Antibiotic pharmacokinetic and pharmacodynamic considerations in critical illness

Intensive Care Medicine

Volumn 30, Issue 12, 2004, Pages 2145-2156

  Mehrotra, Rina ^a   De Gaudio, Raffaele ^b   Palazzo, Mark ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

^b UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Antibiotic activity; Critical care patients; Dose optimasation; Pharmacodynamics; Pharmacokinetics

Indexed keywords

AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMOXICILLIN; AMPHOTERICIN B; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; BETA LACTAM ANTIBIOTIC; CARBAPENEM DERIVATIVE; CEFOTAXIME; CEFTAZIDIME; CEFTRIAXONE; CEFUROXIME; CEPHALOSPORIN DERIVATIVE; CLINDAMYCIN; ERYTHROMYCIN; FLUCYTOSINE; GENTAMICIN; GLYCOPEPTIDE; IMIDAZOLE DERIVATIVE; IMIPENEM; LINEZOLID; MACROLIDE; MEROPENEM; METRONIDAZOLE; PENICILLIN G; PIPERACILLIN; TAZOBACTAM; TEICOPLANIN; TOBRAMYCIN; UNINDEXED DRUG; VANCOMYCIN;

ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; AREA UNDER THE CURVE; BACTERIAL MENINGITIS; BIOEQUIVALENCE; CONCENTRATION RESPONSE; COST CONTROL; CRITICAL ILLNESS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COST; DRUG DISTRIBUTION; DRUG DOSE REDUCTION; DRUG EFFECT; DRUG EFFICACY; DRUG ELIMINATION; DRUG EXCRETION; DRUG MECHANISM; DRUG METABOLISM; DRUG MONITORING; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG TISSUE LEVEL; ENDOCARDITIS; ENTEROBACTER INFECTION; HOSPITAL INFECTION; HUMAN; INTENSIVE CARE; KIDNEY DISEASE; LIVER DYSFUNCTION; LIVER METABOLISM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PNEUMONIA; REVIEW;

ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; CRITICAL CARE; HUMANS; KIDNEY; LIVER; METABOLIC CLEARANCE RATE; MICROBIAL SENSITIVITY TESTS; PROTEIN BINDING; TISSUE DISTRIBUTION;

EID: 12944307865     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-004-2428-9     Document Type: Review

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