Central nervous α1-adrenoceptor stimulation induces duodenal luminal release of melatonin

Journal of Pineal Research

Volumn 36, Issue 2, 2004, Pages 103-108

  Sjöblom, Markus ^a   Flemström, Gunnar ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

6 fluorotryptamine; Brain gut axis; Duodenal mucosal bicarbonate secretion; HPLC; Intestine; Melatonin

Indexed keywords

ALPHA 1 ADRENERGIC RECEPTOR; BICARBONATE; LUZINDOLE; MELATONIN; MELATONIN RECEPTOR; PHENYLEPHRINE; THIOBARBITURIC ACID; THIOBUTABARBITAL;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANNULATION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DUODENUM MUCOSA; DUODENUM SECRETION; ELECTROCHEMISTRY; ENTEROCHROMAFFIN CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MEAN ARTERIAL PRESSURE; NERVE CELL STIMULATION; NONHUMAN; PH; RAT; SYMPATHETIC NERVE; TITRIMETRY; VAGUS NERVE STIMULATION; VASCULARIZATION; ANIMAL; BRAIN; DRUG EFFECT; DRUG POTENTIATION; DUODENUM; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; METABOLISM; TIME;

ANIMALS; BICARBONATES; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DUODENUM; INJECTIONS, INTRAVENTRICULAR; MELATONIN; PHENYLEPHRINE; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; TIME FACTORS;

EID: 1342301485     PISSN: 07423098     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1600-079X.2003.00103.x     Document Type: Article

References (36)

1. HUETHER G. The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates. Experientia 1993; 49:665-670.
2. RAIKHLIN NT, KVETNOY IM, TOLKACHEV VN. Melatonin may be synthesised in enterochromaffin cells. Nature 1975; 255:344-345.
3. QUAY W, MA Y. Demonstration of gastrointestinal hydroxyindole-O- methyltransferase. IRCS Med Sci 1976; 32:563.
4. HONG GX, PANG SF. N-acetyltransferase activity in the quail (Coturnix coturnix jap) duodenum. Comp Biochem Physiol B Biochem Mol Biol 1995; 112:251-255.
5. SJÖBLOM M, FLEMSTRÖM G. Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion. J Pineal Res 2003; 34:288-293.
6. FLEMSTRÖM G, KIVILAAKSO E. Demonstration of a pH gradient at the luminal surface of rat duodenum in vivo and its dependence on mucosal alkaline secretion. Gastroenterology 1983; 84:787-794.
7. FLEMSTRÖM G, ISENBERG JI. Gastroduodenal mucosal alkaline secretion and mucosal protection. News Physiol Sci 2001; 16:23-28.
8. FLEMSTRÖM G. Gastric and duodenal mucosal secretion of bicarbonate. In: Physiology of the Gastrointestinal Tract. Johnson LR, Jacobson ED, Christensen J, Alpers D, Walsh JH, eds. Raven, New York, 1994; pp. 1285-1309.
9. TAKEUCHI K, YAGI K, KATO S et al. Roles of prostaglandin E-receptor subtypes in gastric and duodenal bicarbonate secretion in rats. Gastroenterology 1997; 113:1553-1559.
10. LARSON GM, JEDSTEDT G, NYLANDER O et al. Intracerebral adrenoceptor agonists influence rat duodenal mucosal bicarbonate secretion. Am J Physiol Gastrointest Liver Physiol 1996; 271:G831-G840.
11. SJÖBLOM M, JEDSTEDT G, FLEMSTRÖM G. Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Clin Invest 2001; 108:625-633.
12. FLEMSTRÖM G, JEDSTEDT G. Stimulation of duodenal mucosal bicarbonate secretion in the rat by brain peptides. Gastroenterology 1989; 97:412-420.
13. GERSHON MD. Review article: role played by 5-hydroxytryptamine in the physiology of the bowel. Aliment Pharmacol Ther 1999; 13(Suppl. 2):15-30.
14. FUJIMIYA M, OKUMIYA K, KUWAHARA A. Immunoelectron microscopic study of the luminal release of serotonin from rat enterochromaffin cells induced by high intraluminal pressure. Histochem Cell Biol 1997; 108:105-113.
15. KELLUM J, MCCABE M, SCHNEIER J et al. Neural control of acid-induced serotonin release from rabbit duodenum. Am J Physiol Gastrointest Liver Physiol 1983; 245:G824-G831.
16. KELLUM JM, WU J, DONOWITZ, M. Enteric neural pathways inhibitory to rabbit duodenal serotonin release. Surgery 1984; 96:139-145.
17. SCHWÖRER H, RACKE K, KILBINGER H. Cholinergic modulation of the release of 5-hydroxytryptamine from the guinea pig ileum. Naunyn Schmiedebergs Arch Pharmacol 1987; 336:127-132.
18. SCHWÖRER H, RACKE K, KILBINGER H. Characterization of the muscarine receptors involved in the modulation of serotonin release from the vascularly perfused small intestine of guinea pig. Naunyn Schmiedebergs Arch Pharmacol 1989; 339:263-267.
19. GRÖNSTAD KO, ZINNER MJ, NILSSON O et al. Vagal release of serotonin into gut lumen and portal circulation via separate control mechanisms. J Surg Res 1988; 44:146-151.
20. LEE PP, PANG SF. Melatonin and its receptors in the gastrointestinal tract. Biol Signals 1993; 2:181-193.
21. BUBENIK GA, PANG SF. The role of serotonin and melatonin in gastrointestinal physiology: ontogeny, regulation of food intake, and mutual serotonin-melatonin feedback. J Pineal Res 1994; 16:91-99.
22. CHO CH, PANG SF, CHEN BW et al. Modulating action of melatonin on serotonin-induced aggravation of ethanol ulceration and changes of mucosal blood flow in rat stomachs. J Pineal Res 1989; 6:89-97.
23. BUBENIK GA, DHANVANTARI S. Influence of serotonin and melatonin on some parameters of gastrointestinal activity. J Pineal Res 1989; 7:333-344.
24. DRAGO F, MACAUDA S, SALEHI S. Small doses of melatonin increase intestinal motility in rats. Dig Dis Sci 2002; 47:1969-1974.
25. REITER RJ. Melatonin: lowering the high price of free radicals. News Physiol Sci 2000; 15:246-250.
26. REITER R, TAN D, ALLEGRA M. Melatonin: reducing molecular pathology and dysfunction due to free radicals and associated reactants. Neuroendocrinol Lett 2002; 23(Suppl. 1):3-8.
27. BANDYOPADHYAY D, BANDYOPADHYAY A, DAS PK et al. Melatonin protects against gastric ulceration and increases the efficacy of ranitidine and omeprazole in reducing gastric damage. J Pineal Res 2002; 33:1-7.
28. TAN DX, MANCHESTER LC, HARDELAND R et al. Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin. J Pineal Res 2003; 34:75-78.
29. BRZOZOWSKA I, KONTUREK PC, BRZOZOWSKI T et al. Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan. J Pineal Res 2002; 32:149-162.
30. FUJIMIYA M, YAMAMOTO H, KUWAHARA A. Effect of VIP and PACAP on basal release of serotonin from isolated vascularly and luminally perfused rat duodenum. Am J Physiol Gastrointest Liver Physiol 1998; 275:G731-G739.
31. DAYA S, WALKER RB, GLASS BD et al. The effect of variations in pH and temperature on stability of melatonin in aqueous solution. J Pineal Res 2001; 31:155-158.
32. BUBENIK GA, HACKER RR, BROWN GM et al. Melatonin concentrations in the luminal fluid, mucosa, and muscularis of the bovine and porcine gastrointestinal tract. J Pineal Res 1999; 26:56-63.
33. TAN D, MANCHESTER LC, REITER RJ et al. High physiological levels of melatonin in the bile of mammals. Life Sci 1999; 65:2523-2529.
34. MESSNER M, HUETHER G, LORF T et al. Presence of melatonin in the human hepatobiliary-gastrointestinal tract. Life Sci 2001; 69:543-551.
35. BUBENIK GA. Gastrointestinal melatonin: localization, function, and clinical relevance. Dig Dis Sci 2002; 47:2336-2348.
36. SJÖBLOM M, SÄFSTEN B, FLEMSTRÖM G. Melatonin-induced calcium signaling in clusters of human and rat duodenal enterocytes. Am J Physiol Gastrointest Liver Physiol 2003; 284:G1034-G1044.