Effects of cetylpyridinium chloride resistance and treatment on fluconazole activity versus Candida albicans

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 2, 2005, Pages 843-845

  Edlind, Merritt P ^a   Smith, W Lamar ^a   Edlind, Thomas D ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CETYLPYRIDINIUM SALT; FLUCONAZOLE; FUNGAL PROTEIN; GLYCOPROTEIN P; PROTEIN CDR1; PROTEIN CDR2; PYRROLE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CROSS RESISTANCE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; DRUG SENSITIVITY; FUNGUS GROWTH; IN VITRO STUDY; MINIMUM INHIBITORY CONCENTRATION; MOUTHWASH; MUTANT; NONHUMAN; PRIORITY JOURNAL; UPREGULATION;

ANTI-INFECTIVE AGENTS, LOCAL; ANTIFUNGAL AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; CANDIDA ALBICANS; CETYLPYRIDINIUM; DRUG RESISTANCE, FUNGAL; FLUCONAZOLE; FUNGAL PROTEINS; IMMUNOBLOTTING; MEMBRANE TRANSPORT PROTEINS; MICROBIAL SENSITIVITY TESTS; MOUTHWASHES;

EID: 12944309754     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.2.843-845.2005     Document Type: Article

References (20)

1. Akimitsu, N., H. Hamamoto, R.-I. Inoue, M. Shoji, A. Akamine, K.-I. Takemori, N. Hamasaki, and K. Sekimizu. 1999. Increase in resistance of methicillin-resistant Staphylococcus aureus to β-lactams caused by mutations conferring resistance to benzalkonium chloride, a disinfectant widely used in hospitals. Antimicrob. Agents Chemother. 43:3042-3043.
2. Calderone, R. A. (ed.) 2002. Candida and candidiasis. American Society for Microbiology, Washington, D.C.
3. Chuanchuen, R., K. Beinlich, T. T. Hoang, A. Becher, R. R. Karkhoff-Schweizer, and H. P. Schweizer. 2001. Cross-resistance between triclosan and antibiotics in Pseudomonas aeruginosa is mediated by multidrug efflux pumps: exposure of a susceptible mutant strain to triclosan selects nfxB mutants overexpressing MexCD-OprJ. Antimicrob. Agents Chemother. 45:428-432.
4. Fraise, A. P. 2002. Biocide abuse and antimicrobial resistance - a cause for concern? J. Antimicrob. Chemother. 49:11-12.
5. Gilbert, P., and A. J. McBain. 2003. Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance. Clin. Microbiol. Rev. 16:189-208.
6. Giuliana, G., G. Pizzo, M. E. Milici, G. C. Musotto, and R. Giangreco. 1997. In vitro antifungal properties of mouthrinses containing antimicrobial agents. J. Periodontol. 68:729-733.
7. Giuliana, G., G. Pizzo, M. E. Milici, and R. Giangreco. 1999. In vitro activities of antimicrobial agents against Candida species. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 87:44-49.
8. Henry, K. W., M. C. Cruz, S. K. Katiyar, and T. D. Edlind. 1999. Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents. Antimicrob. Agents Chemother. 43:1968-1974.
9. Hiom, S. J., J. R. Furr, A. D. Russell, and J. R. Dickinson. 1993. Effects of chlorhexidine diacetate and cetylpyridinium chloride on whole cells and protoplasts of Saccharomyces cerevisiae. Microbios 74:111-120.
10. McDonnell, G., and A. D. Russell. 1999. Antiseptics and disinfectants: activity, action, and resistance. Clin. Microbiol. Rev. 12:147-179.
11. Meier, S., C. Collier, M. G. Scaletta, J. Stephens, R. Kimbrough, and J. D. Kettering. 1996. An in vitro investigation of the efficacy of CPC for use in toothbrush decontamination. J. Dent. Hyg. 70:161-165.
12. Nakamoto, K., M. Tamamoto, and T. Hamada. 1995. In vitro effectiveness of mouthrinses against Candida albicans. Int. J. Prosthod. 8:486-489.
13. Perea, S., J. L. López-Ribot, W. R. Kirkpatrick, R. K. McAtee, R. A. Santillán, M. Martínez, D. Calabrese, D. Sanglard, and T. F. Patterson. 2001. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 45:2676-2684.
14. Phillips, B. J., and W. Kaplan. 1976. Effect of cetylpyridinium chloride on pathogenic fungi and Nocardia asteroides in sputum. J. Clin. Microbiol. 3:272-276.
15. Rex, J. H., P. W. Nelson, V. L. Paetznick, M. Lozano-Chiu, A. Espinel-Ingroff, and E. J. Anaissie. 1998. Optimizing the correlation between results of testing in vitro and therapeutic outcome in vivo for fluconazole by testing critical isolates in a murine model of invasive candidiasis. Antimicrob. Agents Chemother. 42:129-134.
16. Russell, A. D. 2002. Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation. J. Antimicrob. Chemother. 49:597-599.
17. Sanglard, D., F. Ischer, M. Monod, and J. Bille. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143:405-416.
18. Sanglard, D., and F. C. Odds. 2002. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect. Dis. 2:73-85.
19. Smith, W. L., and T. D. Edlind. 2002. Histone deacetylase inhibitors enhance Candida albicans sensitivity to azoles and related antifungals: correlation with reduction in CDR and ERG upregulation. Antimicrob. Agents Chemother. 46:3532-3539.
20. White, T. C., S. Holleman, F. Dy, L. F. Mirels, and D. A. Stevens. 2002. Resistance mechanisms in clinical isolates of Candida albicans. Antimicrob. Agents. Chemother. 46:1704-1713.