Alpha-2 adrenoceptor subtypes: Are more better?

British Journal of Pharmacology

Volumn 144, Issue 2, 2005, Pages 159-160

  Bylund, David B ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

Alpha 2 adrenergic receptors; Alpha 2 adrenoceptors; Nomenclature; Receptor subtypes; Zebrafish

Indexed keywords

2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2A ADRENERGIC RECEPTOR; ALPHA 2B ADRENERGIC RECEPTOR; ALPHA 2C ADRENERGIC RECEPTOR; ALPHA 2D ADRENERGIC RECEPTOR; CHLORPROMAZINE; NORADRENALIN; OXYMETAZOLINE; PERTUSSIS TOXIN; PRAZOSIN; RAUWOLSCINE; RECEPTOR SUBTYPE; SERINE; SPIROXATRINE; WB 4104; YOHIMBINE;

DRUG RECEPTOR BINDING; NOMENCLATURE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SPECIES DIFFERENCE; ZEBRA FISH;

ANIMALS; HUMANS; PROTEIN BINDING; RECEPTORS, ADRENERGIC, ALPHA-2;

EID: 13444257486     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706060     Document Type: Review

References (13)

1. 2. Br. J. Pharmacol., 141 (Suppl. 1), S9.
2. 2-adrenoceptors: pharmacological and molecular biological evidence converge. Trends Pharmacol. Sci., 9, 356-361.
3. BYLUND, D.B., EIKENBERG, D.C., HIEBLE, J.P., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P., MOLINOFF, P.B., RUFFOLO, R.R. & TRENDELENBURG, A.U. (1994). IV. International Union of Pharmacology Nomenclature of Adrenoceptors. Pharmacol. Rev., 46, 121-136.
4. 3H]rauwolscine. J. Neurochem., 51, 81-86.
5. GOLDSMITH, P. (2004). Zebrafish as a pharmacological tool: the how, why and when. Curr. Opin. Pharmacol., 4, 504-512.
6. KENAKIN, T. (2002). Drug efficacy at G protein-coupled receptors. Annu. Rev. Pharmacol. Toxicol., 42, 349-379.
7. LINK, R.E., DAUNT, D.A., BARSH, G.S., CHRUSCINSKI, A.J. & KOBILKA, B.K. (1992). Cloning of two mouse genes encoding alpha-2 adrenergic receptor subtypes and identification of a single amino acid in the mouse alpha-2C10 homolog responsible for an interspecies variation in antagonist binding. Mol. Pharmacol., 42, 16-27.
8. MA, P.M. (1997). Catecholaminergic systems in the zebrafish. III. Organization and projection pattern of medullary dopaminergic and noradrenergic neurons. J. Comp. Neurol., 381, 411-427.
9. 2A-pharmacology. J. Pharmacol. Exp. Ther., 298, 219-225.
10. O'ROURKE, M.F., IVERSEN, L.J., LOMASNEY, J.W. & BYLUND, D.B. (1994). Species orthologues of the alpha-2A adrenergic receptor: the pharmacological properties of the bovine and rat receptors differ from the human and porcine receptors. J. Pharmacol. Exp. Ther., 271, 735-740.
11. α-proteins. Biochem. Pharmacol., 61, 1079-1092.
12. 2-adrenoceptors. Br. J. Pharmacol., (in press).
13. 2A-adrenoceptor subtype by cloning and mapping of five receptor genes in zebrafish. Mol. Biol. Evol., 21, 14-28.