Expression of human islet amyloid polypeptide/amylin impairs insulin secretion in mouse pancreatic β cells

Metabolism: Clinical and Experimental

Volumn 46, Issue 9, 1997, Pages 1044-1051

  Tokuyama, Tatsuhiko ^b   Yagui, Kazuo ^b   Yamaguchi, Takahide ^b   Huang, Choung I ^b   Kuramoto, Nobuhiko ^b   Shimada, Fumio ^b   Miyazaki, Jun Ichi ^b   Horie, Hiroshi ^b   Saito, Yasushi ^b   Makino, Hideichi ^b   Kanatsuka, Azuma ^a  

^a CHIBA UNIVERSITY   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMYLIN; AMYLOID; INSULIN; PROINSULIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC TRANSFECTION; IMMUNOHISTOCHEMISTRY; IMPAIRED GLUCOSE TOLERANCE; INSULIN RELEASE; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; NORTHERN BLOTTING; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; TRANSGENIC MOUSE;

EID: 12644318780     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0026-0495(97)90276-6     Document Type: Article

References (38)

1. Opie E: The relation of diabetes mellitus to lesion of the pancreas. Hyaline degeneration of the islands of Langerhans. J Exp Med 5:527-540, 1901
2. Westermark P, Wernstedt C, Wilander E, et al: Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells. Proc Natl Acad Sci USA 84:3881-3885, 1987
3. Cooper GJS, Willis AC, Clark A, et al: Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients, Proc Natl Acad Sci USA 84:8628-8632, 1987
4. Kanatsuka A, Makino H, Yamaguchi T, et al: Islet amyloid polypeptide/amylin in pancreatic β-cell line derived from transgenic mouse insulinoma. Diabetes 41:1409-1414, 1992
5. Lukinius A, Wilandar E, Westermark GT, et al: Co-localization of islet amyloid polypeptide and insulin in the B cell secretory granules of the human pancreatic islets. Diabetologia 32:240-244, 1989
6. Kanatsuka A, Makino H, Ohsawa H, et al: Secretion of islet amyloid polypeptide in response to glucose. FEBS Lett 259:199-201, 1989
7. Ohsawa H, Kanatsuka A, Yamaguchi T, et al: Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets. Biochem Biophys Res Commun 160:961-967, 1989
8. Silvestre RA, Peiro E, Degano P, et al: Inhibitory effect of rat amylin on the insulin response to glucose and arginine in the perfused rat pancreas. Regul Pept 31:23-31, 1990
9. Leighton B, Cooper GJS: Pancreatic amylin and calcitonin gene-related peptide cause resistance to insulin in skeletal muscle in vitro. Nature 335:632-635, 1988
10. Tokuyama Y, Kanatsuka A, Ohsawa H, et al: Hypersecretion of islet amyloid polypeptide from pancreatic islets of ventromedial hypothalamic-lesioned rats and obese Zucker rats. Endocrinology 128:2739-2744, 1991
11. Tokuyama Y, Kanatsuka A, Yamaguchi T, et al: Islet amyloid polypeptide/amylin contents in pancreata increase in genetically obese and diabetic mice. Horm Metab Res 25:289-291, 1992
12. Johnson KH, O'Brien TD, Jordan K, et al: Impaired glucose tolerance is associated with increased islet amyloid polypeptide (IAPP) immunoreactivity in pancreatic beta cells. Am J Pathol 135:245-250, 1989
13. Howard CF: Longitudinal studies on the development of diabetes in individual Macaca, nigra. Diabetologia 29:301-306, 1986
14. Westermark P, Erigstrom U, Johnson KH, et al: Islet amyloid polypeptide: Pinpointing amino acid residues linked to amyloid fibril formation. Proc Natl Acad Sci USA 87:5036-5040, 1990
15. Yagui K, Yamaguchi T, Kanatsuka A, et al: Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin. Eur J Endocrinol 132:487-496, 1995
16. Miyazaki J, Araki K, Yamato E, et al: Establishment of a pancreatic β cell line that retains glucose-inducible insulin secretion: Special reference to expression of glucose transporter isoforms. Endocrinology 127:126-132, 1990
17. Chomczynski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159, 1987
18. Kanatsuka A, Makino H, Matsushima Y, et al: Effect of glucose in somatostatin secretion from isolated pancreatic islets of normal and streptozotocin-diabetic rats. Endocrinology 109:652-657, 1981
19. Sanke T, Bell GI, Sample C, et al: An islet amyloid peptide is derived from an 89-amino acid precursor by proteolytic processing. J Biol Chem 263:17243-17246, 1988
20. Niwa H, Yamamura K, Miyazaki J: Efficient selection for high-expression transfectants with novel eukaryotic vector. Gene 108: 193-200, 1991
21. Felgner PL, Gadek TR, Holm M, et al: Lipofectin: A highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84:7413-7417, 1987
22. Kanatsuka A, Makino H, Yagui K, et al: Islet amyloid polypeptide and its N-terminal and C-terminal flanking peptides' immunoreactivity in islet amyloid of diabetic patients. Diabetes Res Clin Pract 26:101-107, 1994
23. Ohsawa H, Kanatsuka A, Tokuyama Y, et al: Amyloid protein in somatostatinoma differs from human islet amyloid polypeptide. Acta Endocrinol (Copenh) 124:45-53, 1991
24. Bennet WM, Smith DM, Bloom SR: Islet amyloid polypeptide: Does it play a pathophysiological role in the development of diabetes? Diabet Med 11:825-829, 1994
25. Degano P, Silvestre RA, Salas M, et al: Amylin inhibits glucose-induced insulin secretion in a dose-dependent manner. Study in the perfused rat pancreas. Regul Pept 43:91-96, 1993
26. Wang ZL, Bennet WM, Ghatei MA, et al: Influence of islet amyloid polypeptide and the 8-37 fragment of islet amyloid polypeptide on insulin release from perifused rat islets. Diabetes 42:330-335, 1993
27. Bennet WM, Beis CS, Ghatei MA, et al: Amylin tonally regulates arginine-stimulated insulin secretion in rats. Diabetologia 37:436-438, 1994
28. Lorenzo A, Razzaboni B, Weir GC, et al: Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756-760, 1994
29. Wagoner PK, Chen C, Worley JF, et al: Amylin modulates β-cell glucose sensing via effects on stimulus-secretion coupling. Proc Natl Acad Sci USA 90:9145-9149, 1993
30. Höppener JWM, Verbeek JS, de Koning EJP, et al: Chronic overproduction of islet amyloid polypeptide/amylin in transgenic mice: Lysosomal localization of human islet amyloid polypeptide and lack of marked hyperglycaemia or hyperinsulinaemia. Diabetologia 36:1258-1265, 1993
31. Nagamatsu S, Carroll RJ, Grodsky GM, et al: Lack of islet amyloid polypeptide regulation of insulin biosynthesis or secretion in normal rat islets. Diabetes 39:871-874, 1990
32. Verchere CB, D'Alessio DA, Palmiter RD, et al: Transgenic mice overproducing islet amyloid polypeptide have increased insulin storage and secretion in vitro. Diabetologia 37:725-728, 1994
33. D'Alessio DA, Verchere CB, Kahn SE, et al: Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse. Diabetes 43:1457-1461, 1994
34. Stridsberg M, Berne C, Sandier S, et al: Inhibition of insulin secretion, but normal peripheral insulin sensitivity, in a patient with a malignant endocrine pancreatic tumour producing high amount of an islet amyloid polypeptide-like molecule. Diabetologia 36:843-849, 1993
35. Butler PC, Chou J, Carter WB, et al: Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans. Diabetes 39:752-756, 1990
36. Sanke T, Hanabusa T, Nakano Y, et al: Plasma islet amyloid polypeptide (amylin) levels and their responses to oral glucose in type 2 (non-insulin-dependent) diabetic patients. Diabetologia 34:129-132, 1991
37. Verchere CB, D'Alessio DA, Palmiter RD, et al: Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide. Proc Natl Acad Sci USA 93:3492-3496, 1996
38. Janson J, Soeller WC, Roche PC, et al: Spontaneous diabetes mellitus in transgenic mice expressing human islet amyloid polypeptide. Proc Natl Acad Sci USA 93:7283-7288, 1996