Severe pyridine nucleotide depletion in fibroblasts from Lesch-Nyhan patients

Biochemical Journal

Volumn 366, Issue 1, 2002, Pages 265-272

  Fairbanks, Lynette D ^a   Jacomelli, Gabriella ^a   Micheli, Vanna ^a   Slade, Tina ^a   Simmonds, H Anne ^a  

^a GUY S HOSPITAL   (United Kingdom)

Author keywords

Lesch Nyhan disease; NAD; Neurological deficit; Purine; Pyrimidine nucleotide

Indexed keywords

DISEASES; DNA; METABOLISM;

PATHOPHYSIOLOGY;

ENZYMES;

CYTIDINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PYRIDINE NUCLEOTIDE; URIDINE; URIDINE DIPHOSPHATE;

ANIMAL CELL; APOPTOSIS; ARTICLE; BASAL GANGLION; CELL CULTURE; COGNITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE SEVERITY; DNA REPAIR; DOPAMINERGIC NERVE CELL; FIBROBLAST; HUMAN; HUMAN CELL; ISOTOPE LABELING; LESCH NYHAN SYNDROME; LYMPHOBLAST; NERVE CELL LESION; NONHUMAN; NUCLEOTIDE METABOLISM; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PURINE METABOLISM; PYRIMIDINE METABOLISM;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTIDINE TRIPHOSPHATE; DNA REPAIR; FIBROBLASTS; GUANOSINE TRIPHOSPHATE; HUMANS; LESCH-NYHAN SYNDROME; MODELS, BIOLOGICAL; NEURONS; PURINES; PYRIDINES; TIME FACTORS;

ANIMALIA;

EID: 0037103748     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20020148     Document Type: Article

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