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Volumn 25, Issue 3, 2004, Pages 140-146

The heterogeneous course of drug transit through the body

Author keywords

[No Author keywords available]

Indexed keywords

CHAOTIC DYNAMICS; COMPARTMENT MODEL; DRUG ABSORPTION; DRUG DISPOSITION; DRUG EFFECT; DRUG MECHANISM; DRUG RELEASE; DRUG SOLUBILITY; FRACTAL ANALYSIS; GASTROINTESTINAL ABSORPTION; GASTROINTESTINAL TRANSIT; HUMAN; NONLINEAR SYSTEM; PHARMACODYNAMICS; PRIORITY JOURNAL; REVIEW; STOCHASTIC MODEL;

EID: 1342328081     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2004.01.008     Document Type: Article
Times cited : (24)

References (67)
  • 3
    • 33744544180 scopus 로고
    • Fractal reaction kinetics
    • Kopelman R. Fractal reaction kinetics. Science. 241:1988;1620-1626.
    • (1988) Science , vol.241 , pp. 1620-1626
    • Kopelman, R.1
  • 4
    • 0026458123 scopus 로고
    • Viscous fingering of HCl through gastric mucin
    • Bhaskar K.R., et al. Viscous fingering of HCl through gastric mucin. Nature. 360:1992;458-461.
    • (1992) Nature , vol.360 , pp. 458-461
    • Bhaskar, K.R.1
  • 5
    • 0025035031 scopus 로고
    • Microscopy of acid transport at the gastric surface in vivo
    • Holm L., Flemstrom G. Microscopy of acid transport at the gastric surface in vivo. J. Intern. Med. Suppl. 732:1990;91-95.
    • (1990) J. Intern. Med. Suppl. , vol.732 , pp. 91-95
    • Holm, L.1    Flemstrom, G.2
  • 6
    • 1342317550 scopus 로고
    • Three-dimensional fractals: Experimental measurements using capillary effects
    • Lenormand R., et al. Three-dimensional fractals: experimental measurements using capillary effects. Phys. Rev. A. 36:1987;1855-1858.
    • (1987) Phys. Rev. A. , vol.36 , pp. 1855-1858
    • Lenormand, R.1
  • 7
    • 0000092948 scopus 로고
    • Chemical dissolution of a porous medium by a reactive fluid
    • Daccord G. Chemical dissolution of a porous medium by a reactive fluid. Phys. Rev. Lett. 58:1987;479-482.
    • (1987) Phys. Rev. Lett. , vol.58 , pp. 479-482
    • Daccord, G.1
  • 8
    • 0000395880 scopus 로고
    • Fractal growth of viscous fingers - Quantitative characterization of a fluid instability phenomenon
    • Nittmann J., et al. Fractal growth of viscous fingers - quantitative characterization of a fluid instability phenomenon. Nature. 314:1985;141-144.
    • (1985) Nature , vol.314 , pp. 141-144
    • Nittmann, J.1
  • 9
    • 0030796952 scopus 로고    scopus 로고
    • Gastrointestinal drug absorption: Is it time to consider heterogeneity as well as homogeneity?
    • Macheras P., Argyrakis P. Gastrointestinal drug absorption: is it time to consider heterogeneity as well as homogeneity? Pharm. Res. 14:1997;842-847.
    • (1997) Pharm. Res. , vol.14 , pp. 842-847
    • MacHeras, P.1    Argyrakis, P.2
  • 10
    • 0032939195 scopus 로고    scopus 로고
    • Heterogeneous tube model for the study of small intestinal transit flow
    • Kalampokis A., et al. Heterogeneous tube model for the study of small intestinal transit flow. Pharm. Res. 16:1999;87-91.
    • (1999) Pharm. Res. , vol.16 , pp. 87-91
    • Kalampokis, A.1
  • 11
    • 0032750117 scopus 로고    scopus 로고
    • A heterogeneous tube model of intestinal drug absorption based on probabilistic concepts
    • Kalampokis A., et al. A heterogeneous tube model of intestinal drug absorption based on probabilistic concepts. Pharm. Res. 16:1999;1764-1769.
    • (1999) Pharm. Res. , vol.16 , pp. 1764-1769
    • Kalampokis, A.1
  • 12
    • 0034526971 scopus 로고    scopus 로고
    • Ursodeoxycholic acid modulates cyclosporin a oral absorption in liver transplant recipients
    • Caroli-Bosc F.X., et al. Ursodeoxycholic acid modulates cyclosporin A oral absorption in liver transplant recipients. Fundam. Clin. Pharmacol. 14:2000;601-609.
    • (2000) Fundam. Clin. Pharmacol. , vol.14 , pp. 601-609
    • Caroli-Bosc, F.X.1
  • 13
    • 0034753850 scopus 로고    scopus 로고
    • Time-dependent oral absorption models
    • Higaki K., et al. Time-dependent oral absorption models. J. Pharmacokinet. Pharmacodyn. 28:2001;109-128.
    • (2001) J. Pharmacokinet. Pharmacodyn. , vol.28 , pp. 109-128
    • Higaki, K.1
  • 14
    • 0030818251 scopus 로고    scopus 로고
    • A population growth model of dissolution
    • Dokoumetzidis A., Macheras P. A population growth model of dissolution. Pharm. Res. 14:1997;1122-1126.
    • (1997) Pharm. Res. , vol.14 , pp. 1122-1126
    • Dokoumetzidis, A.1    MacHeras, P.2
  • 15
    • 0032919130 scopus 로고    scopus 로고
    • Modeling of supersaturated dissolution data
    • Valsami G., et al. Modeling of supersaturated dissolution data. Int. J. Pharm. 181:1999;153-157.
    • (1999) Int. J. Pharm. , vol.181 , pp. 153-157
    • Valsami, G.1
  • 16
    • 0032862166 scopus 로고    scopus 로고
    • Does the dose-solubility ratio affect the mean dissolution time of drugs?
    • Lansky P., Weiss M. Does the dose-solubility ratio affect the mean dissolution time of drugs? Pharm. Res. 16:1999;1470-1476.
    • (1999) Pharm. Res. , vol.16 , pp. 1470-1476
    • Lansky, P.1    Weiss, M.2
  • 17
    • 0035404207 scopus 로고    scopus 로고
    • Modeling heterogeneity of properties and random effects in drug dissolution
    • Lansky P., Weiss M. Modeling heterogeneity of properties and random effects in drug dissolution. Pharm. Res. 18:2001;1061-1067.
    • (2001) Pharm. Res. , vol.18 , pp. 1061-1067
    • Lansky, P.1    Weiss, M.2
  • 18
    • 0043211980 scopus 로고    scopus 로고
    • Classification of dissolution profiles in terms of fractional dissolution rate and a novel measure of heterogeneity
    • Lansky P., Weiss M. Classification of dissolution profiles in terms of fractional dissolution rate and a novel measure of heterogeneity. J. Pharm. Sci. 92:2003;1632-1647.
    • (2003) J. Pharm. Sci. , vol.92 , pp. 1632-1647
    • Lansky, P.1    Weiss, M.2
  • 19
    • 0034058121 scopus 로고    scopus 로고
    • On the heterogeneity of drug dissolution and release
    • Macheras P., Dokoumetzidis A. On the heterogeneity of drug dissolution and release. Pharm. Res. 17:2000;108-112.
    • (2000) Pharm. Res. , vol.17 , pp. 108-112
    • MacHeras, P.1    Dokoumetzidis, A.2
  • 20
    • 0038537306 scopus 로고    scopus 로고
    • A reappraisal of drug release laws using Monte Carlo simulations: The prevalence of the Weibull function
    • Kosmidis K., et al. A reappraisal of drug release laws using Monte Carlo simulations: the prevalence of the Weibull function. Pharm. Res. 20:2003;988-995.
    • (2003) Pharm. Res. , vol.20 , pp. 988-995
    • Kosmidis, K.1
  • 21
    • 0142058495 scopus 로고    scopus 로고
    • Fractal kinetics in drug release from finite fractal matrices
    • Kosmidis K., et al. Fractal kinetics in drug release from finite fractal matrices. J. Chem. Phys. 119:2003;6373-6377.
    • (2003) J. Chem. Phys. , vol.119 , pp. 6373-6377
    • Kosmidis, K.1
  • 22
    • 0030932272 scopus 로고    scopus 로고
    • A general model for the origin of allometric scaling laws in biology
    • West G.B., et al. A general model for the origin of allometric scaling laws in biology. Science. 276:1997;122-126.
    • (1997) Science , vol.276 , pp. 122-126
    • West, G.B.1
  • 23
    • 0033522952 scopus 로고    scopus 로고
    • The fourth dimension of life: Fractal geometry and allometric scaling of organisms
    • West G.B., et al. The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science. 284:1999;1677-1679.
    • (1999) Science , vol.284 , pp. 1677-1679
    • West, G.B.1
  • 24
    • 0037255939 scopus 로고    scopus 로고
    • A tube model for transport and dispersion in the circulatory system based on the vascular fractal tree
    • Dokoumetzidis A., Macheras P. A tube model for transport and dispersion in the circulatory system based on the vascular fractal tree. Ann. Biomed. Eng. 31:2003;284-293.
    • (2003) Ann. Biomed. Eng. , vol.31 , pp. 284-293
    • Dokoumetzidis, A.1    MacHeras, P.2
  • 25
    • 0346497702 scopus 로고    scopus 로고
    • A physiologically based approach for the estimation of recirculatory parameters
    • Karalis V., et al. A physiologically based approach for the estimation of recirculatory parameters. J. Pharmacol. Exp. Ther. 308:2004;198-205.
    • (2004) J. Pharmacol. Exp. Ther. , vol.308 , pp. 198-205
    • Karalis, V.1
  • 27
    • 0034860603 scopus 로고    scopus 로고
    • Fractal volume of drug distribution: It scales proportionally to body mass
    • Karalis V., et al. Fractal volume of drug distribution: it scales proportionally to body mass. Pharm. Res. 18:2001;1056-1060.
    • (2001) Pharm. Res. , vol.18 , pp. 1056-1060
    • Karalis, V.1
  • 28
    • 0036001405 scopus 로고    scopus 로고
    • Drug disposition viewed in terms of the fractal volume of distribution
    • Karalis V., Macheras P. Drug disposition viewed in terms of the fractal volume of distribution. Pharm. Res. 19:2002;696-703.
    • (2002) Pharm. Res. , vol.19 , pp. 696-703
    • Karalis, V.1    MacHeras, P.2
  • 29
    • 12244310481 scopus 로고    scopus 로고
    • Multivariate statistics of disposition pharmacokinetic parameters for structurally unrelated drugs used in therapeutics
    • Karalis V., et al. Multivariate statistics of disposition pharmacokinetic parameters for structurally unrelated drugs used in therapeutics. Pharm. Res. 19:2002;1827-1834.
    • (2002) Pharm. Res. , vol.19 , pp. 1827-1834
    • Karalis, V.1
  • 30
    • 0041331749 scopus 로고    scopus 로고
    • Quantitative structure pharmacokinetic relationships for disposition parameters of cephalosporins
    • Karalis V., et al. Quantitative structure pharmacokinetic relationships for disposition parameters of cephalosporins. Eur. J. Pharm. Sci. 20:2003;115-123.
    • (2003) Eur. J. Pharm. Sci. , vol.20 , pp. 115-123
    • Karalis, V.1
  • 31
    • 0034774798 scopus 로고    scopus 로고
    • The rise and fall of compartmental analysis
    • Rescigno A. The rise and fall of compartmental analysis. Pharmacol. Res. 44:2001;337-342.
    • (2001) Pharmacol. Res. , vol.44 , pp. 337-342
    • Rescigno, A.1
  • 32
    • 0024457258 scopus 로고
    • Two exceptional sets of physiological clearance curves and their mathematical form: Test cases?
    • Wise M.E., Borsboom J.M. Two exceptional sets of physiological clearance curves and their mathematical form: test cases? Bull. Math. Biol. 51:1989;579-596.
    • (1989) Bull. Math. Biol. , vol.51 , pp. 579-596
    • Wise, M.E.1    Borsboom, J.M.2
  • 33
    • 0032469146 scopus 로고    scopus 로고
    • A general approach to non-Markovian compartmental models
    • Matis J.H., Wehrly T.E. A general approach to non-Markovian compartmental models. J. Pharmacokinet. Biopharm. 26:1998;437-456.
    • (1998) J. Pharmacokinet. Biopharm. , vol.26 , pp. 437-456
    • Matis, J.H.1    Wehrly, T.E.2
  • 34
    • 0028630752 scopus 로고
    • A non-Markovian model for calcium kinetics in the body
    • Weiss G.H., et al. A non-Markovian model for calcium kinetics in the body. J. Pharmacokinet. Biopharm. 22:1994;367-379.
    • (1994) J. Pharmacokinet. Biopharm. , vol.22 , pp. 367-379
    • Weiss, G.H.1
  • 35
    • 0029951003 scopus 로고    scopus 로고
    • A fractal approach to heterogeneous drug distribution: Calcium pharmacokinetics
    • Macheras P. A fractal approach to heterogeneous drug distribution: calcium pharmacokinetics. Pharm. Res. 13:1996;663-670.
    • (1996) Pharm. Res. , vol.13 , pp. 663-670
    • MacHeras, P.1
  • 36
    • 0033492871 scopus 로고    scopus 로고
    • The anomalous pharmacokinetics of amiodarone explained by nonexponential tissue trapping
    • Weiss M. The anomalous pharmacokinetics of amiodarone explained by nonexponential tissue trapping. J. Pharmacokinet. Biopharm. 27:1999;383-396.
    • (1999) J. Pharmacokinet. Biopharm. , vol.27 , pp. 383-396
    • Weiss, M.1
  • 37
    • 0030047234 scopus 로고    scopus 로고
    • Anomalous diffusion of water in biological tissues
    • Kopf M., et al. Anomalous diffusion of water in biological tissues. Biophys. J. 70:1996;2950-2958.
    • (1996) Biophys. J. , vol.70 , pp. 2950-2958
    • Kopf, M.1
  • 38
    • 0004145657 scopus 로고    scopus 로고
    • Stochastic population models. A compartmental perspective
    • Bickel P. et al. Springer Verlag
    • Matis J.H., Kiffe T.R. Stochastic population models. A compartmental perspective. Bickel P., et al. Lecture Notes in Statistics. Vol. 145:2000;17-37 Springer Verlag.
    • (2000) Lecture Notes in Statistics , vol.145 , pp. 17-37
    • Matis, J.H.1    Kiffe, T.R.2
  • 39
    • 0024724778 scopus 로고
    • Some generalized stochastic compartment models for digesta flow
    • Matis J.H., et al. Some generalized stochastic compartment models for digesta flow. Biometrics. 45:1989;703-720.
    • (1989) Biometrics , vol.45 , pp. 703-720
    • Matis, J.H.1
  • 40
    • 0035217874 scopus 로고    scopus 로고
    • A stochastic model describes the heterogeneous pharmacokinetics of cyclosporin
    • Claret L., et al. A stochastic model describes the heterogeneous pharmacokinetics of cyclosporin. J. Pharmacokinet. Pharmacodyn. 28:2001;445-463.
    • (2001) J. Pharmacokinet. Pharmacodyn. , vol.28 , pp. 445-463
    • Claret, L.1
  • 41
    • 0007684592 scopus 로고
    • Revision of the methodology in enzyme kinetics: A fractal approach
    • López-Quintela M., Casado J. Revision of the methodology in enzyme kinetics: a fractal approach. J. Theor. Biol. 139:1989;129-139.
    • (1989) J. Theor. Biol. , vol.139 , pp. 129-139
    • López-Quintela, M.1    Casado, J.2
  • 42
    • 0029134903 scopus 로고
    • Michaelis-Menten mechanism reconsidered: Implications of fractal kinetics
    • Savageau M.A. Michaelis-Menten mechanism reconsidered: implications of fractal kinetics. J. Theor. Biol. 176:1995;115-124.
    • (1995) J. Theor. Biol. , vol.176 , pp. 115-124
    • Savageau, M.A.1
  • 43
    • 0031853923 scopus 로고    scopus 로고
    • Development of fractal kinetic theory for enzyme-catalysed reactions and implications for the design of biochemical pathways
    • Savageau M.A. Development of fractal kinetic theory for enzyme-catalysed reactions and implications for the design of biochemical pathways. Biosystems. 47:1998;9-36.
    • (1998) Biosystems , vol.47 , pp. 9-36
    • Savageau, M.A.1
  • 44
    • 0036789480 scopus 로고    scopus 로고
    • Monte Carlo simulations of enzyme reactions in two dimensions: Fractal kinetics and spatial segregation
    • Berry H. Monte Carlo simulations of enzyme reactions in two dimensions: fractal kinetics and spatial segregation. Biophys. J. 83:2002;1891-1901.
    • (2002) Biophys. J. , vol.83 , pp. 1891-1901
    • Berry, H.1
  • 45
    • 41349104044 scopus 로고    scopus 로고
    • Fractal pharmacokinetics of the drug mibefradil in the liver
    • Fuite J., et al. Fractal pharmacokinetics of the drug mibefradil in the liver. Phys. Rev. E Stat. Nonlin. Soft Matter Phys. 66:2002;021904.
    • (2002) Phys. Rev. e Stat. Nonlin. Soft Matter Phys. , vol.66 , pp. 021904
    • Fuite, J.1
  • 46
    • 0032974197 scopus 로고    scopus 로고
    • Modeling pharmacokinetic/pharmacodynamic (PK/PD) relationships: Concepts and perspectives
    • Derendorf H., Meibohm B. Modeling pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives. Pharm. Res. 16:1999;176-185.
    • (1999) Pharm. Res. , vol.16 , pp. 176-185
    • Derendorf, H.1    Meibohm, B.2
  • 47
    • 0034948706 scopus 로고    scopus 로고
    • Nonlinear dynamics and chaos theory: Concepts and applications relevant to pharmacodynamics
    • Dokoumetzidis A., et al. Nonlinear dynamics and chaos theory: concepts and applications relevant to pharmacodynamics. Pharm. Res. 18:2001;415-426.
    • (2001) Pharm. Res. , vol.18 , pp. 415-426
    • Dokoumetzidis, A.1
  • 49
    • 12244304852 scopus 로고    scopus 로고
    • Chaos attractors of ventricular elastance to evaluate cardiac performance
    • Yambe T., et al. Chaos attractors of ventricular elastance to evaluate cardiac performance. Artif. Organs. 27:2003;104-107.
    • (2003) Artif. Organs , vol.27 , pp. 104-107
    • Yambe, T.1
  • 50
    • 0034782125 scopus 로고    scopus 로고
    • Effects of pharmacological adrenergic and vagal modulation on fractal heart rate dynamics
    • Tulppo M.P., et al. Effects of pharmacological adrenergic and vagal modulation on fractal heart rate dynamics. Clin. Physiol. 21:2001;515-523.
    • (2001) Clin. Physiol. , vol.21 , pp. 515-523
    • Tulppo, M.P.1
  • 51
    • 0033151558 scopus 로고    scopus 로고
    • Chaos and the transition to ventricular fibrillation: A new approach to antiarrhythmic drug evaluation
    • Weiss J.N., et al. Chaos and the transition to ventricular fibrillation: a new approach to antiarrhythmic drug evaluation. Circulation. 99:1999;2819-2826.
    • (1999) Circulation , vol.99 , pp. 2819-2826
    • Weiss, J.N.1
  • 52
    • 0034705040 scopus 로고    scopus 로고
    • Preventing ventricular fibrillation by flattening cardiac restitution
    • Garfinkel A., et al. Preventing ventricular fibrillation by flattening cardiac restitution. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6061-6066.
    • (2000) Proc. Natl. Acad. Sci. U. S. A. , vol.97 , pp. 6061-6066
    • Garfinkel, A.1
  • 53
    • 0036711265 scopus 로고    scopus 로고
    • Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity
    • Fenton F.H., et al. Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity. Chaos. 12:2002;852-892.
    • (2002) Chaos , vol.12 , pp. 852-892
    • Fenton, F.H.1
  • 54
    • 0034298181 scopus 로고    scopus 로고
    • Quantification of depth of anesthesia by nonlinear time series analysis of brain electrical activity
    • Widman G., et al. Quantification of depth of anesthesia by nonlinear time series analysis of brain electrical activity. Phys. Rev. E Stat. Phys. Plasmas Fluids Relat. Interdiscip Topics. 62:2000;4898-4903.
    • (2000) Phys. Rev. e Stat. Phys. Plasmas Fluids Relat. Interdiscip Topics , vol.62 , pp. 4898-4903
    • Widman, G.1
  • 55
    • 0032834572 scopus 로고    scopus 로고
    • Non-linear time series analysis of intracranial EEG recordings in patients with epilepsy-an overview
    • Lehnertz K. Non-linear time series analysis of intracranial EEG recordings in patients with epilepsy-an overview. Int. J. Psychophysiol. 34:1999;45-52.
    • (1999) Int. J. Psychophysiol. , vol.34 , pp. 45-52
    • Lehnertz, K.1
  • 56
    • 0033851361 scopus 로고    scopus 로고
    • Nonlinear EEG analysis and its potential role in epileptology
    • Elger C.E. Nonlinear EEG analysis and its potential role in epileptology. Epilepsia. 41:2000;S34-S38.
    • (2000) Epilepsia , vol.41
    • Elger, C.E.1
  • 57
    • 0033031617 scopus 로고    scopus 로고
    • Decreased chaos of midbrain dopaminergic neurons after serotonin denervation
    • Di Mascio M., et al. Decreased chaos of midbrain dopaminergic neurons after serotonin denervation. Neuroscience. 92:1999;237-243.
    • (1999) Neuroscience , vol.92 , pp. 237-243
    • Di Mascio, M.1
  • 58
    • 0032550169 scopus 로고    scopus 로고
    • Spontaneous epileptiform bursts and long-term potentiation in rat CA3 hippocampal slices induced by chaotic stimulation of mossy fibers
    • Ishizuka S., Hayashi H. Spontaneous epileptiform bursts and long-term potentiation in rat CA3 hippocampal slices induced by chaotic stimulation of mossy fibers. Brain Res. 790:1998;108-114.
    • (1998) Brain Res. , vol.790 , pp. 108-114
    • Ishizuka, S.1    Hayashi, H.2
  • 60
    • 0038738223 scopus 로고    scopus 로고
    • Modeling of bone formation and resorption mediated by parathyroid hormone: Response to estrogen/PTH therapy
    • Rattanakul C., et al. Modeling of bone formation and resorption mediated by parathyroid hormone: response to estrogen/PTH therapy. Biosystems. 70:2003;55-72.
    • (2003) Biosystems , vol.70 , pp. 55-72
    • Rattanakul, C.1
  • 61
    • 0034619688 scopus 로고    scopus 로고
    • Modeling the insulin-glucose feedback system: The significance of pulsatile insulin secretion
    • Tolic I.M., et al. Modeling the insulin-glucose feedback system: the significance of pulsatile insulin secretion. J. Theor. Biol. 207:2000;361-375.
    • (2000) J. Theor. Biol. , vol.207 , pp. 361-375
    • Tolic, I.M.1
  • 62
    • 0036965639 scopus 로고    scopus 로고
    • Nonlinear dynamics in clinical pharmacology: The paradigm of cortisol secretion and suppression
    • Dokoumetzidis A., et al. Nonlinear dynamics in clinical pharmacology: the paradigm of cortisol secretion and suppression. Br. J. Clin. Pharmacol. 54:2002;21-29.
    • (2002) Br. J. Clin. Pharmacol. , vol.54 , pp. 21-29
    • Dokoumetzidis, A.1
  • 63
    • 0035658567 scopus 로고    scopus 로고
    • A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia
    • Zuideveld K., et al. A set-point model with oscillatory behavior predicts the time course of 8-OH-DPAT-induced hypothermia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 281:2001;R2059-R2071.
    • (2001) Am. J. Physiol. Regul. Integr. Comp. Physiol. , vol.281
    • Zuideveld, K.1
  • 64
    • 0032893234 scopus 로고    scopus 로고
    • Biological variation of glucose and insulin includes a deterministic chaotic component
    • Kroll M.H. Biological variation of glucose and insulin includes a deterministic chaotic component. Biosystems. 50:1999;189-201.
    • (1999) Biosystems , vol.50 , pp. 189-201
    • Kroll, M.H.1
  • 65
    • 0036616571 scopus 로고    scopus 로고
    • Complexity and non-linear description of diurnal cortisol and growth hormone secretory patterns before and after sleep deprivation
    • Ilias I. Complexity and non-linear description of diurnal cortisol and growth hormone secretory patterns before and after sleep deprivation. Endocr. Regul. 36:2002;63-72.
    • (2002) Endocr. Regul. , vol.36 , pp. 63-72
    • Ilias, I.1
  • 66
    • 0032041942 scopus 로고    scopus 로고
    • Orderliness of hormone release patterns: A complementary measure to conventional pulsatile and circadian analyses
    • Veldhuis J.D., Pincus S.M. Orderliness of hormone release patterns: a complementary measure to conventional pulsatile and circadian analyses. Eur. J. Endocrinol. 138:1998;358-362.
    • (1998) Eur. J. Endocrinol. , vol.138 , pp. 358-362
    • Veldhuis, J.D.1    Pincus, S.M.2
  • 67
    • 0036172467 scopus 로고    scopus 로고
    • Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women
    • Veldhuis J.D., et al. Impact of estradiol supplementation on dual peptidyl drive of GH secretion in postmenopausal women. J. Clin. Endocrinol. Metab. 87:2002;859-866.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 859-866
    • Veldhuis, J.D.1


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