Effects of internal mass transfer and product inhibition on a simulated immobilized enzyme-catalyzed reactor for lactose hydrolysis

Biochemical Engineering Journal

Volumn 23, Issue 2, 2005, Pages 139-153

  Al Muftah, Ali E ^a   Abu Reesh, Ibrahim M ^b  

^a Bahrain Petroleum Company BAPCO   (Bahrain)

^b KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS   (Saudi Arabia)

Author keywords

Biocatalysis; Effectiveness factor; Enzyme bioreactors; Immobilisation; Immobilised enzymes; Internal mass transfer; Product inhibition

Indexed keywords

CHEMICAL REACTORS; COMPUTER SIMULATION; ENZYME IMMOBILIZATION; FINITE ELEMENT METHOD; GALERKIN METHODS; HYDROLYSIS; MATHEMATICAL MODELS; REACTION KINETICS;

AXIAL DISPERSION; MICHAELIS-MENTEN KINETICS; ORTHOGONAL COLLOCATION; PRODUCT INHIBITION;

MASS TRANSFER;

GALACTOSE; LACTOSE;

ARTICLE; BIOREACTOR; CATALYSIS; CATALYST; DIFFUSION COEFFICIENT; DISPERSION; ENZYME IMMOBILIZATION; ENZYME MECHANISM; HYDROLYSIS; KINETICS; MATHEMATICAL MODEL; MICHAELIS CONSTANT; PRIORITY JOURNAL;

EID: 13244292422     PISSN: 1369703X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bej.2004.10.010     Document Type: Article

References (49)

1. Santos, M. Ladero, and F. Garcia-Ochoa Kinetic modeling of lactose hydrolysis by a β-galactosidase from Kluyveromices fragilis Enzyme Microb. Technol. 22 1998 558 567
2. I. Petzelbauer, B. Nidetzky, D. Haltrich, and K. Kulbe Development of an ultra-high-temperature process for the enzymatic hydrolysis of lactose. I. The properties of two thermostable β-galactosidase Biotechnol. Bioeng. 64 1999 322 332
3. C.R. Carrara, and A.C. Rubiolo Determination of kinetics parameters for free and immobilized β-galactosidase Process Biochem. 31 1995 243 248
4. C.R. Carrara, and A.C. Rubiolo A method for evaluating lactose hydrolysis in a fixed bed reactor with β-galactosidase immobilized on chitson Chem. Eng. J. 65 1997 93 98
5. S.T. Yang, and M.R. Okos A new graphical method for determining parameters in Michaelis-Menten-type kinetics for enzymatic lactose hydrolysis Biotechnol. Bioeng. 34 1989 763 773
6. A.P. Bakken, C.G. Hill, and C.H. Amundson Hydrolysis of lactose in skim milk by immobilized β-galactosidase in a spiral flow reactor Biotechnol. Bioeng. 33 1989 1249 1257
7. N. Papayannakos, G. Markas, and D. Kekos Studies on modeling and simulation of lactose hydrolysis by free and immobilized β-galactosidace from Aspergillus niger Chem. Eng. J. 52 1993 B1 B12
8. M. Tomaska, M. Stredansky, A. Tomaskova, and E. Sturdik Lactose hydrolysis in aqueous two-phase system by whole cell β-galactosidase of Kluyveromyces marxianus Bioprocess Eng. 12 1995 17 20
9. R. Lortie, and D. Pelletier Comparison between dispersion and plug-flow models for fixed-bed enzyme reactors AIChE J. 38 1992 1477 1480
10. C.B. Ching, and Y.Y. Ho Flow dynamics of immobilized enzyme reactors Appl. Microbiol. Biotechnol. 20 1984 303 309
11. I.M. Abu-Reesh Predicting the performance of immobilized enzyme reactors using reversible Michaelis-Menten kinetics Bioprocess Eng. 17 1997 131 137
12. A. Bódalo, E. Gómez, J.L. Gomez, J. Bastida, and M.F. Maximo Fluidized bed reactors operating with immobilized enzyme systems: design model and its experimental verification Enzyme Microb. Technol. 17 1995 915 922
13. T. Kisser, G.A. Oertzen, and W. Bauer Modeling of a fluidized bed bioreactor for immobilized enzyme (part 1) Chem. Eng. Technol. 13 1990 20 26
14. M.M. Hassan, M. Atiqullah, S.A. Beg, and M. Chowdhury Analysis of nonisothermal tubular reactor packed with immobilized enzyme systems Biochem. Eng. J. 58 1995 275 283
15. M.M. Hassan, M. Atiqullah, S.A. Beg, and M.H.M. Chowdhury Effects of enzyme microcapsule shape on the performance of a nonisothermal packed-bed tubular reactor J. Chem. Technol. 66 1996 41 55
16. M.M. Hassan, and S.A. Beg Theoretical analysis of a packed-bed biological reactor for various reaction kinetics Chem. Eng. J. 36 1987 15 27
17. D. Vasic-Racki, N. Pavlovic, S. Cizmek, M. Drazic, and B. Husadzic Development of reactor model for glucose isomerization catalyzed by whole-cell immobilized glucose isomerase Bioprocess Eng. 7 1991 183 187
18. Y.H. Park, M.H. Han, and H.K. Rhee Effect of external mass transfer in a packed-bed reactor system for a reversible enzyme reaction J. Chem. Technol. Biotechnol. 34B 1984 57 69
19. T. Kobayashi, and M. Moo-Young Backmixing and mass transfer in the design of immobilized-enzyme reactors Biotechnol. Bioeng. 13 1971 893 910
20. C.B. Ching, and K.H. Chu Modeling of a fixed bed and a fluidized bed immobilized enzyme reactor Appl. Microbiol. Biotechnol. 29 1988 316 322
21. R. Lortie, and D. Thomas Heterogeneous one-dimensional model for fixed bed enzyme reactors Biotechnol. Bioeng. 1986 1256 1260
22. R. Lortie Evaluation of the performance of immobilized enzyme reactors with Michaelis-Menten kinetics J. Chem. Technol. Biotechnol. 60 1994 189 193
23. C.R. Carrara, E.J. Mammarela, and A.C. Rubiolo Prediction of the fixed-bed reactor behavior using dispersion and plug-flow models with different kinetics for immobilized enzyme Chem. Eng. J. 92 1-3 2002 123 129
24. W.N. Marrazzo, and B.J. McCoy Enzyme immobilized in a packed-bed reactor: kinetic parameters and mass transfer effects Biotechnol. Bioeng. 23 1981 1237 1254
25. F. Shiraishi, and S. Fujiwara An efficient method for solving two-point boundary value problems with extremely high accuracy J. Chem. Eng. Jpn. 29 1996 88 94
26. F. Shiraishi, T. Hasegawa, and H. Nagasue Numerical solution of two-point boundary value problem by combined Taylor series method with a technique for rapidly selecting suitable step sizes J. Chem. Eng. Jpn. 28 1995 306 315
27. F. Shiraishi, T. Hasegawa, S. Kasai, N. Makishita, and H. Miyakawa Characteristic of apparent kinetics parameters in a packed-bed immobilized enzyme reactor Chem. Eng. Sci. 51 1996 2847 2852
28. F. Shiraishi, H. Miyakawa, T. Hasegawa, and S. Kasai A computational method for determination of the mass transfer coefficient in packed-bed immobilized enzyme reactors J. Chem. Technol. 66 1996 405 413
29. H. Miyakawa, H. Nagasue, and F. Shiraishi A highly accurate numerical method for calculating apparent kinetics parameters of immobilized enzyme reactions: 1. Theory Biochem. Eng. J. 3 1999 91 101
30. H. Miyakawa, H. Nagasue, and F. Shiraishi A highly accurate numerical method for calculating apparent kinetics parameters of immobilized enzyme reactions: 2. accuracies of calculated values Biochem. Eng. J. 3 1999 103 111
31. A. Bódalo, J.L. Gomez, E. Gómez, J. Bastida, J.L. Iborra, and A. Manjon Analysis of diffusion effects of immobilized enzymes on porous supports with reversible Michaelis-Menten kinetics Enzyme Microb. Technol. 8 1986 433 438
32. A. Bódalo, E. Gómez, J.L. Gomez, J. Bastida, M.F. Maximo, and F. Dia A comparison of different methods of β-galactosidase immobilization Process Biochem. 26 1991 349 353
33. D.D. Do, D.S. Clark, and J.E. Bailey Modeling enzyme immobilization in porous solid supports Biotechnol. Bioeng. 24 1982 1527
34. D.S. Clark, and J.E. Bailey Structure-function relationships in immobilized chymotrypsin catalysis Biotechnol. Bioeng. 25 1983 1027
35. D.S. Clark, and J.E. Bailey Deactivation kinetics of immobilized α-chymotrypsin subpopulations Biotechnol. Bioeng. 26 1984 1090
36. D.S. Clark, J.E. Bailey, and D.D. Do A mathematical model for restricted diffusion effects on macromolecule impregnation in porous supports Biotechnol. Bioeng. 27 1985 208
37. R. Shyan, B. Davidsson, and W.R. Vieth Mass transfer and biochemical reaction in enzyme membrane reactor system 2 expanded analysis for single enzyme system Chem. Eng. Sci. 30 1975 669 678
38. S.H. Lin The effects of mass transfer resistances on encapsulated enzymatic reaction systems Chem. Eng. J. 17 1979 55 61
39. A. Manjon, J.L. Iborra, J.L. Gomez, E. Gómez, J. Bastida, and A. Bódalo Evaluation of effectiveness factor along immobilized enzyme fixed-bed reactors: design of a reactor with naringinase covalently immobilized into glycophase coated porous class Biotechnol. Bioeng. 30 1987 491 497
40. G.-H. Xiu, L. Jiang, and Li Ping Mass-transfer limitations for immobilized enzyme-catalyzed kinetic resolution of Racemate in a fixed-bed reactor Biotechnol. Bioeng. 74 2001 29 39
41. P.V. Danckwerts Continuous flow systems, distribution of residence times Chem. Eng. Sci. 2 1953 1 18
42. J. Villadsen, and M.L. Michelsen Solution of differential equation by polynomial approximation International Series in Physical and Chemical Engineering Series 1978 Prentice-Hall Englewood Cliffs, NJ
43. B.A. Finlayson Nonlinear Analysis in Chemical Engineering 1980 McGraw-Hill New York
44. R.A. Adomaitis, and Y.-H. Lin A technique for accurate collocation residual calculations Chem. Eng. J. 71 1998 127 134
45. R.A. Adomaitis Objects for MWR Comput. Chem. Eng. 26 2002 981 998
46. R.A. Adomaitis, and Y.-H. Lin A technique for accurate collocation residual calculations Chem. Eng. J. 71 1998 127 134
47. Yi-hung Lin, H.-Y. Chang, and R.A. Adomaitis MWRtools: a library for weighted residual method calculations Comput. Chem. Eng. 23 1999 1041 1061
48. H.W. Blanch, and D.S. Clark Biochemical Engineering 1997 Marcel Dekker, Inc. New York
49. J.E. Bailey, and D.E. Ollis Biochemical Engineering Fundamentals second ed. 1986 McGraw-Hill New York