Mineral water fortified with folic acid, vitamins B6, B12 D and calcium improves folate status and decreases plasma homocysteine concentration in men and women

European Journal of Clinical Nutrition

Volumn 58, Issue 2, 2004, Pages 376-385

  Tapola, Niina S ^a   Karvonen, H M ^a   Niskanen, H M ^b   Sarkkinen, E S ^a  

^a Oy Foodfiles Ltd   (Finland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Calcium; Folate; Folic acid; Homocysteine; Humans; Mineral water

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; MAGNESIUM; MINERAL WATER; POTASSIUM; PYRIDOXINE; SODIUM; VITAMIN D;

ADULT; AGED; ALKALINE PHOSPHATASE BLOOD LEVEL; AMINO ACID BLOOD LEVEL; ARTICLE; BONE METABOLISM; CALCIUM EXCRETION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ENZYME ACTIVITY; ERYTHROCYTE; FEEDING BEHAVIOR; FEMALE; FINLAND; FOLIC ACID BLOOD LEVEL; FOOD COMPOSITION; HUMAN; INTERMETHOD COMPARISON; MALE; OUTPATIENT DEPARTMENT; RANDOMIZED CONTROLLED TRIAL; VITAMIN BLOOD LEVEL; VITAMIN SUPPLEMENTATION;

ADULT; BLOOD PRESSURE; CALCIUM, DIETARY; FEMALE; FOLIC ACID; FOOD, FORTIFIED; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; MINERAL WATERS; VITAMIN B COMPLEX; VITAMIN D;

EID: 1342310911     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1601795     Document Type: Article

References (35)

1. Ahola L (2001): Menetelmävalidointiraportti P-Homokysteiini (The method validation report P-homocysteine). Medix Laboratoriot Oy [in Finnish].
2. Arnesen E, Refsum H, Bonaa KH, Ueland PM, Forde OH & Nordrehaug JE (1995): Serum total homocysteine and coronary heart disease. Int. J. Epidemiol. 24, 704-709.
3. Boushey CJ, Beresford SAA, Omenn GS, Motulsky AG (1995): A quantitative assesment of plasma homocysteine as a risk factor for vascular disease. J. Am. Med. Assoc. 274, 1049-1057.
4. Brönstrup A, Hages M, Prinz-Langenohl R & Pietrzik K (1998): Effects of folic acid and combinations of folic acid and vitamin B-12 on plasma homocysteine concentrations in healthy, young women. Am. J. Clin. Nutr. 68, 1104-1110.
5. Brouwer IA, van Dusseldorp M, Thomas CMG, Duran M, Hautvast JGAJ, Eskes TKAB & Steegers-Theunissen RP (1999): Low-dose folic acid supplementation decreases plasma homocysteine concentrations: a randomised trial. Am. J. Clin. Nutr. 69, 99-104.
6. Centers for Disease Control and Prevention (1992): Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm. Rep. 41, 1-7.
7. Chanarin I (1994): Adverse effects of increased dietary folate. Relation to measures to reduce the incidence of neural tube defects. Clin. Invest. Med. 17, 244-252.
8. Delmas PD & Garnero P (1998): Biological markers of bone turnover in osteoporosis. In Osteoporosis, eds. JC Stevenson & R Linday, pp 117-136. London: Chapman & Hall.
9. Eikelboom JW, Lonn E, Genest Jr J, Hankey G & Yusuf S (1999): Homocyst(e)ine and cardiovascular disease: a critical review of the epidemiological evidence. Ann. Intern. Med. 131, 363-375.
10. Fardellone P, Brazier M, Kamel S, Guéris J, Graulet AM, Liénard J & Sebert JL (1998): Biochemical effects of calcium supplementation in postmenopausal women: influence of dietary calcium intake. Am. J. Clin. Nutr. 67, 1273-1278.
11. Ford ES, Smith SJ, Stroup DF, Steinberg KK, Mueller PW & Thacker SB (2002): Homocyst(e)ine and cardiovascular disease: a systematic review of the evidence with special emphasis on case-control studies and nested case-control studies. Int. J. Epidemiol. 31, 59-70.
12. Haapa E, Toponen T, Pietinen P & Räsnen L (1985): Annoskuvakirja (Portion size picture booklet). National Public Health Institute and Department of Nutrition, University of Helsinki [in Finnish].
13. Hammarsten G (1955): Klinisk kemi (Clinical chemistry) In Kliniska ladboratorionsmetoder, del V (in Swedish) (Clinical Laboratory Methods, Vol V), ed. G Hammarsten, pp 237-239. Södertälje [in Swedish]: AB Astra.
14. den Heijer M, Brouwer IA, Bos GM, Blom HJ, van der Put NM, Spaans AP, Rosendaal FR, Thomas CM, Haak HL, Wijermans PW & Gerrits WB (1998): Vitamin supplementation reduces blood homocysteine levels. A controlled trial in patients with venous thrombosis and healthy volunteers. Arterioscler. Thromb. Vasc. Biol. 18, 356-361.
15. Homocysteine Lowering Trialists' Collaboration (1998): Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 316, 894-898.
16. Kawano Y, Yoshimi H, Matsuoka H, Takishita S & Omae T (1998): Calcium supplementation in patients with essential hypertension: assessment by office, home and ambulatory blood pressure. J. Hypertens. 16, 1693-1699.
17. Kleemola P, Virtanen M & Pietinen P (1994): The 1992 dietary survey of Finnish adults. Publications of National Public Health Institute B2/1994. Helsinki: Academic Press.
18. Law M (2000): Fortifying food with folic acid. Semin. Thromb. Hemost. 26, 349-352.
19. Malinow MR, Duell PB, Hess DL, Anderson PH, Kruger WD, Phillipson BE, Gluckman RA, Block PC & Upson BM (1998): Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. N. Engl. J. Med. 338, 1009-1015.
20. Malinow MR, Duell PB, Irvin-Jones A, Upson BM & Graf EE (2000): Increased plasma homocyst(e)ine after withdrawal of ready-to-eat breakfast cereal from the diet: prevention by breakfast cereal providing 200 μg folic acid. J. Am. Coll. Nutr. 19, 452-457.
21. Molloy AM (2002): Folate bioavailability and health. Int. J. Vitam. Res. 72, 46-52.
22. National Public Health Institute (1998): The 1997 dietary survey of Finnish adults. Publications of National Public Health Institute B8/1998. Helsinki: Hakapaino Oy.
23. Nygård O, Nordrehaug JE, Refsum H, Ueland PM, Farstad M & Vollset SE (1997): Plasma homocysteine levels and mortality in patients with coronary artery diesease. N. Engl. J. Med. 337, 230-236.
24. Penttilä IM, Jokela AH, Viitala AJ, Heikkinen E, Nummi S, Pystynen P & Saastamoinen J (1975): Activities of aspartate and alanine aminotransferase and alkaline phosphatase in sera of healthy subjects. Scand. J. Clin. Lab. Invest. 35, 275-284.
25. Pietinen P, Hartman AM, Haapa E, Räsänen L, Haapakoski J, Palmgren J, Albanes D, Virtamo J & Huttunen JK (1988): Reproducibility and validity of dietary assessment instruments. I. A self-administered food use questionnaire with a portion size picture booklet. Am. J. Epidemiol. 128, 655-666.
26. Rader JI (2002): Folic acid fortification, folate status and plasma homocysteine. J. Nutr. 132, (Suppl), S2466-S2470.
27. Riddell LJ, Chisholm A, Williams S & Mann JI (2000): Dietary strategies for lowering homocysteine concentrations. Am. J. Clin. Nutr. 71, 1448-1454.
28. Schnyder G, Roffi M, Riccardo P, Flammer Y, Lange H, Eberli FR, Meier B, Turi ZG & Hess OM (2001): Decreased rate of coronary restenosis after lowering of plasma homocysteine levels. N. Engl. J. Med. 345, 1593-1600.
29. 6 on clinical outcome after percutaneous coronary intervention. The Swiss Heart Study: a randomized controlled trial. JAMA 288, 973-979.
30. Schorah CJ, Devitt H, Lucock M & Dowell AC (1998): The responsiveness of plasma homocysteine to small increases in dietary folic acid: primary care study. Eur. J. Clin. Nutr. 52, 407-411.
31. Taylor BV, Oudit GY & Evans M. (2000): Homocysteine, vitamins, and coronary artery disease. Comprehensive review of the literature. Can. Fam. Phys. 46, 2236-2245.
32. The Committee on Enzymes of the Scandinavian Society for Clinical Chemistry and Clinical Physiology (1974): Recommended methods for the determination of four enzymes in blood. Scand. J. Clin. Lab. Invest. 33, 291-306.
33. Venn BJ, Mann JI, Williams SM, Riddell LJ, Chisholm A, Harper MJ, Aitken W & Rossaak JI (2002): Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind intervention trial. Eur. J. Clin. Nutr. 56, 748-754.
34. Wald DS, Bishop L, Wald NJ, Law M, Hennessy E, Weir D, McPartlin J & Scott J (2001): Randomized trial of folic acid supplementation and serum homocysteine levels. Arch. Intern. Med. 161, 695-700.
35. Williams CP, Child DF, Hudson PR, Davies GK, John R, Anandaram PS & De Bolla AR (2001): Why oral calcium supplements may reduce renal stone disease: report of pilot study. J. Clin. Pathol. 54, 54-62.