Guanine nucleotide depletion induces differentiation and aberrant neurite outgrowth in human dopaminergic neuroblastoma lines: A model for basal ganglia dysfunction in Lesch-Nyhan disease

Neuroscience Letters

Volumn 375, Issue 2, 2005, Pages 97-100

  Messina, Elisa ^a   Micheli, Vanna ^b   Giacomello, Alessandro ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

Author keywords

GDP; GTP; Mycophenolic acid; Neuroblastoma cell lines; p27; Retinoic acid

Indexed keywords

GUANINE NUCLEOTIDE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; INOSINATE DEHYDROGENASE; MYCOPHENOLIC ACID; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P21; PROTEIN P27; PROTEIN P53; RETINOIC ACID;

ARTICLE; BASAL GANGLION; BRAIN DEVELOPMENT; BRAIN DYSFUNCTION; CELL LINE; CELL STRUCTURE; CHOLINERGIC NERVE CELL; CLINICAL FEATURE; COGNITION; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME INHIBITION; GENE CONTROL; HUMAN; HUMAN CELL; LESCH NYHAN SYNDROME; NERVE CELL CULTURE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; OBSERVATION; PHENOTYPE; PRIORITY JOURNAL; UPREGULATION;

BASAL GANGLIA; BASAL GANGLIA DISEASES; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; CELL ENLARGEMENT; CELL LINE; ENZYME INHIBITORS; GUANINE NUCLEOTIDES; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; IMP DEHYDROGENASE; LESCH-NYHAN SYNDROME; MODELS, NEUROLOGICAL; MYCOPHENOLIC ACID; NEURITES; NEUROBLASTOMA; NEUROFILAMENT PROTEINS; TRETINOIN; UP-REGULATION;

EID: 12744256726     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2004.10.076     Document Type: Article

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