Incidence and mechanism of ciprofloxacin resistance in Campylobacter spp. isolated from commercial poultry flocks in the United Kingdom before, during, and after fluoroquinolone treatment

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 2, 2005, Pages 699-707

  Griggs, Deborah J ^a   Johnson, Maggie M ^a   Frost, Jennifer A ^b   Humphrey, Tom ^c   Jørgensen, Frieda ^d   Piddock, Laura J V ^a,e  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c UNIVERSITY OF BRISTOL   (United Kingdom)

^d UNIVERSITY OF BRISTOL   (United Kingdom)

^e UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING) A; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIOPHAGE; BACTERIUM ISOLATION; CAMPYLOBACTER COLI; CAMPYLOBACTER JEJUNI; CONTROLLED STUDY; DENATURING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; DNA SEQUENCE; DRUG MECHANISM; FECES ANALYSIS; FOOD CHAIN; FOOD CONTAMINATION; GENETIC VARIABILITY; GRAM NEGATIVE INFECTION; HERD; IN VITRO STUDY; IN VIVO STUDY; MINIMUM INHIBITORY CONCENTRATION; MULTIDRUG RESISTANCE; NONHUMAN; PHENOTYPE; POULTRY FARMING; PRIORITY JOURNAL; UNITED KINGDOM;

ANIMALS; ANTI-BACTERIAL AGENTS; CAMPYLOBACTER; CAMPYLOBACTER INFECTIONS; CAMPYLOBACTER JEJUNI; CHICKENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIPROFLOXACIN; DNA GYRASE; DRUG RESISTANCE, BACTERIAL; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ESCHERICHIA COLI; FLUOROQUINOLONES; GENOTYPE; GREAT BRITAIN; MICROBIAL SENSITIVITY TESTS; POULTRY DISEASES;

EID: 12944335169     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.2.699-707.2005     Document Type: Article

References (42)

1. Bachoual, R., S. Ouabdesselam, F. Mory, C. Lascols, C. J. Soussy, and J. Tankovic. 2001. Single or double mutational alterations of GyrA associated with fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli. Microb. Drug Resist. Mechanisms Epidemiol. Dis. 7:257-261.
2. Best, E. L., E. J. Powell, C. Swift, K. A. Grant, and J. A. Frost. 2003. Applicability of a rapid duplex real-time PCR assay for speciation of Campylobacter jejuni and Campylobacter coli directly from culture plates. FEMS Microbiol. Lett. 229:237-241.
3. Bolton, F. J., D. R. A. Wareing, M. B. Skirrow, and D. N. Hutchinson. 2001. Identification and biotyping of campylobacters, p. 151-161. In G. R. Board, D. Jones, and F. A. Skinner (ed.), Identification methods in applied and environmental microbiology. Blackwell Scientific Publications, Oxford, United Kingdom.
4. Carattoli, A., A. Dionisi, and I. Luzzi. 2002. Use of a LightCycler gyrA mutation assay for identification of ciprofloxacin-resistant Campylobacter coli. FEMS Microbiol. Lett. 214:87-93.
5. Charvalos, E., E. Peteinaki, I. Spyridaki, S. Manetas, and Y. Tselentis. 1996. Detection of ciprofloxacin resistance mutations in Campylobacter jejuni gyrA by nonradioisotopic single-strand conformation polymorphism and direct DNA sequencing. J. Clin. Lab. Anal. 10:129-133.
6. Charvalos, E., Y. Tselentis, M. M. Hamzehpour, T. Kohler, and J. C. Pechere. 1995. Evidence for an efflux pump in multidrug-resistant Campylobacter jejuni. Antimicrob. Agents Chemother. 39:2019-2022.
7. Chuma, T., T. Ikeda, T. Maeda, H. Niwa, and K. Okamoto. 2001. Antimicrobial susceptibilities of Campylobacter strains isolated from broilers in the southern part of Japan from 1995 to 1999. J. Vet. Med. Sci. 63:1027-1029.
8. Eaves, D. J., E. Liebana, M. J. Woodward, and L. J. V. Piddock. 2002. Detection of gyrA mutations in quinolone-resistant Salmonella enterica by denaturing high-performance liquid chromatography. J. Clin. Microbiol. 40:4121-4125.
9. Endtz, H. P., G. J. Ruijs, B. van Klingeren, W. H. Jansen, R. T. van der, and R. P. Mouton. 1991. Quinolone resistance in campylobacter isolated from man and poultry following the introduction of fluoroquinolones in veterinary medicine. J. Antimicrob. Chemother. 27:199-208.
10. Engberg, J., F. M. Aarestrup, D. E. Taylor, P. Gerner-Smidt, and I. Nachamkin. 2001. Quinolone and macrolide resistance in Campylobacter jejuni and C. coli: resistance mechanisms and trends in human isolates. Emerg. Infect. Dis. 7:24-34.
11. Everett, M. J., Y. F. Jin, V. Ricci, and L. J. V. Piddock. 1996. Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals. Antimicrob. Agents Chemother. 40:2380-2386.
12. Fermer, C., and E. O. Engvall. 1999. Specific PCR identification and differentiation of the thermophilic campylobacters, Campylobacter jejuni, C. coli, C. lari, and C. upsaliensis. J. Clin. Microbiol. 37:3370-3373.
13. Frost, J. A., A. N. Oza, R. T. Thwaites, and B. Rowe. 1998. Serotyping scheme for Campylobacter jejuni and Campylobacter coli based on direct agglutination of heat-stable antigens. J. Clin. Microbiol. 36:335-339.
14. Frost, J. A., J. M. Kramer, and S. A. Gillanders. 1999. Phage typing of C. jejuni and C. coli. Epidemiol. Infect. 123:47-55.
15. Gaunt, P. N., and L. J. V. Piddock. 1996. Ciprofloxacin resistant Campylobacter spp in humans: an epidemiological and laboratory study. J. Antimicrob. Chemother. 37:747-757.
16. Gibreel, A., E. Sjogren, B. Kaijser, B. Wretlind, and O. Skold. 1998. Rapid emergence of high-level resistance to quinolones in Campylobacter jejuni associated with mutational changes in gyrA and parC. Antimicrob. Agents Chemother. 42:3276-3278.
17. Gootz, T. D., and B. A. Martin. 1991. Characterization of high-level quinolone resistance in Campylobacter jejuni. Antimicrob. Agents Chemother. 35:840-845.
18. Griggs, D. J., K. Gensberg, and L. J. V. Piddock. 1996. Mutations in gyrA gene of quinolone-resistant salmonella serotypes isolated from humans and animals. Antimicrob. Agents Chemother. 40:1009-1013.
19. Hakanen, A., M. Lehtopolku, A. Siitonen, P. Huovinen, and P. Kotilainen. 2003. Multidrug resistance in Campylobacter jejuni strains collected from Finnish patients during 1995-2000. Antimicrob. Agents Chemother. 52:1035-1039.
20. Hakanen, A., J. Jalava, P. Kotilainen, H. Jousimies-Somer, A. Siitonen, and P. Huovinen. 2002. gyrA polymorphism in Campylobacter jejuni: detection of gyrA mutations in 162 C. jejuni isolates by single-strand conformation polymorphism and DNA sequencing. Antimicrob. Agents Chemother. 46:2644-2647.
21. 20a. Humphrey, T. J., F. Jørgensen, J. A. Frost, H. Wadda, G. Domingue, N. C. Elviss, D. J. Griggs, and L. J. V. Piddock. 2005. Prevalence and subtypes of ciprofloxacin-resistant Campylobacter spp. in commercial poultry flocks before, during, and after treatment with fluoroquinolones. Antimicrob. Agents Chemother. 49:690-698.
22. Lin, J., L. O. Michel, and Q. Zhang. 2002. CmeABC functions as a multidrug efflux system in Campylobacter jejuni. Antimicrob. Agents Chemother. 46:2124-2131.
23. Luo, N., O. Sahin, J. Lin, L. O. Michel, and Q. J. Zhang. 2003. In vivo selection of Campylobacter isolates with high levels of fluoroquinolone resistance associated with gyrA mutations and the function of the CmeABC efflux pump. Antimicrob. Agents Chemother. 47:390-394.
24. MacGowan, A., P., and R. Wise. 2001. Establishing MIC breakpoints and the interpretation of in vitro susceptibility tests. J. Antimicrob. Chemother. 48:17-28.
25. McDermott, P. F., S. M. Bodeis, F. M. Aarestrup, S. Brown, M. Traczewski, P. Fedorka-Cray, M. Wallace, I. A. Critchley, C. Thornsberry, S. Graff, R. Flamm, J. Beyer, D. Shortridge, L. J. Piddock, V. Ricci, M. M. Johnson, R. N. Jones, B. Reller, S. Mirrett, J. Aldrobi, R. Rennie, C. Brosnikoff, L. Turnbull, G. Stein, S. Schooley, R. A. Hanson, and R. D. Walker. 2004. Development of a standardized susceptibility test for campylobacter with quality-control ranges for ciprofloxacin, doxycycline, erythromycin, gentamicin, and meropenem. Microb. Drug Resist. 10:124-131.
26. National Committee for Clinical Laboratory Standards. 2003. Performance standards for antimicrobial disk susceptibility tests; approved standard M2-A8, vol. 23, no. 1. National Committee for Clinical Laboratory Standards, Wayne, Pa.
27. Parkhill, J., B. W. Wren, K. Mungall, J. M. Ketley, C. Churcher, D. Basham, T. Chillingworth, R. M. Davies, T. Feltwell, S. Holroyd, K. Jagels, A. V. Karlyshev, S. Moule, M. J. Pallen, C. W. Penn, M. A. Quail, M. A. Rajandream, K. M. Rutherford, A. H. van Vliet, S. Whitehead, and B. G. Barrell. 2000. The genome sequence of the food-borne pathogen Campylobacter jejuni reveals hypervariable sequences. Nature 403:665-668.
28. Payot, S., A. Cloeckaert, and E. Chaslus-Dancla. 2002. Selection and characterization of fluoroquinolone-resistant mutants of Campylobacter jejuni using enrofloxacin. Microb. Drug Resist. Mechanisms Epidemiol. Dis. 8:335-343.
29. Petersen, L., S. L. W. On, and D. W. Ussery. 2002. Visualization and significance of DNA structural motifs in the Campylobacter jejuni genome. Genome Lett. 1:16-25.
30. Piddock, L. J. V. 1999. Quinolone resistance and campylobacter. Clin. Microbiol. Infect. 5:239-243.
31. Piddock, L. J. V., V. Ricci, L. Pumbwe, M. J. Everett, and D. J. Griggs. 2003. Fluoroquinolone resistance in Campylobacter species from man and animals: detection of mutations in topoisomerase genes. J. Antimicrob. Chemother. 51:19-26.
32. Pumbwe, L., and L. J. V. Piddock. 2002. Identification and molecular characterisation of CmeB, a Campylobacter jejuni multidrug efflux pump. FEMS Microbiol. Lett. 206:185-189.
33. Pumbwe, L., L. P. Randall, M. J. Woodward, and L. J. Piddock. 2004. Expression of the efflux pump genes cmeB, cmeF and the porin gene porA in multiply antibiotic-resistant Campylobacer jejuni J. Antimicrob. Chemother. 54:341-347.
34. Ruiz, J., P. Goni, F. Marco, F. Gallardo, B. Mirelis, T. J. De Anta, and J. Vila. 1998. Increased resistance to quinolones in Campylobacter jejuni: a genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates. Microbiol. Immunol. 42:223-226.
35. Smith, K. E., J. M. Besser, C. W. Hedberg, F. T. Leano, J. B. Bender, J. H. Wicklund, B. P. Johnson, K. A. Moore, and M. T. Osterholm. 1999. Quinolone-resistant Campylobacter jejuni infections in Minnesota, 1992-1998. N. Engl. J. Med. 340:1525-1532.
36. Thwaites, R. T., and J. A. Frost. 1999. Drug resistance in Campylobacter jejuni, C. coli, and C. lari isolated from humans in north west England and Wales, 1997. J. Clin. Pathol. 52:812-814.
37. Unicomb, L., J. Ferguson, T. V. Riley, and P. Collignon. 2003. Fluoroquinolone resistance in campylobacter absent from isolates, Australia. Emerg. Infect. Dis. 9:1482-1483.
38. Van Looveren, M., G. Daube, L. De Zutter, J. M. Dumont, C. Lammens, M. Wijdooghe, P. Vandamme, M. Jouret, M. Cornelis, and H. Goossens. 2001. Antimicrobial susceptibilities of Campylobacter strains isolated from food animals in Belgium. J. Antimicrob. Chemother. 48:235-240.
39. Wang, Y., W. M. Huang, and D. E. Taylor. 1993. Cloning and nucleotide-sequence of the Campylobacter jejuni gyrA gene and characterization of quinolone resistance mutations. Antimicrob. Agents Chemother. 37:457-463.
40. Wilson, D. L., S. R. Abner, T. C. Newman, L. S. Mansfield, and J. E. Linz. 2000. Identification of ciprofloxacin-resistant Campylobacter jejuni by use of a fluorogenic PCR assay. J. Clin. Microbiol. 38:3971-3978.
41. Zirnstein, G., L. Helsel, Y. Li, B. Swaminathan, and J. Besser. 2000. Characterization of gyrA mutations associated with fluoroquinolone resistance in Campylobacter coli by DNA sequence analysis and MAMA PCR. FEMS Microbiol. Lett. 190:1-7.
42. Zirnstein, G., Y. Li, B. Swaminathan, and F. Angulo. 1999. Ciprofloxacin resistance in Campylobacter jejuni isolates: detection of gyrA resistance mutations by mismatch amplification mutation assay PCR and DNA sequence analysis. J. Clin. Microbiol. 37:3276-3280.