In vitro treatment of dendritic cells with tacrolimus: Impaired T-cell activation and IP-10 expression

Nephrology Dialysis Transplantation

Volumn 19, Issue 3, 2004, Pages 553-560

  Tiefenthaler, Martin ^a   Hofer, Susanne ^b   Ebner, Susanne ^b   Ivarsson, Lennart ^b   Neyer, Susanne ^b   Herold, Manfred ^b   Mayer, Gert ^a   Fritsch, Peter ^b   Heufler, Christine ^b  

^a UNIVERSITY OF INNSBRUCK   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

Author keywords

Chemokines; Dendritic cells; Immunosupression; T lymphocytes; Transplantation

Indexed keywords

CD69 ANTIGEN; CHEMOKINE RECEPTOR; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; IP 10 PROTEIN; PROTEIN P70; TACROLIMUS; UNCLASSIFIED DRUG;

ARTICLE; CELL MATURATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DRUG EFFECT; GENETIC TRANSCRIPTION; GRAFT REJECTION; HUMAN; HUMAN CELL; IMMUNOSTIMULATION; IMMUNOSUPPRESSIVE TREATMENT; IN VITRO STUDY; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; TH2 CELL; UPREGULATION;

CELL CULTURE TECHNIQUES; CHEMOKINES, CXC; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LYMPHOCYTE ACTIVATION; RNA, MESSENGER; T-LYMPHOCYTES; TACROLIMUS;

EID: 1342263718     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/gfg594     Document Type: Article

References (31)

1. Steinman RM. The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 1991; 9: 271-296
2. Ibrahim MAA, Chain BM, Katz DR. The injured cell: the role of the dendritic cell system as a sentinel receptor pathway. Immunol Today 1995; 16: 181-186
3. Lechler R, Ng WF, Steinman RM. Dendritic cells in transplantation - friend or foe? Immunity 2001; 14: 357-368
4. Roake JA, Rao AS, Morris PJ et al. Dendritic cell loss from nonlymphoid tissues after systemic administration of lipopolysaccharide, tumor necrosis factor, and interleukin 1. J Exp Med 1995; 181: 2237-2248
5. Romani N, Ratzinger G, Pfaller K et al. Migration of dendritic cells into lymphatics - the Langerhans cell example: routes, regulation, and relevance. Int Rev Cytol 2001; 207: 237-270
6. Ingulli E, Mondino A, Khoruts A, Jenkins MK. In vivo detection of dendritic cell antigen presentation to CD4+ T cells. J Exp Med 1997; 185: 2133-2141
7. Romani N, Inaba K, Pure E et al. A small number of anti-CD3 molecules on dendritic cells stimulates DNA synthesis in mouse T lymphocytes. J Exp Med 1989; 169: 1153-1168
8. Mellman I, Steinman RM. Dendritic cells: specialized and regulated antigen processing machines. Cell 2001; 106: 255-258
9. Ho S, Clipstone N, Timmermann L et al. The mechanism of action of cyclosporin A and FK506. Clin Immunol Immunopathol 1996; 80: S40-S45
10. + T cells toward Th2 responses. J Leukocyte Biol 2000; 68: 633-640
11. Szabo G, Gavala C, Mandrekar P. Tacrolimus and cyclosporine A inhibit allostimulatory capacity and cytokine production of human myeloid dendritic cells. J Invest Med 2001; 49: 442-449
12. Matsue H, Yang CD, Matsue K et al. Contrasting impacts of immunosuppressive agents (rapamycin, FK506, cyclosporin A, and dexamethasone) on bidirectional dendritic cell-T cell interaction during antigen presentation. J Immunol 2002; 169: 3555-3564
13. Woltman AM, de Fijter JW, Kamerling SWA et al. The effect of calcineurin inhibitors and corticosteroids on the differentiation of human dendritic cells. Eur J Immunol 2000; 30: 1807-1812
14. Romani N, Reider D, Heuer M et al. Generation of mature dendritic cells from human blood - an improved method with special regard to clinical applicability. J Immunol Methods 1996; 196: 137-151
15. Ebner S, Neyer S, Hofer S et al. Generation of large numbers of human dendritic cells from whole blood passaged through leukocyte removal filters: an alternative to standard buffy coats. J Immunol Methods 2001; 252: 93-104
16. Romani N, Bhardwaj N, Pope M et al. Dendritic cells. In: Herzenberg LA, Weir DM, Herzenberg L, Blackwell C, eds. Weir's Handbook of Experimental Immunology. Blackwell Science, Oxford: 1997; 156.1-156.14
17. Graf D, Korthäuer U, Mages HW, Senger G, Kroczek RA. Cloning of TRAP, a ligand for CD40 on human T cells. Eur J Immunol 1992; 22: 3191-3194
18. De Saint-Vis B, Vincent J, Vandenabeele S et al. A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 1998; 9: 325-336
19. Jonuleit H, Schmitt E, Steinbrink K, Enk AH. Dendritic cells as a tool to induce anergic and regulatory T cells. Immunol Today 2001; 22: 394-400
20. Papiernik M. Natural CD4+ CD25+ regulatory T cells. Their role in the control of superantigen responses. Immunol Rev 2001; 182: 180-189
21. Hancock WW, Gao W, Csizmadia V et al. Donor-derived IP-10 initiates development of acute allograft rejection. J Exp Med 2001; 193: 975-980
22. Inngjerdingen M, Damaj B, Maghazachi AA. Expression and regulation of chemokine receptors in human natural killer cells. Blood 2001; 97: 367-375
23. Bonecchi R, Bianchi G, Bordignon PP et al. Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 1998; 187: 129-134
24. Lalor PF, Adams DH. Lymphocyte homing to allografts. Transplantation 2000; 70: 1131-1139
25. Arakelov A, Lakkis FG. The alloimmune response and effector mechanisms of allograft rejection. Semin Nephrol 2000; 20: 95-102
26. Willment JA, Gordon S, Brown GD. Characterization of the human beta-glucan receptor and its alternatively spliced isoforms. J Biol Chem 2001; 276: 43 818-43 823
27. Kato M, Neil TK, Clark GJ et al. cDNA cloning of human DEC-205, a putative antigen-uptake receptor on dendrilic cells. Immunogenetics 1998; 47: 442-450
28. Swiggard WJ, Mirza A, Nussenzweig MC, Steinman RM. DEC-205, a 205-kDa protein abundant on mouse dendritic cells and thymic epithelium that is detected by the monoclonal antibody NLDC-145: purification, characterization, and N-terminal amino acid sequence. Cell Immunol 1995; 165: 302-311
29. Hawiger D, Inaba K, Dorsett Y et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J Exp Med 2001; 194: 769-779
30. Mayer AD, Dmitrewski J, Squifflet JP et al. Multicenter randomized trial comparing tacrolimus (FK506) and cyclosporine in the prevention of renal allograft rejection: a report of the European Tacrolimus Multicenter Renal Study group. Transplantation 1997; 64: 436-443
31. Margreiter R, European Tacrolimus vs Ciclosporin Microemulsion Renal Transplantation Study Group. Efficacy and safety of tacrolimus compared with ciclosporin microemulsion in renal transplantation: a randomised multicentre study. Lancet 2002; 359: 741-746