Mimotope-hormesis and mortalin/grp75/mthsp70: A new hypothesis on how infectious disease-associated epitope mimicry may explain low cancer burden in developing nations

FEBS Letters

Volumn 579, Issue 3, 2005, Pages 586-590

  Deocaris, Custer C ^a,b,c   Taira, Kazunari ^a,b   Kaul, Sunil C ^a   Wadhwa, Renu ^a  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c PHILIPPINE NUCLEAR RESEARCH INSTITUTE   (Philippines)

Author keywords

Autoimmunity; Cancer; Heat shock protein; Mimotope; Mortalin

Indexed keywords

HEAT SHOCK PROTEIN;

ARTICLE; AUTOIMMUNITY; CANCER; CANCER PREVENTION; CANCER SURVIVAL; CARCINOGENESIS; CELL IMMORTALIZATION; CELL PROLIFERATION; DEVELOPING COUNTRY; HORMESIS; IMMUNE SYSTEM; INFECTION; NUCLEOTIDE SEQUENCE; ONSET AGE; PATHOGENESIS; PRIORITY JOURNAL;

COMMUNICABLE DISEASES; DEVELOPING COUNTRIES; EPITOPES; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MEMBRANE PROTEINS; MOLECULAR MIMICRY; NEOPLASMS;

EID: 12744277354     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.11.108     Document Type: Article

References (63)

1. H. Kuper, H.O. Adami, and D. Trichopoulos Infections as a major preventable cause of human cancer J. Intern. Med. 248 2000 171 183
2. W. Ye, M. Held, J. Lagergren, L. Engstrand, W.J. Blot, J.K. McLaughlin, and O. Nyren Helicobacter pylori infection and gastric atrophy: risk of adenocarcinoma and squamous-cell carcinoma of the esophagus and adenocarcinoma of the gastric cardia J. Natl. Cancer Inst. 96 2004 388 396
3. A.K. Vijh High infectious burden, low cancer incidence, and early malignancy in developing countries: a molecular hypothesis in term of the role of nitric oxide Med. Hypotheses 63 2004 208 210
4. A.K. Vijh Observations on the proposed relationship between infection burden and early malignancy in developing countries (e.g., India) Med. Hypotheses 62 2004 233 236
5. C.J. Murray, and A.D. Lopez Mortality by cause for eight regions of the world: global burden of disease study Lancet 349 1997 1269 1276
6. H. Kato, W.J. Schull, A. Awa, M. Akiyama, and M. Otake Dose-response analyses among atomic bomb survivors exposed to low-level radiation Health Phys. 52 1987 645 652
7. A. Yakovlev, A.D. Tsodikov, and L. Bass A stochastic model of hormesis Math. Biosci. 116 1993 197 219
8. T.N. Kristensen, J.G. Sorensen, and V. Loeschcke Mild heat stress at a young age in Drosophila melanogaster leads to increased Hsp70 synthesis after stress exposure later in life J. Genet. 82 2003 89 94
9. P. Verbeke, B.F. Clark, and S.I. Rattan Modulating cellular aging in vitro: hormetic effects of repeated mild heat stress on protein oxidation and glycation Exp. Gerontol. 35 2000 787 794
10. M.J. Hercus, V. Loeschcke, and S.I. Rattan Lifespan extension of Drosophila melanogaster through hormesis by repeated mild heat stress Biogerontol. 4 2003 149 156
11. S.I. Rattan Mechanisms of hormesis through mild heat stress on human cells Ann. NY Acad. Sci. 1019 2004 554 558
12. T.D. Luckey Nurture with ionizing radiation: a provocative hypothesis Nutr. Cancer 34 1999 1 11
13. M. Sioud How does autoimmunity cause tumor regression. A potential mechanism involving cross-reaction through epitope mimicry Mol. Med. 8 2002 115 119
14. L. Xu, B.Q. Jin, and D.M. Fan Selection and identification of mimic epitopes for gastric cancer-associated antigen MG7 Ag Mol. Cancer Ther. 2 2003 301 306
15. T. Linnemann, S. Tumenjargal, S. Gellrich, K. Wiesmuller, K. Kaltoft, W. Sterry, and P. Walden Mimotopes for tumor-specific T lymphocytes in human cancer determined with combinatorial peptide libraries Eur. J. Immunol. 31 2001 156 165
16. S. Tumenjargal, S. Gellrich, T. Linnemann, J.M. Muche, A. Lukowsky, H. Audring, K.H. Wiesmuller, W. Sterry, and P. Walden Anti-tumor immune responses and tumor regression induced with mimotopes of a tumor-associated T cell epitope Eur. J. Immunol. 33 2003 3175 3185
17. A.B. Riemer, M. Klinger, S. Wagner, A. Bernhaus, L. Mazzucchelli, H. Pehamberger, O. Scheiner, C.C. Zielinski, and E. Jensen-Jarolim Generation of Peptide mimics of the epitope recognized by trastuzumab on the oncogenic protein Her-2/neu J. Immunol. 173 2004 394 401
18. T. Sherev, K.H. Wiesmuller, and P. Walden Mimotopes of tumor-associated T-cell epitopes for cancer vaccines determined with combinatorial peptide libraries Mol. Biotechnol. 25 2003 53 61
19. M.H. Hansen, B. Ostenstad, and M. Sioud Identification of immunogenic antigens using a phage-displayed cDNA library from an invasive ductal breast carcinoma tumour Int. J. Oncol. 19 2001 1303 1309
20. S.H. Kaufmann Heat shock proteins and autoimmunity: facts or fiction? Curr. Biol. 1 1991 359 361
21. D.G. Millar, K.M. Garza, B. Odermatt, A.R. Elford, N. Ono, Z. Li, and P.S. Ohashi Hsp70 promotes antigen-presenting cell function and converts T-cell tolerance to autoimmunity in vivo Nat. Med. 9 2003 1469 1476
22. J. Palo, J. Duchesne, and J. Wilkstrom Malignant diseases among patients with multiple sclerosis J. Neurol. 216 1977 217 222
23. P.R. Clark, and A. Menoret The inducible Hsp70 as a marker of tumor immunogenicity Cell Stress Chaperones 6 2001 121 125
24. X.Y. Wang, Y. Kaneko, E. Repasky, and J.R. Subjeck Heat shock proteins and cancer immunotherapy Immunol. Invest. 29 2000 131 137
25. S.M. Todryk, M.J. Gough, and A.G. Pockley Facets of heat shock protein 70 show immunotherapeutic potential Immunologist 110 2003 1 9
26. C. Massa, C. Guiducci, I. Arioli, M. Parenza, M.P. Colombo, and C. Melani Enhanced efficacy of tumor cell vaccines transfected with secretable hsp70 Cancer Res. 64 2004 1502 1508
27. A.G. Pockley Heat shock proteins as regulators of the immune response Lancet 362 2003 469 476
28. E. Weigl, P. Kopecek, M. Raska, and S. Hradilova Heat shock proteins in immune reactions Folia Microbiol. 44 1999 561 566
29. J.D. Smiley, and W.L. Hoffman The role of infections in the rheumatic diseases: molecular mimicry between bacterial and human stress proteins? Am. J. Med. Sci. 301 1991 138 149
30. C. Benoist, and D. Mathis Autoimmunity provoked by infection: how good is the case for T cell epitope mimicry? Nat. Immunol. 2 2001 797 801
31. C. Karopoulos, M.J. Rowley, C.J. Handley, and R.A. Strugnell Antibody reactivity to mycobacterial 65 kDa heat shock protein: relevance to autoimmunity J. Autoimmun. 8 1995 235 248
32. J. Zhu, R.J. Katz, A.A. Quyyumi, D.A. Canos, D. Rott, G. Csako, A. Zalles-Ganley, J. Ogunmakinwa, A.G. Wasserman, and S.E. Epstein Association of serum antibodies to heat-shock protein 65 with coronary calcification levels: suggestion of pathogen-triggered autoimmunity in early atherosclerosis Circulation 109 2004 36 41
33. A. Rambukkana, P.K. Das, L. Witkamp, S. Yong, M.M. Meinardi, and J.D. Bos Antibodies to mycobacterial 65-kDa heat shock protein and other immunodominant antigens in patients with psoriasis J. Invest. Dermatol. 100 1993 87 92
34. P. Jensen, H.K. Johansen, P. Carmi, N. Hoiby, and I.R. Cohen Autoantibodies to pancreatic hsp60 precede the development of glucose intolerance in patients with cystic fibrosis J. Autoimmun. 17 2001 165 172
35. S. Yokota, K. Tsubaki, T. Kuriyama, H. Shimizu, M. Ibe, T. Mitsuda, Y. Aihara, K. Kosuge, and H. Nomaguchi Presence in Kawasaki disease of antibodies to mycobacterial heat-shock protein HSP65 and autoantibodies to epitopes of human HSP65 cognate antigen Clin. Immunol. Immunopathol. 67 1993 163 170
36. T. Lehner The role of heat shock protein, microbial and autoimmune agents in the aetiology of Behcet's disease Int. Rev. Immunol. 14 1997 21 32
37. I. Raz, D. Elias, A. Avron, M. Tamir, M. Metzger, and I.R. Cohen Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial Lancet 358 2001 1749 1753
38. M. Salvetti, C. Buttinelli, G. Ristori, M. Carbonari, M. Cherchi, M. Fiorelli, M.G. Grasso, L. Toma, and C. Pozzilli T-lymphocyte reactivity to the recombinant mycobacterial 65- and 70-kDa heat shock proteins in multiple sclerosis J. Autoimmun. 5 1992 691 702
39. U. Wendling, L. Paul, R. van der Zee, B. Prakken, M. Singh, and W. van Eden A conserved mycobacterial heat shock protein (hsp) 70 sequence prevents adjuvant arthritis upon nasal administration and induces IL-10-producing T cells that cross react with the mammalian self-hsp70 homologue J. Immunol. 164 2000 2711 2717
40. U. Zugel, and S.H.E. Kaufmann Role of heat shock proteins in protection from pathogenesis of infectious diseases Clin. Microbiol. Rev. 12 1999 19 39
41. P.J. Mintz, J. Kim, K.A. Do, X. Wang, R.G. Zinner, M. Cristofanilli, M.A. Arap, W.K. Hong, P. Troncoso, C.J. Logothetis, R. Pasqualini, and W. Arap Fingerprinting the circulating repertoire of antibodies from cancer patients Nat. Biotechnol. 21 2003 57 63
42. R. Wadhwa, S.C. Kaul, Y. Ikawa, and Y. Sugimoto Identification of a novel member of mouse hsp70 family. Its association with cellular mortal phenotype J. Biol. Chem. 268 1993 6615 6621
43. R. Wadhwa, K. Taira, and S.C. Kaul An Hsp70 family chaperone, mortalin/mthsp70/PBP74/Grp75: what, when, and where? Cell Stress Chaperones 7 2002 309 316
44. S.C. Kaul, K. Taira, O.M. Pereira-Smith, and R. Wadhwa Mortalin: present and prospective Exp. Gerontol. 37 2002 1157 1164
45. S.Z. Domanico, D.C. DeNagel, J.N. Dahlseid, J.M. Green, and S.K. Pierce Cloning of the gene encoding peptide-binding protein 74 shows that it is a new member of the heat shock protein 70 family Mol. Cell. Biol. 13 1993 3598 3610
46. S. Sadekova, S. Lehnert, and T.Y. Chow Induction of PBP74/mortalin/Grp75, a member of the hsp70 family, by low doses of ionizing radiation: a possible role in induced radioresistance Int. J. Radiat. Biol. 72 1997 653 660
47. J.N. Dahlseid, R. Lill, J.M. Green, X. Xu, Y. Qiu, and S.K. Pierce PBP74, a new member of the mammalian 70-kDa heat shock protein family, is a mitochondrial protein Mol. Biol. Cell 5 1994 1265 1275
48. R. Wadhwa, O.M. Pereira-Smith, R.R. Reddel, Y. Sugimoto, Y. Mitsui, and S.C. Kaul Correlation between complementation group for immortality and the cellular distribution of mortalin Exp. Cell Res. 216 1995 101 106
49. Q. Ran, R. Wadhwa, R. Kawai, S.C. Kaul, R.N. Sifers, R.J. Bick, J.R. Smith, and O.M. Pereira-Smith Extramitochondrial localization of mortalin/mthsp70/PBP74/GRP75 Biochem. Biophys. Res. Commun. 275 2000 174 179
50. B.K. Shin, H. Wang, A.M. Yim, F. Le Naour, F. Brichory, J.H. Jang, R. Zhao, E. Puravs, J. Tra, C.W. Michael, D.E. Misek, and S.M. Hanash Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function J. Biol. Chem. 278 2003 7607 7616
51. H. Bian, J.F. Reidhaar-Olson, and J. Hammer The use of bioinformatics for identifying class II-restricted T-cell epitopes Methods 29 2003 299 309
52. T. Sturniolo, E. Bono, J. Ding, L. Raddrizzani, O. Tuereci, U. Sahin, M. Braxenthaler, F. Gallazzi, M.P. Protti, F. Sinigaglia, and J. Hammer Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices Nat. Biotechnol. 17 1999 555 561
53. B. Cochlovius, M. Stassar, O. Christ, L. Raddrizzani, J. Hammer, I. Mytilineos, and M. Zoller In vitro and in vivo induction of a Th cell response toward peptides of the melanoma-associated glycoprotein 100 protein selected by the TEPITOPE program J. Immunol. 165 2000 4731 4741
54. G. Consogno, S. Manici, V. Facchinetti, A. Bachi, J. Hammer, B.M. Conti-Fine, C. Rugarli, C. Traversari, and M.P. Protti Identification of immunodominant regions among promiscuous HLA-DR-restricted CD4+ T-cell epitopes on the tumor antigen MAGE-3 Blood 101 2003 1038 1044
55. A.L. Meyer, C. Trollmo, F. Crawford, P. Marrack, A.C. Steere, B.T. Huber, J. Kappler, and D.A. Hafler Direct enumeration of Borrelia-reactive CD4 T cells ex vivo by using MHC class II tetramers Proc. Natl. Acad. Sci. USA 97 2000 11433 11438
56. W.W. Kwok, J.A. Gebe, A. Liu, S. Agar, N. Ptacek, J. Hammer, D.M. Koelle, and G.T. Nepom Rapid epitope identification from complex class-II-restricted T-cell antigens Trend Immunol. 22 2001 583 588
57. P.R. Murray, K.S. Rosenthal, G.S. Kobayashi, and M.A. Pfaller Medical Microbiology 3rd ed. 1998 Mosby-Year Book, Inc. St. Louis, MO
58. P. Minden, T.R. Sharpton, and J.K. McClatchy Shared antigens between human malignant melanoma cells and Mycobacterium bovis (BCG) J. Immunol. 116 1976 1407 1414
59. V. Shevliagin, A.E. Snegireva, G.M. Shaposhnikova, I.A. Lapaeva, and V.G. Petrukhin The effect of gram-negative bacteria lipopolysaccharides on the development of Rauscher leukosis in BALB/c mice Zh. Mikrobiol. Epidemiol. Immunobiol. 4 1989 14 17
60. E.B. Rankin, D. Yu, J. Jiang, H. Shen, E.J. Pearce, M.H. Goldschmidt, D.E. Levy, T.V. Golovkina, C.A. Hunter, and A. Thomas-Tikhonenko An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth Cancer Biol. Ther. 2 2003 687 693
61. C. Kohchi, H. Inagawa, M. Hino, M. Oda, K. Nakata, A. Yoshida, H. Hori, H. Terada, K. Makino, K. Takiguchi, and G. Soma Utilization of macrophages in anticancer therapy: the macrophage network theory Anticancer Res. 24 2004 3311 3320
62. A.Y. Abdel-Rahim Parasitic infections and hepatic neoplasia Dig. Dis. 19 2001 288 291
63. M.I. Gutierrez, A.K. Siraj, H. Khaled, N. Koon, W. El-Rifai, and K. Bhatia CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer Mod. Pathol. 17 2004 1268 1274