Transfection of the tumor metastasis suppressor gene nm23-H1 can targetly suppress the activity of extracellular signal-regulated protein kinase (ERK) in human high-metastasis large cell lung cancer cell line L9981

Chinese Journal of Lung Cancer

Volumn 7, Issue 1, 2004, Pages 8-11

  Li, Yin ^a   Zhou, Qinghua ^a   Sun, Zhilin ^a   Qin, Yang ^a   Zhu, Wen ^a   Wang, Yanping ^a   Liu, Lunxu ^a   Chen, Xiaohe ^a   Sun, Zefang ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Extracellular signal regulated protein kinase (ERK); Human high metastasis large cell lung cancer cell line; L9981; nm23 H1; Signal transduction

Indexed keywords

ENZYME ANTIBODY; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LUNG CANCER; METASTASIS; NM23 H1 GENE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE; WESTERN BLOTTING;

EID: 1342281509     PISSN: 10093419     EISSN: 19996187     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Kauffman EC, Robinson VL, Stadler WM, et al. Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site. J Urol, 2003, 169 (3): 1122-1133.
2. Chen J, Zhou QH, Qin Y, et al. A study on the allelie deletion of nm23 genes in human lung cancer. Chin J Lung Cancer, 2000, 3 (1): 8-13.
3. Chen XF, Zhou QH, Shi YK, et al. Study on expression of metastatic suppression gene of nm23-H1 in human non-small-cell lung cancer. Chin J Clin Thorac Cardiovasc Surg, 1997, 4(2): 80.
4. Zhou QH, Chen J, Sun ZL, et al. A study on the relationship between allelic deletion of nm23-H1 gene and metastasis of human non-small cell lung cancer. Chin J Clin Thorac Cardiovasc Surg, 1998, 5(3): 131-134.
5. Zhou QH, Che GW, Qin Y, et al. Experimental study on nm23-H1 gene reversing phenotype of lung cancer and its molecular mechanism. Chin J Lung Cancer, 2003, 6(2): 141-143.
6. Zhou QH, Wang YP, Che GW, et al. Establishment and their biological characteristics of clonal cell subpopulations (NL9980 and L9981) from a human large cell carcinoma cell fine (WCQH-9801). Chin J Lung Cancer, 2003, 6(6): 464-468.
7. Hunter T. Oncoprotein networks. Cell, 1997, 88(3): 333-346.
8. Duanmu DQ, Li ZH, Wang JZ, et al. MAPK signal Transduction pathway: the study progress. J Cell Biol, 2002, 24(3): 151-154.
9. Liu AH, Jiang Y. Mitogen-activated protein kinase and tumor. Natl Med J China, 81(12): 761-763.
10. Widmann C, Gibson S, Jarpe MB, et al. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Physiol Rev, 1999, 79(1): 143-180.
11. Webb CP, Van Aelst L, Wigler MH, et al. Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proc Natl Acad Sci U S A, 1998, 95(15): 8773-8778.
12. MacNicol MC, Muslin AJ, MacNicol AM. Disruption of the 14-3-3 binding site within the B-Raf kinase domain uncouples catalytic activity from PC12 cell differentiation. J Biol Chem, 2000, 275 (6): 3803-3809.