Direct inhibitory action of galanin on hypothalamic arcuate nucleus neurones expressing galanin receptor Gal-R1 mRNA

Neuroendocrinology

Volumn 78, Issue 2, 2003, Pages 105-117

  Poulain, Pierre ^a   Decrocq, Noëlle ^a   Mitchell, Valérie ^a  

^a INSERM   (France)

Author keywords

Arcuate nucleus; Electrophysiology; Galanin; Galanin receptors; In situ hybridization; Tetrodotoxin

Indexed keywords

GALANIN; GALANIN DERIVATIVE; GALANIN RECEPTOR; MESSENGER RNA; NEUROPEPTIDE; POTASSIUM; TETRODOTOXIN; BIOCYTIN; DRUG DERIVATIVE; GALANTIDE; LOCAL ANESTHETIC AGENT; LYSINE; NEUROPEPTIDE RECEPTOR; SUBSTANCE P;

ANIMAL TISSUE; ARCUATE NUCLEUS; ARTICLE; BRAIN SLICE; CELL HETEROGENEITY; CONTROLLED STUDY; ELECTROPHYSIOLOGY; HORMONE ACTION; HYPERPOLARIZATION; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; MEMBRANE POTENTIAL; MICROELECTRODE; NONHUMAN; PHENOTYPE; POSTSYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL MEMBRANE POTENTIAL; CLASSIFICATION; COMPARATIVE STUDY; DRUG EFFECT; ELECTRIC CONDUCTIVITY; GENE EXPRESSION; GENETICS; IN VITRO STUDY; METABOLISM; NERVE CELL; NERVE CELL INHIBITION; WISTAR RAT;

ANESTHETICS, LOCAL; ANIMALS; ARCUATE NUCLEUS; ELECTRIC CONDUCTIVITY; ELECTROPHYSIOLOGY; GALANIN; GENE EXPRESSION; IN SITU HYBRIDIZATION; LYSINE; MALE; MEMBRANE POTENTIALS; NEURAL INHIBITION; NEURONS; RATS; RATS, WISTAR; RECEPTORS, GALANIN; RECEPTORS, NEUROPEPTIDE; RNA, MESSENGER; SUBSTANCE P; TETRODOTOXIN;

EID: 0141728483     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000071966     Document Type: Article

References (40)

1. Melander T, Hökfelt T, Rokaeus A: Distribution of galaninlike immunoreactivity in the rat central nervous system. J Comp Neurol 1986;248:475-517.
2. Crawley JN: Biological actions of galanin. Regul Peptides 1995;59:1-16.
3. Cheung CC, Clifton DK, Steiner RA: Galanin: An unassuming neuropeptide moves to center stage in reproduction. Trends Endocrinol Metab 1996;7:301-306.
4. Kalra SP, Horvath TL: Neuroendocrine interactions between galanin, opioids, and neuropeptide Y in the control of reproduction and appetite. Ann NY Acad Sci 1998;863:236-240.
5. Bouret S, Croix D, Mariot M, Loyens A, Prévot V, Jégou S, Vaudry H, Beauvillain JC, Mitchell V: Galanin modulates the activity of proopiomelanocortin neurons in the isolated mediobasal hypothalamus of the male rat. Neuroscience 2002;112:475-485.
6. Horvath TL, Kalra SP, Naftolin F, Leranth C: Morphological evidence for a galanin-opiate interaction in the rat mediobasal hypothalamus. J Neuroendocrinol 1995;7:579-588.
7. 125I] galanin binding in rat brain: Relationship with the rate of occupancy of galanin receptors by endogenous galanin. Neuroscience 1992;49:829-847.
8. Planas B, Kolb PE, Raskind MA, Miller MA: Activation of galanin pathways across puberty in the male rat: Assessment of regional densities of galanin binding sites. Neuroscience 1994;63:859-867.
9. Branchek TA, Smith KE, Gerald C, Walker MW: Galanin receptors subtypes. Trends Pharmacol Sci 2000;21:109-116.
10. Gustafson EL, Smith KE, Durkin MM, Gerald C, Branchek TA: Distribution of a rat galanin receptor mRNA in rat brain. Neuroreport 1996;7:953-957.
11. Mitchell V, Habert-Ortoli E, Epelbaum J, Aubert JP, Beauvillain JC: Semiquantitative distribution of galanin-receptor (GAL-R1) mRNA-containing cells in the male rat hypothalamus. Neuroendocrinology 1997;66:160-172.
12. Mitchell V, Bouret S, Howard AD, Beauvillain JC: Expression of the galanin receptor subtype Gal-R2 mRNA in the rat hypothalamus. J Chem Neuroanat 1999;16:265-277.
13. Kolakowski Jr LF, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF: Molecular characterisation and expression of cloned human galanin receptors GALR2 and GALR3. J Neurochem 1998;71:2239-2251.
14. Landry M, Aman K, Hökfelt T: Galanin-R1 receptor in anterior and mid-hypothalamus: Distribution and regulation. J Comp Neurol 1998;399:321-340.
15. Bouret S, Prévot V, Croix D, Howard A, Habert-Ortoli E, Jegou S, Vaudry H, Beauvillain JC, Mitchell V: Expression of GalR1 and GalR2 galanin receptor messenger ribonucleic acid in proopiomelanocortin neurons of the rat arcuate nucleus : effect of testosterone. Endocrinology 2000;141:1780-1794.
16. Schonrock B, Busselberg D, Haas HL: Properties of tuberomammillary histamine neurones and their responses to galanin. Agents Actions 1991;33:135-137.
17. Ma X, Tong YG, Schmidt R, Brown W, Payza K, Hodzic L, Pou C, Godbout C, Hökfelt T, Xu Z-QD: Effects of galanin receptor agonists on locus coeruleus neurons. Brain Res 2001;919:169-174.
18. Xu Z-QD, Tong Y-G, Hökfelt T: Galanin enhances noradrenaline-induced outward current on locus coeruleus noradrenergic neurons. Neuroreport 2001;12:1779-1782.
19. Pieribone VA, Xu Z-QD, Zhang X, Hökfelt T: Electrophysiological effects of galanin on neurons of the central nervous system. Ann NY Acad Sci 1998;863:252-263.
20. Xu Z-QD, Zhang X, Pieribone VA, Grillner S, Hökfelt T: Galanin-5-hydroxytryptamine interactions: Electrophysiological, immunohistochemical and in situ hybridisation studies on rat raphe neurons with a note on galanin R1 and R2 receptors. Neuroscience 1998;87:79-94.
21. Jhamandas JH, Harris KH, MacTavish D, Jassar BS: Novel excitatory actions of galanin on rat cholinergic basal forebrain neurons: Implications for its role in Alzheimer's disease. J Neurophysiol 2002;87:696-704.
22. Kinney GA, Emmerson PJ, Miller RJ: Galanin receptor-mediated inhibition of glutamate release in the arcuate nucleus of the hypothalamus. J Neurosci 1998;18:3489-3500.
23. Rønnekleiv OK, Loose MD, Erickson KR, Kelly MJ: A method for immunocytochemical identification of biocytin-labeled neurons following intracellular recording. Biotechniques 1990;9:432-438.
24. Loose MD, Rønnnekleiv OK, Kelly MJ: Neurons in the rat arcuate nucleus are hyperpolarized by GABAB and μ-opioid receptor agonists: Evidence for convergence at a ligand-gated potassium conductance. Neuroendocrinology 1991;54:537-544.
25. Loose MD, Rønnnekleiv OK, Kelly MJ: Membrane properties and response to opioids of identified dopamine neurons in the guinea pig hypothalamus. J Neurosci 1990;10:3627-3634.
26. Kelly MJ, Loose MD, Rønnnekleiv OK: Opioids hyperpolarize β-endorphin neurons via μ-receptor activation of a potassium conductance. Neuroendocrinology 1990;52:268-275.
27. Lagrange AH, Rønnekleiv OK, Kelly MJ: Estradiol-17β and μ-opioid peptides rapidly hyperpolarize GnRH neurons: A cellular mechanism of negative feedback? Endocrinology 1995;135:2341-2344.
28. MacMillan SJA, Bourque CW: Intracellular recordings from neurons of the arcuate nucleus in superfused explants of rat hypothalamus. Neuroendocrinology 1993;57:159-166.
29. Burdakov D, Ashcroft FM: Cholecystokinin tunes firing of an electrically distinct subset of arcuate nucleus neurons by activating A-type potassium channels. J Neurosci 2002;22:6380-6387.
30. MacMillan SJ: Discharge characteristics and distribution of arcuate neurones from rat hypothalami recorded in vitro. J Physiol (Lond) 1983;38:44.
31. Loose MD, Kelly MJ: Opioid inhibition of spontaneously active neurons of the rat arcuate nucleus in vitro. Brain Res Bull 1989;22:819-823.
32. Smith KE, Walker MW, Artymyshyn R, Bard J, Borowsky B, Tamm JA, Yao W-J, Vaysse PJ-J, Brancek TA, Gerald C, Jones KA: Cloned human and rat galanin GALR3 receptors. J Biol Chem 1998;273:23321-23326.
33. Papas S, Bourque CW: Galanin inhibits continuous and phasic firing in rat hypothalamic magnocellular neurosecretory cells. J Neurosci 1997;17:6048-6056.
34. Breceptor-mediated inhibition of GABAergic neurons in the arcuate nucleus. Neuroreport 1998;9:4171-4177.
35. Knapp JA, Morris NP, Henderson Z, Matthews RT: Electrophysiological characterictics of non-bursting, glutamate decarboxylase messenger RNA-positive neurons of the medial septum/diagonal band nuclei of guinea-pig and rat. Neuroscience 2000;98:661-668.
36. Horvath TL, Naftolin F, Leranth C, Sahu A, Kalra SP: Morphological and pharmacological evidence for neuropeptide Y-galanin interaction in the rat hypothalamus. Endocrinology 1996;137:3069-3078.
37. Merchenthaler I, López F, Negro-Vilar A: Colocalization of galanin and luteinizing hormone-releasing hormone in a subset of preoptic hypothalamic neurons: Anatomical and functional correlates. Proc Natl Acad Sci USA 1990;87:6326-6330.
38. López F, Negro-Vilar A: Galanin stimulates luteinizing hormone-releasing hormone secretion from arcuate nucleus-median eminence fragments in vitro: Involvement of an alpha-adrenergic mechanism. Endocrinology 1990;127:2431-2436.
39. Kalra SA: Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge. Endocrine Rev 1993;14:507-538.
40. Dube MG, Horvath TL, Leranth PS, Kalra PS, Kalra SP: Naloxone reduces the feeding evoked by intracerebroventricular galanin injection. Physiol Behav 1994;56:811-813.