Development of specific inhibitors for heparin-binding proteins based on the cobra cardiotoxin structure: An effective synthetic strategy for rationally modified heparin-like disaccharides and a trisaccharide

Carbohydrate Research

Volumn 340, Issue 3, 2005, Pages 355-372

  Ke, Weijun ^a   Whitfield, Dennis M ^a   Brisson, Jean Robert ^a   Enright, Gary ^a   Jarrell, Harold C ^a   Wu, Wen Guey ^b  

^a NATIONAL RESEARCH COUNCIL CANADA   (Canada)

^b NATIONAL TSING HUA UNIVERSITY   (Taiwan)

Author keywords

1,3 Diaxial interactions; Cobra cardiotoxin; Glycosylations; Heparin like oligosaccharides; l Iduronic acid building blocks

Indexed keywords

BINDING ENERGY; ENZYME INHIBITION; MATHEMATICAL MODELS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SINGLE CRYSTALS; X RAYS;

COBRA CARDIOTOXIN (CTX); ELONGATION; MOLECULAR MODELING; TRISACCHARIDE;

PROTEINS;

2 O ACETYL 4 O LEVULINOYL 3 O PIVALOYL ALPHA IDOPYRANOSYLURONATE TRICHLOROACETIMIDIC ACID; AMINE; CARBON; CARDIOTOXIN; CHLOROACETAMIDE; DISACCHARIDE; GLUCOSE DERIVATIVE; HEPARIN BINDING PROTEIN; HYDROXYL GROUP; IDURONIC ACID; METHYL GROUP; MONOSACCHARIDE; NITROGEN; OXYGEN; PYRANOSIDE; TRISACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; SEQUENCE ANALYSIS; STRUCTURE ANALYSIS; SULFATION; SYNTHESIS; TECHNIQUE; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CARBOHYDRATE SEQUENCE; CARRIER PROTEINS; DIRECT LYTIC FACTORS; DISACCHARIDES; HEPARIN; IDURONIC ACID; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; TRISACCHARIDES;

EID: 13244298382     PISSN: 00086215     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.carres.2004.11.029     Document Type: Article

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