Glutathione reductase is expressed at high levels in pancreatic islet cells

Redox Report

Volumn 9, Issue 6, 2004, Pages 321-324

  Nagaoka, Yuki ^a   Iuchi, Yoshihito ^a   Ikeda, Yoshitaka ^a   Fujii, Junichi ^a  

^a YAMAGATA UNIVERSITY   (Japan)

Author keywords

Diabetogenic stress; Glutathione reductase; Pancreatic islet cells

Indexed keywords

CARMUSTINE; GLUTATHIONE; GLUTATHIONE REDUCTASE; PEROXIREDOXIN; REACTIVE OXYGEN METABOLITE; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; EXOCRINE CELL; IMMUNOHISTOCHEMISTRY; NONHUMAN; OXIDATION REDUCTION REACTION; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; STREPTOZOCIN DIABETES; WESTERN BLOTTING;

ANIMALS; CARMUSTINE; DIABETES MELLITUS, EXPERIMENTAL; GLUTATHIONE REDUCTASE; HEAT-SHOCK PROTEINS; IMMUNOHISTOCHEMISTRY; ISLETS OF LANGERHANS; OXIDATION-REDUCTION; PEROXIDASES; RATS; RATS, WISTAR; STREPTOZOCIN;

EID: 13244254059     PISSN: 13510002     EISSN: None     Source Type: Journal    
DOI: 10.1179/135100004225006812     Document Type: Article

References (13)

1. Grankvist K, Marklund SL, Taljedal IB. CuZn-superoxide dismutase, Mn-superoxide dismutase, catalase and glutathione peroxidase in pancreatic islets and other tissues in the mouse. Biochem J 1981; 199: 393-398.
2. Kondo H, Mori S, Takino H et al. Attenuation of expression of gamma-glutamylcysteine synthetase by ribozyme transfection enhance insulin secretion by pancreatic beta cell line, MIN6. Biochem Biophys Res Commun 2000; 278: 236-240.
3. Kaneto H, Fujii J, Seo HG et al. Apoptotic cell death triggered by nitric oxide in pancreatic β-cells. Diabetes 1995; 44: 733-738.
4. Islam KN, Kayanoki Y, Kaneto H et al. TGF-β triggers oxidative modification and enhances apoptosis in HIT-cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. Free Radic Biol Med 1997; 22: 1007-1017.
5. Kubisch HM, Wang J, Bray TM, Phillips JP. Targeted overexpression of Cu/Zn superoxide dismutase protects pancreatic β -cells against oxidative stress. Diabetes 1997; 46: 1563-1566.
6. Hotta M, Tashiro F, Ikegami H et al. Pancreatic beta cell-specific expression of thioredoxin, an antioxidative and antiapoptotic protein, prevents autoimmune and streptozotocin-induced diabetes. J Exp Med 1998; 188: 1445-1451.
7. Fujii T, Hamaoka R, Fujii J, Taniguchi N. Redox capacity of cells affects inactivation of glutathione reductase by nitrosative stress. Arch Biochem Biophys 2000; 378: 123-130.
8. Fujii T, Endo T, Fujii J, Taniguchi N. Differential expression of glutathione reductase and cytosolic glutathione peroxidase, GPX1, in developing rat lungs and kidneys. Free Radic Res 2002; 36: 1041-1049.
9. Kaneko T, Iuchi Y, Kobayashi T et al. Expression of glutathione reductase in the male reproductive system of rats supports the enzymatic basis of glutathione function in spermatogenesis. Eur J Biochem 2002; 269: 1570-1578.
10. Kaneko T, Iuchi Y, Kawachiya S et al. Alteration of glutathione reductase expression in the female reproductive organs during the estrous cycle. Biol Reprod 2001; 65: 1410-1416.
11. Bast A, Wolf G, Oberbaumer I, Walther R. Oxidative and nitrosative stress induces peroxiredoxins in pancreatic beta cells. Diabetologia 2002; 45: 867-876.
12. Fujii J, Ikeda Y. Peroxiredoxins in mammals: recent advances of multifunctional redox proteins. Redox Report 2002; 7: 123-130.
13. Malaisse WJ, Dufrane SP, Mathias PC et al. The coupling of metabolic to secretory events in pancreatic islets. The possible role of glutathione reductase. Biochim Biophys Acta 1985; 844: 256-64.