scopus 로고
    • Pamidronate for pain control in patients with malignant osteolytic bone disease: A prospective dose effect study
    • Thurlimann B, Morant R, Jungi WF, Radziwill AJ. Pamidronate for pain control in patients with malignant osteolytic bone disease: a prospective dose effect study. Support Care Cancer 1994;2:61-5.
    • (1994) Support Care Cancer , vol.2 , pp. 61-65
    • Thurlimann, B.1    Morant, R.2    Jungi, W.F.3    Radziwill, A.J.4
  • 268
    • 7144264425 scopus 로고    scopus 로고
    • Relationships between biochemical and symptomatic response in a double-blind randomised trial of pamidronate for metastatic bone disease
    • Vinholes JJ, Purohit OP, Abbey ME, Eastell R, Coleman RE. Relationships between biochemical and symptomatic response in a double-blind randomised trial of pamidronate for metastatic bone disease. An Oncol 1997;8:1243-50.
    • (1997) An. Oncol. , vol.8 , pp. 1243-1250
    • Vinholes, J.J.1    Purohit, O.P.2    Abbey, M.E.3    Eastell, R.4    Coleman, R.E.5
  • 269
    • 0032896513 scopus 로고    scopus 로고
    • Assessment of bone response to systemic therapy in an EORTC trial: Preliminary experience with the use of collagen cross-link excretion
    • Vinholes J, Coleman R, Lacombe D, Rose C, Tubiana-Hulin M, Bastit P, et al. Assessment of bone response to systemic therapy in an EORTC trial: preliminary experience with the use of collagen cross-link excretion. Br J Cancer 1999; 80:221-8.
    • (1999) Br. J. Cancer , vol.80 , pp. 221-228
    • Vinholes, J.1    Coleman, R.2    Lacombe, D.3    Rose, C.4    Tubiana-Hulin, M.5    Bastit, P.6
  • 270
    • 80755153404 scopus 로고    scopus 로고
    • Randomised comparative clinical trial of treatment of bone metastatic diseases by infusion of palidronate and clodronate
    • Zhang L, Guan Z, He Y. Randomised comparative clinical trial of treatment of bone metastatic diseases by infusion of palidronate and clodronate. Chin J Cancer 1997;16:430-2.
    • (1997) Chin. J. Cancer , vol.16 , pp. 430-432
    • Zhang, L.1    Guan, Z.2    He, Y.3
  • 271
    • 0032762516 scopus 로고    scopus 로고
    • Treatment of metastatic bone pain with Bonin either alone or combined with chemotherapy
    • Zhang J, Chu Y, Xie S. Treatment of metastatic bone pain with Bonin either alone or combined with chemotherapy. Chin J Clin Oncol 1999; 26:762-4.
    • (1999) Chin. J. Clin. Oncol. , vol.26 , pp. 762-764
    • Zhang, J.1    Chu, Y.2    Xie, S.3
  • 272
    • 0032491037 scopus 로고    scopus 로고
    • Reduction in new metatases in breast cancer with adjuvant clodronate treatment
    • Diel IJ, Solomayer EF, Costa SD, et al. Reduction in new metatases in breast cancer with adjuvant clodronate treatment. N Engl J Med 1998; 339:357-63.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 357-363
    • Diel, I.J.1    Solomayer, E.F.2    Costa, S.D.3
  • 273
    • 0029968633 scopus 로고    scopus 로고
    • Does supportive pamidronate treatment prevent or delay the first manifestation of bone metastases in breast cancer patients?
    • Holten-Verzantvoort AT, Hermans J, Beex LV, Blijham G, Cleton FJ, Eck-Smit BC, et al. Does supportive pamidronate treatment prevent or delay the first manifestation of bone metastases in breast cancer patients? Eur J Cancer 1996;32A:450-4.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 450-454
    • Holten-Verzantvoort, A.T.1    Hermans, J.2    Beex, L.V.3    Blijham, G.4    Cleton, F.J.5    Eck-Smit, B.C.6
  • 274
    • 0030474026 scopus 로고    scopus 로고
    • Clodronate decreases the frequency of skeletal metastases in women with breast cancer
    • Kanis JA, Powles T, Paterson AH, McCloskey EV, Ashley S. Clodronate decreases the frequency of skeletal metastases in women with breast cancer. Bone 1996;19:663-7.
    • (1996) Bone , vol.19 , pp. 663-667
    • Kanis, J.A.1    Powles, T.2    Paterson, A.H.3    McCloskey, E.V.4    Ashley, S.5
  • 275
    • 0033870883 scopus 로고    scopus 로고
    • Adjuvant clodronate therapy in patients with locally advanced breast cancer - Long-term results of a double blind randomised trial
    • Mardiak J, Bohunicky L, Chovanec J, Salek T, Koza I. Adjuvant clodronate therapy in patients with locally advanced breast cancer - long-term results of a double blind randomised trial. Neoplasma 2000;47:177-80.
    • (2000) Neoplasma , vol.47 , pp. 177-180
    • Mardiak, J.1    Bohunicky, L.2    Chovanec, J.3    Salek, T.4    Koza, I.5
  • 276
    • 0036682211 scopus 로고    scopus 로고
    • Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer
    • Powles T, Paterson S, Kanis JA, McCloskey EV, Ashley S, Tidy A, et al. Randomized, placebo-controlled trial of clodronate in patients with primary operable breast cancer. J Clin Oncol 2002;20:3219-24.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 3219-3224
    • Powles, T.1    Paterson, S.2    Kanis, J.A.3    McCloskey, E.V.4    Ashley, S.5    Tidy, A.6
  • 277
    • 0035148170 scopus 로고    scopus 로고
    • Adjuvant clodronate treatment does not reduce skeletal metastases in node positive breast cancer
    • Saarto T, Blomqvist C, Virkkunen P, Elomaa I. Adjuvant clodronate treatment does not reduce skeletal metastases in node positive breast cancer. J Clin Oncol 2001;19:10-17.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 10-17
    • Saarto, T.1    Blomqvist, C.2    Virkkunen, P.3    Elomaa, I.4
  • 278
    • 0035960116 scopus 로고    scopus 로고
    • Pamidronate to prevent bone loss during androgen depravation therapy for prostate cancer
    • Smith MR, McGoven FJ, Zietman AL, et al. Pamidronate to prevent bone loss during androgen depravation therapy for prostate cancer. N Engl J Med 2001;345:948-55.
    • (2001) N. Engl. J. Med. , vol.345 , pp. 948-955
    • Smith, M.R.1    McGoven, F.J.2    Zietman, A.L.3
  • 279
    • 0001265235 scopus 로고    scopus 로고
    • Adjuvant treatment of breast cancer patients with the bisphosphonate clodronate reduces incidence and number of bone and non-bone metastases
    • Abs 461
    • Diel IJ, Solomayer EF, Goerner R, Gollan C, Wallweiner D, Bastea G. Adjuvant treatment of breast cancer patients with the bisphosphonate clodronate reduces incidence and number of bone and non-bone metastases. J Clin Oncol (ASCO) 1997; Abs 461.
    • (1997) J. Clin. Oncol. (ASCO)
    • Diel, I.J.1    Solomayer, E.F.2    Goerner, R.3    Gollan, C.4    Wallweiner, D.5    Bastea, G.6
  • 280
    • 1442345742 scopus 로고
    • Clodronate decreases the incidence of bone metastases in patients with advanced or metastatic breast cancer but no clinical evidence of bone metastases
    • Powles T, Tidy A, Ashley S, Kanis J, Paterson AD. Clodronate decreases the incidence of bone metastases in patients with advanced or metastatic breast cancer but no clinical evidence of bone metastases. Br J Cancer 1995;71 (Suppl 24):15.
    • (1995) Br. J. Cancer , vol.71 , Issue.SUPPL. 24 , pp. 15
    • Powles, T.1    Tidy, A.2    Ashley, S.3    Kanis, J.4    Paterson, A.D.5
  • 282
    • 0000292633 scopus 로고    scopus 로고
    • Adjuvant clodronate reduces the incidence of bone metastases in patients with primary operable breast cancer
    • Abs 468
    • Powles T, Paterson AH, Nevantaus A, Legault S, Pajunen M, Tidy A, et al. Adjuvant clodronate reduces the incidence of bone metastases in patients with primary operable breast cancer. J Clin Oncol (ASCO) 1998;Abs 468.
    • (1998) J. Clin. Oncol. (ASCO)
    • Powles, T.1    Paterson, A.H.2    Nevantaus, A.3    Legault, S.4    Pajunen, M.5    Tidy, A.6
  • 283
    • 0002873024 scopus 로고    scopus 로고
    • A placebo controlled trial of clodronate for prevention of bone metastases in patients with primary operable breast cancer
    • Powles T, Paterson S, Ashley S, Rosenqvist K, Tidy A, Nevantaus A, et al. A placebo controlled trial of clodronate for prevention of bone metastases in patients with primary operable breast cancer. Bone 2000;26 (3 Suppl):42S.
    • (2000) Bone , vol.26 , Issue.3 SUPPL.
    • Powles, T.1    Paterson, S.2    Ashley, S.3    Rosenqvist, K.4    Tidy, A.5    Nevantaus, A.6
  • 284
    • 1442321227 scopus 로고    scopus 로고
    • No reduction of bone metastases with adjuvent clodronate treatment in node-positive breast cancer patients
    • Abs 570
    • Saarto T, Blomqvist C, Virkkunen P, Elomaa I. No reduction of bone metastases with adjuvent clodronate treatment in node-positive breast cancer patients. J Clin Oncol (ASCO), 1999; Abs 570.
    • (1999) J. Clin. Oncol. (ASCO)
    • Saarto, T.1    Blomqvist, C.2    Virkkunen, P.3    Elomaa, I.4
  • 285
    • 24444440554 scopus 로고    scopus 로고
    • The effect of adjuvant clodronate on bone mineral density (BMD) in pre- and postmenopausal breast cancer patients. A randomized 5 year follow-up study
    • Vehmanen L, Saarto T, Blomqvist C, Virkkunen P, Elomaa I. The effect of adjuvant clodronate on bone mineral density (BMD) in pre- and postmenopausal breast cancer patients. A randomized 5 year follow-up study. Eur J Cancer 1999;35 (Suppl 4):S159.
    • (1999) Eur. J. Cancer , vol.35 , Issue.SUPPL. 4
    • Vehmanen, L.1    Saarto, T.2    Blomqvist, C.3    Virkkunen, P.4    Elomaa, I.5
  • 286
    • 0032490125 scopus 로고    scopus 로고
    • Oral clodronate and reduction in loss of bone mineral density in women with operable primary breast cancer
    • Powles T, McCloskey E, Paterson AH, Ashley S, Tidy A, Nevantaus A, et al. Oral clodronate and reduction in loss of bone mineral density in women with operable primary breast cancer. J Nat Cancer Inst 1998;90:704-8.
    • (1998) J. Nat. Cancer Inst. , vol.90 , pp. 704-708
    • Powles, T.1    McCloskey, E.2    Paterson, A.H.3    Ashley, S.4    Tidy, A.5    Nevantaus, A.6
  • 287
    • 0035196356 scopus 로고    scopus 로고
    • Long-term impact of chemotherapy induced ovarian failure on bone mineral density (BMD) in pre-menopausal breast cancer patients. The effect of adjuvant clodronate treatment
    • Vehmanen L, Saarto T, Elomaa I, Makela P, Valimaki M, Blomqvist C. Long-term impact of chemotherapy induced ovarian failure on bone mineral density (BMD) in pre-menopausal breast cancer patients. The effect of adjuvant clodronate treatment. Eur J Cancer 2001;37:2373-8.
    • (2001) Eur. J. Cancer , vol.37 , pp. 2373-2378
    • Vehmanen, L.1    Saarto, T.2    Elomaa, I.3    Makela, P.4    Valimaki, M.5    Blomqvist, C.6
  • 288
    • 0035917670 scopus 로고    scopus 로고
    • The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer
    • Saarto T, Vehmanen L, Elomaa I, Valimaki M, Makela P, Blomqvist C. The effect of clodronate and antioestrogens on bone loss associated with oestrogen withdrawal in postmenopausal women with breast cancer. Br J Cancer 2001;84:1047-51.
    • (2001) Br. J. Cancer , vol.84 , pp. 1047-1051
    • Saarto, T.1    Vehmanen, L.2    Elomaa, I.3    Valimaki, M.4    Makela, P.5    Blomqvist, C.6
  • 289
    • 0031003458 scopus 로고    scopus 로고
    • Chemical castration induced by adjuvant cyclophosphamide, methotrexate and fluorouracil chemotherapy causes rapid bone loss that is reduced by clodronate: A randomised study in premenopausal breast cancer patients
    • Saarto T, Blomqvist C, Valimaki M, Makela P, Sarna S, Elomaa I. Chemical castration induced by adjuvant cyclophosphamide, methotrexate and fluorouracil chemotherapy causes rapid bone loss that is reduced by clodronate: a randomised study in premenopausal breast cancer patients. J Clin Oncol 1997;15:1341-7.
    • (1997) J. Clin. Oncol. , vol.15 , pp. 1341-1347
    • Saarto, T.1    Blomqvist, C.2    Valimaki, M.3    Makela, P.4    Sarna, S.5    Elomaa, I.6
  • 290
    • 0031792448 scopus 로고    scopus 로고
    • Traitement adjuvant du cancer du sein localisé à haut risque de rechute: Et maintenant les diphosphonates
    • Blay JY. Traitement adjuvant du cancer du sein localisé à haut risque de rechute: et maintenant les diphosphonates. Bull Cancer 1998;85:741.
    • (1998) Bull. Cancer , vol.85 , pp. 741
    • Blay, J.Y.1
  • 292
    • 18544395211 scopus 로고    scopus 로고
    • Serum bone sialoprotein in patients with primary breast cancer is a prognostic marker for subsequent bone metastasis
    • Diel IJ, Solomayer EF, Seibel MJ, Pfeilschifter J, Maisenbacher H, Gollan C, et al. Serum bone sialoprotein in patients with primary breast cancer is a prognostic marker for subsequent bone metastasis. Clin Cancer Res 1999;5:3914-19.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 3914-3919
    • Diel, I.J.1    Solomayer, E.F.2    Seibel, M.J.3    Pfeilschifter, J.4    Maisenbacher, H.5    Gollan, C.6
  • 293
    • 0035819527 scopus 로고    scopus 로고
    • Development of matrix metalloproteinase inhibitors in cancer therapy
    • Hidalgo M, Eckhardt SG. Development of matrix metalloproteinase inhibitors in cancer therapy. J Nat Cancer Inst 2001;93:178-93.
    • (2001) J. Nat. Cancer Inst. , vol.93 , pp. 178-193
    • Hidalgo, M.1    Eckhardt, S.G.2
  • 294
    • 0032864675 scopus 로고    scopus 로고
    • MMP inhibition in prostate cancer
    • Lokeshwar BL. MMP inhibition in prostate cancer. Ann N Y Acad Sci 1999;878:271-89.
    • (1999) Ann. N. Y. Acad. Sci. , vol.878 , pp. 271-289
    • Lokeshwar, B.L.1
  • 295
    • 0027989597 scopus 로고
    • Randomized adjuvant breast cancer trials in Sweden
    • Rutqvist LE. Randomized adjuvant breast cancer trials in Sweden. Cancer 1994;74 (3 Suppl):I156-9.
    • (1994) Cancer , vol.74 , Issue.3 SUPPL.
    • Rutqvist, L.E.1
  • 296
    • 31344482625 scopus 로고    scopus 로고
    • Clodronate reduced the incidence of bony and visceral metastases in patients with breast cancer and tumour cells in the bone marrow
    • Smith TJ, Hillner BE. Clodronate reduced the incidence of bony and visceral metastases in patients with breast cancer and tumour cells in the bone marrow. Evid Based Med 1999;4:43.
    • (1999) Evid. Based Med. , vol.4 , pp. 43
    • Smith, T.J.1    Hillner, B.E.2
  • 297
    • 0033493953 scopus 로고    scopus 로고
    • Adjuvant systemic management of early stage carcinoma of the breast
    • Wolff AC, Abeloff MD. Adjuvant systemic management of early stage carcinoma of the breast. Surg Oncol 1999;8:93-101.
    • (1999) Surg. Oncol. , vol.8 , pp. 93-101
    • Wolff, A.C.1    Abeloff, M.D.2
  • 299
    • 0025344623 scopus 로고
    • Didronel IV met 100% korting (I)
    • Beijnen JH, Koks CHW. Didronel IV met 100% korting (I). Pharm Weekbl 1990;125:383-4.
    • (1990) Pharm. Weekbl. , vol.125 , pp. 383-384
    • Beijnen, J.H.1    Koks, C.H.W.2
  • 300
    • 0030908046 scopus 로고    scopus 로고
    • Pamidronate and metastatic breast disease
    • Kao G. Pamidronate and metastatic breast disease. N Engl J Med 1997;336:1609.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1609
    • Kao, G.1
  • 302
    • 0033038158 scopus 로고    scopus 로고
    • Impact budgétaire des anticancéreux et des médicaments des thérapeutiques adjuvantes depuis 10 ans à l'hôpital Saint-Louis
    • Madeline I, Berton B, Paubel P, Faure P. Impact budgétaire des anticancéreux et des médicaments des thérapeutiques adjuvantes depuis 10 ans à l'hôpital Saint-Louis. Haematologie 1999;5 (Suppl 1):89-91.
    • (1999) Haematologie , vol.5 , Issue.SUPPL. 1 , pp. 89-91
    • Madeline, I.1    Berton, B.2    Paubel, P.3    Faure, P.4
  • 303
    • 0034706802 scopus 로고    scopus 로고
    • Multiple myeloma: QALY gains from optimal therapy
    • Anon
    • Anon., Multiple myeloma: QALY gains from optimal therapy. Drugs Ther Perspect 2002;16:12-16.
    • (2002) Drugs Ther. Perspect. , vol.16 , pp. 12-16
  • 304
    • 0025043588 scopus 로고
    • Treating cancer associated hypercalcaemia
    • Consumers Association
    • Consumers Association. Treating cancer associated hypercalcaemia. Drug Ther Bull 1990;28:85-7.
    • (1990) Drug Ther. Bull. , vol.28 , pp. 85-87
  • 305
    • 0007354420 scopus 로고    scopus 로고
    • Cost effectiveness of pamidronate in the treatment of breast cancer in the metastatic and adjuvant setting
    • [meeting abstract 1599]
    • Balducci L. Cost effectiveness of pamidronate in the treatment of breast cancer in the metastatic and adjuvant setting [meeting abstract 1599]. Proc Am Soc Clin Oncol 1998;17:415a.
    • (1998) Proc. Am. Soc. Clin. Oncol. , vol.17
    • Balducci, L.1
  • 306
    • 0032956189 scopus 로고    scopus 로고
    • Economic impact of using clodronate in the management of patients with multiple myeloma
    • Bruce NJ, McCloskey EV, Kanis JA, Guest JF. Economic impact of using clodronate in the management of patients with multiple myeloma. Br J Haematol 1999;104:358-64.
    • (1999) Br. J. Haematol. , vol.104 , pp. 358-364
    • Bruce, N.J.1    McCloskey, E.V.2    Kanis, J.A.3    Guest, J.F.4
  • 307
    • 0034868916 scopus 로고    scopus 로고
    • Incremental cost analysis of ambulatory clinic and home-based intravenous therapy for patients with multiple myeloma
    • Coyte PC, Dobrow MJ, Broadfield L. Incremental cost analysis of ambulatory clinic and home-based intravenous therapy for patients with multiple myeloma. Pharmacoeconomics 2001;19:845-54.
    • (2001) Pharmacoeconomics , vol.19 , pp. 845-854
    • Coyte, P.C.1    Dobrow, M.J.2    Broadfield, L.3
  • 309
    • 0007772499 scopus 로고    scopus 로고
    • Economic assessment of clodronate in the preventive treatment of bone resorption in patients with metastatic breast cancer
    • Guignard E, Dardenne J, Pelc A, et al. Economic assessment of clodronate in the preventive treatment of bone resorption in patients with metastatic breast cancer. Eur J Cancer 1997; 33(Suppl 9):S25.
    • (1997) Eur. J. Cancer , vol.33 , Issue.SUPPL. 9
    • Guignard, E.1    Dardenne, J.2    Pelc, A.3
  • 310
    • 0033989198 scopus 로고    scopus 로고
    • Pamidronate in prevention of bone complications in metastatic breast cancer: A cost-effectiveness analysis
    • Hillner BE, Weeks JC, Desch CE, Smith TJ. Pamidronate in prevention of bone complications in metastatic breast cancer: a cost-effectiveness analysis. J Clin Oncol 2000;18:72-9.
    • (2000) J. Clin. Oncol. , vol.18 , pp. 72-79
    • Hillner, B.E.1    Weeks, J.C.2    Desch, C.E.3    Smith, T.J.4
  • 311
    • 1442345740 scopus 로고    scopus 로고
    • Cost-effectiveness of pamidronate in breast cancer patients with skeletal metastases
    • Marchetti N, Liberato NL, Tamburlini A, Barosi G. Cost-effectiveness of pamidronate in breast cancer patients with skeletal metastases. J Med Decis Making 2000;20:477.
    • (2000) J. Med. Decis. Making , vol.20 , pp. 477
    • Marchetti, N.1    Liberato, N.L.2    Tamburlini, A.3    Barosi, G.4
  • 312
    • 0026695060 scopus 로고
    • Symptomatic hypercalcaemia in lung cancer
    • Puolijoki H, Liippo K. Symptomatic hypercalcaemia in lung cancer. Respir Med 1992; 86:359-60.
    • (1992) Respir. Med. , vol.86 , pp. 359-360
    • Puolijoki, H.1    Liippo, K.2
  • 313
    • 0033804521 scopus 로고    scopus 로고
    • Use of bisphosphonates in skeletal metastases
    • Elomaa I. Use of bisphosphonates in skeletal metastases. Acta Oncol 2001;39:445-54.
    • (2001) Acta Oncol. , vol.39 , pp. 445-454
    • Elomaa, I.1
  • 314
    • 0032406920 scopus 로고    scopus 로고
    • The role of bisphosphonates in the treatment of painful metastatic bone disease: A review of phase III trials
    • Fulfaro F, Casuccio A, Ticozzi C, Ripamonti C. The role of bisphosphonates in the treatment of painful metastatic bone disease: a review of phase III trials. Pain 1998;78:157-69.
    • (1998) Pain , vol.78 , pp. 157-169
    • Fulfaro, F.1    Casuccio, A.2    Ticozzi, C.3    Ripamonti, C.4
  • 315
    • 0030058738 scopus 로고    scopus 로고
    • Formulary management of drugs for cancer-associated hypercalcaemia
    • Gallacher SJ. Formulary management of drugs for cancer-associated hypercalcaemia. Pharmacoeconomics 1996;9:39-50.
    • (1996) Pharmacoeconomics , vol.9 , pp. 39-50
    • Gallacher, S.J.1
  • 316
    • 0033948488 scopus 로고    scopus 로고
    • The role of bisphosphonates in metastatic breast cancer
    • Hillner BE. The role of bisphosphonates in metastatic breast cancer. Semin Radiat Oncol 2000;10:250-3.
    • (2000) Semin. Radiat. Oncol. , vol.10 , pp. 250-253
    • Hillner, B.E.1
  • 317
    • 0032432387 scopus 로고    scopus 로고
    • Use of bisphosphonates in the treatment of multiple myeloma
    • McCloskey EV, Libretto SE. Use of bisphosphonates in the treatment of multiple myeloma. Hematology 1998;3:291-8.
    • (1998) Hematology , vol.3 , pp. 291-298
    • McCloskey, E.V.1    Libretto, S.E.2
  • 318
    • 0034885581 scopus 로고    scopus 로고
    • The clinical and cost considerations of bisphosphonates in preventing bone complications in patients with metastatic breast cancer or multiple myeloma
    • McCloskey E, Guest JF, Kanis JA. The clinical and cost considerations of bisphosphonates in preventing bone complications in patients with metastatic breast cancer or multiple myeloma. Drugs 2001;61:1253-74.
    • (2001) Drugs , vol.61 , pp. 1253-1274
    • McCloskey, E.1    Guest, J.F.2    Kanis, J.A.3
  • 319
    • 0032088311 scopus 로고    scopus 로고
    • The role of bisphosphonates in malignant bone pain: A review
    • Pereira J, Mancini I, Walker P. The role of bisphosphonates in malignant bone pain: a review. J Palliative Care 1998;14:25-36.
    • (1998) J. Palliative Care , vol.14 , pp. 25-36
    • Pereira, J.1    Mancini, I.2    Walker, P.3
  • 320
    • 0027262605 scopus 로고
    • Parathyroid hormone related protein and response to pamidronate in tumor induced hypercalcaemia
    • Gurney H, Grill V, Martin TJ. Parathyroid hormone related protein and response to pamidronate in tumor induced hypercalcaemia. Lancet 1993;341:1611-13.
    • (1993) Lancet , vol.341 , pp. 1611-1613
    • Gurney, H.1    Grill, V.2    Martin, T.J.3
  • 321
    • 0028283787 scopus 로고
    • Response to intravenous bisphosphonate therapy in hypercalcaemic patients with and without bone metastases: The role of parathyroid hormone-related protein
    • Walls J, Ratcliffe WA, Howell A, Bundred NJ. Response to intravenous bisphosphonate therapy in hypercalcaemic patients with and without bone metastases: the role of parathyroid hormone-related protein. Br J Cancer 1994;70:169-72.
    • (1994) Br. J. Cancer , vol.70 , pp. 169-172
    • Walls, J.1    Ratcliffe, W.A.2    Howell, A.3    Bundred, N.J.4
  • 322
    • 0024241270 scopus 로고
    • Antibodies to parathyroid hormone related protein lower serum calcium in athymic mouse models of malignancy associated hypercalcaemia due to human tumours
    • Kukreja SC, Shevrin DH, Wimbiscus SA, Ebeling PR, Danks JA, Rodda CP, et al. Antibodies to parathyroid hormone related protein lower serum calcium in athymic mouse models of malignancy associated hypercalcaemia due to human tumours. J Clin Invest 1988;82:1798-802.
    • (1988) J. Clin. Invest. , vol.82 , pp. 1798-1802
    • Kukreja, S.C.1    Shevrin, D.H.2    Wimbiscus, S.A.3    Ebeling, P.R.4    Danks, J.A.5    Rodda, C.P.6
  • 323
    • 0034767727 scopus 로고    scopus 로고
    • Hypercalcaemia, parathyroid hormone-related protein and malignancy
    • Bayne MC, Illidge TM. Hypercalcaemia, parathyroid hormone-related protein and malignancy. Clin Oncol 2001;13:377.
    • (2001) Clin. Oncol. , vol.13 , pp. 377
    • Bayne, M.C.1    Illidge, T.M.2
  • 324
    • 1442272168 scopus 로고    scopus 로고
    • Decreased efficacy of bisphosphonates for recurrences of tumour-induced hypercalcaemia - Mechanisms and influence of tumour type
    • Abs 169
    • Body JJ, Louviaux I, Dumon JC. Decreased efficacy of bisphosphonates for recurrences of tumour-induced hypercalcaemia - mechanisms and influence of tumour type. J Clin Oncol. (ASCO) 1998; Abs 169.
    • (1998) J. Clin. Oncol. (ASCO)
    • Body, J.J.1    Louviaux, I.2    Dumon, J.C.3
  • 325
    • 1442345741 scopus 로고    scopus 로고
    • Bisphosphonate resistance in Paget's disease
    • Joshua F, Epstein M, Major G. Bisphosphonate resistance in Paget's disease. Bone 2000; 27 (4 Suppl):24S.
    • (2000) Bone , vol.27 , Issue.4 SUPPL.
    • Joshua, F.1    Epstein, M.2    Major, G.3
  • 327
    • 0027180815 scopus 로고
    • Prophylactic treatment of skeletal metastases, tumour-induced osteolysis and hypercalcaemia in rats with the bisphosphonate CL2MBP
    • Krempien B, Manegold C. Prophylactic treatment of skeletal metastases, tumour-induced osteolysis and hypercalcaemia in rats with the bisphosphonate CL2MBP. Cancer 1993;72:91-8.
    • (1993) Cancer , vol.72 , pp. 91-98
    • Krempien, B.1    Manegold, C.2
  • 329
    • 0023848941 scopus 로고
    • Protective effects of prophylactic treatment with APD on the development of tumour osteopathies in the rat: Experimental studies with the Walker carcinosarcoma 256
    • Krempien B, Wingen F, Eichmann T, Muller M, Schmahl D. Protective effects of prophylactic treatment with APD on the development of tumour osteopathies in the rat: experimental studies with the Walker carcinosarcoma 256. Oncology 1988;45:41-6.
    • (1988) Oncology , vol.45 , pp. 41-46
    • Krempien, B.1    Wingen, F.2    Eichmann, T.3    Muller, M.4    Schmahl, D.5
  • 330
    • 0024506261 scopus 로고
    • A randomised clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have oestrogen-receptor-positive tumours
    • Fisher B, Costantino J, Redmond C, Poisson R, Bowman D, Couture J, et al. A randomised clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have oestrogen-receptor-positive tumours. N Engl J Med 1989; 320(8):479-84.
    • (1989) N. Engl. J. Med. , vol.320 , Issue.8 , pp. 479-484
    • Fisher, B.1    Costantino, J.2    Redmond, C.3    Poisson, R.4    Bowman, D.5    Couture, J.6
  • 331
    • 0035282163 scopus 로고    scopus 로고
    • Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy
    • Braun S, Cevalti BS, Assemi C, Janni W, Kentenich CR, Schindlbeck C, et al. Comparative analysis of micrometastasis to the bone marrow and lymph nodes of node-negative breast cancer patients receiving no adjuvant therapy. J Clin Oncol 2001;19:1468-75.
    • (2001) J. Clin. Oncol. , vol.19 , pp. 1468-1475
    • Braun, S.1    Cevalti, B.S.2    Assemi, C.3    Janni, W.4    Kentenich, C.R.5    Schindlbeck, C.6
  • 332
    • 0035586112 scopus 로고    scopus 로고
    • NICE: Faster access to modern treatments? Analysis of guidance on health technologies
    • Raftery J. NICE: faster access to modern treatments? Analysis of guidance on health technologies. BMJ 2001; 323:1300-3.
    • (2001) BMJ , vol.323 , pp. 1300-1303
    • Raftery, J.1
  • 335
    • 0032749810 scopus 로고    scopus 로고
    • Therapeutic options in the treatment of multiple myeloma
    • Wisloff F, Gulbrandsen N, Nord E. Therapeutic options in the treatment of multiple myeloma. Pharmacoeconomics 1999;16:329-41.
    • (1999) Pharmacoeconomics , vol.16 , pp. 329-341
    • Wisloff, F.1    Gulbrandsen, N.2    Nord, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.