-
1
-
-
0028174061
-
Function and activation of NF-κB in the immune system
-
Baeuerle P.A., Henkel T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12:1994;141-179.
-
(1994)
Annu. Rev. Immunol.
, vol.12
, pp. 141-179
-
-
Baeuerle, P.A.1
Henkel, T.2
-
3
-
-
0029874138
-
The NF-κB and IκB proteins: New discoveries and insights
-
Baldwin A.S. Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14:1996;649-683.
-
(1996)
Annu. Rev. Immunol.
, vol.14
, pp. 649-683
-
-
Baldwin, A.S.Jr.1
-
4
-
-
0031897632
-
NF-κB and Rel proteins: Evolutionarily conserved mediators of immune responses
-
Ghosh S., May M.J., Kopp E.B. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:1998;225-260.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 225-260
-
-
Ghosh, S.1
May, M.J.2
Kopp, E.B.3
-
5
-
-
0033596120
-
Regulation of DNA binding by Rel/NF-κB transcription factors: Structural views
-
Chen F.E., Ghosh G. Regulation of DNA binding by Rel/NF-κB transcription factors: structural views. Oncogene. 18:1999;6845-6852.
-
(1999)
Oncogene
, vol.18
, pp. 6845-6852
-
-
Chen, F.E.1
Ghosh, G.2
-
6
-
-
0037376895
-
NF-κB in cancer: A marked target
-
Lin A., Karin M. NF-κB in cancer: a marked target. Semin Cancer Biol. 13:2003;107-114.
-
(2003)
Semin Cancer Biol.
, vol.13
, pp. 107-114
-
-
Lin, A.1
Karin, M.2
-
7
-
-
0033537675
-
Selection and characterization of an RNA decoy for transcription factor NF-κB
-
Lebruska L.L., Maher L.J. III Selection and characterization of an RNA decoy for transcription factor NF-κB. Biochemistry. 38:1999;3168-3174.
-
(1999)
Biochemistry
, vol.38
, pp. 3168-3174
-
-
Lebruska, L.L.1
Maher III, L.J.2
-
8
-
-
0037390035
-
Yeast genetic selections to optimize RNA decoys for transcription factor NF-κB
-
Genetic selection in yeast was used to optimize an in vitro selected RNA aptamer for active NF-κB binding. RNA aptamers derived using these methods exhibit enhanced NF-κB inhibitory activity in yeast. This study illustrates the power of combining both in vitro chemical and in vivo genetic selection techniques to optimize RNA aptamer biological activities.
-
Cassiday L.A., Maher L.J. III Yeast genetic selections to optimize RNA decoys for transcription factor NF-κB. Proc. Natl. Acad. Sci. USA. 100:2003;3930-3935 Genetic selection in yeast was used to optimize an in vitro selected RNA aptamer for active NF-κB binding. RNA aptamers derived using these methods exhibit enhanced NF-κB inhibitory activity in yeast. This study illustrates the power of combining both in vitro chemical and in vivo genetic selection techniques to optimize RNA aptamer biological activities.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 3930-3935
-
-
Cassiday, L.A.1
Maher III, L.J.2
-
9
-
-
0035957109
-
In vivo recognition of an RNA aptamer by its transcription factor target
-
Cassiday L.A., Maher L.J. III In vivo recognition of an RNA aptamer by its transcription factor target. Biochemistry. 40:2001;2433-2438.
-
(2001)
Biochemistry
, vol.40
, pp. 2433-2438
-
-
Cassiday, L.A.1
Maher III, L.J.2
-
10
-
-
0042925463
-
2 complexed to a high-affinity RNA aptamer
-
This paper reports the X-ray crystal structure of the NF-κB p50 RHR-RNA aptamer complex at 2.45 Å resolution. The structure is presented in detail, with a focus on the nucleic acid stereochemistry and protein-RNA interface.
-
2 complexed to a high-affinity RNA aptamer. Proc. Natl. Acad. Sci. USA. 100:2003;9268-9273 This paper reports the X-ray crystal structure of the NF-κB p50 RHR-RNA aptamer complex at 2.45 Å resolution. The structure is presented in detail, with a focus on the nucleic acid stereochemistry and protein-RNA interface.
-
(2003)
Proc. Natl. Acad. Sci. USA
, vol.100
, pp. 9268-9273
-
-
Huang, D.B.1
Vu, D.2
Cassiday, L.A.3
Zimmerman, J.M.4
Maher III, L.J.5
Ghosh, G.6
-
11
-
-
0028979476
-
Structure of the NF-κB p50 homodimer bound to DNA
-
Müller C.W., Rey F.A., Sodeoka M., Verdine G.L., Harrison S.C. Structure of the NF-κB p50 homodimer bound to DNA. Nature. 373:1995;311-317.
-
(1995)
Nature
, vol.373
, pp. 311-317
-
-
Müller, C.W.1
Rey, F.A.2
Sodeoka, M.3
Verdine, G.L.4
Harrison, S.C.5
-
12
-
-
0028979479
-
Structure of NF-κB p50 homodimer bound to a κb site
-
Ghosh G., van Duyne G., Ghosh S., Sigler P.B. Structure of NF-κB p50 homodimer bound to a κB site. Nature. 373:1995;303-310.
-
(1995)
Nature
, vol.373
, pp. 303-310
-
-
Ghosh, G.1
Van Duyne, G.2
Ghosh, S.3
Sigler, P.B.4
-
14
-
-
0032556894
-
Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA
-
Chen F.E., Huang D.B., Chen Y.Q., Ghosh G. Crystal structure of p50/p65 heterodimer of transcription factor NF-κB bound to DNA. Nature. 391:1998;410-413.
-
(1998)
Nature
, vol.391
, pp. 410-413
-
-
Chen, F.E.1
Huang, D.B.2
Chen, Y.Q.3
Ghosh, G.4
-
15
-
-
0037025395
-
The κb DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription
-
Chen-Park F.E., Huang D.B., Noro B., Thanos D., Ghosh G. The κB DNA sequence from the HIV long terminal repeat functions as an allosteric regulator of HIV transcription. J. Biol. Chem. 277:2002;24701-24708.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 24701-24708
-
-
Chen-Park, F.E.1
Huang, D.B.2
Noro, B.3
Thanos, D.4
Ghosh, G.5
-
16
-
-
0030723630
-
Structure of the human NF-κB p52 homodimer-DNA complex at 2.1 Å resolution
-
Cramer P., Larson C.J., Verdine G.L., Müller C.W. Structure of the human NF-κB p52 homodimer-DNA complex at 2.1. Å resolution EMBO J. 16:1997;7078-7090.
-
(1997)
EMBO J.
, vol.16
, pp. 7078-7090
-
-
Cramer, P.1
Larson, C.J.2
Verdine, G.L.3
Müller, C.W.4
-
17
-
-
0031964687
-
A novel DNA recognition mode by the NF-κB p65 homodimer
-
Chen Y.Q., Ghosh S., Ghosh G. A novel DNA recognition mode by the NF-κB p65 homodimer. Nat. Struct. Biol. 5:1998;67-73.
-
(1998)
Nat. Struct. Biol.
, vol.5
, pp. 67-73
-
-
Chen, Y.Q.1
Ghosh, S.2
Ghosh, G.3
-
18
-
-
0034654832
-
NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets
-
Chen Y.Q., Sengchanthalangsy L.L., Hackett A., Ghosh G. NF-κB p65 (RelA) homodimer uses distinct mechanisms to recognize DNA targets. Structure. 8:2000;419-428.
-
(2000)
Structure
, vol.8
, pp. 419-428
-
-
Chen, Y.Q.1
Sengchanthalangsy, L.L.2
Hackett, A.3
Ghosh, G.4
-
19
-
-
0034892132
-
X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2
-
Huang D.B., Chen Y.Q., Ruetsche M., Phelps C.B., Ghosh G. X-ray crystal structure of proto-oncogene product c-Rel bound to the CD28 response element of IL-2. Structure. 9:2001;669-678.
-
(2001)
Structure
, vol.9
, pp. 669-678
-
-
Huang, D.B.1
Chen, Y.Q.2
Ruetsche, M.3
Phelps, C.B.4
Ghosh, G.5
-
20
-
-
0033544719
-
Stitching together RNA tertiary architectures
-
Hermann T., Patel D.J. Stitching together RNA tertiary architectures. J. Mol. Biol. 294:1999;829-849.
-
(1999)
J. Mol. Biol.
, vol.294
, pp. 829-849
-
-
Hermann, T.1
Patel, D.J.2
-
21
-
-
0034603154
-
Adaptive recognition by nucleic acid aptamers
-
Hermann T., Patel D.J. Adaptive recognition by nucleic acid aptamers. Science. 287:2000;820-825.
-
(2000)
Science
, vol.287
, pp. 820-825
-
-
Hermann, T.1
Patel, D.J.2
-
22
-
-
0034653899
-
RNA bulges as architectural and recognition motifs
-
Hermann T., Patel D.J. RNA bulges as architectural and recognition motifs. Structure. 8:2000;R47-R54.
-
(2000)
Structure
, vol.8
-
-
Hermann, T.1
Patel, D.J.2
-
23
-
-
0028500823
-
DNA binding by an amino acid residue in the C-terminal half of the Rel homology region
-
Liu J., Fan Q.R., Sodeoka M., Lane W.S., Verdine G.L. DNA binding by an amino acid residue in the C-terminal half of the Rel homology region. Chem. Biol. 1:1994;47-55.
-
(1994)
Chem. Biol.
, vol.1
, pp. 47-55
-
-
Liu, J.1
Fan, Q.R.2
Sodeoka, M.3
Lane, W.S.4
Verdine, G.L.5
-
24
-
-
0037098937
-
Binding stoichiometry of an RNA aptamer and its transcription factor target
-
The techniques of analytical ultracentrifugation and microelectrospray mass spectrometry were employed to determine the binding stoichiometry of an RNA aptamer and NF-κB p50 homodimer. Both methods predict a binding stoichiometry of one RNA aptamer per NF-κB dimer. Although this contradicts the stoichiometry observed in the complex crystal structure, it appears that each RNA aptamer binds independently to NF-κB p50 subunits and that the binding of two RNAs to one p50 homodimer facilitates crystallization.
-
Cassiday L.A., Lebruska L.L., Benson L.M., Naylor S., Owen W.G., Maher L.J. III Binding stoichiometry of an RNA aptamer and its transcription factor target. Anal. Biochem. 306:2002;290-297 The techniques of analytical ultracentrifugation and microelectrospray mass spectrometry were employed to determine the binding stoichiometry of an RNA aptamer and NF-κB p50 homodimer. Both methods predict a binding stoichiometry of one RNA aptamer per NF-κB dimer. Although this contradicts the stoichiometry observed in the complex crystal structure, it appears that each RNA aptamer binds independently to NF-κB p50 subunits and that the binding of two RNAs to one p50 homodimer facilitates crystallization.
-
(2002)
Anal. Biochem.
, vol.306
, pp. 290-297
-
-
Cassiday, L.A.1
Lebruska, L.L.2
Benson, L.M.3
Naylor, S.4
Owen, W.G.5
Maher III, L.J.6
-
26
-
-
0141780826
-
NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism
-
Sitcheran R., Cogdwell P.C., Baldwin A.S.J. NF-κB mediates inhibition of mesenchymal cell differentiation through a posttranscriptional gene silencing mechanism. Genes Dev. 17:2003;2368-2373.
-
(2003)
Genes Dev.
, vol.17
, pp. 2368-2373
-
-
Sitcheran, R.1
Cogdwell, P.C.2
Baldwin, A.S.J.3
-
27
-
-
0035024217
-
Mammalian expression cloning of two human trophoblast suppressors of major histocompatibility complex genes
-
Peyman J.A. Mammalian expression cloning of two human trophoblast suppressors of major histocompatibility complex genes. Am. J. Reprod. Immunol. 45:2001;382-392.
-
(2001)
Am. J. Reprod. Immunol.
, vol.45
, pp. 382-392
-
-
Peyman, J.A.1
-
28
-
-
0032499801
-
Three-dimensional structure of the Stat3β homodimer bound to DNA
-
Becker S., Groner B., Müller C.W. Three-dimensional structure of the Stat3β homodimer bound to DNA. Nature. 394:1998;145-151.
-
(1998)
Nature
, vol.394
, pp. 145-151
-
-
Becker, S.1
Groner, B.2
Müller, C.W.3
-
29
-
-
0032577678
-
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
-
Chen X., Vinkemeier U., Zhao Y., Jeruzalmi D., Darnell J.E. Jr., Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell. 93:1998;827-839.
-
(1998)
Cell
, vol.93
, pp. 827-839
-
-
Chen, X.1
Vinkemeier, U.2
Zhao, Y.3
Jeruzalmi, D.4
Darnell, J.E.Jr.5
Kuriyan, J.6
-
30
-
-
0141507041
-
An asymmetric NFAT1 dimer on a pseudo-palindromic κb-like DNA site
-
Jin L., Sliz P., Chen L., Macian F., Rao A., Hogan P.G., Harrison S.C. An asymmetric NFAT1 dimer on a pseudo-palindromic κB-like DNA site. Nat. Struct. Biol. 10:2003;807-811.
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 807-811
-
-
Jin, L.1
Sliz, P.2
Chen, L.3
MacIan, F.4
Rao, A.5
Hogan, P.G.6
Harrison, S.C.7
-
31
-
-
0031033293
-
Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc
-
Wolfe S.A., Zhou P., Dotsch V., Chen L., You A., Ho S.N., Crabtree G.R., Wagner G., Verdine G.L. Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. Nature. 385:1997;172-176.
-
(1997)
Nature
, vol.385
, pp. 172-176
-
-
Wolfe, S.A.1
Zhou, P.2
Dotsch, V.3
Chen, L.4
You, A.5
Ho, S.N.6
Crabtree, G.R.7
Wagner, G.8
Verdine, G.L.9
-
32
-
-
0027983669
-
Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumorigenic mutations
-
Cho Y., Gorina S., Jeffrey P.D., Pavletich N.P. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations. Science. 265:1994;346-355.
-
(1994)
Science
, vol.265
, pp. 346-355
-
-
Cho, Y.1
Gorina, S.2
Jeffrey, P.D.3
Pavletich, N.P.4
-
33
-
-
0035656688
-
Non-coding RNA genes and the modern RNA world
-
Eddy S.R. Non-coding RNA genes and the modern RNA world. Nat. Rev. Genet. 2:2001;919-929.
-
(2001)
Nat. Rev. Genet.
, vol.2
, pp. 919-929
-
-
Eddy, S.R.1
-
34
-
-
0035195942
-
Non-coding RNAs: The architects of eukaryotic complexity
-
Mattick J.S. Non-coding RNAs: the architects of eukaryotic complexity. EMBO Rep. 2:2001;986-991.
-
(2001)
EMBO Rep.
, vol.2
, pp. 986-991
-
-
Mattick, J.S.1
-
35
-
-
0036796374
-
Having it both ways: Transcription factors that bind DNA and RNA
-
An excellent review of evidence supporting the binding of some transcription factors to both DNA and RNA targets.
-
Cassiday L.A., Maher L.J. III Having it both ways: transcription factors that bind DNA and RNA. Nucleic Acids Res. 30:2002;4118-4126 An excellent review of evidence supporting the binding of some transcription factors to both DNA and RNA targets.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 4118-4126
-
-
Cassiday, L.A.1
Maher III, L.J.2
|