Lead optimization of antifungal peptides with 3D NMR structures analysis

Protein Science

Volumn 13, Issue 3, 2004, Pages 703-713

  Landon, Céline ^a,c   Barbault, Florent ^a,d   Legrain, Michèle ^b   Menin, Laure ^b,e   Guenneugues, Marc ^b   Schott, Valérie ^b   Vovelle, Françoise ^a   Dimarcq, Jean Luc ^b  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b Entomed SA   (France)

^c CENTRE DE BIOPHYSIQUE MOLÉCULAIRE   (France)

^d CNRS   (France)

^e Geneva Proteomics Inc   (Switzerland)

Author keywords

Antifungal; Antimicrobial; Heliomicin; Insect immunity; NMR structure

Indexed keywords

AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; HELIOMYCIN; ITRACONAZOLE; PEPTIDE ARD 1; PEPTIDE ETD 135; PEPTIDE ETD 151; PEPTIDE ETD 179; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARCHEOPREPONA DEMOPHOON; ARTICLE; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; COMPARATIVE STUDY; CONTROLLED STUDY; DRUG ISOLATION; DRUG POTENCY; DRUG PURIFICATION; DRUG SCREENING; DRUG STRUCTURE; HEMOLYMPH; HYDROPHOBICITY; INSECT; LEPIDOPTERA; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN ISOLATION; PROTEIN PURIFICATION; PROTEIN TERTIARY STRUCTURE; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIFUNGAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; CLONING, MOLECULAR; CRYPTOCOCCUS NEOFORMANS; DRUG DESIGN; ELECTROSTATICS; FUSARIUM; HEMOLYMPH; HYDROPHOBICITY; INSECT PROTEINS; LARVA; LEPIDOPTERA; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SCEDOSPORIUM; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURAL HOMOLOGY, PROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PROPERTIES;

ASPERGILLUS FUMIGATUS; CANDIDA ALBICANS; INSECTA; LEPIDOPTERA; PHACELIA CONGESTA;

EID: 1342289287     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03404404     Document Type: Article

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