Gene-Environment Interactions and the Neurobiology of Social Conflict

Annals of the New York Academy of Sciences

Volumn 1008, Issue , 2003, Pages 132-139

  Suomi, Stephen J ^a  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

5 HAA; Gene environment interactions; Impulsive aggression; Rhesus monkeys

Indexed keywords

SEROTONIN; SEROTONIN TRANSPORTER;

AGGRESSIVENESS; ALCOHOL CONSUMPTION; ANIMAL BEHAVIOR; CONFERENCE PAPER; CONFLICT; DEVELOPMENTAL STAGE; ENVIRONMENTAL FACTOR; EXPERIENCE; GENE INTERACTION; GENETIC POLYMORPHISM; HEREDITY; HERITABILITY; IMPULSIVENESS; LIFESPAN; MOTHER CHILD RELATION; NEUROBIOLOGY; NONHUMAN; RHESUS MONKEY; SEROTONIN METABOLISM; SOCIAL BEHAVIOR; SOCIAL INTERACTION; SOCIOBIOLOGY; STRESS;

ANIMALIA; MACACA MULATTA;

EID: 1342347748     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1196/annals.1301.014     Document Type: Conference Paper

References (27)

1. LORENZ, K. 1966. On Aggression. Harcourt, Brace, & World. New York.
2. SUOMI, S.J. 2000. A biobehavioral perspective on developmental psychopathology: excessive aggression and serotonergic dysfunction in monkeys. In Handbook of Developmental Psychopathology. A. J. Sameroff, M. Lewis, and S. Miller, Eds.: 237-256. Plenum Press. New York.
3. SUOMI, S.J. 1991. Up-tight and laid-back monkeys: individual differences in the response to social challenges. In Plasticity of Development. S. Brauth, W. Hall, and R. Dooling, Eds.: 27-56. MIT Press. Cambridge, MA.
4. HIGLEY, J.D. & S.J. SUOMI. 1996. Reactivity and social competence affect individual differences in reaction to severe stress in children: investigations using nonhuman primates. In Intense Stress and Dental Disturbance in Children. C. R. Pfeffer, Ed.: 3-58. American Psychiatric Press. Washington, DC.
5. MEHLMAN, P.T., J.D. HIGLEY, I. FAUCHER, et al. 1994. Low cerebrospinal fluid 5-hydroxyindoleacetic acid concentrations are correlated with severe aggression and reduced impulse control in free-ranging primates. Am. J. Psychiatry 151: 1485-1491.
6. HIGLEY, J.D., P.T. MEHLMAN, D.M. TAUB, et al. 1992. Cerebrospinal fluid monoamine metabolite and adrenal correlates of aggression in free-ranging rhesus monkeys. Arch. Gen. Psychiatry 49: 436-444.
7. HIGLEY, J.D., S.J. SUOMI & M. LINNOILA. 1992. A longitudinal assessment of CSF monoamine metabolite and plasma cortisol concentrations in young rhesus monkeys. Biol. Psychiatry 32: 127-145.
8. SUOMI, S.J. 2003. How gene-environment interactions can shape the development of socioemotional regulation in rhesus monkeys. In Socioemotional Regulation: Dimensions, Developmental Trends, and Influences. B.S. Zuckerman and A.F. Lieberman, Eds.: in press. Johnson & Johnson. Skillman, NJ.
9. CHAMPOUX, M., S.J. SUOMI & M.L. SCHNEIDER. 1994. Temperamental differences between captive Indian and Chinese-Indian hybrid rhesus macaque infants. Lab. Anim. Sci. 44: 351-357.
10. BENNETT, A.J., T. TSAI, W.D. HOPKINS, et al. 1999. Early social rearing environment influences acquisition of a computerized joystick task in rhesus monkeys (Macaca mulatta). Am. J. Primatol. 49: 33-34.
11. ZAJICEK, K., J.D. HIGLEY, S.J. SUOMI & M. LINNOILA. 1997. Rhesus macaques with high CSF 5-HIAA concentrations exhibit early sleep onset. Psychiatr. Res. 77: 15-25.
12. DOUDET, D., D. HOMMER, J.D. HIGLEY, et al. 1995. Cerebral glucose metabolism, CSF 5-HIAA, and aggressive behavior in rhesus monkeys. Am. J. Psychiatry 152: 1782-1787.
13. HIGLEY, J.D., M.L. HASERT, S.J. SUOMI & M. LINNOILA. 1991. A new nonhuman primate model of alcohol abuse: effects of early experience, personality, and stress on alcohol consumption. Proc. Natl. Acad. Sci. USA 88: 7261-7265.
14. HEINZ, A., J.D. HIGLEY, J.G. GOREY, et al. 1998. In vivo association between alcohol intoxication, aggression, and serotonin transporter availability in nonhuman primates. Am. J. Psychiatry 155: 1023-1028.
15. MEHLMAN, P.T., J.D. HIGLEY, I. FAUCHER, et al. 1995. CSF 5-HIAA concentrations are correlated with sociality and the timing of emigration in free-ranging primates. Am. J. Psychiatry 152: 901-913.
16. HIGLEY, J.D., P.T. MEHLMAN, D.M. TAUB, et al. 1996. Excessive mortality in young free-ranging male nonhuman primates with low CSF 5-HIAA concentrations. Arch. Gen. Psychiatry 53: 537-543.
17. HIGLEY, J.D., S.T. KING, M.F. HASERT, et al. 1996. Stability of individual differences in serotonin function and its relationship to severe aggression and competent social behavior in rhesus macaque females. Neuropsychopharmachology 14: 67-76.
18. HIGLEY, J.D., W.T. THOMPSON, M. CHAMPOUX, et al. 1993. Paternal and maternal genetic and environmental contributions to CSF monoamine metabolites in rhesus monkeys (Macaca mulatta). Arch. Gen. Psychiatry 50: 615-623.
19. HIGLEY, J.D., S.J. SUOMI & M. LINNOILA. 1996. A nonhuman primate model of Type II alcoholism? Part 2: Diminished social competence and excessive aggression correlates with low CSF 5-HIAA concentrations. Alcohol. Clin. Exp. Res. 20: 643-650.
20. LESCH, L.P., J. MEYER, K. GLATZ, et al. 1997. The 5-HT gene-linked polymorphic region (5-HTTLPR) in evolutionary perspective: alternative biallelic variation in rhesus monkeys. J. Neural Transm. 104: 1259-1266.
21. HEILS, A. A. TEUFEL, S. PETRI, et al. 1996. Allelic variation of human serotonin transporter gene expression. J. Neurochem. 6: 2621-2624.
22. BENNETT, A.J., K.P. LESCH, A. HEILS, et al. 2002. Early experience and serotonin transporter gene variation interact to influence primate CNS function. Mol. Psychiatry 17: 118-122.
23. BARR, C.S., T.K. NEWMAN, M.L. BECKER, et al. 2003. Early experience and rh5-HTTPLR genotype interact to influence social behavior and aggression in nonhuman primates. Genes, Brain Behav. In press.
24. CHAMPOUX, M., A.J. BENNETT, K.P. LESCH, et al. 2002. Serotonin transporter gene polymorphism and neurobehavioral development in rhesus monkey neonates. Mol. Psychiatry 7: 1058-1063.
25. BENNETT, A.J., K.P. LESCH, A. HEILS & M. LINNOILA. 1998. Serotonin transporter gene variation, CSF 5-HIAA concentrations, and alcohol-related aggression in rhesus monkeys (Macaca mulatta). Am. J. Primatol. 45: 168-169.
26. BARR, C.S., T.K. NEWMAN, M.L. BECKER, et al. 2003. Serotonin transporter gene variation is associated with alcohol sensitivity in rhesus macaques exposed to early-life stress. Alcohol. Clin. Exp. Res. 27: 812-817.
27. SUOMI, S.J. 1999. Attachment in rhesus monkeys. In Handbook of Attachment: Theory, Research, and Clinical Applications. J. Cassidy and P.R. Shaver, Eds.: 181-197. Guilford Press. New York.