Chronic exposure to high glucose impairs bradykinin-stimulated nitric oxide production by interfering with the phospholipase-C-implicated signalling pathway in endothelial cells: Evidence for the involvement of protein kinase C

Diabetologia

Volumn 47, Issue 12, 2004, Pages 2093-2104

  Tang, Y ^a   Li, G D ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Antioxidant; Bradykinin; Calcium; Diabetes; Endothelial cells; High glucose; Ins(1,4,5)P3; Nitric oxide; Phospholipase C; Protein kinase C

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; 4,5 DIAMINOFLUORESCEIN DIACETATE; ALPHA TOCOPHEROL; ANTIOXIDANT; BISINDOLYLMALEIMIDE; BRADYKININ; BRADYKININ RECEPTOR; CALCIUM ION; FURA 2; GLUCOSE; NITRIC OXIDE; PHOSPHATIDYLINOSITIDE; PHOSPHOLIPASE C; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; ENDOTHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; AORTA; BRADYKININ; CATTLE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; GLUCOSE; IONOMYCIN; NITRIC OXIDE; PHOSPHOLIPASE C; PROTEIN KINASE C; SIGNAL TRANSDUCTION;

EID: 12944326874     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1589-y     Document Type: Article

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